ACPD (1-aminocyclopentane-1,3-dicarboxylic acid) is identified as the mGlu selective agonist. Within the 4 stereoisomers, 1S,3R-ACPD activates group-I and group-II mGlu receptors as well as some group-III receptors (mGlu8) at higher concentrations. The 1S,3S-ACPD isomer is one of the first selective group-II mGlu receptor agonists described. These molecules have been widely used to identify the possible physiological functions of mGlu receptors.
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© 2004 Springer-Verlag
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(2004). ACPD. In: Encyclopedic Reference of Molecular Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29832-0_13
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DOI: https://doi.org/10.1007/3-540-29832-0_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-42843-5
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