Synonyms
Paracetamol.
Trade Names
Tylenol.
Class and Category
Analgesic; antipyretic.
Indications
Arthralgia; dental pain; dysmenorrhea; fever; headache; mild pain; myalgia; osteoarthritis.
Dosage
Adults and children age 12: 325–650mg orally or per rectum every 4–6 hours as needed; or 1000mg orally or per rectum 2–4 times per day. Maximum of 1000mg per dose and 4000mg per day. Children and infants: 10–15mg/kg orally or per rectum every 4–6 hours. Maximum of 5 doses in 24 hours. Neonates: 10–15mg/kg every 6–8 hours.
Contraindications
Relative contraindications: severe liver disease, alcoholism, and prior hypersensitivity reactions to acetaminophen.
Adverse Reactions
Hepatoxicity may occur after acute overdose, or with chronic excessive intake. Acetaminophen in combination with other analgesics may contribute to analgesic nephropathy. Methemoglobinemia with acute overdose.
Drug Interactions
Diflunisal increases acetaminophen drug levels. Regular ethanol consumption increases risk of...
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References
Roberts LJ 2nd, Morrow JD (2001) Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In: Hardman JG, Limbird LE (eds) Pharmacological Basis of Therapeutics, 9th ed. McGraw-Hill, New York, pp 687–731
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© 2004 Springer-Verlag
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(2004). Acetaminophen. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_13
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DOI: https://doi.org/10.1007/3-540-29662-X_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
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