Definition
Nonlymphoid cells which are required to induce a T-cell dependent immune response.
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Accessory cells are nonlymphoid cells such as macrophages, dendritic cells, and Langerhans cells (epithelial dendritic cells) that function to present antigens to MHC-restricted T cells. They are not antigen specific and they present different costimulatory molecules, either soluble cytokines or memebrane bound peptides, with the antigen to the T-cells. The specific combination of antigen, MHC-restricted T cell, and expressed costimulatory molecules determines the specific immune response.
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References
Yung RL (2000) Geriatric rheumatology, changes in immune function with age. Rheum Dis Clin North Am 26:455–73
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© 2004 Springer-Verlag
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(2004). Accessory cells. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_11
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DOI: https://doi.org/10.1007/3-540-29662-X_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
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