Introduction
All members of the genus Haemophilus are small, pleomorphic, Gram-negative coccobacilli. The genus consists of diverse species, including some that are pathogens in humans and others that are pathogens in animals. Additional species are commensal organisms and are not associated with disease. The type species is H. influenzae, which was first isolated during the 1889 influenza pandemic and was originally believed to be the causative agent of influenza.
Taxonomy
Over the years, the taxonomy of the genus Haemophilus has been subject to considerable revision. At one time Haemophilus was included in the family Brucellaceae. In the eighth edition of [{http:\\www.cme.msu.edu\bergeys}{Bergey’s Manual of Determinative Bacteriology}] (Zinnemann and Biberstein, 1974), this genus was grouped with “Genera of Uncertain Affiliation.” Since 1984, Haemophilus has been included along with Actinobacillus and Pasteurella in the family Pasteurellaceae (Kilian and Biberstein, 1984).
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Literature Cited
American Academy of Pediatrics Committee on Infectious Diseases. 1985 Haemophilus influenzae type b polysaccharide vaccine Pediatrics 76 322–324
Adeyemi-Doro, F. A., A. C. Hui, F. N. Ho, and M. Ip. 1998 Haemophilus aphrophilus meningitis complicated by hydrocephalus in an immunocompetent adult Infection 26 405–407
Adhikari, P., S. D. Kirby, A. J. Nowalk, K. L. Veraldi, A. B. Schryvers, and T. A. Mietzner. 1995 Biochemical characterization of a Haemophilus influenzae periplasmic iron transport operon J. Biol. Chem. 270 25142–25149
Akkoyunlu, M., M. Ruan, and A. Forsgren. 1991 Distribution of protein D, an immunoglobulin D-binding protein, in Haemophilus strains Infect. Immun. 59 1231–1238
Albritton, W. L. 1989 Biology of Haemophilus ducreyi Microbiol. Rev. 53 377–389
Alexander, H. E., and G. Leidy. 1951 Induction of heritable new type in type-specific strains of H. influenzae Proc. Soc. Exp. Biol. Med. 78 625–626
Alexander, H. E., G. Leidy, and E. Hahn. 1954 Studies on the nature of Haemophilus influenzae cells susceptible to heritable changes by desoxyribonucleic acids J. Exp. Med. 99 505–533
Alfa, M. J., P. DeGagne, and P. A. Totten. 1996 Haemophilus ducreyi hemolysin acts as a contact cytotoxin and damages human foreskin fibroblasts in cell culture Infect. Immun. 64 2349–2352
Al-Tawfiq, J. A., K. R. Fortney, B. P. Katz, A. F. Hood, C. Elkins, and S. M. Spinola. 2000 An isogenic hemoglobin receptor-deficient mutant of Haemophilus ducreyi is attenuated in the human model of experimental infection J. Infect. Dis. 181 1049–1054
Anderson, P., G. Peter, R. B. Johnston Jr., L. H. Wetterlow, and D. H. Smith. 1972 Immunization of humans with polyribophosphate, the capsular antigen of Haemophilus influenzae, type b J. Clin. Invest. 51 39–44
Bangsborg, J. M., M. Tvede, and P. Skinhoj. 1988 Haemophilus segnis endocarditis J. Infect. 16 81–85
Barany, F., M. E. Kahn, and H. O. Smith. 1983 Directional transport and integration of donor DNA in Haemophilus influenzae transformation Proc. Natl. Acad. Sci. USA 80 7274–7278
Barany, F., and M. E. Kahn. 1985 Comparison of transformation mechanisms of Haemophilus parainfluenzae and Haemophilus influenzae J. Bacteriol. 161 72–79
Barcak, G. J., M. S. Chandler, R. J. Redfield, and J. F. Tomb. 1991 Genetic systems in Haemophilus influenzae Methods Enzymol. 204 321–342
Barenkamp, S. J., and E. Leininger. 1992 Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella pertussis Infect. Immun. 60 1302–1313
Barenkamp, S. J. 1996a Immunization with high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae modifies experimental otitis media in Chinchillas Infect. Immun. 64 1246–1251
Barenkamp, S. J., and J. W. St. Geme 3rd. 1996b Identification of a second family of high-molecular-weight adhesion proteins expressed by non-typable Haemophilus influenzae Molec. Microbiol. 19 1215–1223
Batista, N., O. Diez, and A. Moreno. 1999 Haemophilus parainfluenzae and cholecystitis: Description of one case and review of the literature Enferm. Infecc. Microbiol. Clin. 17 416–417
Bauer, M. E., and S. M. Spinola. 1999 Binding of Haemophilus ducreyi to extracellular matrix proteins Infect. Immun. 67 2649–2652
Beattie, K. L., and J. K. Setlow. 1970 Transformation between Haemophilus influenzae and Haemophilus parainfluenzae J. Bacteriol. 104 390–400
Beattie, K. L., and J. K. Setlow. 1971 Transformation-defective strains of Haemophilus influenzae Nature New Biol. 231 177–179
Bengston, I. A. 1933 Seasonal acute conjunctivitis occurring in the southern states Public Health Rep. 48 917
Biberstein, E. L., and P. D. Spencer. 1962 Oxidative metabolism of Haemophilus species grown at different levels of hemin supplementation J. Bacteriol. 84 916–920
Biberstein, E. L., P. D. Mini, and M. G. Gills. 1963 Action of Haemophilus cultures on δ-aminolevulinic acid J. Bacteriol. 86 814–819
Bisgard, K. M., A. Kao, J. Leake, P. M. Strebel, B. A. Perkins, and M. Wharton. 1998 Haemophilus influenzae invasive disease in the United States, 1994–1995: Near disappearance of a vaccine-preventable childhood disease Emerg. Infect. Dis. 4 229–237
Boling, M. E., D. P. Allison, and J. K. Setlow. 1973 Bacteriophage of Haemophilus influenzae. 3: Morphology, DNA homology, and immunity properties of HPlcl, S2, and the defective bacteriophage from strain Rd J. Virol. 11 585–591
Botsford, J. L., and J. G. Harman. 1992 Cyclic AMP in prokaryotes Microbiol. Rev. 56 100–122
Brazilian Purpuric Fever Study Group. 1987a Brazilian purpuric fever: Epidemic purpura fulminans associated with antecedent purulent conjunctivitis Lancet 2 757–761
Brazilian Purpuric Fever Study Group. 1987b Haemophilus aegyptius bacteraemia in Brazilian purpuric fever Lancet 2 761–763
Brenner, D. J., L. W. Mayer, G. M. Carlone, L. H. Harrison, W. F. Bibb, M. C. Brandileone, F. O. Sottnek, K. Irino, M. W. Reeves, J. M. Swenson, et al., Birkness, K. A., Weyant, R. S., Berkley, S. F., Woods, T. C., Steigerwalt, A. G., Grimont, P. A. D., McKinney, R. M., Fleming, D. W., Gheesling, L. L., Cooksey, R. C., Arko, R. J., Broome, C. V., and The Brazillian Purpuric Fever Study Group. 1988 Biochemical, genetic, and epidemiologic characterization of Haemophilus influenzae biogroup aegyptius (Haemophilus aegyptius) strains associated with Brazilian purpuric fever J. Clin. Microbiol. 26 1524–1534
Brentjens, R. J., M. Ketterer, M. A. Apicella, and S. M. Spinola. 1996 Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili J. Bacteriol. 178 808–816
Brumfitt, W. 1959 Some growth requirements of Haemophilus influenzae and Haemophilus pertussis J. Pathol. Bacteriol. 77 95–100
Bruns, C. M., A. J. Nowalk, A. S. Arvai, M. A. McTigue, K. G. Vaughan, T. A. Mietzner, and D. E. McRee. 1997 Structure of Haemophilus influenzae Fe3+-binding protein reveals convergent evolution within a superfamily Nature Struct. Biol. 4 919–924
Buehler, J. W., J. T. Holloway, R. A. Goodman, and R. K. Sikes. 1983 Gnat sore eyes: Seasonal, acute conjunctivitis in a southern state South. Med. J. 76 587–589
Bullock, D. W., and P. G. Devitt. 1981 Pancreatic abscess and septicaemia caused by Haemophilus segnis J. Infect. 3 82–85
Busse, J., E. Hartmann, and C. A. Lingwood. 1997 Receptor affinity purification of a lipid-binding adhesin from Haemophilus influenzae J. Infect. Dis 175 77–83
Carson, H. J., S. Rezmer, and J. Belli. 1997 Haemophilus segnis cholecystitis: A case report and literature review J. Infect. 35 85–86
Casari, G., M. A. Andrade, P. Bork, J. Boyle, A. Daruvar, C. Ouzounis, R. Schneider, J. Tamames, A. Valencia, and C. Sander. 1995 Challenging times for bioinformatics Nature 376 647–648
Centers for Disease Control, and Prevention. 1998a 1998 Guidelines for Treatment of Sexually Transmitted Diseases Morb. Mortal. Weekly Rep. 47 1–116
Centers for Disease Control, and Prevention. 1998b Haemophilus influenzae invasive disease among children aged <5 years—California, 1990–1996 Morb. Mortal. Weekly Rep. 47 737–740
Charland, N., C. G. D’Silva, R. A. Dumont, and D. F. Niven. 1995 Contact-dependent acquisition of transferrin-bound iron by two strains of Haemophilus parasuis Can. J. Microbiol. 41 70–74
Chladek, D. W. 1975 Bovine abortion associated with Haemophilus somnus Am. J. Vet. Res. 36 1041
Cochi, S. L., C. V. Broome, and A. W. Hightower. 1985 Immunization of US children with Haemophilus influenzae type b polysaccharide vaccine: A cost-effectiveness model of strategy assessment JAMA 253 521–529
Cole, S. P., D. G. Guiney, and L. B. Corbeil. 1992 Two linked genes for outer membrane proteins are absent in four non-disease strains of Haemophilus somnus Molec. Microbiol. 6 1895–1902
Cole, S. P., D. G. Guiney, and L. B. Corbeil. 1993 Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus J. Gen. Microbiol. 139 2135–2143
Cope, L. D., S. E. Thomas, J. L. Latimer, C. A. Slaughter, U. Muller-Eberhard, and E. J. Hansen. 1994 The 100 kDa haem:haemopexin-binding protein of Haemophilus influenzae: Structure and localization Molec. Microbiol. 13 863–873
Cope, L. D., R. Yogev, U. Muller-Eberhard, and E. J. Hansen. 1995 A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b J. Bacteriol. 177 2644–2653
Cope, L. D., S. Lumbley, J. L. Latimer, J. Klesney-Tait, M. K. Stevens, L. S. Johnson, M. Purven, R. S. Munson Jr., T. Lagergard, J. D. Radolf, and E. J. Hansen. 1997 A diffusible cytotoxin of Haemophilus ducreyi Proc. Natl. Acad. Sci. USA 94 4056–4061
Cope, L. D., S. E. Thomas, Z. Hrkal, and E. J. Hansen. 1998 Binding of heme-hemopexin complexes by soluble HxuA protein allows utilization of this complexed heme by Haemophilus influenzae Infect. Immun. 66 4511–4516
Cope, L. D., Z. Hrkal, and E. J. Hansen. 2000 Detection of phase variation in expression of proteins involved in hemoglobin and hemoglobin-haptoglobin binding by nontypeable Haemophilus influenzae Infect. Immun. 68 4092–4101
Corbeil, L. B., F. D. Bastida-Corcuera, and T. J. Beveridge. 1997 Haemophilus somnus immunoglobulin binding proteins and surface fibrils Infect. Immun. 65 4250–4257
Cortes-Bratti, X., E. Chaves-Olarte, T. Lagergard, and M. Thelestam. 1999 The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase J. Clin. Invest. 103 107–115
Children’s Vaccine Initiative. 1999 Vaccination news: Haemophilus influenzae, Hib use rising slowly Newswatch 1 7–8
Danner, D. B., and M. L. Pifer. 1982a Plasmid cloning vectors resistant to ampicillin and tetracycline which can replicate in both E. coli and Haemophilus cells Gene 18 101–105
Danner, D. B., H. O. Smith, and S. A. Narang. 1982b Construction of DNA recognition sites active in Haemophilus transformation Proc. Natl. Acad. Sci. USA 79 2393–2397
Davis, D. J., and J. Pittman. 1950 Acute conjunctivitis caused by Haemophilus Am. J. Dis. Child. 79 211
Davis, D. J., and V. D. Hines. 1952 Conjunctivitis in elementary schools Public Health Rep. 67 147
Dawid, S., S. J. Barenkamp, and J. W. St. Geme 3rd. 1999 Variation in expression of the Haemophilus influenzae HMW adhesins: A prokaryotic system reminiscent of eukaryotes Proc. Natl. Acad. Sci. USA 96 1077–1082
Dawid, S., S. Grass, and J. W. St. Geme 3rd. 2001 Mapping of the binding domains of the nontypeable Haemophilus influenzae HMW1 and HMW2 adhesins Infect. Immun. 69:1 307–314
Deich, R. A., and H. O. Smith. 1980 Mechanism of homospecific DNA uptake in Haemophilus influenzae transformation Molec. Gen. Genet. 177 369–374
Deich, R. A., and B. A. Green. 1987 Mobilization of Haemophilus influenzae chromosomal markers by an Escherichia coli F’ factor J. Bacteriol. 169 1905–1910
Desjardins, M., L. G. Filion, S. Robertson, L. Kobylinski, and D. W. Cameron. 1996 Evaluation of humoral and cell-mediated inducible immunity to Haemophilus ducreyi in an animal model of chancroid Infect. Immun. 64 1778–1788
Dewire, P., B. E. McGrath, and C. Brass. 1999 Haemophilus aphrophilus osteomyelitis after dental prophylaxis: A case report Clin. Orthoped. 363 196–202
Dixon, L. G., W. L. Albritton, and P. J. Willson. 1994 An analysis of the complete nucleotide sequence of the Haemophilus ducreyi broad-host-range plasmid pLS88 Plasmid 32 228–232
Dougherty, B. A., and H. O. Smith. 1999 Identification of Haemophilus influenzae Rd transformation genes using cassette mutagenesis Microbiology 145 401–409
Dower, W. J., J. F. Miller, and C. W. Ragsdale. 1988 High efficiency transformation of E. coli by high voltage electroporation Nucleic Acids Res. 16 6127–6145
Dutro, S. M., G. E. Wood, and P. A. Totten. 1999 Prevalence of, antibody response to, and immunity induced by Haemophilus ducreyi hemolysin Infect. Immun. 67 3317–3328
El-Adhami, W., J. M. Kyd, D. A. Bastin, and A. W. Cripps. 1999 Characterization of the gene encoding a 26-kilodalton protein (OMP26) from nontypeable Haemophilus influenzae and immune responses to the recombinant protein Infect. Immun. 67 1935–1942
Elkins, C. 1995a Identification and purification of a conserved heme-regulated hemoglobin-binding outer membrane protein from Haemophilus ducreyi Infect. Immun. 63 1241–1245
Elkins, C., C. J. Chen, and C. E. Thomas. 1995b Characterization of the hgbA locus encoding a hemoglobin receptor from Haemophilus ducreyi Infect. Immun. 63 2194–2200
Elkins, C., K. J. Morrow Jr., and B. Olsen. 2000 Serum resistance in Haemophilus ducreyi requires outer membrane protein DsrA Infect. Immun. 68 1608–1619
Evans, N. M., and D. D. Smith. 1972 The effect of the medium and source of growth factors on the satellitism test for Haemophilus species J. Med. Microbiol. 5 509–514
Evans, N. M., D. D. Smith, and A. J. Wicken. 1974 Haemin and nicotinamide adenine dinucleotide requirements of Haemophilus influenzae and Haemophilus parainfluenzae J. Med. Microbiol. 7 359–365
Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. Bult, J. F. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, Sutton, FitzHugh, C. Fields, J. D. Gocayne, J. Scott, R. Shirley, L.-I. Liu, A. Glodek, J. M. Kelley, J. F. Weidman, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, T. R. Utterback, M. C. Hanna, D. T. Nguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, J. L. Fuhrmann, N. S. M. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, and J. C. Venter. 1995 Whole-genome random sequencing and assembly of Haemophilus influenzae Rd Science 269 496–512
Forsgren, J., A. Samuelson, A. Ahlin, J. Jonasson, B. Rynnel-Dagoo, and A. Lindberg. 1994 Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay Infect. Immun. 62 673–679
Forsgren, J., A. Samuelson, S. Borrelli, B. Christensson, J. Jonasson, and A. A. Lindberg. 1996 Persistence of nontypeable Haemophilus influenzae in adenoid macrophages: A putative colonization mechanism Acta Otolaryngol. 116 766–773
Foxwell, A. R., J. M. Kyd, and A. W. Cripps. 1998 Nontypeable Haemophilus influenzae: Pathogenesis and prevention Microbiol. Molec. Biol. Rev. 62 294–308
Foxwell, A. R., and A. W. C. Cripps. 2000 Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis (Cochrane Review) In: The Cochrane Library, 4, 2000. Oxford: Updated Software
Frangipane, M. E., D. J. Morton, J. A. Wooten, J. M. Pozsgay, and T. L. Stull. 1994 Binding of human hemoglobin by Haemophilus influenzae FEMS Microbiol. Lett. 118 243–248
Frazer, J., and K. B. Rogers. 1972 The isolation of an X-dependent strain of Haemophilus from otitis media identified as H. haemoglobinophilus (canis) J. Clin. Pathol. 25 179–180
Friesen, C. A., and C. T. Cho. 1986 Characteristic features of neonatal sepsis due to Haemophilus influenzae Rev. Infect. Dis. 8 777–780
Frisk, A., and T. Lagergard. 1998a Characterization of mechanisms involved in adherence of Haemophilus ducreyi to eukaryotic cells APMIS 106 539–546
Frisk, A., C. A. Ison, and T. Lagergard. 1998b GroEL heat shock protein of Haemophilus ducreyi: Association with cell surface and capacity to bind to eukaryotic cells Infect. Immun. 66 1252–1257
Galil, K., R. Singleton, O. S. Levine, M. A. Fitzgerald, L. Bulkow, M. Getty, B. A. Perkins, and A. Parkinson. 1999 Reemergence of invasive Haemophilus influenzae type b disease in a well-vaccinated population in remote Alaska J. Infect. Dis. 179 101–106
Gelfanova, V., E. J. Hansen, and S. M. Spinola. 1999 Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells Infect. Immun. 67 6394–6402
Geraci, J. E., C. J. Wilkowske, W. R. Wilson, and J. A. D. Washington. 1977 Haemophilus endocarditis: Report of 14 patients Mayo Clin. Proc. 52 209–215
Gigliotti, F., W. T. Williams, F. G. Hayden, J. O. Hendley, J. Benjamin, M. Dickens, C. Gleason, V. A. Perriello, and J. Wood. 1981 Etiology of acute conjunctivitis in children J. Pediatr. 98 531–536
Gilder, H., and S. Granick. 1947 Studies on the Haemophilus group of organisms: Quantitative aspects of growth on various porphin compounds J. Gen. Physiol. 31 103–117
Gilligan, P. H. 1991 Microbiology of airway disease in patients with cystic fibrosis Clin. Microbiol. Rev. 4 35–51
Gomis, S. M., D. L. Godson, G. A. Wobeser, and A. A. Potter. 1997 Effect of Haemophilus somnus on nitric oxide production and chemiluminescence response of bovine blood monocytes and alveolar macrophages Microb. Pathog. 23 327–333
Gomis, S. M., D. L. Godson, G. A. Wobeser, and A. A. Potter. 1998 Intracellular survival of Haemophilus somnus in bovine blood monocytes and alveolar macrophages Microb. Pathog. 25 227–235
Gonzales, A. E., J. R. Glisson, and M. W. Jackwood. 1996 Transposon mutagenesis of Haemophilus paragallinarum with Tn916 Vet. Microbiol. 48 283–291
Goodgal, S. H., and R. M. Herriott. 1961 Studies on transformation of Haemophilus influenzae. I: Competence J. Gen. Physiol. 44 1201–1227
Goodgal, S. H., and M. Mitchell. 1984 Uptake of heterologous DNA by Haemophilus influenzae J. Bacteriol. 157 785–788
Gratten, M., and J. Montgomery. 1991 The bacteriology of acute pneumonia and meningitis in children in Papua New Guinea: Assumptions, facts and technical strategies Papua New Guinea Med. J. 34 185–198
Gray-Owen, S. D., and A. B. Schryvers. 1995a Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae Infect. Immun. 63 3809–3815
Gray-Owen, S. D., S. Loosmore, and A. B. Schryvers. 1995b Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae Infect. Immun. 63 1201–1210
Green, B. A., W. J. Doyle, and J. L. Cowell. 1994 Chinchilla model of experimental otitis media for study of nontypable Haemophilus influenzae vaccine efficacy Methods Enzymol. 235 59–68
Gromkova, R., and S. Goodgal. 1979 Transformation by plasmid and chromosomal DNAs in Haemophilus parainfluenzae Biochem. Biophys. Res. Commun. 88 1428–1434
Gromkova, R. C., T. C. Mottalini, and M. G. Dove. 1998 Genetic transformation in Haemophilus parainfluenzae clinical isolates Curr. Microbiol. 37 123–126
Groom, S. C., and P. B. Little. 1988 Effects of vaccination of calves against induced Haemophilus somnus pneumonia Am. J. Vet. Res. 49 793–800
Grotelueschen, D. M., R. G. Mortimer, and R. P. Ellis. 1994 Vesicular adenitis syndrome in beef bulls J. Am. Vet. Med. Assoc. 205 874–877
Guerina, N. G., S. Langermann, H. W. Clegg, T. W. Kessler, D. A. Goldmann, and J. R. Gilsdorf. 1982 Adherence of piliated Haemophilius influenzae type b to human oropharyngeal cells J. Infect. Dis. 146 564
Gwinn, M. L., D. Yi, H. O. Smith, and J. F. Tomb. 1996 Role of the two-component signal transduction and the phosphoenolpyruvate:carbohydrate phosphotransferase systems in competence development of Haemophilus influenzae Rd J. Bacteriol. 178 6366–6368
Gwinn, M. L., A. E. Stellwagen, N. L. Craig, J. F. Tomb, and H. O. Smith. 1997 In vitro Tn7 mutagenesis of Haemophilus influenzae Rd and characterization of the role of atpA in transformation J. Bacteriol. 179 7315–7320
Gwinn, M. L., R. Ramanathan, H. O. Smith, and J. F. Tomb. 1998 A new transformation-deficient mutant of Haemophilus influenzae Rd with normal DNA uptake J. Bacteriol. 180 746–748
Hammond, G. W., C. J. Lian, J. C. Wilt, W. L. Albritton, and A. R. Ronald. 1978 Determination of the hemin requirement of Haemophilus ducreyi: Evaluation of the porphyrin test and media used in the satellite growth test J. Clin. Microbiol. 7 243–246
Hansen, E. J., and G. B. Toews. 1992 Animal models for the study of noninvasive Haemophilus influenzae disease: Pulmonary clearance systems J. Infect. Dis. 165, Suppl. S185–S187
Hansen, E. J., S. R. Lumbley, J. A. Richardson, B. K. Purcell, M. K. Stevens, L. D. Cope, J. Datte, and J. D. Radolf. 1994 Induction of protective immunity to Haemophilus ducreyi in the temperature-dependent rabbit model of experimental chancroid J. Immunol. 152 184–92
Hanson, M. S., S. E. Pelzel, J. Latimer, U. Muller-Eberhard, and E. J. Hansen. 1992a Identification of a genetic locus of Haemophilus influenzae type b necessary for the binding and utilization of heme bound to human hemopexin Proc. Natl. Acad. Sci. USA 89 1973–1977
Hanson, M. S., C. Slaughter, and E. J. Hansen. 1992b The hbpA gene of Haemophilus influenzae type b encodes a heme-binding lipoprotein conserved among heme-dependent Haemophilus species Infect. Immun. 60 2257–2266
Hardie, K. R., R. A. Adams, and K. J. Towner. 1993 Transferrin-binding ability of invasive and commensal isolates of Haemophilus spp J. Med. Microbiol. 39 218–224
Hart, A. J., P. Thompson, A. T. Casey, A. P. Davies, and A. J. Stannard. 1998 Haemophilus paraphrophilus; a rare cause of intracranial abscess J. Infect. 37 75–76
Hartmann, E., and C. Lingwood. 1997 Brief heat shock treatment induces a long-lasting alteration in the glycolipid receptor binding specificity and growth rate of Haemophilus influenzae Infect. Immun. 65 1729–1733
Hawkes, S., B. West, S. Wilson, H. Whittle, and D. Mabey. 1995 Asymptomatic carriage of Haemophilus ducreyi confirmed by the polymerase chain reaction Genitourinary Med. 71 224–227
Heidecker, G. J., J. M. Pozsgay, and T. L. Stull. 1994 Construction of an ori cassette for adapting shuttle vectors for use in Haemophilus influenzae Gene 150 141–144
Henderson, I. R., F. Navarro-Garcia, and J. P. Nataro. 1998 The great escape: Structure and function of the autotransporter proteins Trends Microbiol. 6 370–378
Hendrixson, D., M. de la Morena, C. Stathopoulos, and J. W. St. Geme 3rd. 1997 Structural determinates of processing and secretion of the Haemophilus influenzae Hap protein Molec. Microbiol. 26 505–518
Hendrixson, D. R., and J. W. St. Geme 3rd. 1998 The Haemophilus influenzae Hap serine protease promotes adherence and microcolony formation, potentiated by a soluble host protein Mol. Cell. 2 841–850
Herrington, D. A., and P. F. Sparling. 1985 Haemophilus influenzae can use human transferrin as a sole source for required iron Infect. Immun. 48 248–251
Herriott, R. M., E. M. Meyer, and M. Vogt. 1970 Defined nongrowth media for stage II development of competence in Haemophilus influenzae J. Bacteriol. 101 517–524
Hinz, K. H., and H. E. Muller. 1977 The occurrence of neuraminidase and N-acylneuraminate pyruvate lyase in Haemophilus paragallinarum and Haemophilus paravium n. sp [author’s translation] Zentralbl. Bakteriol. 237 72–79
Hoiseth, S. K. 1992 The genus Haemophilus In: M. Dworkin (Ed.) [lcub;http://www.prokaryotes.comrcub;The Prokaryotes], 2nd ed. Springer-Verlag New York NY 3309–3330
Holland, J., P. R. Langford, K. J. Towner, and P. Williams. 1992 Evidence for in vivo expression of transferring binding proteins in Haemophilus influenzae type b Infect. Immun. 60 2986–2991
Holland, J., T. R. Parsons, A. A. Hasan, S. M. Cook, P. Stevenson, E. Griffiths, and P. Williams. 1996 Conservation and antigenic cross-reactivity of the transferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis Microbiology 142 3505–3513
Holländer, R., and W. Manheim. 1975 Characterization of hemophilic and related bacteria by their respiratory quinones and cytochromes Int. J. Syst. Bacteriol. 25 102–107
Holländer, R. 1976a Energy metabolism of some representatives of the Haemophilus group Ant. v. Leeuwenhoek 42 429–444
Holländer, R. 1976b Correlation of the function of demethylmenaquinone in bacterial electron transport with its redox potential FEBS Lett. 72 98–100
Holländer, R., A. Hess-Reihse, and W. Mannheim. 1981 Respiratory quinones in Haemophilus, Pasturella, and Actinobacillus: Pattern, functions, and taxonomic evaluation In: Kilian, M., Frederiksen, W., and Biberstein, E. L. (Eds.) Haemophilus, Pasturella, and Actinobacillus Academic Press London 83–97
Holt, L. B. 1962 The growth factor requirements of Haemophilus influenzae J. Gen. Microbiol. 27 317–322
Hultgren, S. J., S. Abraham, M. Caparon, P. Falk, J. W. I. St. Geme, and S. Normark. 1993 Pilus and nonpilus bacterial adhesins: Assembly and function in cell recognition Cell 73 887–901
Hung, C. C., P. R. Hsueh, Y. C. Chen, C. T. Fang, S. C. Chang, K. T. Luh, and W. C. Hsieh. 1997 Haemophilus aphrophilus bacteraemia complicated with vertebral osteomyelitis and spinal epidural abscess in a patient with liver cirrhosis J. Infect. 35 304–308
Ingvarson, L., K. Lundgen, and J. Ursing. 1982 The bacterial flora in the nasopharynx in healthy children Acta Otolaryngol. 386 94–96
Insel, R. A., P. Z. Allen, and I. D. Berkowitz. 1982 Types and frequencies of Haemophilus influenzae IgA1 proteases In: L. Weinstein and B. N. Fields (Eds.) Seminars in Infectious Diseases Stratton New York NY 225–231
Inzana, T. J., and J. Todd. 1992 Immune response of cattle to Haemophilus somnus lipid A-protein conjugate vaccine and efficacy in a mouse abortion model Am. J. Vet. Res. 53 175–179
Janson, H., A. Melhus, A. Hermansson, and A. Forsgren. 1994 Protein D, the glycerophosphodiester phosphodiesterase from Haemophilus influenzae with affinity for human immunoglobulin D, influences virulence in a rat otitis model Infect. Immun. 62 4848–4854
Janson, H., N. B. Carl, A. Cervin, A. Forsgren, A. B. Magnusdottir, S. Lindberg, and T. Runer. 1999 Effects on the ciliated epithelium of protein D-producing and-nonproducing nontypeable Haemophilus influenzae in nasopharyngeal tissue cultures J. Infect. Dis. 180 737–746
Jarosik, G. P., J. D. Sanders, L. D. Cope, U. Muller-Eberhard, and E. J. Hansen. 1994 A functional tonB gene is required for both utilization of heme and virulence expression by Haemophilus influenzae type b Infect. Immun. 62 2470–2477
Jarosik, G. P., I. Maciver, and E. J. Hansen. 1995 Utilization of transferrin-bound iron by Haemophilus influenzae requires an intact tonB gene Infect. Immun. 63 710–713
Jin, H., Z. Ren, J. M. Pozsgay, C. Elkins, P. W. Whitby, D. J. Morton, and T. L. Stull. 1996 Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae Infect. Immun. 64 3134–3141
Jin, H., Z. Ren, P. W. Whitby, D. J. Morton, and T. L. Stull. 1999 Characterization of hgpA, a gene encoding a haemoglobin/haemoglobin-haptoglobin-binding protein of Haemophilus influenzae Microbiology 145 905–914
Johnson, A. P., and T. J. Inzana. 1986 Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae J. Med. Microbiol. 22 265–268
Kahn, M. E., F. Barany, and H. O. Smith. 1983 Transformasomes: Specialized membranous structures that protect DNA during Haemophilus transformation Proc. Natl. Acad. Sci. USA 80 6927–6931
Kahn, M. E., and H. O. Smith. 1984 Transformation in Haemophilus: A problem in membrane biology J. Membr. Biol. 81 89–103
Kanthakumar, K., G. W. Taylor, D. R. Cundell, R. B. Dowling, M. Johnson, P. J. Cole, and R. Wilson. 1996 The effect of bacterial toxins on levels of intracellular adenosine nucleotides and human ciliary beat frequency Pulm. Pharmacol. 9 223–230
Kauc, L., and S. H. Goodgal. 1989 Introduction of transposon Tn916 DNA into Haemophilus influenzae and Haemophilus parainfluenzae J. Bacteriol. 171 6625–6628
Kilbourn, J. P., H. Haas, J. F. Morris, and S. Samson. 1983 Haemophilus influenzae biotypes and chronic bronchitis Am. Rev. Resp. Dis. 128 1093–1094
Kilian, J., J. Heine-Jenson, and P. Bulow. 1972 Haemophilus in the upper respiratory tract of children Acta Pathol. Microbiol. Scand. Section B 80 571–578
Kilian, M. 1974 A rapid method for the differentiation of Haemophilus strains: The porphyrin test Acta Pathol. Microbiol. Scand. Microbiol. Immunol. 82 835–842
Kilian, M. 1976 A taxonomic study of the genus Haemophilus, with the proposal of a new species J. Gen. Microbiol. 93 9–62
Kilian, M., J. Mestecky, R. Kulhavy, M. Tomana, and W. T. Butler. 1980 IgA1 proteases from Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, and Streptococcus sanguis: Comparative immunochemical studies J. Immunol. 124 2596–2600
Kilian, M., and B. Thomsen. 1983a Antigenic heterogeneity of immunoglobulin A1 proteases from encapsulated and non-encapsulated Haemophilus influenzae Infect. Immun. 42 126–132
Kilian, M., B. Thomsen, T. E. Petersen, and H. Bleeg. 1983b Molecular biology of Haemophilus influenzae IgA1 proteases Molec. Immunol. 20 1051–1058
Kilian, M., and E. L. Biberstein. 1984 Haemophilus In: N. R. Krieg and J. G. Holt (Eds.) [lcub;http://www.cme.msu.edu/bergeysrcub;Bergey’s Manual of Systematic Bacteriology] Williams & Wilkins Baltimore MD 558–569
Kirby, S. D., S. D. Gray-Owen, and A. B. Schryvers. 1997 Characterization of a ferric-binding protein mutant in Haemophilus influenzae Molec. Microbiol. 25 979–987
Klein, J. R. 1940 The oxidation of 1(-) aspartic and 1(+) glutamic acids by Haemophilus parainfluenzae. Note on the preparation of pyridine nucleotides from baker’s yeast by the method of Warburg and Christian J. Biol. Chem. 134 43–57
Koch, R. 1883 Report on the activities of the German Cholera Commission in Egypt and East India Wien. Med. Wochenschr. 227 1548
Kodama, S., S. Suenaga, T. Hirano, M. Suzuki, and G. Mogi. 2000 Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization Infect. Immun. 68 2294–2300
Kraiss, A., S. Schlor, and J. Reidl. 1998 In vivo transposon mutagenesis in Haemophilus influenzae Appl. Environ. Microbiol. 64 4697–4702
Kraut, M. S., H. R. Attebery, S. M. Finegold, and V. L. Sutter. 1972 Detection of Haemophilus aphrophilus in the human oral flora with a selective medium J. Infect. Dis. 126 189–192
Kroll, J. S., and R. Booy. 1996 Haemophilus influenzae: Capsule vaccine and capsulation genetics Molec. Med. Today 2 160–165
Kubiet, M., R. Ramphal, A. Weber, and A. Smith. 2000 Pilus-mediated adherence of Haemophilus influenzae to human respiratory mucins Infect. Immun. 68 3362–3367
Kuklinska, D., and M. Kilian. 1984 Relative proportions of Haemophilus species in the throat of healthy children and adults Eur. J. Clin. Microbiol. 3 249–252
Larson, T. G., and S. H. Goodgal. 1991 Sequence and transcriptional regulation of com101A, a locus required for genetic transformation in Haemophilus influenzae J. Bacteriol. 173 4683–4691
Lavine, L. S., H. D. Isenberg, W. Rubins, and J. I. Berkman. 1974 Unusual osteomyelitis following superficial dog bite Clin. Orthop. 98 251–253
Lee, B. C. 1992 Isolation of an outer membrane hemin-binding protein of Haemophilus influenzae type b Infect. Immun. 60 810–816
Lehmann, D. 1992 Epidemiology of acute respiratory tract infections, especially those due to Haemophilus influenzae, in Papua New Guinean children J. Infect. Dis. 165, Suppl. 1 S20–S25
Leidy, G., E. Hahn, and H. E. Alexander. 1956 On the specificity of the desoxyribonucleic acid which induces streptomycin resistance in Haemophilus J. Exp. Med. 104 305–320
Leidy, G., E. Hahn, and H. E. Alexander. 1959 Interspecific transformation in Haemophilus: A possible index of relationship between H. influenzae and H. aegyptius Proc. Soc. Exp. Biol. Med. 102 86–88
Leidy, G., I. Jaffee, and H. E. Alexander. 1965 Further evidence of a high degree of genetic homology between H. influenzae and H. aegyptius Proc. Soc. Exp. Biol. Med. 118 671–679
Lethem, M. I., S. L. James, C. Marriott, and J. F. Burke. 1990 The origin of DNA associated with mucus glycoproteins in cystic fibrosis sputum Eur. Respir. J. 3 19–23
Levine, O., J. Wenger, Y. B. Perkins, N. Rosenstein, and A. Schuchat. 1998 Haemophilus influenzae type B infection Bull. WHO 76, Suppl 2 131–132
Lichtensteiger, C. A., and E. R. Vimr. 1997 Neuraminidase (sialidase) activity of Haemophilus parasuis FEMS Microbiol. Lett. 152 269–274
Loeb, M. R. 1995 Ferrochelatase activity and protoporphyrin IX utilization in Haemophilus influenzae J. Bacteriol. 177 3613–3615
Lysenko, E. S., J. Gould, R. Bals, J. M. Wilson, and J. N. Weiser. 2000a Bacterial phosphorylcholine decreases susceptibility to the antimicrobial peptide LL-37/hCAP18 expressed in the upper respiratory tract Infect. Immun. 68 1664–1671
Lysenko, E., J. C. Richards, A. D. Cox, A. Stewart, A. Martin, M. Kapoor, and J. N. Weiser. 2000b The position of phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae affects binding and sensitivity to C-reactive protein-mediated killing Molec. Microbiol. 35 234–245
Macfadyen, L. P., and R. J. Redfield. 1996a Life in mucus: Sugar metabolism in Haemophilus influenzae Res. Microbiol. 147 541–551
Macfadyen, L. P., I. R. Dorocicz, J. Reizer, M. H. Saier Jr., and R. J. Redfield. 1996b Regulation of competence development and sugar utilization in Haemophilus influenzae Rd by a phosphoenolpyruvate:fructose phosphotransferase system Molec. Microbiol. 21 941–952
Macfadyen, L. P., C. Ma, and R. J. Redfield. 1998 A 3′,5′ cyclic AMP (cAMP) phosphodiesterase modulates cAMP levels and optimizes competence in Haemophilus influenzae Rd J. Bacteriol. 180 4401–4405
MacInnes, J. I., and R. Desrosiers. 1999 Agents of the “suis-ide diseases” of swine: Actinobacillus suis, Haemophilus parasuis, and Streptococcus suis Can. J. Vet. Res. 63 83–89
Maciver, I., J. L. Latimer, H. H. Liem, U. Muller-Eberhard, Z. Hrkal, and E. J. Hansen. 1996 Identification of an outer membrane protein involved in utilization of hemoglobin-haptoglobin complexes by nontypeable Haemophilus influenzae Infect. Immun. 64 3703–3712
Makela, P. H., H. Peltola, H. Kayhty, H. Jousimies, O. Pettay, E. Ruoslahti, A. Sivonen, and O. V. Renkonen. 1977 Polysaccharide vaccines of group A Neisseria meningtitidis and Haemophilus influenzae type b: A field trial in Finland J. Infect. Dis. 136, Suppl. S43–S50
Male, C. 1979 Immunoglobulin A1 protease by Haemophilus influenzae and Streptococcus pneumoniae Infect. Immun. 26 254–261
Margelli, D., and E. Streit. 1996 Haemophilus aphrophilus as a rare cause of bacterial spondylitis Schweiz. Med. Wochenschr. 126 311–315
Mathis, L. S., and J. J. Scocca. 1982 Haemophilus influenzae and Neisseria gonorrhoeae recognize different specificity determinants in the DNA uptake step of genetic transformation J. Gen. Microbiol. 128 1159–1161
Matthews, L., S. Spector, J. Lemm, and J. Potter. 1963 Studies on pulmonary secretions.1: The overt chemical composition of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy Am. Rev. Respir. Dis. 88 199–204
McCarthy, D., N. L. Clayton, and J. K. Setlow. 1982 A plasmid cloning vehicle for Haemophilus influenzae and Escherichia coli J. Bacteriol. 151 1605–1607
McIntyre, P., G. Wheaton, J. Erlich, and D. Hansman. 1987 Brasilian purpuric fever in central Australia Lancet 2 112
Miflin, J. K., R. F. Horner, P. J. Blackall, X. Chen, G. C. Bishop, C. J. Morrow, T. Yamaguchi, and Y. Iritani. 1995 Phenotypic and molecular characterization of V-factor (NAD)-independent Haemophilus paragallinarum Avian Dis. 39 304–308
Monto, A. S. 1989 Acute respiratory infection in children of developing countries: Challenge of the 1990’s Rev. Infect. Dis. 11 498–505
Morton, D. J., and P. Williams. 1990 Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b J. Gen. Microbiol. 136 927–933
Morton, D. J., P. W. Whitby, H. Jin, Z. Ren, and T. L. Stull. 1999 Effect of multiple mutations in the hemoglobin-and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b Infect. Immun. 67 2729–2739
Moxon, E. R., M. P. Glode, A. Sutton, and J. B. Robbins. 1977 The infant rat as a model of bacterial meningitis J. Infect. Dis. 136 S186–S190
Moxon, E. R. 1992 Molecular basis of invasive Haemophilus influenzae type b disease J. Infect. Dis. 165, Suppl. 1 S77–S81
Mulks, M. H., S. J. Kornfeld, and A. G. Plaut. 1980 Specific proteolysis of human IgA by Streptococcus pneumoniae and Haemophilus influenzae J. Infect. Dis. 141 450–456
Mulks, M. H., Kornfeld, S. J., Frangione, B., and Plaut, A. G. 1982 Relationship between the specificity of IgA proteases and serotypes in Haemophilus influenzae J. Infect. Dis. 146 266–274
Muller, H. E., and K. H. Hinz. 1977 The occurrence of neuraminidase and N-acetylneuraminate-pyruvate lyase in pathogenic haemophili of man [author’s translation] Zentralbl. Bakteriol. 239 231–239
Murphy, T. F. 2000 Haemophilus influenzae in chronic bronchitis Semin. Respir. Infect. 15 41–51
Musser, J. M., S. J. Barenkamp, D. M. Granoff, and R. K. Selander. 1986 Genetic relationships of serologically nontypable and serotype b strains of Haemophilus influenzae Infect. Immun. 52 183–191
Musser, J. M., J. S. Kroll, E. R. Moxon, and R. K. Selander. 1988 Clonal population structure of encapsulated Haemophilus influenzae Infect. Immun. 56 1837–1845
Musser, J. M., J. S. Kroll, D. M. Granoff, E. R. Moxon, B. R. Brodeur, J. Campos, H. Dabernat, W. Frederiksen, J. Hamel, G. Hammond, A. Hoiby, K. E. Jonsdottir, M. Kabeer, I. Kallings, W. N. Khan, M. Kilian, K. Knowles, H. J. Koornhof, B. Law, J. Piffaretti, A. K. Takala, M. L. Thong, R. A. Wall, J. I. Ward, and R. K. Selander. 1990 Global genetic structure and molecular epidemiology of encapsulated Haemophilus influenzae Rev. Infect. Dis. 12 75–111
Namnyak, S. S., D. H. Martin, J. D. Ferguson, P. E. Chiquito, and D. F. Hughes. 1991 Haemophilus segnis appendicitis J. Infect. 23 339–341
Nelson, M. B., R. S. Munson Jr., M. A. Apicella, D. J. Sikkema, J. P. Molleston, and T. F. Murphy. 1991 Molecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: Analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms Infect. Immun. 59 2658–2663
Nsanze, H., F. A. Plummer, A. B. Maggwa, G. Maitha, J. Dylewski, P. Piot, and A. R. Ronald. 1984 Comparison of media for the primary isolation of Haemophilus ducreyi Sex. Transm. Dis. 11 6–9
Ogunnariwo, J. A., C. Cheng, J. Ford, and A. B. Schryvers. 1990 Response of Haemophilus somnus to iron limitation: Expression and identification of a bovine-specific transferrin receptor Microb. Pathog. 9 397–406
Ogura, Y., S. Suzuki, T. Shirakawa, M. Masuda, H. Nakamura, K. Iijima, and N. Yoshikawa. 2000 Haemophilus parainfluenzae antigen and antibody in children with IgA nephropathy and Henoch-Schonlein nephritis Am. J. Kidney Dis. 36 47–52
Otto, B. R., A. M. J. J. Verweij-vanVught, and D. M. MacLaren. 1992 Transferrins and heme-comounds as iron sources for pathogenic bacteria Crit. Rev. Microbiol. 18 217–233
Pagotto, F. J., H. Salimnia, P. A. Totten, and J. R. Dillon. 2000 Stable shuttle vectors for Neisseria gonorrhoeae, Haemophilus spp. and other bacteria based on a single origin of replication Gene 244 13–19
Palmer, K. L., and R. S. Munson Jr. 1995 Cloning and characterization of the genes encoding the hemolysin of Haemophilus ducreyi Molec. Microbiol. 18 821–830
Palmer, K. L., A. C. Thornton, K. R. Fortney, A. F. Hood, R. S. Munson Jr., and S. M. Spinola. 1998 Evaluation of an isogenic hemolysin-deficient mutant in the human model of Haemophilus ducreyi infection J. Infect. Dis. 178 191–199
Parsons, L. M., R. J. Limberger, and M. Shayegani. 1997 Alterations in levels of DnaK and GroEL result in diminished survival and adherence of stressed Haemophilus ducreyi Infect. Immun. 65 2413–2419
Peltola, H., H. Kayhty, M. Virtanen, and P. H. Makela. 1984 Prevention of Haemophilus influenzae type b bacteremic infections with the capsular polysaccharide vaccine N. Engl. J. Med. 310 1561–1566
Peltola, H. 2000 Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: Global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates Clin. Microbiol. Rev. 13 302–317
Petsios, A., M. Nakou, and F. Manti. 1995 Microflora in adult periodontitis J. Periodontal Res. 30 325–331
Pfeifer, C. G., M. Campos, T. Beskorwayne, L. A. Babiuk, and A. A. Potter. 1992 Effect of Haemophilus somnus on phagocytosis and hydrogen peroxide production by bovine polymorphonuclear leukocytes Microb. Pathog. 13 191–202
Pichichero, M. E., P. Anderson, M. Loeb, and D. H. Smith. 1982 Do pili play a role in pathogenicity of Haemophilus influeanzae type b? Lancet ii 960–962
Pifer, M. L. 1986 Plasmid establishment in competent Haemophilus influenzae occurs by illegitimate transformation J. Bacteriol. 168 683–687
Plaut, A. G. 1978 Microbial IgA proteases N. Engl. J. Med. 298 1459–1463
Porto, M. H., G. J. Noel, and P. J. Edelson. 1989 Resistance to serum bactericidal activity distinguishes Brazilian purpuric fever (BPF) case strains of Haemophilus influenzae biogroup aegyptius (H. aegyptius) from non-BPF strains: Brazilian Purpuric Fever Study Group J. Clin. Microbiol. 27 792–794
Postle, K. 1990 TonB and the Gram-negative dilemma Molec. Microbiol. 4 2019–2025
Postma, P. W., J. W. Lengeler, and G. R. Jacobson. 1993 Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria Microbiol. Rev. 57 543–594
Prasadarao, N. V., E. Lysenko, C. A. Wass, K. S. Kim, and J. N. Weiser. 1999 Opacity-associated protein A contributes to the binding of Haemophilus influenzae to chang epithelial cells Infect. Immun. 67 4153–4160
Qiu, J., G. P. Brackee, and A. G. Plaut. 1996 Analysis of the specificity of bacterial immunoglobulin A (IgA) proteases by a comparative study of ape serum IgAs as substrates Infect. Immun. 64 933–937
Quentin, R., J. M. Musser, M. Mellouet, P. Y. Sizaret, R. K. Selander, and A. Goudeau. 1989 Typing of urogenital, maternal, and neonatal isolates of Haemophilus influenzae and Haemophilus parainfluenzae in correlation with clinical source of isolation and evidence for a genital specificity of H. influenzae biotype IV J. Clin. Microbiol. 27 2286–2294
Quentin, R., R. Ruimy, A. Rosenau, J. M. Musser, and R. Christen. 1996 Genetic identification of cryptic genospecies of Haemophilus causing urogenital and neonatal infections by PCR using specific primers targeting genes coding for 16S rRNA J. Clin. Microbiol. 34 1380–1385
Rao, V. K., G. P. Krasan, D. R. Hendrixson, S. Dawid, and J. W. St. Geme 3rd. 1999 Molecular determinants of the pathogenesis of disease due to non-typable Haemophilus influenzae FEMS Microbiol. Rev. 23 99–129
Read, R., R. Wilson, A. Rutman, V. Lund, H. Todd, A. Brian, P. Jeffery, and P. Cole. 1991 Interaction of nontypable Haemophilus influenzae with human respiratory mucosa in vitro J. Infect. Dis. 163 549–558
Read, R. C., A. A. Rutman, P. K. Jeffery, V. J. Lund, A. P. R. Brian, E. R. Moxon, P. J. Cole, and R. Wilson. 1992 Interaction of capsulate Haemophilus influenzae with human airway mucosa in vitro Infect. Immun. 60 3244–3252
Reddy, M. S., J. M. Bernstein, T. F. Murphy, and H. S. Faden. 1996 Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin Infect. Immun. 64 1477–1479
Redfield, R. J. 1991 sxy-1, a Haemophilus influenzae mutation causing greatly enhanced spontaneous competence J. Bacteriol. 173 5612–5618
Ren, Z., H. Jin, D. J. Morton, and T. L. Stull. 1998 hgpB, a gene encoding a second Haemophilus influenzae hemoglobin-and hemoglobin-haptoglobin-binding protein Infect. Immun. 66 4733–4741
Ren, Z., H. Jin, P. W. Whitby, D. J. Morton, and T. L. Stull. 1999 Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzae J. Bacteriol. 181 5865–5870
Rivers, T. M. 1922 Influenza-like bacilli: Growth of influenza-like bacilli on media containing only an autoclave-labile substance as an accessory food factor Johns Hopkins Hosp. Bull. 33 149–151
Roche, R. J., and E. R. Moxon. 1995 Phenotypic variation of carbohydrate surface antigens and the pathogenesis of Haemophilus influenzae infections Trends Microbiol. 3 304–309
Rosenstein, N. E., and B. A. Perkins. 2000 Update on Haemophilus influenzae serotype b and meningococcal vaccines Pediatr. Clin. North. Am. 47 337–352
Rowji, P., R. Gromkova, and H. Koornhof. 1989 Genetic transformation in encapsulated clinical isolates of Haemophilus influenzae type b J. Gen. Microbiol. 135 2775–2782
Rubin, L. G., V. B. Peters, and M. C. Ferez. 1993 Bactericidal activity of human sera against a Brazilian purpuric fever (BPF) strain of Haemophilus influenzae biogroup aegyptius correlates with age-related occurrence of BPF J. Infect. Dis. 167 1262–1264
Samuel, W., M. Dryden, M. Sampson, A. Page, and H. Shepherd. 1997 Spinal abscess of Haemophilus paraphrophilus: A case report Spine 22 2763–2765
Sanders, J. D., L. D. Cope, and E. J. Hansen. 1994 Identification of a locus involved in the utilization of iron by Haemophilus influenzae Infect. Immun. 62 4515–4525
Sanders, J. D., Y. Tagawa, R. E. Briggs, and L. B. Corbeil. 1997 Transformation of a virulence associated gene of Haemophilus somnus into a strain lacking the gene FEMS Microbiol. Lett. 154 251–258
Sandoval, V. E., H. R. Terzolo, and P. J. Blackall. 1994 Complicated infectious coryza outbreaks in Argentina Avian Dis. 38 672–678
Schaeffer, P. 1958 Interspecific reactions in bacterial transformation Gene 11 311–318
Schmid, G. P., L. L. Sanders Jr., J. H. Blount, and E. R. Alexander. 1987 Chancroid in the United States: Reestablishment of an old disease JAMA 258 3265–3268
Schryvers, A. B. 1988 Characterization of the human transferrin and lactoferrin receptors in Haemophilus influenzae Molec. Microbiol. 2 467–472
Schryvers, A. B. 1989 Identification of the transferrin-and lactoferrin-binding proteins in Haemophilus influenzae J. Med. Microbiol. 29 121–130
Schryvers, A. B., and S. Gray-Owen. 1992 Iron acquisition in Haemophilus influenzae: Receptors for human transferrin J. Infect. Dis. 165, Suppl. S103–S104
Scocca, J. J., R. L. Poland, and K. C. Zoon. 1974 Specificity in deoxyribonucleic acid uptake by transformable Haemophilus influenzae J. Bacteriol. 118 369–373
Senior, B. W., and C. L. Ip. 1999 An investigation into the influences of species and biotype on the type of IgA1 protease produced by isolates of Haemophilus J. Med. Microbiol. 48 389–394
Silva, S. V., and P. B. Little. 1990 The protective effect of vaccination against experimental pneumonia in cattle with Haemophilus somnus outer membrane antigens and interference by lipopolysaccharide Can. J. Vet. Res. 54 326–330
Sinkovics, G. 1976 Intestinal flora studies in rabbit mucoid enteritis Vet. Rec. 98 151–152
Sisco, K. L., and H. O. Smith. 1979 Sequence-specific DNA uptake in Haemophilus transformation Proc. Natl. Acad. Sci. USA 76 972–976
Smith, H. O., M. L. Gwinn, and S. L. Salzberg. 1999 DNA uptake signal sequences in naturally transformable bacteria Res. Microbiol. 150 603–616
Sottnek, F. O., J. W. Biddle, S. J. Kraus, R. E. Weaver, and J. A. Stewart. 1980 Isolation and identification of Haemophilus ducreyi in a clinical study J. Clin. Microbiol. 12 170–174
Steinhardt, W. L., and R. M. Herriott. 1968 Genetic integration in the heterospecific transformation of Haemophilus influenzae cells by Haemophilus parainfluenzae DNA J. Bacteriol. 96 1725–1731
Stevens, M. K., L. D. Cope, J. D. Radolf, and E. J. Hansen. 1995 A system for generalized mutagenesis of Haemophilus ducreyi Infect. Immun. 63 2976–2982
Stevens, M. K., J. L. Latimer, S. R. Lumbley, C. K. Ward, L. D. Cope, T. Lagergard, and E. J. Hansen. 1999 Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin Infect. Immun. 67 3900–3908
Stevenson, P., P. Williams, and E. Griffiths. 1992 Common antigenic domains in transferrin-binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae type b Infect. Immun. 60 2391–2396
St. Geme 3rd, J. W., and S. Falkow. 1991a Loss of capsule expression by Haemophilus influenzae type b results in enhanced adherence to and invasion of human cells Infect. Immun. 59 1325–1333
St. Geme 3rd, J. W., J. R. Gilsdorf, and S. Falkow. 1991b Surface structures and adherence properties of diverse strains of Haemophilus influenzae biogroup aegyptius Infect. Immun. 59 3366–3371
St. Geme 3rd, J. W., and S. Falkow. 1992 Capsule loss by Haemophilus influenzae type b results in enhanced adherence to and entry into human cells J. Infect. Dis. 165, Suppl. 1 S117–S118
St. Geme 3rd, J. W. 1994a The HMW1 adhesin of nontypeable Haemophilus influenzae recognizes sialylated glycoprotein receptors on cultured human epithelial cells Infect. Immun. 62 3881–3889
St. Geme 3rd, J. W., M. L. de la Morena, and S. Falkow. 1994b A Haemophilus influenzae IgA protease-like protein promotes intimate interaction with human epithelial cells Molec. Microbiol. 14 217–233
St. Geme 3rd, J. W., D. Cutter, and S. J. Barenkamp. 1996 Characterization of the genetic locus encoding Haemophilus influenzae type b surface fibrils J. Bacteriol. 178 6281–6287
St. Geme 3rd, J. W. 1997 Insights into the mechanism of respiratory tract colonization by nontypable Haemophilus influenzae Pediatr. Infect. Dis. J. 16 931–935
St. Geme 3rd, J. W., V. V. Kumar, D. Cutter, and S. J. Barenkamp. 1998 Prevalence and distribution of the hmw and hia genes and the HMW and Hia adhesins among genetically diverse strains of nontypeable Haemophilus influenzae Infect. Immun. 66 364–368
Stull, T. L., P. M. Mendelman, J. E. Haas, M. A. Schoenborn, K. D. Mack, and A. L. Smith. 1984 Characterization of Haemophilus influenzae type b pili Infect. Immun. 46 787–796
Stull, T. L., J. J. LiPuma, and T. D. Edlind. 1988 A broad-spectrum probe for molecular epidemiology of bacteria: Ribosomal RNA J. Infect. Dis. 157 280–286
Sturm, A. W., and H. C. Zanen. 1984 Characteristics of Haemophilus ducreyi in culture J. Clin. Microbiol. 19 672–674
Stuy, J. H. 1962 Transformability of H. influenzae J. Gen. Microbiol. 29 537–549
Stuy, J. H. 1978 On the nature of nontypable Haemophilus influenzae Ant. v. Leeuwenhoek 44 367–376
Sun, J., J. Chen, Z. Cheng, J. B. Robbins, J. F. Battey, and X. X. Gu. 2000 Biological activities of antibodies elicited by lipooligosaccharide based-conjugate vaccines of nontypeable Haemophilus influenzae in an otitis media model Vaccine 18 1264–1272
Suzuki, S., Y. Nakatomi, H. Sato, H. Tsukada, and M. Arakawa. 1994 Haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with IgA nephropathy Lancet 343 12–16
Suzuki, S., H. Kimura, and F. Gejyo. 1998 Haemophilus parainfluenzae antigens in IgA nephropathy Rinsho Byori 46 17–25
Suzuki, S, S. Fujieda, H. Sunaga, H. Sugimoto, C. Yamamoto, H. Kimura, T. Abo, and F. Gejyo. 2000a Immune response of tonsillar lymphocytes to Haemophilus parainfluenzae in patients with IgA nephropathy Clin. Exp. Immunol. 119 328–332
Suzuki, S., S. Fujieda, H. Sunaga, C. Yamamoto, H. Kimura, and F. Gejyo. 2000b Synthesis of immunoglobulins against Haemophilus parainfluenzae by tonsillar lymphocytes from patients with IgA nephropathy Nephrol. Dial. Transplant. 15 619–624
Swords, W. E., B. A. Buscher, K. Ver Steeg Ii, A. Preston, W. A. Nichols, J. N. Weiser, B. W. Gibson, and M. A. Apicella. 2000 Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor Molec. Microbiol. 37 13–27
Takala, A. K., J. Eskola, M. Leinonen, H. Kayhty, A. Nissinen, E. Pekkanen, and P. H. Makela. 1991 Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine J. Infect. Dis. 164 982–986
Targowski, S., and H. Targowski. 1979 Characterization of a Haemophilus paracuniculus isolated from gastrointestinal tracts of rabbits with mucoid enteritis J. Clin. Microbiol. 9 33–37
Tegtmeier, C., A. Uttenthal, N. F. Friis, N. E. Jensen, and H. E. Jensen. 1999 Pathological and microbiological studies on pneumonic lungs from Danish calves Zentralbl. Veterinärmed. 46 693–700
Tomb, J. F., G. J. Barcak, M. S. Chandler, R. J. Redfield, and H. O. Smith. 1989 Transposon mutagenesis, characterization, and cloning of transformation genes of Haemophilus influenzae Rd J. Bacteriol. 171 3796–3802
Tomb, J. F. 1992 A periplasmic protein disulfide oxidoreductase is required for transformation of Haemophilus influenzae Rd Proc. Natl. Acad. Sci. USA 89 10252–10256
Totten, P. A., D. V. Norn, and W. E. Stamm. 1995 Characterization of the hemolytic activity of Haemophilus ducreyi Infect. Immun. 63 4409–4416
Trieu, V. N., and D. McCarthy. 1990 Improved plasmid shuttle vectors for Haemophilus influenzae and Escherichia coli Gene 86 99–102
Van Alphen, L., L. Geelen-van den Broek, L. Blaas, M. van Ham, and J. Dankert. 1991 Blocking of fimbria-mediated adherence of Haemophilus influenzae by sialyl gangliosides Infect. Immun. 59 4473–4477
Van Donkersgoed, J., E. D. Janzen, A. A. Potter, and R. J. Harland. 1994a The occurrence of Haemophilus somnus in feedlot calves and its control by postarrival prophylactic mass medication Can. Vet. J. 35 573–580
Van Donkersgoed, J., A. A. Potter, B. Mollison, and R. J. Harland. 1994b The effect of a combined Pasteurella haemolytica and Haemophilus somnus vaccine and a modified-live bovine respiratory syncytial virus vaccine against enzootic pneumonia in young beef calves Can. Vet. J. 35 239–241
Van Donkersgoed, J., C. Guenther, B. N. Evans, A. A. Potter, and R. J. Harland. 1995 Effects of various vaccination protocols on passive and active immunity to Pasteurella haemolytica and Haemophilus somnus in beef calves Can. Vet. J. 36 424–429
Van Schilfgaarde, M., L. van Alphen, P. Eijk, V. Everts, and J. Dankert. 1995 Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells Infect. Immun. 63 4729–4737
Van Schilfgaarde, M., P. van Ulsen, W. van Der Steeg, V. Winter, P. Eijk, V. Everts, J. Dankert, and L. van Alphen. 2000 Cloning of genes of nontypeable Haemophilus influenzae involved in penetration between human lung epithelial cells Infect. Immun. 68 4616–4623
Vimr, E., C. Lichtensteiger, and S. Steenbergen. 2000 Sialic acid metabolism’s dual function in Haemophilus influenzae Molec. Microbiol. 36 1113–1123
Virkola, R., M. Brummer, H. Rauvala, L. van Alphen, and T. K. Korhonen. 2000 Interaction of fimbriae of Haemophilus influenzae type b with heparin-binding extracellular matrix proteins Infect. Immun. 68 5696–5701
Waldhalm, D. G., R. F. Hall, W. A. Meinershagen, C. S. Card, and F. W. Frank. 1974 Haemophilus somnus infection in the cow as a possible contributing factor to weak calf syndrome: Isolation and animal inoculation studies Am. J. Vet. Res. 35 1401–1403
Ward, A. C., M. D. Jaworski, J. M. Eddow, and L. B. Corbeil. 1995 A comparative study of bovine and ovine Haemophilus somnus isolates Can. J. Vet. Res. 59 173–178
Ward, C. K., S. R. Lumbley, J. L. Latimer, L. D. Cope, and E. J. Hansen. 1998 Haemophilus ducreyi secretes a filamentous hemagglutinin-like protein J. Bacteriol. 180 6013–6022
Ward, A. C., N. W. Dyer, and L. B. Corbeil. 1999 Characterization of putative Haemophilus somnus isolates from tonsils of American bison (Bison bison) Can. J. Vet. Res. 63 166–169
Wasserheit, J. N. 1992 Epidemiological synergy: Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases Sex. Transm. Dis. 19 61–77
Webb, D. C., and A. W. Cripps. 1999 Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lung Infect. Immun. 67 2138–2144
Webb, D. C., and A. W. Cripps. 2000 A P5 peptide that is homologous to peptide 10 of OprF from Pseudomonas aeruginosa enhances clearance of nontypeable Haemophilus influenzae from acutely infected rat lung in the absence of detectable peptide-specific antibody Infect. Immun. 68 377–381
Weeks, J. E. 1886 The bacillus of acute conjunctival catarrh, or “pink eye” Arch Ophthalmol 15 441
Weeks, J. E. 1887 The pathogenic microbe of acute catarrhal conjunctivitis Theor. Med. Rec. 31 571
Weeks, J. E. 1895 The status of our knowledge of the aetiological factors in acute conjunctivitis NY Eye Infirm. Rep. 24–36
Weinberg, E. D. 1978 Iron and infection Microbiol. Rev. 42 45–66
Weiser, J. N., S. T. Chong, D. Greenberg, and W. Fong. 1995 Identification and characterization of a cell envelope protein of Haemophilus influenzae contributing to phase variation in colony opacity and nasopharyngeal colonization Molec. Microbiol. 17 555–564
Weiser, J. N., M. Shchepetov, and S. T. Chong. 1997 Decoration of lipopolysaccharide with phosphorylcholine: A phase-variable characteristic of Haemophilus influenzae Infect. Immun. 65 943–950
Weiser, J. N., N. Pan, K. L. McGowan, D. Musher, A. Martin, and J. Richards. 1998 Phosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive protein J. Exp. Med. 187 631–640
Weyant, R. S., F. D. Quinn, E. A. Utt, M. Worley, V. G. George, F. J. Candal, and E. W. Ades. 1994 Human microvascular endothelial cell toxicity caused by Brazilian purpuric fever-associated strains of Haemophilus influenzae biogroup aegyptius J. Infect. Dis. 169 430–433
Whitby, P. W., K. E. Sim, D. J. Morton, J. A. Patel, and T. L. Stull. 1997 Transcription of genes encoding iron and heme acquisition proteins of Haemophilus influenzae during acute otitis media Infect. Immun. 65 4696–4700
White, D. C. 1963 Respiratory systems in the hemin-requiring Haemophilus species J. Bacteriol. 85 84–96
White, D. C., G. Leidy, J. D. Jamieson, and R. E. Shope. 1964 Porcine contagious pleuropneumonia. III: Inter-relationship of Haemophilus pleuropneumoniae to other species of Haemophilus: Nutritional, metabolic, transformation, and electron microscopy studies J. Exp. Med. 120 1–12
White, D. C. 1966 The obligatory involvement of the electron transport system in the catabolic metabolism of Haemophilus parainfluenzae Ant. v. Leeuwenhoek 32 139–158
White, D. C., and P. R. Sinclair. 1971 Branched electron-transport systems in bacteria Adv. Microb. Physiol. 5 173–211
White, D. R., S. K. Mukherji, M. E. Mangum, and H. J. Hamrick. 2000 Recurrent cervical lymphadenitis caused by Haemophilus aphrophilus Clin. Infect. Dis. 30 627–629
Willson, P. J., W. L. Albritton, L. Slaney, and J. K. Setlow. 1989 Characterization of a multiple antibiotic resistance plasmid from Haemophilus ducreyi Antimicrob. Agents Chemother. 33 1627–1630
Wilson, R., R. Dowling, and A. Jackson. 1996 The effects of bacterial products on airway cells and their function Am. J. Resp. Crit. Care Med. 154 S197–S201
Wong, J. C., J. Holland, T. Parsons, A. Smith, and P. Williams. 1994 Identification and characterization of an iron-regulated hemopexin receptor in Haemophilus influenzae type b Infect. Immun. 62 48–59
Wong, J. C. Y., R. Patel, D. Kendall, P. W. Whitby, A. Smith, J. Holland, and P. Williams. 1995 Affinity, conservation, and surface exposure of hemopexin-binding proteins in Haemophilus influenzae Infect. Immun. 63 2327–2333
Wood, G. E., S. M. Dutro, and P. A. Totten. 1999 Target cell range of Haemophilus ducreyi hemolysin and its involvement in invasion of human epithelial cells Infect. Immun. 67 3740–3749
Yamamoto, C., and S. Suzuki. 1999 Haemophilus parainfluenzae and IgA nephropathy Rinsho Byori 47 730–736
Yang, Y. F., M. J. Sylte, and C. J. Czuprynski. 1998a Apoptosis: A possible tactic of Haemophilus somnus for evasion of killing by bovine neutrophils? Microb. Pathog. 24 351–359
Yang, Y. P., S. M. Loosmore, B. J. Underdown, and M. H. Klein. 1998b Nasopharyngeal colonization with nontypeable Haemophilus influenzae in chinchillas Infect. Immun. 66 1973–1980
Yarnall, M., P. R. Widders, and L. B. Corbeil. 1988 Isolation and characterization of Fc receptors from Haemophilus somnus Scand. J. Immunol. 28 129–137
Zinnemann, K., K. B. Rogers, J. Frazer, and S. K. Devaraj. 1971 A haemolytic V-dependent CO2-preferring Haemophilus species (Haemophilus paraphrohaemolyticus nov. spec.) J. Med. Microbiol. 4 139–143
Zinnemann, K., and E. L. Biberstein. 1974 Genus Haemophilus In: R. E. Buchanan and N. E. Gibbons (Eds.) [lcub;http://www.cme.msu.edu/bergeysrcub;Bergey’s Manual of Determinative Bacteriology] Williams & Wilkins Baltimore MD 364–368
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Fink, D.L., Geme, J.W. (2006). The Genus Haemophilus. In: Dworkin, M., Falkow, S., Rosenberg, E., Schleifer, KH., Stackebrandt, E. (eds) The Prokaryotes. Springer, New York, NY. https://doi.org/10.1007/0-387-30746-X_40
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