Introduction and History
Parts of this chapter were modified from the same chapter of the previous book edition, written by William Pasculle.
Legionnaires’ disease is an acute pneumonic illness caused by Gram-negative bacilli of the genus Legionella. Pontiac fever is a febrile, nonpneumonic, systemic illness closely associated with, if not caused by, Legionella spp.
Legionnaires’ disease was first recognized as a distinct clinical entity when it caused an epidemic of pneumonia at an American Legion convention in Philadelphia in 1976; 221 people were affected, and 34 died (Fraser et al., 1977). Despite intensive laboratory investigation, the cause of the outbreak went undetected for many months. This mystery provoked considerable fear and widespread speculation about the cause, including claims that it was a government plot, a germ warfare experiment, and a toxin. A thorough epidemiologic investigation determined that the disease was most likely airborne, and focused primarily at one...
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Edelstein, P.H., Cianciotto, N.P. (2006). Legionella Species and Legionnaires’ Disease. In: Dworkin, M., Falkow, S., Rosenberg, E., Schleifer, KH., Stackebrandt, E. (eds) The Prokaryotes. Springer, New York, NY. https://doi.org/10.1007/0-387-30746-X_39
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