The Moraxella genus currently contains at least 14 different species, including M. catarrhalis, M. bovis, M. lacunata, M. osloensis, M. nonliquefaciens, M. atlantae, M. lincolnii, M. ovis, M. caviae, M. canis, M. equi, M. cuniculi, M. caprae and M. boevreii, which colonize both humans and animals. The genus is under constant revision, with recent taxonomic restructuring placing the bacterial species formerly known as Moraxella phenylpyruvica in the genus Psychrobacter as Psychrobacter phenylpyruvica and Moraxella urethralis in the Oligella genus as Oligella urethralis (Fig. 1).
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Literature Cited
Abbott, M. 1992a Neisseriaceae and Moraxella sp.: The role of related microorganisms associated with conjunctivitis in the newborn Int. J. STD AIDS 3 212–213
Abbott, M., and A. Nageswaran. 1992b Bacteremia and septic arthritis caused by Moraxella catarrhalis Clin. Infect. Dis. 14 368–369
Abe, M., F. Takaichi, H. Amano, S. Tazawa, T. Satoh, M. Nishizawa, T. Takagi, and T. Miyamoto. 2002 Antimicrobial susceptibility and beta-lactamase producibility of bacteria clinically isolated during the period from December 1999 to February 2000 [in Japanese] Jpn. J. Antibiot. 55, Suppl. A 54–64
Abuhammour, W. M., N. M. Abdel-Haq, B. I. Asmar, and A. S. Dajani. 1999 Moraxella catarrhalis bacteremia: A 10-year experience South Med. J. 92 1071–1074
Aebi, C., B. Stone, M. Beucher, L. D. Cope, I. Maciver, S. E. Thomas, G. H. McCracken Jr., P. F. Sparling, and E. J. Hansen. 1996 Expression of the CopB outer membrane protein by Moraxella catarrhalis is regulated by iron and affects iron acquisition from transferrin and lactoferrin Infect. Immun. 64 2024–2030
Aebi, C., I. Maciver, J. L. Latimer, L. D. Cope, M. K. Stevens, S. E. Thomas, G. H. McCracken Jr., and E. J. Hansen. 1997 A protective epitope of Moraxella catarrhalis is encoded by two different genes Infect. Immun. 65 4367–4377
Aebi, C., L. D. Cope, J. L. Latimer, S. E. Thomas, C. A. Slaughter, G. H. McCracken Jr., and E. J. Hansen. 1998a Mapping of a protective epitope of the CopB outer membrane protein of Moraxella catarrhalis Infect. Immun. 66 540–548
Aebi, C., E. R. Lafontaine, L. D. Cope, J. L. Latimer, S. L. Lumbley, G. H. McCracken Jr., and E. J. Hansen. 1998b Phenotypic effect of isogenic uspA1 and uspA2 mutations on Moraxella catarrhalis 035E Infect. Immun. 66 3113–3119
Ahmed, K., N. Rikitomi, A. Ichinose, and K. Matsumoto. 1991 Possible presence of a capsule in Branhamella catarrhalis Microbiol. Immunol. 35 361–366
Ahmed, K., K. Matsumoto, N. Rikitomi, and T. Nagatake. 1996 Attachment of Moraxella catarrhalis to pharyngeal epithelial cells is mediated by a glycosphingolipid receptor FEMS Microbiol. Lett. 135 305–309
Ahmed, A., S. Hafiz, M. Rafiq, N. Tariq, E. M. Abdulla, S. Hussain, R. Azim, S. J. Siddiqui, A. Awan, K. Z. Khan, and A. Fareed. 2002 Determination of antimicrobial activity of Cefaclor on common respiratory tract pathogens in Pakistan J. Pak. Med. Assoc. 52 7–11
Alligood, G. A., and J. F. Kenny. 1989 Tracheitis and supraglottis associated with Branhamella catarrhalis and respiratory syncytial virus Pediatr. Infect. Dis. J. 8 190–191
Angelos, J. A., J. F. Hess, and L. W. George. 2003 An RTX operon in hemolytic Moraxella bovis is absent from nonhemolytic strains Vet. Microbiol. 92 363–377
Annuar, B. O., and G. E. Wilcox. 1985 Adherence of Moraxella bovis to cell cultures of bovine origin Res. Vet. Sci. 39 241–246
Anthonisen, N. R. 2002 Bacteria and exacerbations of chronic obstructive pulmonary disease N. Engl. J. Med. 347 526–527
Arends, J. J., R. E. Wright, P. B. Barto, and K. S. Lusby. 1984 Transmission of Moraxella bovis from blood agar cultures to Hereford cattle by face flies (Diptera: Muscidae) J. Econ. Entomol. 77 394–398
Arkwright, J. A. 1907 On the occurence of Micrococcus catarrhalis in normal and catarrhal noses and its differentiation from the other Gram-negative diplococci J. Hyg. 7 145–154
Aul, J. J., K. W. Anderson, R. M. Wadowsky, W. J. Doyle, L. A. Kingsley, J. C. Post, and G. D. Ehrlich. 1998 Comparative evaluation of culture and PCR for the detection and determination of persistence of bacterial strains and DNAs in the Chinchilla laniger model of otitis media Ann. Otol. Rhinol. Laryngol. 107 508–513
Bakaletz, L. O., D. M. Murwin, and J. M. Billy. 1995 Adenovirus serotype 1 does not act synergistically with Moraxella (Branhamella) catarrhalis to induce otitis media in the chinchilla Infect. Immun. 63 4188–4190
Bakaletz, L. O., G. J. White, J. C. Post, and G. D. Ehrlich. 1998 Blinded multiplex PCR analyses of middle ear and nasopharyngeal fluids from chinchilla models of single-and mixed-pathogen-induced otitis media Clin. Diagn. Lab. Immunol. 5 219–224
Bakri, F., A. L. Brauer, S. Sethi, and T. F. Murphy. 2002 Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease J. Infect. Dis. 185 632–640
Barreiro, B., L. Esteban, E. Prats, E. Verdaguer, J. Dorca, and F. Manresa. 1992 Branhamella catarrhalis respiratory infections Eur. Respir. J. 5 675–679
Bartos, L. C., and T. F. Murphy. 1988 Comparison of the outer membrane proteins of 50 strains of Branhamella catarrhalis J. Infect. Dis. 158 761–765
Beaulieu, D., M. G. Bergeron, and P. H. Roy. 1991 Development of a species-specific DNA probe for Moraxella (Branhamella) catarrhalis Molec. Cell Probes 5 37–48
Bell, J. M., J. D. Turnidge, and R. N. Jones. 2002 Antimicrobial resistance trends in community-acquired respiratory tract pathogens in the Western Pacific Region and South Africa: Report from the SENTRY antimicrobial surveillance program (1998–1999), including an in vitro evaluation of BMS284756 Int. J. Antimicrob. Agents 19 125–132
Berg, R. A., and D. L. Bartley. 1987 Pneumonia associated with Branhamella catarrhalis in infants Pediatr. Infect. Dis. J. 6 569–573
Berger, U. 1963 Die anspruchslosen Neisserien Exp. Ther. 36 97–167
Berk, S. L., and A. Verghese. 1989 Emerging pathogens in nosocomial pneumonia Eur. J. Clin. Microbiol. Infect. Dis. 8 11–14
Berner, R., R. F. Schumacher, M. Brandis, and J. Forster. 1996 Colonization and infection with Moraxella catarrhalis in childhood Eur. J. Clin. Microbiol. Infect. Dis. 15 506–509
Bernstein, J. M., and M. Reddy. 2000 Bacteria-mucin interaction in the upper aerodigestive tract shows striking heterogeneity: Implications in otitis media, rhinosinusitis, and pneumonia Otolaryngol. Head Neck Surg. 122 514–520
Bhushan, R., R. Craigie, and T. F. Murphy. 1994 Molecular cloning and characterization of outer membrane protein E of Moraxella (Branhamella) catarrhalis J. Bacteriol. 176 6636–6643
Bhushan, R., C. Kirkham, S. Sethi, and T. F. Murphy. 1997 Antigenic characterization and analysis of the human immune response to outer membrane protein E of Branhamella catarrhalis Infect. Immun. 65 2668–2675
Billson, F. M., J. L. Hodgson, J. R. Egerton, A. W. Lepper, W. P. Michalski, C. L. Schwartzkoff, P. R. Lehrbach, and J. M. Tennent. 1994 A haemolytic cell-free preparation of Moraxella bovis confers protection against infectious bovine keratoconjunctivitis FEMS Microbiol. Lett. 124 69–73
Billson, F. M., C. Harbour, W. P. Michalski, J. M. Tennent, J. R. Egerton, and J. L. Hodgson. 2000 Characterization of hemolysin of Moraxella bovis using a hemolysis-neutralizing monoclonal antibody Infect. Immun. 68 3469–3474
Black, A. J., and T. S. Wilson. 1988 Immunoglobulin G (IgG) serological response to Branhamella catarrhalis in patients with acute bronchopulmonary infections J. Clin. Pathol. 41 329–333
Block, S. L. 1997 Causative pathogens, antibiotic resistance and therapeutic considerations in acute otitis media Pediatr. Infect. Dis. J. 16 449–456
Bonnah, R. A., R. Yu, and A. B. Schryvers. 1995 Biochemical analysis of lactoferrin receptors in the Neisseriaceae: Identification of a second bacterial lactoferrin receptor protein Microb. Pathog. 19 285–297
Bonnah, R. A., and A. B. Schryvers. 1998a Preparation and characterization of Neisseria meningitidis mutants deficient in production of the human lactoferrin-binding proteins LbpA and LbpB J. Bacteriol. 180 3080–3090
Bonnah, R. A., R. H. Yu, H. Wong, and A. B. Schryvers. 1998b Biochemical and immunological properties of lactoferrin binding proteins from Moraxella (Branhamella) catarrhalis Microb. Pathog. 24 89–100
Bonnah, R. A., H. Wong, S. M. Loosmore, and A. B. Schryvers. 1999 Characterization of Moraxella (Branhamella) catarrhalis lbpB, lbpA, and lactoferrin receptor orf3 isogenic mutants Infect. Immun. 67 1517–1520
Bootsma, H. J., H. van Dijk, J. Verhoef, A. Fleer, and F. R. Mooi. 1996 Molecular characterization of the BRO beta-lactamase of Moraxella (Branhamella) catarrhalis Antimicrob. Agents Chemother. 40 966–972
Bootsma, H. J., P. C. Aerts, G. Posthuma, T. Harmsen, J. Verhoef, H. van Dijk, and F. R. Mooi. 1999 Moraxella (Branhamella) catarrhalis BRO beta-lactamase: A lipoprotein of gram-positive origin? J. Bacteriol. 181 5090–5093
Bootsma, H. J., H. G. van der Heide, S. van de Pas, L. M. Schouls, and F. R. Mooi. 2000a Analysis of Moraxella catarrhalis by DNA typing: Evidence for a distinct subpopulation associated with virulence traits J. Infect. Dis. 181 1376–1387
Bootsma, H. J., H. van Dijk, P. Vauterin, J. Verhoef, and F. R. Mooi. 2000b Genesis of BRO beta-lactamase-producing Moraxella catarrhalis: Evidence for transformation-mediated horizontal transfer Molec. Microbiol. 36 93–104
Boswell, F. J., J. M. Andrews, G. Jevons, and R. Wise. 2002 Comparison of the in vitro activities of several new fluoroquinolones against respiratory pathogens and their abilities to select fluoroquinolone resistance J. Antimicrob. Chemother. 50 495–502
Bovre, K., and L. O. Froholm. 1972 Variation of colony morphology reflecting fimbriation in Moraxella bovis and two reference strains of M. nonliquefaciens Acta Pathol. Microbiol. Scand. [B] Microbiol. Immunol. 80 629–640
Boyle, F. M., P. R. Georghiou, M. H. Tilse, and J. G. McCormack. 1991 Branhamella (Moraxella) catarrhalis: Pathogenic significance in respiratory infections Med. J. Australia 154 592–596
Brook, I., and P. H. van de Heyning. 1994 Microbiology and management of otitis media Scand. J. Infect. Dis. Suppl. 93 20–32
Brook, I. 2002 Bacteriology of acute and chronic frontal sinusitis Arch. Otolaryngol. Head Neck Surg. 128 583–585
Brorson, J. E., A. Axelsson, and S. E. Holm. 1976 Studies on Branhamella catarrhalis (Neisseria catarrhalis) with special reference to maxillary sinusitis Scand. J. Infect. Dis. 8 151–155
Brorson, J. E., and B. E. Malmvall. 1981 Branhamella catarrhalis and other bacteria in the nasopharynx of children with longstanding cough Scand. J. Infect. Dis. 13 111–113
Brown, E. J., K. A. Joiner, and M. M. Frank. 1983 The role of complement in host resistance to bacteria Springer Semin. Immunopathol. 6 349–360
Calder, M. A., M. J. Croughan, D. T. McLeod, and F. Ahmad. 1986 The incidence and antibiotic susceptibility of Branhamella catarrhalis in respiratory infections Drugs 31, Suppl. 3 11–16
Campagnari, A. A., S. M. Spinola, A. J. Lesse, Y. A. Kwaik, R. E. Mandrell, and M. A. Apicella. 1990 Lipooligosaccharide epitopes shared among Gram-negative non-enteric mucosal pathogens Microb. Pathog. 8 353–362
Campagnari, A. A., T. F. Ducey, and C. A. Rebmann. 1996 Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella (Branhamella) catarrhalis, binds human transferrin Infect. Immun. 64 3920–3924
Carson, R. T., D. F. McDonald, M. A. Kehoe, and J. E. Calvert. 1994 Influence of Gm allotype on the IgG subclass response to streptococcal M protein and outer membrane proteins of Moraxella catarrhalis Immunology 83 107–113
Cates, K. L. 1983 Host factors in bacteremia Am. J. Med. 75 19–25
Catlin, B. W. 1970 Transfer of the organism named Neisseria catarrhalis to Branhamella gen. nov Int. J. Syst. Bacteriol. 20 155–159
Catlin, B. W. 1990 Branhamella catarrhalis: An organism gaining respect as a pathogen Clin. Microbiol. Rev. 3 293–320
Catlin, B. W. 1991 Branhamaceae fam. nov., a proposed family to accommodate the genera Branhamella and Moraxella Int. J. Syst. Bacteriol. 41 320–323
Caye-Thomasen, P., A. Hermansson, M. Tos, and K. Prellner. 2000 Middle ear secretory capacity after acute otitis media caused by Streptococcus pneumoniae, Moraxella catarrhalis, non-typeable or type B Haemophilus influenzae. A comparative analysis based on goblet cell density Acta Otolaryngol. Suppl. 543 54–55
Chaibi, E. B., P. Mugnier, M. D. Kitzis, F. W. Goldstein, and J. F. Acar. 1995 Beta-lactamases of Branhamella catarrhalis and their phenotypic implications Res. Microbiol. 146 761–771
Chan, J., and J. Hadley. 2001 The microbiology of chronic rhinosinusitis: Results of a community surveillance study Ear Nose Throat J. 80 143–145
Chapman Jr., A. J., D. M. Musher, S. Jonsson, J. E. Clarridge, and R. J. Wallace Jr. 1985 Development of bactericidal antibody during Branhamella catarrhalis infection J. Infect. Dis. 151 878–882
Chen, D., J. C. McMichael, K. R. VanDerMeid, D. Hahn, T. Mininni, J. Cowell, and J. Eldridge. 1996 Evaluation of purified UspA from Moraxella catarrhalis as a vaccine in a murine model after active immunization Infect. Immun. 64 1900–1905
Chen, D., V. Barniak, K. R. VanDerMeid, and J. C. McMichael. 1999a The levels and bactericidal capacity of antibodies directed against the UspA1 and UspA2 outer membrane proteins of Moraxella (Branhamella) catarrhalis in adults and children Infect. Immun. 67 1310–1316
Chen, D., J. C. McMichael, K. R. VanDerMeid, A. W. Masi, E. Bortell, J. D. Caplan, D. N. Chakravarti, and V. L. Barniak. 1999b Evaluation of a 74-kDa transferrin-binding protein from Moraxella (Branhamella) catarrhalis as a vaccine candidate Vaccine 18 109–118
Chong, C. Y., W. H. Lim, J. T. Heng, and O. M. Chay. 1997 The changing trend in the pattern of infective etiologies in childhood acute lower respiratory tract infection Acta Paediatr. Jpn. 39 317–321
Christensen, J. J., J. Keiding, H. Schumacher, and B. Bruun. 1991 Recognition of a new Branhamella catarrhalis beta-lactamase—BRO-3 J. Antimicrob. Chemother. 28 774–775
Christensen, J. J., P. Gerner-Smidt, and B. Bruun. 1995 Moraxella (Branhamella) catarrhalis: Restriction enzyme analysis typing with HinfI, HaeIII and PstI FEMS Immunol. Med. Microbiol. 12 43–46
Christensen, J. J., N. Q. Hansen, and B. Bruun. 1996 Serum antibody response to outer membrane proteins of Moraxella (Branhamella) catarrhalis in patients with bronchopulmonary infection Clin. Diagn. Lab. Immunol. 3 717–721
Chung, M. H., R. Enrique, D. J. Lim, and T. F. De Maria. 1994 Moraxella (Branhamella) catarrhalis-induced experimental otitis media in the chinchilla Acta Otolaryngol. 114 415–422
Clinkenbeard, K. D., and A. E. Thiessen. 1991 Mechanism of action of Moraxella bovis hemolysin Infect. Immun. 59 1148–1152
Cohen, R., C. Levy, M. Boucherat, J. Langue, E. Autret, P. Gehanno, and F. de La Rocque. 2000 Five vs. ten days of antibiotic therapy for acute otitis media in young children Pediatr. Infect. Dis. J. 19 458–463
Cole, L. E., T. H. Kawula, K. L. Toffer, and C. Elkins. 2002 The Haemophilus ducreyi serum resistance antigen DsrA confers attachment to human keratinocytes Infect. Immun. 70 6158–6165
Collazos, J., J. de Miguel, and R. Ayarza. 1992 Moraxella catarrhalis bacteremic pneumonia in adults: Two cases and review of the literature Eur. J. Clin. Microbiol. Infect. Dis. 11 237–240
Commisso, R., F. Romero-Orellano, P. B. Montanaro, F. Romero-Moroni, and R. Romero-Diaz. 2000 Acute otitis media: Bacteriology and bacterial resistance in 205 pediatric patients Int. J. Pediatr. Otorhinolaryngol. 56 23–31
Conceicao, F. R., O. A. Dellagostin, F. Paolichi, A. C. Leturia, and C. Gil Turnes. 2004 Molecular diversity of Moraxella bovis isolated from Brazil, Argentina and Uruguay over a period of three decades Vet. J. 167 53–58
Cook, P. P., D. W. Hecht, and D. R. Snydman. 1989 Nosocomial Branhamella catarrhalis in a paediatric intensive care unit: Risk factors for disease J. Hosp. Infect. 13 299–307
Cooke, R. P., R. Williams, and C. M. Bannister. 1990 Shunt-associated ventriculitis caused by Branhamella catarrhalis J. Hosp. Infect. 15 197–198
Cope, L. D., E. R. Lafontaine, C. A. Slaughter, C. A. Hasemann Jr., C. Aebi, F. W. Henderson, G. H. McCracken Jr., and E. J. Hansen. 1999 Characterization of the Moraxella catarrhalis uspA1 and uspA2 genes and their encoded products J. Bacteriol. 181 4026–4034
Daele, J. J. 1997 Chronic sinusitis in children Acta Otorhinolaryngol. Belg. 51 285–304
Daoud, A., F. Abuekteish, and H. Masaadeh. 1996 Neonatal meningitis due to Moraxella catarrhalis and review of the literature Ann. Trop. Paediatr. 16 199–201
Davies, B. I., and F. P. Maesen. 1988 The epidemiology of respiratory tract pathogens in southern Netherlands Eur. Respir. J. 1 415–420
Denamur, E., G. Suermondt, A. Debroca, C. Defouilloy, G. Laurans, J. F. Muir, and J. Orfila. 1989 Nosocomial pulmonary infections caused by Branhamella catarrhalis in intensive care units Agressologie 30 251–253
Denamur, E., N. Picard-Pasquier, C. Mura, B. Picard, J. Orfila, and R. Krishnamoorthy. 1991 Comparison of molecular epidemiological tools for Branhamella catarrhalis typing Res. Microbiol. 142 585–589
Deshpande, L. M., and R. N. Jones. 2000 Antimicrobial activity of advanced-spectrum fluoroquinolones tested against more than 2000 contemporary bacterial isolates of species causing community-acquired respiratory tract infections in the United States (1999) Diagn. Microbiol. Infect. Dis. 37 139–142
DiGiovanni, C., T. V. Riley, G. F. Hoyne, R. Yeo, and P. Cooksey. 1987 Respiratory tract infections due to Branhamella catarrhalis: Epidemiological data from Western Australia Epidemiol. Infect. 99 445–453
Doern, G. V., and S. A. Morse. 1980 Branhamella (Neisseria) catarrhalis: Criteria for laboratory identification J. Clin. Microbiol. 11 193–195
Doern, G. V., M. J. Miller, and R. E. Winn. 1981 Branhamella (Neisseria) catarrhalis systemic disease in humans: Case reports and review of the literature Arch. Intern. Med. 141 1690–1692
Doern, G. V., A. B. Brueggemann, G. Pierce, T. Hogan, H. P. Holley Jr., and A. Rauch. 1996 Prevalence of antimicrobial resistance among 723 outpatient clinical isolates of Moraxella catarrhalis in the United States in 1994 and 1995: Results of a 30-center national surveillance study Antimicrob. Agents Chemother. 40 2884–2886
Domingo, P., M. Puig, R. Pericas, B. Mirelis, and G. Prats. 1995 Moraxella catarrhalis bacteraemia in an immunocompetent adult Scand. J. Infect. Dis. 27 95
Doyle, W. J. 1989 Animal models of otitis media: Other pathogens Pediatr. Infect. Dis. J. 8 S45–S47
Du, R. P., Q. Wang, Y. P. Yang, A. B. Schryvers, P. Chong, M. H. Klein, and S. M. Loosmore. 1998 Cloning and expression of the Moraxella catarrhalis lactoferrin receptor genes Infect. Immun. 66 3656–3665
Dubay, S. A., E. S. Williams, K. Mills, and A. M. Boerger-Fields. 2000 Association of Moraxella ovis with keratoconjunctivitis in mule deer and moose in Wyoming J. Wildl. Dis. 36 241–247
du Plessis, M. 2001 Rapid discrimination between BRO beta-lactamases from clinical isolates of Moraxella catarrhalis using restriction endonuclease analysis Diagn. Microbiol. Infect. Dis. 39 65–67
Edebrink, P., P. E. Jansson, M. M. Rahman, G. Widmalm, T. Holme, M. Rahman, and A. Weintraub. 1994 Structural studies of the O-polysaccharide from the lipopolysaccharide of Moraxella (Branhamella) catarrhalis serotype A (strain ATCC 25238) Carbohydr. Res. 257 269–284
Edebrink, P., P. E. Jansson, M. M. Rahman, G. Widmalm, T. Holme, and M. Rahman. 1995 Structural studies of the O-antigen oligosaccharides from two strains of Moraxella catarrhalis serotype C Carbohydr. Res. 266 237–261
Edebrink, P., P. E. Jansson, G. Widmalm, T. Holme, and M. Rahman. 1996 The structures of oligosaccharides isolated from the lipopolysaccharide of Moraxella catarrhalis serotype B, strain CCUG 3292 Carbohydr. Res. 295 127–146
Ejlertsen, T., E. Thisted, F. Ebbesen, B. Olesen, and J. Renneberg. 1994a Branhamella catarrhalis in children and adults. A study of prevalence, time of colonisation, and association with upper and lower respiratory tract infections J. Infect. 29 23–31
Ejlertsen, T., E. Thisted, P. A. Ostergaard, and J. Renneberg. 1994b Maternal antibodies and acquired serological response to Moraxella catarrhalis in children determined by an enzyme-linked immunosorbent assay Clin. Diagn. Lab. Immunol. 1 464–468
El Ahmer, O. R., S. D. Essery, A. T. Saadi, M. W. Raza, M. M. Ogilvie, D. M. Weir, and C. C. Blackwell. 1999 The effect of cigarette smoke on adherence of respiratory pathogens to buccal epithelial cells FEMS Immunol. Med. Microbiol. 23 27–36
El-Ahmer, O. R., J. M. Braun, S. G. Amyes, D. M. Weir, J. Beuth, and C. C. Blackwell. 2003 Comparison of Moraxella catarrhalis isolates from children and adults for growth on modified New York City medium and potential virulence factors J. Med. Microbiol. 52 853–859
Eliasson, I., and C. Kamme. 1985 Characterization of the plasmid-mediated beta-lactamase in Branhamella catarrhalis, with special reference to substrate affinity J. Antimicrob. Chemother. 15 139–149
Eliasson, I., C. Kamme, M. Vang, and S. G. Waley. 1992 Characterization of cell-bound papain-soluble beta-lactamases in BRO-1 and BRO-2 producing strains of Moraxella (Branhamella) catarrhalis and Moraxella nonliquefaciens Eur. J. Clin. Microbiol. Infect. Dis. 11 313–321
Eller, J., A. Ede, T. Schaberg, M. S. Niederman, H. Mauch, and H. Lode. 1998 Infective exacerbations of chronic bronchitis: Relation between bacteriologic etiology and lung function Chest 113 1542–1548
Emerson, F. G., G. E. Kolb, and F. A. VanNatta. 1983 Chronic cholera-like lesions caused by Moraxella osloensis Avian Dis. 27 836–838
Enright, M. C., P. E. Carter, L. A. MacLean, and H. McKenzie. 1994 Phylogenetic relationships between some members of the genera Neisseria, Acinetobacter, Moraxella, and Kingella based on partial 16S ribosomal DNA sequence analysis Int. J. System. Bacteriol. 44 387–391
Enright, M. C., and H. McKenzie. 1997 Moraxella (Branhamella) catarrhalis—clinical and molecular aspects of a rediscovered pathogen J. Med. Microbiol. 46 360–371
Ernst, T. N., and M. Philp. 1987 Bacterial tracheitis caused by Branhamella catarrhalis Pediatr. Infect. Dis. J. 6 574
Esposito, S., S. Noviello, and F. Ianniello. 2000 Comparative in vitro activity of older and newer fluoroquinolones against respiratory tract pathogens Chemotherapy 46 309–314
Evy, F., and E. S. Walker. 2004 BRO (beta)-lactamase alleles, antibiotic resistance and a test of the BRO-1 selective replacement hypothesis in Moraxella catarrhalis J. Antimicrob. Chemother. 53 371–374
Faden, H., J. Stanievich, L. Brodsky, J. Bernstein, and P. L. Ogra. 1990 Changes in nasopharyngeal flora during otitis media of childhood Pediatr. Infect. Dis. J. 9 623–626
Faden, H., M. J. Waz, J. M. Bernstein, L. Brodsky, J. Stanievich, and P. L. Ogra. 1991 Nasopharyngeal flora in the first three years of life in normal and otitis-prone children Ann. Otol. Rhinol. Laryngol. 100 612–615
Faden, H., J. Bernstein, L. Brodsky, J. Stanievich, and P. L. Ogra. 1992a Effect of prior antibiotic treatment on middle ear disease in children Ann. Otol. Rhinol. Laryngol. 101 87–91
Faden, H., J. Hong, and T. Murphy. 1992b Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media Infect. Immun. 60 3824–3829
Faden, H., Y. Harabuchi, and J. J. Hong. 1994 Epidemiology of Moraxella catarrhalis in children during the first 2 years of life: Relationship to otitis media J. Infect. Dis. 169 1312–1317
Faden, H., L. Duffy, R. Wasielewski, J. Wolf, D. Krystofik, and Y. Tung. 1997 Relationship between nasopharyngeal colonization and the development of otitis media in children: Tonawanda/Williamsville Pediatrics J. Infect. Dis. 175 1440–1445
Faden, H. 2001 The microbiologic and immunologic basis for recurrent otitis media in children Eur. J. Pediatr. 160 407–413
Finegold, S. M., M. J. Flynn, F. V. Rose, H. Jousimies-Somer, C. Jakielaszek, M. McTeague, H. M. Wexler, E. Berkowitz, and B. Wynne. 2002 Bacteriologic findings associated with chronic bacterial maxillary sinusitis in adults Clin. Infect. Dis. 35 428–433
Fitzgerald, M., R. Mulcahy, S. Murphy, C. Keane, D. Coakley, and T. Scott. 1997 A 200 kDa protein is associated with haemagglutinating isolates of Moraxella (Branhamella) catarrhalis FEMS Immunol. Med. Microbiol. 18 209–216
Fomsgaard, J. S., A. Fomsgaard, N. Hoiby, B. Bruun, and C. Galanos. 1991 Comparative immunochemistry of lipopolysaccharides from Branhamella catarrhalis strains Infect. Immun. 59 3346–3349
Forsgren, A., M. Brant, A. Mollenkvist, A. Muyombwe, H. Janson, N. Woin, and K. Riesbeck. 2001 Isolation and characterization of a novel IgD-binding protein from Moraxella catarrhalis J. Immunol. 167 2112–2120
Forsgren, A., M. Brant, M. Karamehmedovic, and K. Riesbeck. 2003 The immunoglobulin D-binding protein MID from Moraxella catarrhalis is also an adhesin Infect. Immun. 71 3302–3309
Franciolli, M. 1991 Beta-lactam/beta-lactamase inhibitor combinations for oral administration Schweiz. Med. Wochenschr. 121 1399–1407
Frank, S. K., and J. D. Gerber. 1981 Hydrolytic enzymes of Moraxella bovis J. Clin. Microbiol. 13 269–271
Furano, K., and A. A. Campagnari. 2003 Inactivation of the Moraxella catarrhalis 7169 ferric uptake regulator increases susceptibility to the bactericidal activity of normal human sera Infect. Immun. 71 1843–1848
Gabre-Selasie, S. 1998 Human antibody response to Moraxella catarrhalis antigens East Afr. Med. J. 75 175–179
Garcia-Rodriguez, J. A., and M. J. Fresnadillo Martinez. 2002 Dynamics of nasopharyngeal colonization by potential respiratory pathogens J. Antimicrob. Chemother. 50, Suppl. S2 59–73
Gehanno, P., A. Panajotopoulos, B. Barry, L. Nguyen, D. Levy, E. Bingen, and P. Berche. 2001 Microbiology of otitis media in the Paris, France, area from 1987 to 1997 Pediatr. Infect. Dis. J. 20 570–573
George, L. W., W. D. Wilson, J. D. Baggot, and J. E. Mihalyi. 1984 Antibiotic treatment of Moraxella bovis infection in cattle J. Am. Vet. Med. Assoc. 185 1206–1209
George, L. W., and J. A. Smith. 1985 Treatment of Moraxella bovis infections in calves using a long-acting oxytetracycline formulation J. Vet. Pharmacol. Ther. 8 55–61
Gil-Turnes, C., and F. L. de Araujo. 1982 Serological characterization of strains of Moraxella bovis using double immunodiffusion Can. J. Comp. Med. 46 165–168
Gil-Turnes, C., and I. M. Albuquerque. 1984 Serotypes and antibiotic sensitivity of Moraxella bovis isolated from an outbreak of infectious bovine keratoconjunctivitis Can. J. Comp. Med. 48 428–430
Gil-Turnes, C., and J. A. Aleixo. 1991 Quantification of Moraxella bovis haemagglutinating adhesins with monoclonal antibodies Lett. Appl. Microbiol. 13 55–57
Gjorloff Wingren, A., R. Hadzic, A. Forsgren, and K. Riesbeck. 2002 The novel IgD binding protein from Moraxella catarrhalis induces human B lymphocyte activation and Ig secretion in the presence of Th2 cytokines J. Immunol. 168 5582–5588
Glass Jr., H. W., and R. R. Gerhardt. 1984 Transmission of Moraxella bovis by regurgitation from the crop of the face fly (Diptera: Muscidae) J. Econ. Entomol. 77 399–401
Goldblatt, D., N. D. Seymour, R. J. Levinsky, and M. W. Turner. 1990a An enzyme-linked immunosorbent assay for the determination of human IgG subclass antibodies directed against Branhamella catarrhalis J. Immunol. Meth. 128 219–225
Goldblatt, D., M. W. Turner, and R. J. Levinsky. 1990b Branhamella catarrhalis: Antigenic determinants and the development of the IgG subclass response in childhood J. Infect. Dis. 162 1128–1135
Goldblatt, D., G. K. Scadding, V. J. Lund, A. M. Wade, M. W. Turner, and J. P. Pandey. 1994 Association of Gm allotypes with the antibody response to the outer membrane proteins of a common upper respiratory tract organism, Moraxella catarrhalis J. Immunol. 153 5316–5320
Gorter, A. D., P. S. Hiemstra, S. de Bentzmann, S. van Wetering, J. Dankert, and L. van Alphen. 2000 Stimulation of bacterial adherence by neutrophil defensins varies among bacterial species but not among host cell types FEMS Immunol. Med. Microbiol. 28 105–111
Gray, J. T., P. J. Fedorka-Cray, and D. G. Rogers. 1995 Partial characterization of a Moraxella bovis cytolysin Vet. Microbiol. 43 183–196
Greiner, O., P. J. Day, M. Altwegg, and D. Nadal. 2003 Quantitative detection of Moraxella catarrhalis in nasopharyngeal secretions by real-time PCR J. Clin. Microbiol. 41 1386–1390
Gu, X. X., J. Chen, S. J. Barenkamp, J. B. Robbins, C. M. Tsai, D. J. Lim, and J. Battey. 1998 Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis Infect. Immun. 66 1891–1897
Haddad, J., A. Le Faou, U. Simeoni, and J. Messer. 1986 Hospital-acquired bronchopulmonary infection in premature infants due to Branhamella catarrhalis J. Hosp. Infect. 7 301–302
Hager, H., A. Verghese, S. Alvarez, and S. L. Berk. 1987 Branhamella catarrhalis respiratory infections Rev. Infect. Dis. 9 1140–1149
Harmsen, D., C. Singer, J. Rothganger, T. Tonjum, G. S. de Hoog, H. Shah, J. Albert, and M. Frosch. 2001 Diagnostics of Neisseriaceae and Moraxellaceae by ribosomal DNA sequencing: Ribosomal differentiation of medical microorganisms J. Clin. Microbiol. 39 936–942
Hart, V. K. 1927 The bacteriology of acute ears Laryngoscope 37 56–61
Hays, J. P., K. Eadie, C. M. Verduin, J. Hazelzet, H. Verbrugh, and A. van Belkum. 2003a Changes in genetic types and population dynamics of Moraxella catarrhalis in hospitalized children are not associated with an exacerbation of existing disease J. Med. Microbiol. 52 815–820
Hays, J. P., C. van der Schee, A. Loogman, K. Eadie, C. Verduin, H. Faden, H. Verbrugh, and A. van Belkum. 2003b Total genome polymorphism and low frequency of intra-genomic variation in the uspA1 and uspA2 genes of Moraxella catarrhalis in otitis prone and non-prone children up to 2 years of age: Consequences for vaccine design? Vaccine 21 1118–1124
Hellio, R., M. Guibourdenche, E. Collatz, and J. Y. Riou. 1988 The envelope structure of Branhamella catarrhalis as studied by transmission electron microscopy Ann. Inst. Pasteur Microbiol. 139 515–525
Helminen, M. E., I. Maciver, J. L. Latimer, L. D. Cope, G. H. McCracken Jr., and E. J. Hansen. 1993 A major outer membrane protein of Moraxella catarrhalis is a target for antibodies that enhance pulmonary clearance of the pathogen in an animal model Infect. Immun. 61 2003–2010
Helminen, M. E., I. Maciver, J. L. Latimer, J. Klesney-Tait, L. D. Cope, M. Paris, G. H. McCracken Jr., and E. J. Hansen. 1994 A large, antigenically conserved protein on the surface of Moraxella catarrhalis is a target for protective antibodies J. Infect. Dis. 170 867–872
Helminen, M. E., R. Beach, I. Maciver, G. Jarosik, E. J. Hansen, and M. Leinonen. 1995 Human immune response against outer membrane proteins of Moraxella (Branhamella) catarrhalis determined by immunoblotting and enzyme immunoassay Clin. Diagn. Lab. Immunol. 2 35–39
Hendolin, P. H., U. Karkkainen, T. Himi, A. Markkanen, and J. Ylikoski. 1999 High incidence of Alloiococcus otitis in otitis media with effusion Pediatr. Infect. Dis. J. 18 860–865
Henson, J. B., and L. C. Grumbles. 1960 Infectious bovine keratoconjunctivitis. I: Etiology Am. J. Vet. Res. 21 761–766
Hill, D. J., and M. Virji. 2003 A novel cell-binding mechanism of Moraxella catarrhalis ubiquitous surface protein UspA: Specific targeting of the N-domain of carcinoembryonic antigen-related cell adhesion molecules by UspA1 Molec. Microbiol. 48 117–129
Hoban, D. J., G. V. Doern, A. C. Fluit, M. Roussel-Delvallez, and R. N. Jones. 2001 Worldwide prevalence of antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the SENTRY Antimicrobial Surveillance Program, 1997–1999 Clin. Infect. Dis. 32, Suppl. 2 S81–S93
Hoban, D., and D. Felmingham. 2002 The PROTEKT surveillance study: Antimicrobial susceptibility of Haemophilus influenzae and Moraxella catarrhalis from community-acquired respiratory tract infections J. Antimicrob. Chemother. 50, Suppl. S1 49–59
Hoberman, A., C. D. Marchant, S. L. Kaplan, and S. Feldman. 2002 Treatment of acute otitis media consensus recommendations Clin. Pediatr. (Philadelphia) 41 373–390
Hoiczyk, E., A. Roggenkamp, M. Reichenbecher, A. Lupas, and J. Heesemann. 2000 Structure and sequence analysis of Yersinia YadA and Moraxella UspAs reveal a novel class of adhesins EMBO J. 19 5989–5999
Hoien-Dalen, P. S., R. F. Rosenbusch, and J. A. Roth. 1990 Comparative characterization of the leukocidic and hemolytic activity of Moraxella bovis Am. J. Vet. Res. 51 191–196
Hol, C., C. M. Verduin, E. van Dijke, J. Verhoef, and H. van Dijk. 1993 Complement resistance in Branhamella (Moraxella) catarrhalis Lancet 341 1281
Hol, C., E. E. van Dijke, C. M. Verduin, J. Verhoef, and H. van Dijk. 1994 Experimental evidence for Moraxella-induced penicillin neutralization in pneumococcal pneumonia J. Infect. Dis. 170 1613–1616
Hol, C., C. M. Verduin, E. E. van Dijke, J. Verhoef, A. Fleer, and H. van Dijk. 1995 Complement resistance is a virulence factor of Branhamella (Moraxella) catarrhalis FEMS Immunol. Med. Microbiol. 11 207–211
Hol, C., C. Schalen, C. M. Verduin, E. E. Van Dijke, J. Verhoef, A. Fleer, and H. van Dijk. 1996 Moraxella catarrhalis in acute laryngitis: Infection or colonization? J. Infect. Dis. 174 636–638
Holm, M. M., S. L. Vanlerberg, D. D. Sledjeski, and E. R. Lafontaine. 2003 The Hag protein of Moraxella catarrhalis strain O35E is associated with adherence to human lung and middle ear cells Infect. Immun. 71 4977–4984
Holme, T., M. Rahman, P. E. Jansson, and G. Widmalm. 1999 The lipopolysaccharide of Moraxella catarrhalis structural relationships and antigenic properties Eur. J. Biochem. 265 524–529
Hou, Y., W. G. Hu, T. Hirano, and X. X. Gu. 2002 A new intra-NALT route elicits mucosal and systemic immunity against Moraxella catarrhalis in a mouse challenge model Vaccine 20 2375–2381
Hsiao, C. B., S. Sethi, and T. F. Murphy. 1995 Outer membrane protein CD of Branhamella catarrhalis: Sequence conservation in strains recovered from the human respiratory tract Microb. Pathog. 19 215–225
Hu, W. G., J. Chen, F. M. Collins, and X. X. Gu. 1999 An aerosol challenge mouse model for Moraxella catarrhalis Vaccine 18 799–804
Hu, W. G., J. Chen, J. F. Battey, and X. X. Gu. 2000 Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins Infect. Immun. 68 4980–4985
Ikeda, F., Y. Yokota, Y. Mine, and T. Yamada. 1993 Characterization of BRO enzymes and beta-lactamase transfer of Moraxella (Branhamella) catarrhalis isolated in Japan Chemotherapy 39 88–95
Ikram, R. B., M. Nixon, J. Aitken, and E. Wells. 1993 A prospective study of isolation of Moraxella catarrhalis in a hospital during the winter months J. Hosp. Infect. 25 7–14
Ioannidis, J. P., M. Worthington, J. K. Griffiths, and D. R. Snydman. 1995 Spectrum and significance of bacteremia due to Moraxella catarrhalis Clin. Infect. Dis. 21 390–397
Janicka, G., A. Mikucka, A. Sekowska, T. Zwierzchlewski, and M. Wroblewski. 2002 Autoaggregation, hydrophobic, and hydrophylic properties of Moraxella catarrhalis strains Acta Microbiol. Pol. 51 23–30
Jayappa, H. G., and C. Lehr. 1986 Pathogenicity and immunogenicity of piliated and nonpiliated phases of Moraxella bovis in calves Am. J. Vet. Res. 47 2217–2221
Jecker, P., A. McWilliam, S. Napoli, P. G. Holt, R. Pabst, M. Westhofen, and J. Westermann. 1999 Acute laryngitis in the rat induced by Moraxella catarrhalis and Bordetella pertussis: Number of neutrophils, dendritic cells, and T and B lymphocytes accumulating during infection in the laryngeal mucosa strongly differs in adjacent locations Pediatr. Res. 46 760–766
Jiao, X., T. Hirano, Y. Hou, and X. X. Gu. 2002 Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine Infect. Immun. 70 5982–5989
Johnson, D. M., H. S. Sader, T. R. Fritsche, D. J. Biedenbach, and R. N. Jones. 2003 Susceptibility trends of Haemophilus influenzae and Moraxella catarrhalis against orally administered antimicrobial agents: Five-year report from the SENTRY Antimicrobial Surveillance Program Diagn. Microbiol. Infect. Dis. 47 373–376
Joki-Erkkila, V. P., J. Aittoniemi, R. Vuento, and H. Puhakka. 2002 Beta-lactamase-producing Moraxella catarrhalis may prevent the emergence of penicillin-resistant Streptococcus pneumoniae in children with recurrent acute otitis media Int. J. Pediatr. Otorhinolaryngol. 63 219–222
Jones, M. E., J. A. Karlowsky, R. Blosser-Middleton, I. A. Critchley, C. Thornsberry, and D. F. Sahm. 2002 Apparent plateau in beta-lactamase production among clinical isolates of Haemophilus influenzae and Moraxella catarrhalis in the United States: Results from the LIBRA Surveillance initiative Int. J. Antimicrob. Agents 19 119–123
Jones, M. E., R. S. Blosser-Middleton, I. A. Critchley, J. A. Karlowsky, C. Thornsberry, and D. F. Sahm. 2003 In vitro susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis: A European multicenter study during 2000–2001 Clin. Microbiol. Infect. 9 590–599
Jones, R. N. 2002 Microbiology of newer fluoroquinolones: Focus on respiratory pathogens Diagn. Microbiol. Infect. Dis. 44 213–220
Jordan, K. L., S. H. Berk, and S. L. Berk. 1990 A comparison of serum bactericidal activity and phenotypic characteristics of bacteremic, pneumonia-causing strains, and colonizing strains of Branhamella catarrhalis Am. J. Med. 88 28S–32S
Jorgensen, J. H., G. V. Doern, L. A. Maher, A. W. Howell, and J. S. Redding. 1990 Antimicrobial resistance among respiratory isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae in the United States Antimicrob. Agents Chemother. 34 2075–2080
Juni, E., G. A. Heym, and R. A. Bradley. 1984 General approach to bacterial nutrition: Growth factor requirements of Moraxella nonliquefaciens J. Bacteriol. 160 958–965
Juni, E., G. A. Heym, and M. Avery. 1986 Defined medium for Moraxella (Branhamella) catarrhalis Appl. Environ. Microbiol. 52 546–551
Juni, E., G. A. Heym, M. J. Maurer, and M. L. Miller. 1987 Combined genetic transformation and nutritional assay for identification of Moraxella nonliquefaciens J. Clin. Microbiol. 25 1691–1694
Juni, E., G. A. Heym, and R. D. Newcomb. 1988 Identification of Moraxella bovis by qualitative genetic transformation and nutritional assays Appl. Environ. Microbiol. 54 1304–1306
Kadry, A. A., S. I. Fouda, N. A. Elkhizzi, and A. M. Shibl. 2003 Correlation between susceptibility and BRO type enzyme of Moraxella catarrhalis strains Int. J. Antimicrob. Agents 22 532–536
Kagonyera, G. M., L. George, and M. Miller. 1989 Effects of Moraxella bovis and culture filtrates on 51Cr-labeled bovine neutrophils Am. J. Vet. Res. 50 18–21
Kaijalainen, T., E. Ruokokoski, P. Ukkonen, and E. Herva. 2004 Survival of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis frozen in skim milk-tryptone-glucose-glycerol medium J. Clin. Microbiol. 42 412–414
Kamme, C., M. Wang, and S. Stahl. 1984 Intrageneric and intergeneric transfer of Branhamella catarrhalis beta-lactamase production Scand. J. Infect. Dis. 16 153–155
Kamme, C., I. Eliasson, B. K. Knutson, and M. Vang. 1986 Plasmid-mediated beta-lactamase in Branhamella catarrhalis Drugs 31 55–63
Karalus, R., and A. Campagnari. 2000 Moraxella catarrhalis: A review of an important human mucosal pathogen Microb. Infect. 2 547–559
Karjalainen, H., M. Koskela, J. Luotonen, and P. Sipila. 1991 Secretory antibodies specific to Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis in middle ear effusion during acute otitis media Acta Otolaryngol. 111 524–529
Kawakami, Y., I. Ueno, T. Katsuyama, K. Furihata, and H. Matsumoto. 1994 Restriction fragment length polymorphism (RFLP) of genomic DNA of Moraxella (Branhamella) catarrhalis isolates in a hospital Microbiol. Immunol. 38 891–895
Kelly, J., H. Masoud, M. B. Perry, J. C. Richards, and P. Thibault. 1996 Separation and characterization of O-deacylated lipooligosaccharides and glycans derived from Moraxella catarrhalis using capillary electrophoresis-electrospray mass spectrometry and tandem mass spectrometry Analyt. Biochem. 233 15–30
Kilpi, T., E. Herva, T. Kaijalainen, R. Syrjanen, and A. K. Takala. 2001 Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life Pediatr. Infect. Dis. J. 20 654–662
Klein, J. O., M. Tos, B. Hussl, R. F. Naunton, M. Ohyama, and P. B. van Cauwenberge. 1989 Recent advances in otitis media. Definition and classification Ann. Otol. Rhinol. Laryngol. Suppl 139 10
Klein, J. O. 1994 Otitis media Clin. Infect. Dis. 19 823–833
Klingman, K. L., A. Pye, T. F. Murphy, and S. L. Hill. 1995 Dynamics of respiratory tract colonization by Branhamella catarrhalis in bronchiectasis Am. J. Respir. Crit. Care Med. 152 1072–1078
Kodjo, A., A. Moussa, E. Borges, and Y. Richard. 1993 Identification of Moraxella-like bacteria isolated from caprine and ovine nasal flora Zentralbl. Veterinärmed. B40 97–104
Kovatch, A. L., E. R. Wald, and R. H. Michaels. 1983 Beta-lactamase-producing Branhamella catarrhalis causing otitis media in children J. Pediatr. 102 261–264
Krishnaswamy, G., R. Martin, E. Walker, C. Li, F. Hossler, K. Hall, and D. S. Chi. 2003 Moraxella catarrhalis induces mast cell activation and nuclear factor kappa B-dependent cytokine synthesis Front. Biosci. 8 a40–A47
Kurtti, P., R. Isoaho, L. von Hertzen, T. Keistinen, S. L. Kivela, and M. Leinonen. 1997 Influence of age, gender and smoking on Streptococcus pneumoniae, Haemophilus influenzae and Moraxella (Branhamella) catarrhalis antibody titres in an elderly population Scand. J. Infect. Dis. 29 485–489
Kyd, J. M., A. W. Cripps, and T. F. Murphy. 1998 Outer-membrane antigen expression by Moraxella (Branhamella) catarrhalis influences pulmonary clearance J. Med. Microbiol. 47 159–168
Kyd, J., A. John, A. Cripps, and T. F. Murphy. 1999 Investigation of mucosal immunisation in pulmonary clearance of Moraxella (Branhamella) catarrhalis Vaccine 18 398–406
Kyd, J., and A. Cripps. 2000 Identifying vaccine antigens and assessing delivery systems for the prevention of bacterial infections J. Biotechnol. 83 85–90
Labia, R., M. Barthelemy, C. B. Le Bouguennec, and A. Buu Hoi-Dang Van. 1986 Classification of beta-lactamases from Branhamella catarrhalis in relation to penicillinases produced by other bacterial species Drugs 31, Suppl. 3 40–47
Lafontaine, E. R., N. J. Wagner, and E. J. Hansen. 2001 Expression of the Moraxella catarrhalis UspA1 protein undergoes phase variation and is regulated at the transcriptional level J. Bacteriol. 183 1540–1551
Lepper, A. W. 1988a Vaccination against infectious bovine keratoconjunctivitis: Protective efficacy and antibody response induced by pili of homologous and heterologous strains of Moraxella bovis Australian Vet. J. 65 310–316
Lepper, A. W., and B. E. Power. 1988b Infectivity and virulence of Australian strains of Moraxella bovis for the murine and bovine eye in relation to pilus serogroup sub-unit size and degree of piliation Australian Vet. J. 65 305–309
Lepper, A. W., L. J. Moore, J. L. Atwell, and J. M. Tennent. 1992 The protective efficacy of pili from different strains of Moraxella bovis within the same serogroup against infectious bovine keratoconjunctivitis Vet. Microbiol. 32 177–187
Lepper, A. W., J. L. Atwell, P. R. Lehrbach, C. L. Schwartzkoff, J. R. Egerton, and J. M. Tennent. 1995 The protective efficacy of cloned Moraxella bovis pili in monovalent and multivalent vaccine formulations against experimentally induced infectious bovine keratoconjunctivitis (IBK) Vet. Microbiol. 45 129–138
Leskinen, K., and J. Jero. 2003 Acute mastoiditis caused by Moraxella catarrhalis Int. J. Pediatr. Otorhinolaryngol. 67 31–33
Livermore, D. M. 1995 Beta-lactamases in laboratory and clinical resistance Clin. Microbiol. Rev. 8 557–584
Loos, M., and F. Clas. 1987 Antibody-independent killing of gram-negative bacteria via the classical pathway of complement Immunol. Lett. 14 203–208
Luke, N. R., T. A. Russo, N. Luther, and A. A. Campagnari. 1999 Use of an isogenic mutant constructed in Moraxella catarrhalis To identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6 Infect. Immun. 67 681–687
Luke, N. R., S. Allen, B. W. Gibson, and A. A. Campagnari. 2003 Identification of a 3-deoxy-D-manno-octulosonic acid biosynthetic operon in Moraxella catarrhalis and analysis of a KdsA-deficient isogenic mutant Infect. Immun. 71 6426–6434
Luna, V. A., S. Cousin Jr., W. L. Whittington, and M. C. Roberts. 2000 Identification of the conjugative mef gene in clinical Acinetobacter junii and Neisseria gonorrhoeae isolates Antimicrob. Agents Chemother. 44 2503–2506
Maciver, I., M. Unhanand, G. H. McCracken Jr., and E. J. Hansen. 1993 Effect of immunization of pulmonary clearance of Moraxella catarrhalis in an animal model J. Infect. Dis. 168 469–472
Macsai, M. S., D. S. Hillman, and J. B. Robin. 1988 Branhamella keratitis resistant to penicillin and cephalosporins: Case report Arch. Ophthalmol. 106 1506–1507
Mandrell, R. E. 1992 Further antigenic similarities of Neisseria gonorrhoeae lipooligosaccharides and human glycosphingolipids Infect. Immun. 60 3017–3020
Manninen, R., P. Huovinen, and A. Nissinen. 1997 Increasing antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in Finland J. Antimicrob. Chemother. 40 387–392
Marchant, C. D., S. A. Carlin, C. E. Johnson, and P. A. Shurin. 1992 Measuring the comparative efficacy of antibacterial agents for acute otitis media: The “Pollyanna phenomenon” J. Pediatr. 120 72–77
Marrs, C. F., W. W. Ruehl, G. K. Schoolnik, and S. Falkow. 1988 Pilin-gene phase variation of Moraxella bovis is caused by an inversion of the pilin genes J. Bacteriol. 170 3032–3039
Marrs, C. F., and S. Weir. 1990 Pili (fimbriae) of Branhamella species Am. J. Med. 88 36S–40S
Martinez, G., K. Ahmed, C. H. Zheng, K. Watanabe, K. Oishi, and T. Nagatake. 1999 DNA restriction patterns produced by pulsed-field gel electrophoresis in Moraxella catarrhalis isolated from different geographical areas Epidemiol. Infect. 122 417–422
Masaki, H., N. Asoh, K. Kawazoe, K. Watanabe, T. Onizuka, S. Shimogama, T. Yamaryo, H. Watanabe, K. Oishi, and T. Nagatake. 2003 Possible relationship of PFGE patterns of Moraxella catarrhalis between hospital-and community-acquired respiratory infections in a community hospital Microbiol. Immunol. 47 379–385
Masuda, K., R. Masuda, J. Nishi, K. Tokuda, M. Yoshinaga, and K. Miyata. 2002 Incidences of nasopharyngeal colonization of respiratory bacterial pathogens in Japanese children attending day-care centers Pediatr. Int. 44 376–380
Mathers, K. E., D. Goldblatt, C. Aebi, R. Yu, A. B. Schryvers, and E. J. Hansen. 1997 Characterisation of an outer membrane protein of Moraxella catarrhalis FEMS Immunol. Med. Microbiol. 19 231–236
Mathers, K., M. Leinonen, and D. Goldblatt. 1999 Antibody response to outer membrane proteins of Moraxella catarrhalis in children with otitis media Pediatr. Infect. Dis. J. 18 982–988
Mattinson, A. D., and P. J. Cox. 1982 Use of Tween 80 agar in the study of Moraxella bovis infection in cattle Vet. Rec. 111 395–396
McCormick, D. P. 2002 Definition and diagnostic criteria for acute otitis media Pediatrics 109 717–718; author reply 717–718
McDonald, T. J., and G. W. Pugh Jr. 1986 Plasmid profiles of Moraxella bovis isolates Am. J. Vet. Res. 47 964–966
McGregor, K., B. J. Chang, B. J. Mee, and T. V. Riley. 1998 Moraxella catarrhalis: Clinical significance, antimicrobial susceptibility and BRO beta-lactamases Eur. J. Clin. Microbiol. Infect. Dis. 17 219–234
McLeod, D. T., F. Ahmad, S. Capewell, M. J. Croughan, M. A. Calder, and A. Seaton. 1986 Increase in bronchopulmonary infection due to Branhamella catarrhalis Br. Med. J. (Clin. Res. Ed.) 292 1103–1105
McMichael, J. C., M. J. Fiske, R. A. Fredenburg, D. N. Chakravarti, K. R. VanDerMeid, V. Barniak, J. Caplan, E. Bortell, S. Baker, R. Arumugham, and D. Chen. 1998 Isolation and characterization of two proteins from Moraxella catarrhalis that bear a common epitope Infect. Immun. 66 4374–4381
McMichael, J. C. 2000a Progress toward the development of a vaccine to prevent Moraxella (Branhamella) catarrhalis infections Microb. Infect. 2 561–568
McMichael, J. C. 2000b Vaccines for Moraxella catarrhalis Vaccine 19, Suppl. 1 S101–S107
McMichael, J. C., and B. A. Green. 2003 Vaccines for Moraxella catarrhalis and non-typeable Haemophilus influenzae Curr. Opin. Invest. Drugs 4 953–958
Meier, P. S., R. Troller, I. N. Grivea, G. A. Syrogiannopoulos, and C. Aebi. 2002 The outer membrane proteins UspA1 and UspA2 of Moraxella catarrhalis are highly conserved in nasopharyngeal isolates from young children Vaccine 20 1754–1760
Meier, P. S., S. Freiburghaus, A. Martin, N. Heiniger, R. Troller, and C. Aebi. 2003 Mucosal immune response to specific outer membrane proteins of Moraxella catarrhalis in young children Pediatr. Infect. Dis. J. 22 256–262
Melhus, A., and A. F. Ryan. 2003 A mouse model for acute otitis media Acta Pathol. Microbiol. Immunol. Scand. 111 989–994
Memish, Z. A., A. M. Shibl, and Q. A. Ahmed. 2002 Guidelines for the management of community-acquired pneumonia in Saudi Arabia: A model for the Middle East region Int. J. Antimicrob. Agents 20 Suppl 1 S1–S12
Miravitlles, M., C. Espinosa, E. Fernandez-Laso, J. A. Martos, J. A. Maldonado, and M. Gallego. 1999 Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD: Study Group of Bacterial Infection in COPD Chest 116 40–46
Mollenkvist, A., T. Nordstrom, C. Hallden, J. J. Christensen, A. Forsgren, and K. Riesbeck. 2003 The Moraxella catarrhalis immunoglobulin D-binding protein MID has conserved sequences and is regulated by a mechanism corresponding to phase variation J. Bacteriol. 185 2285–2295
Moore, L. J., and J. M. Rutter. 1987 Antigenic analysis of fimbrial proteins from Moraxella bovis J. Clin. Microbiol. 25 2063–2070
Moore, L. J., and J. M. Rutter. 1989 Attachment of Moraxella bovis to calf corneal cells and inhibition by antiserum Australian Vet. J. 66 39–42
Moore, L. J., and A. W. Lepper. 1991 A unified serotyping scheme for Moraxella bovis Vet. Microbiol. 29 75–83
Murphy, T. F. 1989a The surface of Branhamella catarrhalis: A systematic approach to the surface antigens of an emerging pathogen Pediatr. Infect. Dis. J. 8 S75–S77
Murphy, T. F., and M. R. Loeb. 1989b Isolation of the outer membrane of Branhamella catarrhalis Microb. Pathog. 6 159–174
Murphy, T. F. 1990 Studies of the outer membrane proteins of Branhamella catarrhalis Am. J. Med. 88 41S–45S
Murphy, T. F., C. Kirkham, and A. J. Lesse. 1993 The major heat-modifiable outer membrane protein CD is highly conserved among strains of Branhamella catarrhalis Molec. Microbiol. 10 87–97
Murphy, S., M. Fitzgerald, R. Mulcahy, C. Keane, D. Coakley, and T. Scott. 1997 Studies on haemagglutination and serum resistance status of strains of Moraxella catarrhalis isolated from the elderly Gerontology 43 277–282
Murphy, T. F. 1998 Lung infections. 2: Branhamella catarrhalis—epidemiological and clinical aspects of a human respiratory tract pathogen Thorax 53 124–128
Murphy, T. F., C. Kirkham, E. DeNardin, and S. Sethi. 1999 Analysis of antigenic structure and human immune response to outer membrane protein CD of Moraxella catarrhalis Infect. Immun. 67 4578–4585
Murphy, T. F., A. L. Brauer, N. Yuskiw, and T. J. Hiltke. 2000 Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutants Infect. Immun. 68 6250–6256
Murphy, T. F., A. L. Brauer, N. Yuskiw, E. R. McNamara, and C. Kirkham. 2001 Conservation of outer membrane protein E among strains of Moraxella catarrhalis Infect. Immun. 69 3576–3580
Murphy, T. F., and S. Sethi. 2002 Chronic obstructive pulmonary disease: Role of bacteria and guide to antibacterial selection in the older patient Drugs Aging 19 761–775
Murphy, T. F., C. Kirkham, D. F. Liu, and S. Sethi. 2003 Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease Infect. Immun. 71 1288–1294
Murray, P. R. et al. (Eds.). 1999 Nonfermentative Gram-negative rods In: P. R. Murray et al. (Eds.) Manual of Clinical Microbiology, 7th ed American Society for Microbiology, Washington, DC 544
Myers, L. E., Y. P. Yang, R. P. Du, Q. Wang, R. E. Harkness, A. B. Schryvers, M. H. Klein, and S. M. Loosmore. 1998 The transferrin binding protein B of Moraxella catarrhalis elicits bactericidal antibodies and is a potential vaccine antigen Infect. Immun. 66 4183–4192
Nash, D. R., C. Flanagan, L. C. Steele, and R. J. Wallace Jr. 1991 Comparison of the activity of cefixime and activities of other oral antibiotics against adult clinical isolates of Moraxella (Branhamella) catarrhalis containing BRO-1 and BRO-2 and Haemophilus influenzae Antimicrob. Agents Chemother. 35 192–194
Nayar, P. S., and J. R. Saunders. 1973 Identification of Moraxella bovis by immunofluorescence Can. J. Comp. Med. 37 105–106
Neumayer, U., H. K. Schmidt, K. P. Mellwig, and G. Kleikamp. 1999 Moraxella catarrhalis endocarditis: Report of a case and literature review J. Heart Valve Dis. 8 114–117
Nicotra, B., M. Rivera, J. I. Luman, and R. J. Wallace Jr. 1986 Branhamella catarrhalis as a lower respiratory tract pathogen in patients with chronic lung disease Arch. Intern. Med. 146 890–893
Nordstrom, T., A. Forsgren, and K. Riesbeck. 2002 The immunoglobulin D-binding part of the outer membrane protein MID from Moraxella catarrhalis comprises 238 amino acids and a tetrameric structure J. Biol. Chem. 277 34692–34699
Oguri, T., J. Igari, K. Hiramatsu, A. Watanabe, M. Inoue, M. Abe, N. Yamane, M. Aihara, and H. Hashimoto. 2002 Beta-lactamase-producing activity and antimicrobial susceptibility of major pathogenic bacteria isolated from clinical samples: Japan Beta-lactamase Research Group [in Japanese] Jpn. J. Antibiot. 55, Suppl. A 1–28
Oishi, K., H. Tanaka, F. Sonoda, S. Borann, K. Ahmed, Y. Utsunomiya, K. Watanabe, T. Nagatake, M. Vaneechoutte, G. Verschraegen, and K. Matsumoto. 1996 A monoclonal antibody reactive with a common epitope of Moraxella (Branhamella) catarrhalis lipopolysaccharides Clin. Diagn. Lab. Immunol. 3 351–354
Olivieri, I., A. Padula, L. Armignacco, V. Sabatella, and M. Mancino. 2004 Septic arthritis caused by Moraxella catarrhalis associated with infliximab treatment in a patient with undifferentiated spondarthritis Ann. Rheum. Dis. 63 105–106
Onofrio, J. M., A. N. Shulkin, P. J. Heidbrink, G. B. Toews, and A. K. Pierce. 1981 Pulmonary clearance and phagocytic cell response to normal pharyngeal flora Am. Rev. Respir. Dis. 123 222–225
Ostle, A. G., and R. F. Rosenbusch. 1984 Moraxella bovis hemolysin Am. J. Vet. Res. 45 1848–1851
Ostle, A. G., and R. F. Rosenbusch. 1985 Immunogenicity of Moraxella bovis hemolysin Am. J. Vet. Res. 46 1011–1014
Patel, J. A., B. Reisner, N. Vizirinia, M. Owen, T. Chonmaitree, and V. Howie. 1995 Bacteriologic failure of amoxicillin-clavulanate in treatment of acute otitis media caused by nontypeable Haemophilus influenzae J. Pediatr. 126 799–806
Patel, I. S., T. A. Seemungal, M. Wilks, S. J. Lloyd-Owen, G. C. Donaldson, and J. A. Wedzicha. 2002 Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations Thorax 57 759–764
Patterson, T. F., J. E. Patterson, B. L. Masecar, G. E. Barden, W. J. Hierholzer Jr., and M. J. Zervos. 1988 A nosocomial outbreak of Branhamella catarrhalis confirmed by restriction endonuclease analysis J. Infect. Dis. 157 996–1001
Patterson, J. E., T. F. Patterson, P. Farrel, W. J. Hierholzer Jr., and M. J. Zervos. 1989 Evaluation of restriction endonuclease analysis as an epidemiologic typing system for Branhamella catarrhalis J. Clin. Microbiol. 27 944–946
Paul, A. C., S. Varkki, M. S. Mathews, and P. D. Moses. 2000 Pseudo-gonococcal ophthalmia neonatorum Indian Pediatr. 37 1368–1370
Peak, I. R., M. P. Jennings, D. W. Hood, M. Bisercic, and E. R. Moxon. 1996 Tetrameric repeat units associated with virulence factor phase variation in Haemophilus also occur in Neisseria spp. and Moraxella catarrhalis FEMS Microbiol. Lett. 137 109–114
Pearson, M. M., E. R. Lafontaine, N. J. Wagner, J. W. St Geme 3rd, and E. J. Hansen. 2002 A hag mutant of Moraxella catarrhalis strain O35E is deficient in hemagglutination, autoagglutination, and immunoglobulin D-binding activities Infect. Immun. 70 4523–4533
Peiris, V., and J. Heald. 1992 Rapid method for differentiating strains of Branhamella catarrhalis J. Clin. Pathol. 45 532–534
Peiris, V., C. Bennett, and S. Norris. 1994 Use of API NH system for identification of Moraxella catarrhalis J. Clin. Microbiol. 32 2628
Pettersson, B., A. Kodjo, M. Ronaghi, M. Uhlen, and T. Tonjum. 1998 Phylogeny of the family Moraxellaceae by 16S rDNA sequence analysis, with special emphasis on differentiation of Moraxella species Int. J. System. Bacteriol. 48(1) 75–89
Pichichero, M. E. 2000 Recurrent and persistent otitis media Pediatr. Infect. Dis. J. 19 911–916
Pichichero, M. E., and J. R. Casey. 2002 Otitis media Expert Opin. Pharmacother. 3 1073–1090
Pollard, J. A., R. J. Wallace Jr., D. R. Nash, J. I. Luman, and R. W. Wilson. 1986 Incidence of Branhamella catarrhalis in the sputa of patients with chronic lung disease Drugs 31, Suppl. 3 103–108
Post, J. C., J. J. Aul, G. J. White, R. M. Wadowsky, T. Zavoral, R. Tabari, B. Kerber, W. J. Doyle, and G. D. Ehrlich. 1996 PCR-based detection of bacterial DNA after antimicrobial treatment is indicative of persistent, viable bacteria in the chinchilla model of otitis media Am. J. Otolaryngol. 17 106–111
Powe, T. A., K. E. Nusbaum, T. R. Hoover, S. R. Rossmanith, and P. C. Smith. 1992 Prevalence of nonclinical Moraxella bovis infections in bulls as determined by ocular culture and serum antibody titer J. Vet. Diagn. Invest. 4 78–79
Prellner, K. 1980 Bacteria associated with acute otitis media have high Clq binding capacity Acta Pathol. Microbiol. Scand. [C] 88 187–190
Prellner, K., P. Christensen, B. Hovelius, and C. Rosen. 1984 Nasopharyngeal carriage of bacteria in otitis-prone and non-otitis-prone children in day-care centres Acta Otolaryngol. 98 343–350
Prellner, K., M. Fogle-Hansson, F. Jorgensen, O. Kalm, and C. Kamme. 1994 Prevention of recurrent acute otitis media in otitis-prone children by intermittent prophylaxis with penicillin Acta Otolaryngol. 114 182–187
Prieto, C. I., O. M. Aguilar, and O. M. Yantorno. 1999 Analyses of lipopolysaccharides, outer membrane proteins and DNA fingerprints reveal intraspecies diversity in Moraxella bovis isolated in Argentina Vet. Microbiol. 70 213–223
Pugh Jr., G. W., D. E. Hughes, and T. J. McDonald. 1966 The isolation and characterization of Moraxella bovis Am. J. Vet. Res. 27 957–962
Pugh Jr., G. W., and T. J. McDonald. 1977a Infectious bovine keratoconjunctivitis: Treatment of Moraxella bovis infections with antibiotics Proc. Ann. Meet. US Anim. Health Assoc. 1977 120–130
Pugh Jr., G. W., D. E. Hughes, and G. D. Booth. 1977b Experimentally induced infections bovine keratoconjunctivitis: Effectiveness of a pilus vaccine against exposure to homologous strains of Moraxella bovis Am. J. Vet. Res. 38 1519–1522
Pugh Jr., G. W., M. Phillips, T. J. McDonald, and K. E. Kopecky. 1981 Isolation of Moraxella bovis ribosomes and their subsequent use in a vaccine against infectious bovine keratoconjunctivitis Am. J. Vet. Res. 42 516–520
Pugh Jr., G. W., T. J. McDonald, and K. E. Kopecky. 1982 Experimental infectious bovine keratoconjunctivitis: Efficacy of a vaccine prepared from nonhemolytic strains of Moraxella bovis Am. J. Vet. Res. 43 1081–1084
Pugh Jr., G. W., K. E. Kopecky, and T. J. McDonald. 1984 Infectious bovine keratoconjunctivitis: Enhancement of Moraxella bovis pili immunogenicity with diphtheria-tetanus toxoids and pertussis vaccine Am. J. Vet. Res. 45 661–665
Rahman, M., T. Holme, I. Jonsson, and A. Krook. 1995 Lack of serotype-specific antibody response to lipopolysaccharide antigens of Moraxella catarrhalis during lower respiratory tract infection Eur. J. Clin. Microbiol. Infect. Dis. 14 297–304
Rahman, M., and T. Holme. 1996 Antibody response in rabbits to serotype-specific determinants in lipopolysaccharides from Moraxella catarrhalis J. Med. Microbiol. 44 348–354
Rahman, M., T. Holme, I. Jonsson, and A. Krook. 1997 Human immunoglobulin isotype and IgG subclass response to different antigens of Moraxella catarrhalis Acta Pathol. Microbiol. Immunol. Scand. 105 213–220
Reddy, M. S., T. F. Murphy, H. S. Faden, and J. M. Bernstein. 1997 Middle ear mucin glycoprotein: Purification and interaction with nontypable Haemophilus influenzae and Moraxella catarrhalis Otolaryngol. Head Neck Surg. 116 175–180
Rice, P. A. 1989 Molecular basis for serum resistance in Neisseria gonorrhoeae Clin. Microbiol. Rev. 2 (Suppl.) S112–S117
Richards, S. J., A. P. Greening, M. C. Enright, M. G. Morgan, and H. McKenzie. 1993 Outbreak of Moraxella catarrhalis in a respiratory unit Thorax 48 91–92
Richter, S. S., P. L. Winokur, A. B. Brueggemann, H. K. Huynh, P. R. Rhomberg, E. M. Wingert, and G. V. Doern. 2000 Molecular characterization of the beta-lactamases from clinical isolates of Moraxella (Branhamella) catarrhalis obtained from 24 U.S. medical centers during 1994–1995 and 1997–1998 Antimicrob. Agents Chemother. 44 444–446
Rikitomi, N., M. Akiyama, and K. Matsumoto. 1989 Role of normal microflora in the throat in inhibition of adherence of pathogenic bacteria to host cells: In vitro competitive adherence between Corynebacterium pseudodiphtheriticum and Branhamella catarrhalis Kansenshogaku Zasshi 63 118–124
Rikitomi, N., B. Andersson, K. Matsumoto, R. Lindstedt, and C. Svanborg. 1991 Mechanism of adherence of Moraxella (Branhamella) catarrhalis Scand. J. Infect. Dis. 23 559–567
Roantree, R., and I. Rantz. 1960 A study of the relationship of the normal bactericidal activity of human serum to bactericidal infections J. Clin. Invest. 39 72–81
Rotta, A. T., B. I. Asmar, N. Ballal, and A. Canady. 1995 Moraxella catarrhalis ventriculitis in a child with hydrocephalus and an external ventricular drain Pediatr. Infect. Dis. J. 14 397–398
Ruehl, W. W., C. F. Marrs, R. Fernandez, S. Falkow, and G. K. Schoolnik. 1988 Purification, characterization, and pathogenicity of Moraxella bovis pili J. Exp. Med. 168 983–1002
Ruehl, W. W., C. Marrs, M. K. Beard, V. Shokooki, J. R. Hinojoza, S. Banks, D. Bieber, and J. S. Mattick. 1993 Q pili enhance the attachment of Moraxella bovis to bovine corneas in vitro Molec. Microbiol. 7 285–288
Samukawa, T., N. Yamanaka, S. Hollingshead, K. Klingman, and H. Faden. 2000a Immune responses to specific antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the respiratory tract Infect. Immun. 68 1569–1573
Samukawa, T., N. Yamanaka, S. Hollingshead, T. F. Murphy, and H. Faden. 2000b Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media J. Infect. Dis. 181 1842–1845
Sandhu, T. S., F. H. White, and C. F. Simpson. 1974 Association of pili with rough colony type of Moraxella bovis Am. J. Vet. Res. 35 437–439
Sandhu, T. S., and F. H. White. 1977 Production and characterization of Moraxella bovis hemolysin Am. J. Vet. Res. 38 883–885
Sarubbi, F. A., J. W. Myers, J. J. Williams, and C. G. Shell. 1990 Respiratory infections caused by Branhamella catarrhalis: Selected epidemiologic features Am. J. Med. 88 9S–14S
Sato, K. 1997 Experimental otitis media induced by nonviable Moraxella catarrhalis in the guinea pig model Auris Nasus Larynx 24 233–238
Schalen, L. 1988 Acute laryngitis in adults: Diagnosis, etiology, treatment Acta Otolaryngol. Suppl. 449 31
Schalen, L., I. Eliasson, S. Fex, C. Kamme, and C. Schalen. 1992 Acute laryngitis in adults: Results of erythromycin treatment Acta Otolaryngol. Suppl. 492 55–57
Schalen, L., I. Eliasson, C. Kamme, and C. Schalen. 1993 Erythromycin in acute laryngitis in adults Ann. Otol. Rhinol. Laryngol. 102 209–214
Schmitz, F. J., A. Beeck, M. Perdikouli, M. Boos, S. Mayer, S. Scheuring, K. Kohrer, J. Verhoef, and A. C. Fluit. 2002 Production of BRO beta-lactamases and resistance to complement in European Moraxella catarrhalis isolates J. Clin. Microbiol. 40 1546–1548
Seib, K. L., I. R. Peak, and M. P. Jennings. 2002 Phase variable restriction-modification systems in Moraxella catarrhalis FEMS Immunol. Med. Microbiol. 32 159–165
Sethi, S., J. M. Surface, and T. F. Murphy. 1997 Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella) catarrhalis Infect. Immun. 65 3666–3671
Sethi, S., N. Evans, B. J. Grant, and T. F. Murphy. 2002 New strains of bacteria and exacerbations of chronic obstructive pulmonary disease N. Engl. J. Med. 347 465–471
Shryock, T. R., D. W. White, and C. S. Werner. 1998 Antimicrobial susceptibility of Moraxella bovis Vet. Microbiol. 61 305–309
Shurin, P. A., C. D. Marchant, C. H. Kim, G. F. Van Hare, C. E. Johnson, M. A. Tutihasi, and L. J. Knapp. 1983 Emergence of beta-lactamase-producing strains of Branhamella catarrhalis as important agents of acute otitis media Pediatr. Infect. Dis. 2 34–38
Sims, K. L., and A. B. Schryvers. 2003 Peptide-peptide interactions between human transferrin and transferrin-binding protein B from Moraxella catarrhalis J. Bacteriol. 185 2603–2610
Smith, J. A., and L. W. George. 1985 Treatment of acute ocular Moraxella bovis infections in calves with a parenterally administered long-acting oxytetracycline formulation Am. J. Vet. Res. 46 804–807
Smith, H. 1995 The revival of interest in mechanisms of bacterial pathogenicity Biol. Rev. Camb. Philos. Soc. 70 277–316
Soto-Hernandez, J. L., S. Holtsclaw-Berk, L. M. Harvill, and S. L. Berk. 1989 Phenotypic characteristics of Branhamella catarrhalis strains J. Clin. Microbiol. 27 903–908
Stefani, S., M. B. Pellegrino, G. Russo, and G. Nicoletti. 1991 Direct and indirect pathogenicity of beta-lactamase-producing bacteria in respiratory tract infection in children. Role of cephalosporins resistant to enzymatic hydrolysis Drugs 42 14–18
Stefanou, J., A. V. Agelopoulou, N. V. Sipsas, N. Smilakou, and A. Avlami. 2000 Moraxella catarrhalis endocarditis: Case report and review of the literature Scand. J. Infect. Dis. 32 217–218
Stenfors, L. E., and S. Raisanen. 1993 Secretory IgA-, IgG-and C3b-coated bacteria in the nasopharynx of otitis-prone and non-otitis-prone children Acta Otolaryngol. 113 191–195
Stutzmann Meier, P., N. Heiniger, R. Troller, and C. Aebi. 2003 Salivary antibodies directed against outer membrane proteins of Moraxella catarrhalis in healthy adults Infect. Immun. 71 6793–6798
Tabassum, N., and A. Ahmed. 2002 Determination of anti-microbial susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis J. Pak. Med. Assoc. 52 87–90
Takada, R., Y. Harabuchi, T. Himi, and A. Kataura. 1998 Antibodies specific to outer membrane antigens of Moraxella catarrhalis in sera and middle ear effusions from children with otitis media with effusion Int. J. Pediatr. Otorhinolaryngol. 46 185–195
Tanaka, H., K. Oishi, F. Sonoda, A. Iwagaki, T. Nagatake, and R. Matsumoto. 1992 Biochemical analysis of lipopolysaccharides from respiratory pathogenic Branhamella catarrhalis strains and the role of anti-LPS antibodies in Branhamella respiratory infections [in Japanese] Kansenshogaku Zasshi 66 709–715
Teele, D. W., J. O. Klein, and B. Rosner. 1989a Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study J. Infect. Dis. 160 83–94
Teele, D. W., K. Lundgren, M. L. Casselbrant, K. A. Daly, L. Ingvarsson, P. Karma, C. D. Marchant, N. Roydhouse, M. Tos, P. B. van Cauwenberge, and et al. 1989b Recent advances in otitis media: Epidemiology and natural history Ann. Otol. Rhinol. Laryngol. Suppl. 139 11–13
Thorsson, B., V. Haraldsdottir, and M. Kristjansson. 1998 Moraxella catarrhalis bacteraemia: A report on 3 cases and a review of the literature Scand. J. Infect. Dis. 30 105–109
Timpe, J. M., M. M. Holm, S. L. Vanlerberg, V. Basrur, and E. R. Lafontaine. 2003 Identification of a Moraxella catarrhalis outer membrane protein exhibiting both adhesin and lipolytic activities Infect. Immun. 71 4341–4350
Toews, G. B., E. J. Hansen, and R. M. Strieter. 1990 Pulmonary host defenses and oropharyngeal pathogens Am. J. Med. 88 20S–24S
Tonjum, T., D. A. Caugant, and K. Bovre. 1992 Differentiation of Moraxella nonliquefaciens, M. lacunata, and M. bovis by using multilocus enzyme electrophoresis and hybridization with pilin-specific DNA probes J. Clin. Microbiol. 30 3099–3107
Troncoso, G., S. Sanchez, M. T. Criado, and C. Ferreiros. 2004 Analysis of Moraxella catarrhalis outer membrane antigens cross-reactive with Neisseria meningitidis and Neisseria lactamica FEMS Immunol. Med. Microbiol. 40 89–94
Turfrey, B. A. 1985 The use of immuno-peroxidase techniques for the identification of Moraxella bovis in tissue sections Br. Vet. J. 141 195–196
Turner, D., E. Leibovitz, A. Aran, L. Piglansky, S. Raiz, A. Leiberman, and R. Dagan. 2002 Acute otitis media in infants younger than two months of age: Microbiology, clinical presentation and therapeutic approach Pediatr. Infect. Dis. J. 21 669–674
Unhanand, M., I. Maciver, O. Ramilo, O. Arencibia-Mireles, J. C. Argyle, G. H. McCracken Jr., and E. J. Hansen. 1992 Pulmonary clearance of Moraxella catarrhalis in an animal model J. Infect. Dis. 165 644–650
Vaneechoutte, M., G. Verschraegen, G. Claeys, and P. Flamen. 1988 Rapid identification of Branhamella catarrhalis with 4-methylumbelliferyl butyrate J. Clin. Microbiol. 26 1227–1228
Vaneechoutte, M., G. Verschraegen, G. Claeys, and A. M. Van Den Abeele. 1990 Serological typing of Branhamella catarrhalis strains on the basis of lipopolysaccharide antigens J. Clin. Microbiol. 28 182–187
Van Hare, G. F., P. A. Shurin, C. D. Marchant, N. A. Cartelli, C. E. Johnson, D. Fulton, S. A. Carlin, and C. H. Kim. 1987 Acute otitis media caused by Branhamella catarrhalis: Biology and therapy Rev. Infect. Dis. 9 16–27
Varon, E., C. Levy, F. De La Rocque, M. Boucherat, D. Deforche, I. Podglajen, M. Navel, and R. Cohen. 2000 Impact of antimicrobial therapy on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, and Branhamella catarrhalis in children with respiratory tract infections Clin. Infect. Dis. 31 477–481
Verduin, C. M., M. Jansze, C. Hol, T. E. Mollnes, J. Verhoef, and H. van Dijk. 1994a Differences in complement activation between complement-resistant and complement-sensitive Moraxella (Branhamella) catarrhalis strains occur at the level of membrane attack complex formation Infect. Immun. 62 589–595
Verduin, C. M., M. Jansze, J. Verhoef, A. Fleer, and H. van Dijk. 1994b Complement resistance in Moraxella (Branhamella) catarrhalis is mediated by a vitronectin-binding surface protein Clin. Exp. Immunol. 97 50
Verduin, C. M., M. Kools-Sijmons, J. van der Plas, J. Vlooswijk, M. Tromp, H. van Dijk, J. Banks, H. Verbrugh, and A. van Belkum. 2000 Complement-resistant Moraxella catarrhalis forms a genetically distinct lineage within the species FEMS Microbiol. Lett. 184 1–8
Verduin, C. M., C. Hol, A. Fleer, H. van Dijk, and A. van Belkum. 2002 Moraxella catarrhalis: From emerging to established pathogen Clin. Microbiol. Rev. 15 125–144
Verghese, A., E. Berro, J. Berro, and B. W. Franzus. 1990 Pulmonary clearance and phagocytic cell response in a murine model of Branhamella catarrhalis infection J. Infect. Dis. 162 1189–1192
Virji, M., J. N. Weiser, A. A. Lindberg, and E. R. Moxon. 1990 Antigenic similarities in lipopolysaccharides of Haemophilus and Neisseria and expression of a digalactoside structure also present on human cells Microb. Pathog. 9 441–450
Vu-Thien, H., C. Dulot, D. Moissenet, B. Fauroux, and A. Garbarg-Chenon. 1999 Comparison of randomly amplified polymorphic DNA analysis and pulsed-field gel electrophoresis for typing of Moraxella catarrhalis strains J. Clin. Microbiol. 37 450–452
Wald, E. R., C. Byers, N. Guerra, M. Casselbrant, and D. Beste. 1989 Subacute sinusitis in children J. Pediatr. 115 28–32
Wald, E. R. 1992a Microbiology of acute and chronic sinusitis in children J. Allergy Clin. Immunol. 90 452–456
Wald, E. R. 1992b Sinusitis in infants and children Ann. Otol. Rhinol. Laryngol. Suppl. 155 37–41
Wald, E. R. 1997 The microbiology of chronic sinusitis in children: A review Acta Otorhinolaryngol. Belg. 51 51–54
Wald, E. R. 1998 Microbiology of acute and chronic sinusitis in children and adults Am. J. Med. Sci. 316 13–20
Walker, E. S., R. A. Preston, J. C. Post, G. D. Ehrlich, J. H. Kalbfleisch, and K. L. Klingman. 1998 Genetic diversity among strains of Moraxella catarrhalis: Analysis using multiple DNA probes and a single-locus PCR-restriction fragment length polymorphism method J. Clin. Microbiol. 36 1977–1983
Wallace Jr., R. J., V. A. Steingrube, D. R. Nash, D. G. Hollis, C. Flanagan, B. A. Brown, A. Labidi, and R. E. Weaver. 1989 BRO beta-lactamases of Branhamella catarrhalis and Moraxella subgenus Moraxella, including evidence for chromosomal beta-lactamase transfer by conjugation in B. catarrhalis, M. nonliquefaciens, and M. lacunata Antimicrob. Agents Chemother. 33 1845–1854
Wallace Jr., R. J., D. R. Nash, and V. A. Steingrube. 1990 Antibiotic susceptibilities and drug resistance in Moraxella (Branhamella) catarrhalis Am. J. Med. 88 46S–50S
Wannemuehler, Y., K. Johansen, and R. Rosenbusch. 1989 Identification of Moraxella bovis by using a monoclonal antibody to a lipopolysaccharide epitope J. Clin. Microbiol. 27 2881–2883
Webber, J. J., W. H. Fales, and L. A. Selby. 1982 Semiselective medium for isolation of Moraxella bovis from cattle with infectious keratoconjunctivitis J. Clin. Microbiol. 16 193–194
Weiss, A., J. H. Brinser, and V. Nazar-Stewart. 1993 Acute conjunctivitis in childhood J. Pediatr. 122 10–14
Westman, E., A. Melhus, S. Hellstrom, and A. Hermansson. 1999 Moraxella catarrhalis-induced purulent otitis media in the rat middle ear: Structure, protection, and serum antibodies Acta Pathol. Microbiol. Immunol. Scand. 107 737–746
Wilt, G. R., G. Wu, and R. C. Bird. 1989 Characterization of the plasmids of Moraxella bovis Am. J. Vet. Res. 50 1678–1683
Wood, G. M., B. C. Johnson, and J. G. McCormack. 1996 Moraxella catarrhalis: Pathogenic significance in respiratory tract infections treated by community practitioners Clin. Infect. Dis. 22 632–636
Wright, P. W., and R. J. Wallace Jr. 1989 Pneumonia due to Moraxella (Branhamella) catarrhalis Semin. Respir. Infect. 4 40–46
Yang, Y. P., L. E. Myers, U. McGuinness, P. Chong, Y. Kwok, M. H. Klein, and R. E. Harkness. 1997 The major outer membrane protein, CD, extracted from Moraxella (Branhamella) catarrhalis is a potential vaccine antigen that induces bactericidal antibodies FEMS Immunol. Med. Microbiol. 17 187–199
Yano, H., M. Suetake, A. Kuga, K. Irinoda, R. Okamoto, T. Kobayashi, and M. Inoue. 2000 Pulsed-field gel electrophoresis analysis of nasopharyngeal flora in children attending a day care center J. Clin. Microbiol. 38 625–629
Yu, R. H., and A. B. Schryvers. 1993 The interaction between human transferrin and transferrin binding protein 2 from Moraxella (Branhamella) catarrhalis differs from that of other human pathogens Microb. Pathog. 15 433–445
Yu, R. H., R. A. Bonnah, S. Ainsworth, and A. B. Schryvers. 1999 Analysis of the immunological responses to transferrin and lactoferrin receptor proteins from Moraxella catarrhalis Infect. Immun. 67 3793–3799
Zaleski, A., N. K. Scheffler, P. Densen, F. K. Lee, A. A. Campagnari, B. W. Gibson, and M. A. Apicella. 2000 Lipooligosaccharide P(k) (Galalpha1-4Galbeta1-4Glc) epitope of Moraxella catarrhalis is a factor in resistance to bactericidal activity mediated by normal human serum Infect. Immun. 68 5261–5268
Zhanel, G. G., J. A. Karlowsky, D. E. Low, and D. J. Hoban. 2000 Antibiotic resistance in respiratory tract isolates of Haemophilus influenzae and Moraxella catarrhalis collected from across Canada in 1997–1998 J. Antimicrob. Chemother. 45 655–662
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Hays, J.P. (2006). The Genus Moraxella. In: Dworkin, M., Falkow, S., Rosenberg, E., Schleifer, KH., Stackebrandt, E. (eds) The Prokaryotes. Springer, New York, NY. https://doi.org/10.1007/0-387-30746-X_38
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