Skip to main content

The Family Streptomycetaceae, Part II: Molecular Biology

  • Firmicutes with High GC Content of DNA
  • Reference work entry
  • First Online:
The Prokaryotes

Introduction

Some members of the order of Actinomycetales were already identified about a century ago (for review, see Kutzner, 1981). The current phylogenetic tree includes Bifidobacteriaceae, Actinomycetaceae, Arthrobacteriaceae, Cellulomonadaceae, Microbacteriaceae, Dermathophylaceae, Propionobacteriaceae, Nocardioidaceae, Frankiaceae, Corynebacteriaceae, Mycobacteriaceae, Nocardiaceae, Actinoplanaceae, Pseudonocardiaceae, Streptomycetaceae and Streptosporangiaceae.

The family Streptomycetaceae includes the genus Streptomyces, which comprises strains formerly classified as Chania, Elytrosporangium, Kitasatoa, Kitasosporia, Actinosporangium and Streptoverticillium. All members of the Streptomycetaceae family have a complex life cycle, featuring an extended vegetative substrate mycelium and aerial hyphae, in which spores form upon depletion of nutrients. They contain specific menaquinones, incorporate LL-diaminopimelic acid (a diagnostic amino acid) into their peptidoglycan, but lack...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 700.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literature Cited

  • Aharonowitz, Y., and G. Cohen. 1992 Penicillin and cephalosporin biosynthesis genes: Structure, organization, regulation, and evolution Ann. Rev. Microbiol. 46 461–495

    Article  CAS  Google Scholar 

  • Ahel, I., D. Vujaklija, A. Mikoc, and V. Gamulin. 2002 Transcriptional analysis of the recA gene in Streptomyces rimosus: Identification of the new type of promoter FEMS Microbiol. Lett. 209 133–137

    Article  CAS  PubMed  Google Scholar 

  • Ainsa, J. A., N. J. Ryding, N. Hartley, K. C. Findlay, C. J. Bruton, and K. F. Chater. 2000 WhiA, a protein of unknown function conserved among Gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2) J. Bacteriol. 182 5470–5478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amoroso, M. J., D. Schubert, P. Mitscherlich, P. Schumann, and E. Kothe. 2000 Evidence for high affinity nickel transporter genes in heavy metal resistant Streptomyces spec J. Basic Microbiol. 40 295–301

    Article  CAS  PubMed  Google Scholar 

  • Aparicio, J. F., P. Caffrey, A. F. A. Marsden, J. Stauton, and P. F. Leadlay. 1994 Limited proteolysis and active-site studies of the first multienzyme component of the erythromycin-producing polyketide synthase J. Biol. Chem. 269 8524–8528

    CAS  PubMed  Google Scholar 

  • Arias, M. E., M. Arenas, J. Rodriguez, J. Soliveri, A. S. Ball, and M. Hernandez. 2003 Kraft pulp biobleaching and mediated oxidation of a nonphenolic substrate by laccase from Streptomyces cyaneus CECT 3335 Appl. Environ. Microbiol. 69 1953–1958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • August, P. R., L. Tang, Y. J. Yoon, S. Ning, R. Muller, T. W. Yu, M. Taylor, D. Hoffmann, C. G. Kim, X. H. Zhang, C. R. Hutchinson, and H. G. Floss. 1998 Biosynthesis of the ansamycin antibiotic rifamycin—deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699 Chem. Biol. 5 69–79

    Article  CAS  PubMed  Google Scholar 

  • Bailey, C. R., C. J. Bruton, M. J. Butler, K. F. Chater, J. E. Harris, and D. A. Hopwood. 1986 Properties of in vitro recombinant derivatives of pJV1, a multi-copy plasmid from Streptomyces phaeochromogenes J. Gen. Microbiol. 132 2071–2078

    CAS  PubMed  Google Scholar 

  • Baltz, R. H., M. A. McHenney, C. A. Cantwell, S. W. Queener, and P. J. Solenberg. 1997 Applications of transposition mutagenesis in antibiotic producing streptomycetes Ant. v. Leeuwenhoek 71 179–187

    Article  CAS  Google Scholar 

  • Banchio, C., and H. C. Gramajo. 1997 Medium-and long-chain fatty acid uptake and utilization by Streptomyces coelicolor A3(2): First characterization of a Gram-positive bacterial system Microbiology 143 2439–2447

    Article  CAS  PubMed  Google Scholar 

  • Bao, K., and S. N. Cohen. 2001 Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces Genes Dev. 15 1518–1527

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bao, K., and S. N. Cohen. 2003 Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication Genes Dev. 17 774–785

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bentley, S. D., K. F. Chater, A. M. Cerdeno-Tarraga, G. L. Challis, N. R. Thomson, K. D. James, D. E. Harris, M. A. Quail, H. Kieser, D. Harper, A. Bateman, S. Brown, G. Chandra, C. W. Chen, M. Collins, A. Cronin, A. Fraser, A. Goble, J. Hidalgo, T. Hornsby, S. Howarth, C. H. Huang, T. Kieser, L. Larke, L. Murphy, K. Oliver, S. O’Neil, E. Rabbinowitsch, M. A. Rajandream, K. Rutherford, S. Rutter, K. Seeger, D. Saunders, S. Sharp, R. Squares, S. Squares, K. Taylor, T. Warren, A. Wietzorrek, J. Woodward, B. G. Barrell, J. Parkhill, and D. A. Hopwood. 2002 Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) Nature 9 141–147

    Article  Google Scholar 

  • Betzler, M., I. Tlolka, and H. Schrempf. 1997 Amplification of a Streptomyces lividans 4.3 kb DNA element causes overproduction of a novel hypha-and vesicle-associated protein Microbiology 143 1243–1252

    Article  CAS  PubMed  Google Scholar 

  • Bhatt, A., H. M. Kieser, R. E. Melton, and T. Kieser. 2002 Plasmid transfer from Streptomyces to Mycobacterium smegmatis by spontaneous transformation Molec. Microbiol. 43 135–146

    Article  CAS  Google Scholar 

  • Bibb, M. J., S. Biro, H. Motamedi, J. F. Collins, and C. R. Hutchinson. 1989 Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis EMBO J. 8 2727–2736

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bibb, M. J., D. H. Sherman, S. Omura, and D. A. Hopwood. 1994 Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin Gene 142 31–39

    Article  CAS  PubMed  Google Scholar 

  • Bibb, M. J., and M. J. Buttner. 2003 The Streptomyces coelicolor developmental transcription factor sigma(BldN) is synthesized as a proprotein J. Bacteriol. 185 2338–2345

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Binnie, C., M. Warren, and M. J. Butler. 1989 Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis J. Bacteriol. 171 887–895

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blaak, H., and H. Schrempf. 1995 Binding and substrate specificities of a Streptomyces olivaceoviridis chitinase in comparison with its proteolytically processed form Eur. J. Biochem. 229 132–139

    Article  CAS  PubMed  Google Scholar 

  • Blanco, G., M. R. Rodicio, A. M. Puglia, C. Méndez, C. J. Thompson, and J. A. Salas. 1994 Synthesis of ribosomal proteins during growth of Streptomyces coelicolor Molec. Microbiol. 12 375–385

    Article  CAS  Google Scholar 

  • Böckle, B., and R. Müller. 1997 Reduction of disulfide bonds by Streptomyces pactum during growth on chicken feathers Appl. Environ. Microbiol. 63 790–792

    PubMed  PubMed Central  Google Scholar 

  • Bode, H. B., K. Kerkhoff, and D. Jendrossek. 2001 Bacterial degradation of natural and synthetic rubber Biomacromolecules 2 295–303

    Article  CAS  PubMed  Google Scholar 

  • Bormann, C., V. Möhrle, and C. Bruntner. 1996 Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tü901 in Streptomyces lividans J. Bacteriol. 178 1216–1218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bucca, G., A. M. Brassington, G. Hotchkiss, V. Mersinias, and C. P. Smith. 2003 Negative feedback regulation of dnaK, clpB and lon expression by the DnaK chaperone machine in Streptomyces coelicolor, identified by transcriptome and in vivo DnaK-depletion analysis Molec. Microbiol. 50 153–166

    Article  CAS  Google Scholar 

  • Bukhalid, R. A., and R. Loria. 1997 Cloning and expression of a gene from Streptomyces scabies encoding a putative pathogenicity factor J. Bacteriol. 179 7776–7783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burke, J., D. Schneider, and J. Westpheling. 2001 Generalized transduction in Streptomyces coelicolor Proc. Natl. Acad. Sci. USA 98 6289–6294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Butler, M. J., P. Bruheim, S. Jovetic, F. Marinelli, P. W. Postma, and M. J. Bibb. 2002 Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans Appl. Environ. Microbiol. 68 4731–4739

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Calcutt, M. J., and F. J. Schmidt. 1992 Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome J. Bacteriol. 174 3220–3226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Challis, G. L., and D. A. Hopwood. 2003 Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species Proc. Natl. Acad. Sci. USA 100 (Suppl. 2) 14555–14561. Epub;14555–14561

    Google Scholar 

  • Champness, W. 1999 Cloning and analysis of regulatory genes involved in streptomycete secondary metabolite biosynthesis In: A. L. Demain and J. E. Davies (Eds.) Manual of Industrial Microbiology and Biotechnology, 2nd ed American Society for Microbiology, Washington, DC 725–739

    Google Scholar 

  • Chater, K. F., and C. J. Bruton. 1983 Mutational cloning in Streptomyces and the isolation of antibiotic production genes Gene 26 67–78

    Article  CAS  PubMed  Google Scholar 

  • Chater, K. F., and C. J. Bruton. 1985 Resistance, regulatory and production genes for the antibiotic methylenomycin are clustered EMBO J. 4 1893–1897

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chater, K. F., and S. Horinouchi. 2003 Signalling early developmental events in two highly diverged Streptomyces species Molec. Microbiol. 48 9–15

    Article  CAS  Google Scholar 

  • Chen, C. W. 1995 The unstable ends of the Streptomyces linear chromosomes: A nuisance without cures? Trends Biotechnol. 13 157–160

    Article  CAS  Google Scholar 

  • Chung, S.-T., and L. L. Crose. 1989 Streptomyces transposon Tn4556 and its applications In: C. L. Hershberger, S. W. Queener, and G. Hegeman (Eds.) Genetics and Molecular Biology of Industrial Microorganisms American Society for Microbiology, Washington, DC 168–175

    Google Scholar 

  • Claessen, D., H. A. Wosten, G. van Keulen, O. G. Faber, A. M. Alves, W. G. Meijer, and L. Dijkhuizen. 2002 Two novel homologous proteins of Streptomyces coelicolor and Streptomyces lividans are involved in the formation of the rodlet layer and mediate attachment to a hydrophobic surface Molec. Microbiol. 44 1483–1492

    Article  CAS  Google Scholar 

  • Combes, P., R. Till, S. Bee, and M. C. Smith. 2002 The Streptomyces genome contains multiple pseudo-attB sites for the phiC31-encoded site-specific recombination system J. Bacteriol. 184 5746–5752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cortes, J., S. F. Haydock, G. A. Roberts, D. J. Bevitt, and P. F. Leadlay. 1990 An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea Nature 348 176–178

    Article  CAS  PubMed  Google Scholar 

  • Cowlishaw, D. A., and M. C. Smith. 2002 A gene encoding a homologue of dolichol phosphate-beta-D-mannose synthase is required for infection of Streptomyces coelicolor A3(2) by phage (phi)C31 J. Bacteriol. 184 6081–6083

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crawford, D. L., and E. McCoy. 1972 Cellulases of Thermomonospora fusca and Streptomyces thermodiastaticus Appl. Microbiol. 24 150–152

    CAS  PubMed  PubMed Central  Google Scholar 

  • Crespi, M., E. Messens, A. B. Caplan, M. Vanmontagu, and J. Desomer. 1992 Fasciation induction by the phytopathogen Rhodococcus fascians depends upon a linear plasmid encoding a cytokinin synthase gene EMBO J. 11 795–804

    CAS  PubMed  PubMed Central  Google Scholar 

  • Decker, H., and S. Haag. 1995 Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tu2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation J. Bacteriol. 177 6126–6136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dharmatilake, A. J., and K. E. Kendrick. 1994 Expression of the division-controlling gene ftsZ during growth and sporulation of the filamentous bacterium Streptomyces griseus Gene 147 21–28

    Article  CAS  PubMed  Google Scholar 

  • Distler, J., A. Ebert, K. Mansouri, K. Pissowotzki, M. Stockmann, and W. Piepersberg. 1987 Gene cluster for streptomycin biosynthesis in Streptomyces griseus: Nucleotide sequence of three genes and analysis of transcriptional activity Nucleic Acids Res. 15 8041–8056

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dittrich, W., M. Betzler, and H. Schrempf. 1991 An amplifiable and deletable chloramphenicol-resistance determinant of Streptomyces lividans 1326 encodes a putative transmembrane protein Molec. Microbiol. 5 2789–2797

    Article  CAS  Google Scholar 

  • Donadio, S., M. Staver, J. B. McAlpine, S. J. Swanson, and L. Katz. 1991 Modular organization of genes required for complex polyketide biosynthesis Science 252 675–679

    Article  CAS  PubMed  Google Scholar 

  • Dosch, D. C., W. R. Strohl, and H. G. Floss. 1988 Molecular cloning of the nosiheptide resistance gene from Streptomyces actuosus ATCC 25421 Biochem. Biophys. Res. Commun. 156 517–523

    Article  CAS  PubMed  Google Scholar 

  • Ducote, M. J., S. Prakash, and G. S. Pettis. 2000 Minimal and contributing sequence determinants of the cis-acting locus of transfer (clt) of streptomycete plasmid pIJ101 occur within an intrinsically curved plasmid region J. Bacteriol. 182 6834–6841

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Embley, T. M., and E. Stackebrandt. 1994 The molecular phylogeny and systematics of the Actinomycetes Ann. Rev. Microbiol. 48 257–289

    Article  CAS  Google Scholar 

  • Epp, J. K., S. G. Burgett, and B. E. Schoner. 1987 Cloning and nucleotide sequence of a carbomycin-resistance gene from Streptomyces thermotolerans Gene 53 73–83

    Article  CAS  PubMed  Google Scholar 

  • Feitelson, J. S., and D. A. Hopwood. 1983 Cloning of a Streptomyces gene for an O-methyltransferase involved in antibiotic biosynthesis Molec. Gen. Genet. 190 394–398

    Article  CAS  PubMed  Google Scholar 

  • Fernandez-Moreno, M. A., E. Martinez, L. Boto, D. A. Hopwood, and F. Malpartida. 1992 Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin J. Biol. Chem. 267 19278–19290

    CAS  PubMed  Google Scholar 

  • Fishman, S. E., K. Cox, J. L. Larson, P. A. Reynolds, E. T. Seno, W. K. Yeh, R. van Frank, and C. L. Hershberger. 1987 Cloning genes for the biosynthesis of a macrolide antibiotic Proc. Natl. Acad. Sci. USA 84 8248–8252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Flardh, K. 2003 Essential role of DivIVA in polar growth and morphogenesis in Streptomyces coelicolor A3(2) Molec. Microbiol. 49 1523–1536

    Article  CAS  Google Scholar 

  • Gadkari, D., G. Mörsdorf, and O. Meyer. 1992 Chemolithoautotrophic assimilation of dinitrogen by Streptomyces thermoautotrophicus UTB1: Identification of an unusual N2-fixing system J. Bacteriol. 174 6840–6843

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gandlur, S. M., L. Wei, J. Levine, J. Russell, and P. Kaur. 2004 Membrane topology of the DrrB protein of the doxorubicin transporter of Streptomyces peucetius J. Biol. Chem. 279 27799–27806

    Article  CAS  PubMed  Google Scholar 

  • Geueke, B., and W. Hummel. 2003 Heterologous expression of Rhodococcus opacus L-amino acid oxidase in Streptomyces lividans Protein Expr. Purif. 28 303–309

    Article  CAS  PubMed  Google Scholar 

  • Geukens, N., V. Parro, L. A. Rivas, R. P. Mellado, and J. Ann. 2001 Functional analysis of the Streptomyces lividans type I signal peptidases Arch. Microbiol. 176 377–380

    Article  CAS  PubMed  Google Scholar 

  • Goodfellow, M., L. J. Stanton, K. E. Simpson, and D. E. Minnikin. 1990 Numerical and chemical classification of Actinoplanes and related Actinomycetes J. Gen. Microbiol. 136 19–36

    Article  Google Scholar 

  • Grantcharova, N., W. Ubhayasekera, S. L. Mowbray, J. R. McCormick, and K. Flardh. 2003 A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2) Molec. Microbiol. 47 645–656

    Article  CAS  Google Scholar 

  • Gravius, B., D. Glocker, J. Pigac, K. Pandza, D. Hranueli, and J. Cullum. 1994 The 387 kb linear plasmid pPZG101 of Streptomyces rimosus and its interactions with the chromosome Microbiology 140 2271–2277

    Article  CAS  PubMed  Google Scholar 

  • Hagege, J., J.-L. Pernodet, A. Friedmann, and M. Guérineau. 1993 Mode and origin of replication of pSAM2, a conjugative integrating element of Streptomyces ambofaciens Molec. Microbiol. 10 799–812

    Article  CAS  Google Scholar 

  • Hagege, J. M., M. A. Brasch, and S. N. Cohen. 1999 Regulation of transfer functions by the imp locus of the Streptomyces coelicolor plasmidogenic element SLP1 J. Bacteriol. 181 5976–5983

    CAS  PubMed  PubMed Central  Google Scholar 

  • Han, L., K. Yang, E. Ramalingam, R. H. Mosher, and L. C. Vining. 1994 Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230 Microbiology 140 3379–3389

    Article  CAS  PubMed  Google Scholar 

  • Han, L., and K. A. Reynolds. 1997 A novel alternate anaplerotic pathway to the glyoxylate cycle in streptomycetes J. Bacteriol. 179 5157–5164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Haug, I., A. Weissenborn, D. Brolle, S. Bentley, T. Kieser, and J. Altenbuchner. 2003 Streptomyces coelicolor A3(2) plasmid SCP2*: Deductions from the complete sequence Microbiology 149 505–513

    Article  CAS  PubMed  Google Scholar 

  • Hayashi, K. I., A. M. Jones, K. Ogino, A. Yamazoe, Y. Oono, M. Inoguchi, H. Kondo, and H. Nozaki. 2003 Yokonolide B, a novel inhibitor of auxin action, blocks degradation of Aux/IAA factors J. Biol. Chem. 278 23797–23806

    Article  CAS  PubMed  Google Scholar 

  • Healy, F. G., M. Wach, S. B. Krasnoff, D. M. Gibson, and R. Loria. 2000 The txtAB genes of the plant pathogen Streptomyces acidiscabies encode a peptide synthetase required for phytotoxin thaxtomin A production and pathogenicity Molec. Microbiol. 38 794–804

    Article  CAS  Google Scholar 

  • Hesketh, A. R., G. Chandra, A. D. Shaw, J. J. Rowland, D. B. Kell, M. J. Bibb, and K. F. Chater. 2002a Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor Molec. Microbiol. 46 917–932

    Article  CAS  Google Scholar 

  • Hesketh, A., D. Fink, B. Gust, H. U. Rexer, B. Scheel, K. Chater, W. Wohlleben, and A. Engels. 2002b The GlnD and GlnK homologues of Streptomyces coelicolor A3(2) are functionally dissimilar to their nitrogen regulatory system counterparts from enteric bacteria Molec. Microbiol. 46 319–330

    Article  CAS  Google Scholar 

  • Hiraga, K., T. Suzuki, and K. Oda. 2000 A novel double-headed proteinaceous inhibitor for metalloproteinase and serine proteinase J. Biol. Chem. 275 25173–25179

    Article  CAS  PubMed  Google Scholar 

  • Hiratsu, K., S. Mochizuki, and H. Kinashi. 2000 Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei Molec. Gen. Genet. 263 1015–1021

    Article  CAS  PubMed  Google Scholar 

  • Hirochika, H., K. Nakamura, and K. Sakaguchi. 1984 A linear DNA plasmid from Streptomyces rochei with an inverted terminal repetition of 614 base pairs EMBO J. 3 761–766

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hong, S. T., J. R. Carney, and S. J. Gould. 1997 Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016 J. Bacteriol. 179 470–476

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hopwood, D. A., M. J. Bibb, K. F. Chater, T. Kieser, C. J. Bruton, H. M. Kieser, D. J. Lydiate, C. P. Smith, J. M. Ward, and H. Schrempf. 1985 Genetic Manipulation of Streptomyces: A Laboratory Manual John Innes Foundation, Norwich, UK

    Google Scholar 

  • Hopwood, D. A., and D. H. Sherman. 1990 Molecular genetics of polyketides and its comparison to fatty acid biosynthesis Ann. Rev. Genet. 24 37–66

    Article  CAS  PubMed  Google Scholar 

  • Horinouchi, S., and T. Beppu. 1992 Autoregulatory factors and communication in Actinomycetes Ann. Rev. Microbiol. 46 377–398

    Article  CAS  Google Scholar 

  • Horinouchi, S. 2002 A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus Front. Biosci. 7 d2045–d2057

    CAS  PubMed  Google Scholar 

  • Hornemann, U., C. J. Otto, and X. Y. Zhang. 1989 DNA amplification in Streptomyces achromogenes subsp. rubradiris is accompanied by a deletion, and the amplified sequences are conditionally stable and can be eliminated by two pathways J Bacteriol. 171 5817–5822

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsieh, C.-J., and G. H. Jones. 1995 Nucleotide sequence, transcriptional analysis, and glucose regulation of the phenoxazinone synthase gene (phsA) from Streptomyces antibioticus J. Bacteriol. 177 5740–5747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang, C.-H., Y.-S. Lin, Y.-L. Yang, S. Huang, and C. W. Chen. 1998 The telomeres of Streptomyces chromosomes contain conserved palindromic sequences with potential to form complex secondary structures Molec. Microbiol. 28 905–916

    Article  CAS  Google Scholar 

  • Huang, J., C. J. Lih, K. H. Pan, and S. N. Cohen. 2001 Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays Genes Dev. 15 3183–3192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang, C.-H., C. Y. Chen, H. H. Tsai, C. Chen, Y.-S. Lin, and C. W. Chen. 2003 Linear plasmid SLP2 of Streptomyces lividans is a composite replicon Molec. Microbiol. 47 1563–1576

    Article  CAS  Google Scholar 

  • Huddleston, A. S., N. Cresswell, M. C. P. Neves, J. E. Beringer, S. Baumberg, D. I. Thomas, and E. M. H. Wellington. 1997 Molecular detection of streptomycin-producing streptomycetes in Brazilian soils Appl. Environ. Microbiol. 63 1288–1297

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hutchinson, C. R., and I. Fujii. 1995 Polyketide synthase gene manipulation: A structure-function approach in engineering novel antibiotics Ann. Rev. Microbiol. 49 201–238

    Article  CAS  Google Scholar 

  • Hütter, R., and T. Eckhardt. 1988 Genetic manipulation In: M. Goodfellow, S. T. Williams, and M. Mordarski (Eds.) Actinomycetes in Biotechnology Academic Press, London, UK 89–184

    Google Scholar 

  • Ikeda, H., Y. Takada, C.-H. Pang, H. Tanaka, and S. Omura. 1993 Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis J. Bacteriol. 175 2077–2082

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ikeda, H., J. Ishikawa, A. Hanamoto, M. Shinose, H. Kikuchi, T. Shiba, Y. Sakaki, M. Hattori, and S. Omura. 2003 Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis Nature Biotechnol. 21(5) 526–531

    Article  Google Scholar 

  • Jakimowicz, D., J. Majka, W. Messer, C. Speck, M. Fernandez, M. Cruz Martin, J. Sanchez, F. Schauwecker, U. Keller, H. Schrempf, and J. Zakrzewska-Czerwinska. 1998 Structural elements of the Streptomyces oriC region and their interactions with the DnaA protein Microbiology 144 1281–1290

    Article  CAS  PubMed  Google Scholar 

  • Jakimowicz, D., J. Majka, G. Konopa, G. Wegrzyn, W. Messer, H. Schrempf, and J. Zakrzewska-Czerwinska. 2000 Architecture of the Streptomyces lividans DnaA protein-replication origin complexes J. Molec. Biol. 298 351–364

    Article  CAS  PubMed  Google Scholar 

  • Jendrossek, D., G. Tomasi, and R. M. Kroppenstedt. 1997 Bacterial degradation of natural rubber: A privilege of Actinomycetes? FEMS Microbiol. Lett. 150 179–188

    Article  CAS  PubMed  Google Scholar 

  • Jiang, C.-L., and L.-H. Xu. 1996 Diversity of aquatic Actinomycetes in lakes of the Middle Plateau, Yunnan, China Appl. Environ. Microbiol. 62 249–253

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jonsbu, E., B. Christensen, and J. Nielsen. 2001 Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture Appl. Microbiol. Biotechnol, 56 93–100

    Article  CAS  PubMed  Google Scholar 

  • Kalkus, J., C. Dörrie, D. Fischer, M. Reh, and H. G. Schlegel. 1993 The giant linear plasmid pHG207 from Rhodococcus sp. encoding hydrogen autotrophy: Characterization of the plasmid and its termini J. Gen. Microbiol. 139 2055–2065

    Article  CAS  PubMed  Google Scholar 

  • Kamerbeek, J., L. Schouls, A. Kolk, M. van Agterveld, D. van Soolingen, S. Kuijper, A. Bunschoten, H. Molhuizen, R. Shaw, M. Goyal, and J. D. A. van Embden. 1997 Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology J. Clin. Microbiol. 35 907–914

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kataoka, M., T. Seki, and T. Yoshida. 1991 Five genes involved in self-transmission of pSN22, a Streptomyces plasmid J. Bacteriol. 173 4220–4228

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kebeler, M., E. R. Dabbs, B. Averhoff, and G. Gottschalk. 1996 Studies on the isopropylbenzene 2,3-dioxygenase and the 3’-isopropylcatechol 2,3-dioxygenase genes encoded by the linear plasmid of Rhodococcus erythropolis BD2 Microbiology 142 3241–3251

    Article  Google Scholar 

  • Kelemen, G. H., M. Zalacain, E. Culebras, E. T. Seno, and E. Cundliffe. 1994 Transcriptional attenuation control of the tylosin-resistance gene tlrA in Streptomyces fradiae Molec. Microbiol. 14 833–842

    Article  CAS  Google Scholar 

  • Khokhlov, A. S., I. I. Tovarova, L. N. Borisova, S. A. Pliner, L. A. Schevchenko, E. Y. Kornitskaya, N. S. Ivkina, and I. A. Rapoport. 1967 A-factor responsible for the biosynthesis of streptomycin by a mutant strain of Actinomyces streptomycini Dokl. Akad. Nauk. SSSR 177 232–235

    CAS  PubMed  Google Scholar 

  • Kim, I. S., and K. J. Lee. 1995 Physiological roles of leupeptin and extracellular proteases in mycelium development of Streptomyces exfoliatus SMF13 Microbiology 141 1017–1025

    Article  CAS  PubMed  Google Scholar 

  • Kim, Y. S. 2002 Malonate metabolism: Biochemistry, molecular biology, physiology, and industrial application J. Biochem. Molec. Biol. 35 443–451

    CAS  Google Scholar 

  • Kinashi, H., M. Shimaji-Murayama, and T. Hanafusa. 1991 Nucleotide sequence analysis of the unusually long terminal inverted repeats of a giant linear plasmid, SCP1 Plasmid 26 123–130

    Article  CAS  PubMed  Google Scholar 

  • King, R. R., and C. H. Lawrence. 1996 Characterization of new thaxtomin A analogues generated in vitro by Streptomyces scabies J. Agric. Food Chem. 44 1108–1110

    Article  CAS  Google Scholar 

  • Kluepfel, D., F. Shareck, F. Mondou, and R. Morosoli. 1986 Characterisation of cellulase and xylanase activities of Streptomyces lividans Appl. Microbiol. Biotechnol. 24 230–234

    Article  CAS  Google Scholar 

  • Kolbe, S., S. Fischer, A. Becirevic, P. Hinz, and H. Schrempf. 1998 The Streptomyces reticuli α-chitin-binding protein CHB2 and its gene Microbiology 144 1291–1297

    Article  CAS  PubMed  Google Scholar 

  • Kosono, S., M. Maeda, F. Fuji, H. Arai, and T. Kudo. 1997 Three of the seven bphC genes of Rhodococcus erythropolis TA421, isolated from a termite ecosystem, are located on an indigenous plasmid associated with biphenyl degradation Appl. Environ. Microbiol. 63 3282–3285

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kumon, Y., Y. Sasaki, I. Kato, N. Takaya, H. Shoun, and T. Beppu. 2002 Codenitrification and denitrification are dual metabolic pathways through which dinitrogen evolves from nitrate in Streptomyces antibioticus J. Bacteriol. 184 2963–2968

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kutzner, H. J. 1981 The family Streptomycetaceae In: M. P. Starr, H. Stolp, H. G. Trüper, A. Balows, and H. Schlegel (Eds.) The Prokaryotes Springer-Verlag, Berlin, Germany 2028–2090

    Google Scholar 

  • Lacalle, R. A., J. A. Tercero, and A. Jimenez. 1992 Cloning of the complete biosynthetic gene cluster for an aminonucleoside antibiotic, puromycin, and its regulated expression in heterologous hosts EMBO J. 11 785–792

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lammertyn, E., and J. Anné. 1998 Modifications of Streptomyces signal peptides and their effects on protein production and secretion FEMS Microbiol. Lett. 160 1–10

    Article  CAS  PubMed  Google Scholar 

  • Lawen, A., and R. Zocher. 1990 Cyclosporin synthetase: The most complex peptide synthesizing multienzyme polypeptide so far described J. Biol. Chem. 265 11355–11360

    CAS  PubMed  Google Scholar 

  • Leblond, P., and B. Decaris. 1994 New insights into the genetic instability of Streptomyces FEMS Microbiol. Lett. 123 225–232

    Article  CAS  PubMed  Google Scholar 

  • Leblond, P., G. Fischer, F. Francou, F. Berger, M. Guérineau, and B. Decaris. 1996 The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA Molec. Microbiol. 19 261–271

    Article  CAS  Google Scholar 

  • Lee, D. S., and S. H. Lee. 2001 Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor FEBS Lett. 501 84–86

    Article  CAS  PubMed  Google Scholar 

  • Lezhava, A., T. Mizukami, T. Kajitani, D. Kameoka, M. Redenbach, H. Shinkawa, O. Nimi, and H. Kinashi. 1995 Physical map of the linear chromosome of Streptomyces griseus J. Bacteriol. 177 6492–6498

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin, Y. S., H. M. Kieser, D. A. Hopwood, and C. W. Chen. 1993 The chromosomal DNA of Streptomyces lividans 66 is linear Molec. Microbiol. 10 923–933

    Article  CAS  Google Scholar 

  • Lombo, F., G. Blanco, E. Fernandez, C. Mendez, and J. A. Salas. 1996 Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor antibiotic mithramycin Gene 172 87–91

    Article  CAS  PubMed  Google Scholar 

  • Lomovskaya, N. D., K. F. Chater, and N. M. Mkrtumian. 1980 Genetics and molecular biology of Streptomyces bacteriophages Microbiol. Rev. 44 206–229

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lutkenhaus, J. 1997 Bacterial cytokinesis: Let the light shine in Curr. Biol. 7 573–575

    Article  Google Scholar 

  • Malpartida, F., and D. A. Hopwood. 1984 Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host Nature 309 462–464

    Article  CAS  PubMed  Google Scholar 

  • Malpartida, F., J. Niemi, R. Navarrete, and D. A. Hopwood. 1990 Cloning and expression in a heterologous host of the complete set of genes for biosynthesis of the Streptomyces coelicolor antibiotic undecylprodigiosin Gene 93 91–99

    Article  CAS  PubMed  Google Scholar 

  • Margolin, W. 2003 Bacterial division: The fellowship of the ring Curr. Biol. 13 16–18

    Article  Google Scholar 

  • Martin, C., J. Timm, J. Rauzier, R. Gomez-Lus, J. Davies, and B. Gicquel. 1990 Transposition of an antibiotic resistance element in mycobacteria Nature 345 739–743

    Article  CAS  PubMed  Google Scholar 

  • McCue, L. A., J. Kwak, J. Wang, and K. E. Kendrick. 1996 Analysis of a gene that suppresses the morphological defect of bald mutants of Streptomyces griseus J. Bacteriol. 178 2867–2875

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Méndez, C., and J. A. Salas. 1998 ABC transporters in antibiotic-producing Actinomycetes FEMS Microbiol. Lett. 158 1–8

    Article  PubMed  Google Scholar 

  • Meurer, G., and C. R. Hutchinson. 1999 Genes for the biosynthesis of microbial secondary metabolites In: A. L. Demain et al. (Eds.) Industrial Microbiology and Biotechnology, 2nd ed American Society for Microbiology, Washington, DC 740–758

    Google Scholar 

  • Meuser, D., H. Splitt, R. Wagner, and H. Schrempf. 2001 Mutations stabilizing an open conformation within the external region of the permeation pathway of the potassium channel KcsA Eur. Biophys. J. 30 385–391

    Article  CAS  PubMed  Google Scholar 

  • Minambres, B., E. R. Olivera, R. A. Jensen, and J. M. Luengo. 2000 A new class of glutamate dehydrogenases (GDH): Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus J. Biol. Chem. 275 39529–39542

    Article  CAS  PubMed  Google Scholar 

  • Miyashita, K., T. Fujii, and Y. Sawada. 1991 Molecular cloning and characterization of chitinase genes from Streptomyces lividans 66 J. Gen. Microbiol. 137 2065–2072

    Article  CAS  Google Scholar 

  • Morosoli, R., S. Ostiguy, and C. Dupont. 1999 Effect of carbon source, growth and temperature on the expression of the sec genes of Streptomyces lividans 1326 Can. J. Microbiol. 45 1043–1049

    Article  CAS  PubMed  Google Scholar 

  • Motamedi, H., and C. R. Hutchinson. 1987 Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic of Streptomyces glaucescens Proc. Natl. Acad. Sci. USA 84 4445–4449

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murakami, T., S. Anzai, S. Imai, A. Satoh, K. Nagaoka, and C. J. Thompson. 1986 The bialalphos biosynthetic genes of Streptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster Molec. Gen. Genet. 205 42–50

    Article  CAS  Google Scholar 

  • Muth, G., M. Farr, V. Hartmann, and W. Wohlleben. 1995 Streptomyces ghanaensis plasmid pSG5: Nucleotide sequence analysis of the self-transmissible minimal replicon and characterization of the replication mode Plasmid 33 113–126

    Article  CAS  PubMed  Google Scholar 

  • Nakai, R., S. Horinouchi, and T. Beppu. 1988 Cloning and nucleotide sequence of a cellulase gene, casA, from an alkalophilic Streptomyces strain Gene 65 229–238

    Article  CAS  PubMed  Google Scholar 

  • Nakata, K., S. Horinouchi, and T. Beppu. 1989 Cloning and characterization of the carbapenem biosynthetic genes from Streptomyces fulvoviridis FEMS Microbiol. Lett. 48 51–55

    Article  CAS  PubMed  Google Scholar 

  • Neeno-Eckwall, E. C., L. L. Kinkel, and J. L. Schottel. 2001 Competition and antibiosis in the biological control of potato scab Can. J. Microbiol. 47 332–340

    Article  CAS  PubMed  Google Scholar 

  • Nguyen, J., F. Francou, M.-J. Virolle, and M. Guérineau. 1997 Amylase and chitinase genes in Streptomyces lividans are regulated by reg1, a pleiotropic regulatory gene J. Bacteriol. 179 6383–6390

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Novotna, J. et al. 2003 Proteomic studies of diauxic lag in the differentiating prokaryote Streptomyces coelicolor reveal a regulatory network of stress-induced proteins and central metabolic enzymes Molec. Microbiol. 48 1289–1303

    Article  CAS  Google Scholar 

  • Obanye, A. I. C., G. Hobbs, D. C. J. Gardner, and S. G. Oliver. 1996 Correlation between carbon flux through the pentose phosphate pathway and production of the antibiotic methylenomycin in Streptomyces coelicolor A3(2) Microbiology 142 133–137

    Article  CAS  Google Scholar 

  • Obojska, A., and B. Lejczak. 2003 Utilisation of structurally diverse organophosphonates by streptomycetes Appl. Microbiol. Biotechnol. 62 567–563

    Article  CAS  Google Scholar 

  • O’Connor, T. J., P. Kanellis, and J. R. Nodwell. 2002 The ramC gene is required for morphogenesis in Streptomyces coelicolor and expressed in a cell type-specific manner under the direct control of RamR Molec. Microbiol. 45 45–57

    Article  Google Scholar 

  • Ohnuki, T., T. Imanaka, and S. Aiba. 1985 Self-cloning in Streptomyces griseus of an str gene cluster for streptomycin biosynthesis and streptomycin resistance J. Bacteriol. 164 85–94

    CAS  PubMed  PubMed Central  Google Scholar 

  • Okami, Y., T. Okazaki, T. Kitahara, and H. Umezawa. 1976 Studies on marine microorganisms. V: A new antibiotic, aplasmomycin, produced by a streptomycete isolated from shallow sea mud J. Antibiot. Ser. A 29 1019–1025

    Article  CAS  Google Scholar 

  • Onaka, H., T. Nakagawa, and S. Horinouchi. 1998 Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis Molec. Microbiol. 28 743–753

    Article  CAS  Google Scholar 

  • Pagé, N., D. Kluepfel, F. Shareck, and R. Morosoli. 1996 Effect of signal peptide alterations and replacement on export of xylanase A in Streptomyces lividans Appl. Environ. Microbiol. 62 109–114

    PubMed  PubMed Central  Google Scholar 

  • Pahl, A., A. Gewies, and U. Keller. 1997 ScCypB is a novel second cytosolic cyclophilin from Streptomyces chrysomallus which is phylogenetically distant from ScCypA Microbiology 143 117–126

    Article  CAS  PubMed  Google Scholar 

  • Pang, X., Y. Sun, J. Liu, X. Zhou, and Z. Deng. 2002a A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22 FEMS Microbiol. Lett. 19:208 25–28

    Article  Google Scholar 

  • Pang, X., X. Zhou, Y. Sun, and Z. Deng. 2002b Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions J. Bacteriol. 184 1958–1965

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Paradkar, A. S., K. A. Aidoo, A. Wong, and S. E. Jensen. 1996 Molecular analysis of a β-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus J. Bacteriol. 178 6266–6274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Parche, S., H. Nothaft, A. Kamionka, and F. Titgemeyer. 2000 Sugar uptake and utilisation in Streptomyces coelicolor: A PTS view to the genome Ant. v. Leeuwenhoek 78 243–251

    Article  CAS  Google Scholar 

  • Peczynska-Czoch, W., and M. Mordarski. 1988 Actinomycete enzymes In: M. Goodfellow, S. T. Williams, and M. Mordarski (Eds.) Actinomycetes in Biotechnology Academic Press, London, UK 219–283

    Google Scholar 

  • Pelaez, A. I., R. M. Ribas-Aparicio, A. Gomez, and M. R. Rodicio. 2001 Structural and functional characterization of the recR gene of Streptomyces Molec. Genet. Genom. 265 663–672

    Article  CAS  Google Scholar 

  • Pernodet, J.-L., J.-M. Simonet, and M. Guérineau. 1984 Plasmids in different strains of Streptomyces ambofaciens: Free and integrated form of plasmid pSAM2 Molec. Gen. Genet. 198 35–41

    Article  CAS  PubMed  Google Scholar 

  • Philipp, W. J., S. Poulet, K. Eiglmeier, L. Pascopella, V. Balasubramanian, B. Heym, S. Bergh, B. R. Bloom, W. R. Jacobs Jr. and S. T. Cole. 1996 An integrated map of the genome of the tubercle bacillus, Mycobacterium tuberculosis H37Rv, and comparison with Mycobacterium leprae Proc. Natl. Acad. Sci. USA 93 3132–3137

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Picardeau, M., and V. Vincent. 1998 Mycobacterial linear plasmids have an invertron-like structure related to other linear replicons in Actinomycetes Microbiology 144 1981–1988

    Article  CAS  PubMed  Google Scholar 

  • Pitman, A., P. Herron, and P. Dyson. 2002 Cointegrate resolution following transposition of Tn1792 in Streptomyces avermitilis facilitates analysis of transposon-tagged genes J. Microbiol. Meth. 49 89–96

    Article  CAS  Google Scholar 

  • Possoz, C., C. Ribard, J. Gagnat, J. L. Pernodet, and M. Guérineau. 2001 The integrative element pSAM2 from Streptomyces: Kinetics and mode of conjugal transfer Molec. Microbiol. 42 159–166

    Article  CAS  Google Scholar 

  • Qin, Z., and S. N. Cohen. 2002 Survival mechanisms for Streptomyces linear replicons after telomere damage Molec. Microbiol. 45 785–794

    Article  CAS  Google Scholar 

  • Ravel, J., H. Schrempf, and R. T. Hill. 1998 Mercury resistance is encoded by transferable giant linear plasmids in two Chesapeake Bay Streptomyces strains Appl. Environ. Microbiol. 64 3383–3388

    CAS  PubMed  PubMed Central  Google Scholar 

  • Redenbach, M., H. M. Kieser, D. Denapaite, A. Eichner, J. Cullum, H. Kinashi, and D. A. Hopwood. 1996 A set of ordered cosmids and a detailed genetic and physical map for the 8 MB Streptomyces coelicolor A3(2) chromosome Molec. Microbiol. 21 77–96

    Article  CAS  Google Scholar 

  • Redenbach, M., J. Scheel, J. Cullum, and U. Schmidt. 1998 The chromosome of various Actinomycetes strains is linear (Abstract) In: G. Cohen and Y. Aharonowitz (Eds.) 8th International Symposium on the Genetics of Industrial Microorganisms, June 28–July 2, 1998, Jerusalem, Israel, 69–70

    Google Scholar 

  • Ribbe, M., D. Gadkari, and O. Meyer. 1997 N2 fixation by Streptomyces thermoautotrophicus involves a molybdenum-dinitrogenase and a manganese-superoxide oxidoreductase that couple N2 reduction to the oxidation of superoxide produced from O2 by a molybdenum-CO dehydrogenase J. Biol. Chem. 272 26627–26633

    Article  CAS  PubMed  Google Scholar 

  • Robbins, P. W., C. Albright, and B. Benfield. 1988 Cloning and expression of a Streptomyces plicatus chitinase (chitinase-63) in Escherichia coli J. Biol. Chem. 263 443–447

    CAS  PubMed  Google Scholar 

  • Rodríguez-García, A., M. Ludovice, J. F. Martín, and P. Liras. 1997 Arginine boxes and the argR gene in Streptomyces clavuligerus: Evidence for a clear regulation of the arginine pathway Molec. Microbiol. 25 219–228

    Article  Google Scholar 

  • Roller, C., W. Ludwig, and K.-H. Schleifer. 1992 Gram-positive bacteria with a high DNA G+C content are characterized by a common insertion within their 23S rRNA genes J. Gen. Microbiol. 138 167–175

    Article  Google Scholar 

  • Rose, K., and A. Steinbuchel. 2002 Construction and intergeneric conjugative transfer of a pSG5-based cosmid vector from Escherichia coli to the polyisoprene rubber degrading strain Micromonospora aurantiaca W2b FEMS Microbiol. Lett. 211 129–132

    Article  CAS  PubMed  Google Scholar 

  • Rueda, B., E. M. Miguelez, C. Hardisson, and M. B. Manzanal. 2001 Changes in glycogen and trehalose content of Streptomyces brasiliensis hyphae during growth in liquid cultures under sporulating and non-sporulating conditions FEMS Microbiol. Lett. 194 181–185

    Article  CAS  PubMed  Google Scholar 

  • Ruiz-Arribas, A., G. G. Zhadan, V. P. Kutyshenko, R. I. Santamaría, M. Cortijo, E. Villar, J. M. Fernandez-Abalos, J. J. Calvete, and V. L. Shnyrov. 1998 Thermodynamic stability of two variants of xylanase (Xys1) from Streptomyces halstedii JM8 Eur. J. Biochem. 253 462–468

    Article  CAS  PubMed  Google Scholar 

  • Saito, N., K. Matsubara, M. Watanabe, F. Kato, and K. Ochi. 2003 Genetic and biochemical characterization of EshA, a protein that forms large multimers and affects developmental processes in Streptomyces griseus J. Biol. Chem. 278 5902–5911

    Article  CAS  PubMed  Google Scholar 

  • Salas, J. A., C. Hernandez, C. Mendez, C. Olano, L. M. Quiros, A. M. Rodriguez, and C. Vilches. 1994 Intracellular glycosylation and active efflux as mechanisms for resistance to oleandomycin in Streptomyces antibioticus, the producer organism Microbiologia 10 37–48

    CAS  PubMed  Google Scholar 

  • Schaerlaekens, K., M. Schierova, E. Lammertyn, N. Geukens, J. Anné, and L. van Mellaert. 2001 Twin-arginine translocation pathway in Streptomyces lividans J. Bacteriol. 183 6727–6732

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schlochtermeier, A., S. Walter, J. Schröder, M. Moormann, and H. Schrempf. 1992 The gene encoding the cellulase (Avicelase) Cel1 from Streptomyces reticuli and analysis of protein domains Molec. Microbiol. 6 3611–3621

    Article  CAS  Google Scholar 

  • Schlösser, A., and H. Schrempf. 1996 A lipid-anchored binding protein is a component of an ATP-dependent cellobiose/-triose transport system from the cellulose degrader Streptomyces reticuli Eur. J. Biochem. 242 332–338

    Article  PubMed  Google Scholar 

  • Schlösser, A., T. Kampers, and H. Schrempf. 1997 The Streptomyces ATP-binding component MsiK assists in cellobiose and maltose transport J. Bacteriol. 179 2092–2095

    Article  PubMed  PubMed Central  Google Scholar 

  • Schneider, D., C. J. Bruton, and K. F. Chater. 2000 Duplicated gene clusters suggest an interplay of glycogen and trehalose metabolism during sequential stages of aerial mycelium development in Streptomyces coelicolor A3(2) Molec. Gen. Genet. 263 543–553

    Article  CAS  PubMed  Google Scholar 

  • Schrempf, H., P. Dyson, W. Dittrich, M. Betzler, C. Habiger, B. Mahro, V. Brönneke, A. Kessler, and H. Düvel. 1989 Genetic instability in Streptomyces In: Y. Okami, T. Beppu, and H. Ogawara (Eds.) Biology of Actinomycetes’ 88 Scientific Press, Tokyo, Japan 145–150

    Google Scholar 

  • Schrempf, H. et al. 1995 A prokaryotic potassium ion channel with two predicted transmembrane segments from Streptomyces lividans EMBO J. 14 5170–5178

    CAS  PubMed  PubMed Central  Google Scholar 

  • Schwecke, T., J. F. Aparicio, I. Molnar, A. Konig, L. E. Khaw, S. F. Haydock, M. Oliynyk, P. Caffrey, J. Cortes, J. B. Lester, G. A. Bohm, J. Staunton, and P. F. Leadlay. 1995 The biosynthesis gene cluster for the polyketide immunosuppressant rampamycin Proc. Natl. Acad. Sci. USA 92 7839–7843

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Servín-González, L. 1993 Relationship between the replication functions of Streptomyces plasmids pJV1 and pIJ101 Plasmid 30 131–140

    Article  PubMed  Google Scholar 

  • Servín-González, L., C. Castro, C. Pérez, M. Rubio, and F. Valdez. 1997 bldA-dependent expression of the Streptomyces exfoliatus M11 lipase gene (lipA) is mediated by the product of a contiguous gene, lipR, encoding a putative transcriptional activator J. Bacteriol. 179 7816–7826

    Article  PubMed  PubMed Central  Google Scholar 

  • Sezonov, G., A.-M. Duchêne, A. Friedmann, M. Guérineau, and J.-L. Pernodet. 1998 Replicase, excisionase, and integrase genes of the Streptomyces element pSAM2 constitute an operon positively regulated by the pra gene J. Bacteriol. 180 3056–3061

    CAS  PubMed  PubMed Central  Google Scholar 

  • Sherman, D. H., F. Malpartida, M. J. Bibb, H. M. Kieser, and D. A. Hopwood. 1989 Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber TU22 EMBO J. 8 2717–2725

    CAS  PubMed  PubMed Central  Google Scholar 

  • Soh, B. S., P. Loke, and T. S. Sim. 2001 Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585 Biochim. Biophys. Acta 1522 112–117

    Article  CAS  PubMed  Google Scholar 

  • Sohng, J. K., T. J. Oh, J. J. Lee, and C. G. Kim. 1997 Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061 Molec. Cells 7 674–681

    CAS  PubMed  Google Scholar 

  • Sola-Landa, A., R. S. Moura, and J. F. Martin. 2003 The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans Proc. Natl. Acad. Sci. USA 100 6133–6138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sommer, P., C. Bormann, and F. Götz. 1997 Genetic and biochemical characterization of a new extracellular lipase from Streptomyces cinnamomeus Appl. Environ. Microbiol. 63 3553–3560

    CAS  PubMed  PubMed Central  Google Scholar 

  • Spiteller, D., A. Jux, J. Piel, and W. Boland. 2002 Feeding of [5,5-2H(2)]-1-desoxy-D-xylulose and [4,4,6,6,6-2H(5)]-mevalolactone to a geosmin-producing Streptomyces sp. and Fossombronia pusilla Phytochemistry 61 827–834

    Article  CAS  PubMed  Google Scholar 

  • Spychaj, A., and M. Redenbach. 2001 The terminal inverted repeats of the linear plasmid SCP1 of Streptomyces coelicolor A3(2) possess a truncated copy of the transposon Tn4811 of Streptomyces lividans 66 Ant. v. Leeuwenhoek 79 49–52

    Article  CAS  Google Scholar 

  • Stindl, A., and U. Keller. 1994 Epimerization of the D-valine portion in the biosynthesis of actinomycin D Biochemistry 33 9358–9364

    Article  CAS  PubMed  Google Scholar 

  • Stutzman-Engwall, K. J., and C. R. Hutchinson. 1989 Multigene families for anthracycline antibiotic production in Streptomyces peucetius Proc. Natl. Acad. Sci. USA 86 3135–3139

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Swan, D. G., A. M. Rodriguez, C. Vilches, C. Méndez, and J. A. Salas. 1994 Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence Molec. Gen. Genet. 242 358–362

    Article  CAS  PubMed  Google Scholar 

  • Taguchi, S., T. Endo, Y. Naoi, and H. Momose. 1995 Molecular cloning and sequence analysis of a gene encoding an extracellular serine protease from Streptomyces lividans 66 Biosci. Biotechnol. Biochem. 59 1386–1388

    Article  CAS  PubMed  Google Scholar 

  • Tsujibo, H., T. Ohtsuki, T. Iio, I. Yamazaki, K. Miyamoto, M. Sugiyama, and Y. Inamori. 1997 Cloning and sequence analysis of genes encoding xylanases and acetyl xylan esterase from Streptomyces thermoviolaceus OPC-520 Appl. Environ. Microbiol. 63 661–664

    CAS  PubMed  PubMed Central  Google Scholar 

  • Van Keulen, G., H. M. Jonkers, D. Claessen, L. Dijkhuizen, and H. A. Wosten. 2003 Differentiation and anaerobiosis in standing liquid cultures of Streptomyces coelicolor J. Bacteriol. 185 1455–1458

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vara, J., M. Lewandowska-Skarbek, Y. G. Wang, S. Donadio, and C. R. Hutchinson. 1989 Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus) J. Bacteriol. 171 5872–5881

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verma, S., Y. Bhatia, S. P. Valappil, and I. Roy. 2002 A possible role of poly-3-hydroxybutyric acid in antibiotic production in Streptomyces Arch. Microbiol. 179 66–69

    Article  CAS  PubMed  Google Scholar 

  • Virolle, M.-J., and M. J. Bibb. 1988 Cloning, characterization and regulation of an α-amylase gene from Streptomyces limosus Molec. Microbiol. 2 197–208

    Article  CAS  Google Scholar 

  • Voelker, F., and S. Altaba. 2001 Nitrogen source governs the patterns of growth and pristinamycin production in Streptomyces pristinaespiralis Microbiology 147 2447–2459

    Article  CAS  PubMed  Google Scholar 

  • Volff, J. N., and J. Altenbuchner. 1997 High-frequency transposition of IS1373, the insertion sequence delimiting the amplifiable element AUD2 of Streptomyces lividans J. Bacteriol. 179 5639–5642

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Von Döhren, H., and H. Kleinkauf. 1997 Enzymology of peptide synthetases In: W. R. Strohl (Ed.) Biotechnology of Antibiotics, 2nd ed Marcel Dekker, New York, NY 217–240

    Google Scholar 

  • Vujaklija, D. et al. 2002 A novel streptomycete lipase: Cloning, sequencing and high-level expression of the Streptomyces rimosus GDS(L)-lipase gene Arch. Microbiol. 178 124–130

    Article  CAS  PubMed  Google Scholar 

  • Walter, S., E. Wellmann, and H. Schrempf. 1998 The cell wall-anchored Streptomyces reticuli Avicel-binding protein (AbpS) and its gene J. Bacteriol. 180 1647–1654

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang, F., X. Xiao, A. Saito, and H. Schrempf. 2002 Streptomyces olivaceoviridis possesses a phosphotransferase system that mediates specific, phosphoenolpyruvate-dependent uptake of N-acetylglucosamine Molec. Genet. Genom. 268 344–351

    Article  CAS  Google Scholar 

  • Wang, L., S. Li, and Y. Li. 2003 Identification and characterization of a new exopolysaccharide biosynthesis gene cluster from Streptomyces FEMS Microbiol. Lett. 220 21–27

    Article  CAS  PubMed  Google Scholar 

  • Weber, T., K. Welzel, S. Pelzer, A. Vente, and W. Wohlleben. 2003 Exploiting the genetic potential of polyketide producing streptomycetes J. Biotechnol. 106 221–232

    Article  CAS  PubMed  Google Scholar 

  • Wehmeier, U. F. 2001 Molecular cloning, nucleotide sequence and structural analysis of the Streptomyces galbus DSM40480 fda gene: The S. galbus fructose-1,6-bisphosphate aldolase is a member of the class II aldolases FEMS Microbiol. Lett. 197 53–58

    Article  CAS  PubMed  Google Scholar 

  • Xiao, X., F. Wang, A. Saito, J. Majka, A. Schlösser, and H. Schrempf. 2002 The novel Streptomyces olivaceoviridis ABC transporter Ngc mediates uptake of N-acetylglucosamine and N,N’-diacetylchitobiose Molec. Genet. Genom. 267 429–439

    Article  CAS  Google Scholar 

  • Yang, C. C., C. H. Huang, C. Y. Li, Y. G. Tsay, S. C. Lee, and C. W. Chen. 2002 The terminal proteins of linear Streptomyces chromosomes and plasmids: A novel class of replication priming proteins Molec. Microbiol. 43 297–305

    Article  Google Scholar 

  • Yu, T. W., M. J. Bibb, W. P. Revill, and D. A. Hopwood. 1994 Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus J. Bacteriol. 176 2627–2634

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yuan, W. M., and D. L. Crawford. 1995 Characterization of Streptomyces lydicus WYEC108 as a potential biocontrol agent against fungal root and seed rots Appl. Environ. Microbiol. 61 3119–3128

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zakrzewska-Czerwinska, J., and H. Schrempf. 1992 Characterization of an autonomously replicating region from the Streptomyces lividans chromosome J. Bacteriol. 174 2688–2693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang, X., C. A. Clark, and G. S. Pettis. 2003 Interstrain inhibition in the sweet potato pathogen Streptomyces ipomoeae: Purification and characterization of a highly specific bacteriocin and cloning of its structural gene Appl. Environ. Microbiol. 69 2201–2208

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zotchev, S. B., and H. Schrempf. 1994 The linear Streptomyces plasmid BL1: Analyses of transfer functions Molec. Gen. Genet. 242 374–382

    Article  CAS  PubMed  Google Scholar 

  • Zuber, P., and M. A. Marahiel. 1997 Structure, function and regulation of genes encoding multidomain peptide synthetases In: W. R. Strohl (Ed.) Biotechnology of Antibiotics, 2nd ed Marcel Dekker, New York, NY 187–216

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag

About this entry

Cite this entry

Schrempf, H. (2006). The Family Streptomycetaceae, Part II: Molecular Biology. In: Dworkin, M., Falkow, S., Rosenberg, E., Schleifer, KH., Stackebrandt, E. (eds) The Prokaryotes. Springer, New York, NY. https://doi.org/10.1007/0-387-30743-5_23

Download citation

Publish with us

Policies and ethics