Encyclopedia of Ionic Liquids

Living Edition
| Editors: Suojiang Zhang

Conversion of Chitin in Ionic Liquids

  • Caroline Hadad
  • Eric Husson
  • Albert Nguyen Van NhienEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-6739-6_80-1


Present in the exoskeleton of arthropods or in the cell walls of fungi, chitin belongs to the most abundant polysaccharides after cellulose and is composed of linear chains of β-(1 → 4)- N-acetyl-D-glucosamine. There are three types of chitins (α-, β-, γ-chitin) with different crystallographic structures. Among them, α-chitin, the most prominent form, is arranged in an antiparallel fashion and is found in both crustacean and insects’ sources [ 21]. Despite its excellent biodegradability, biocompatibility, antimicrobial activity, nontoxicity, low immunogenicity, and good mechanical properties, chitin remains underutilized. This limitation in terms of application is mainly due to: (i) the low extraction efficiency, (ii) the extraction costs excessively high and not environmentally friendly, and (iii) the lack of solubility of this hydrophobic biopolymer. To overcome this weak solubility, pretreatments (chemical, mechanical, enzymatic, …) are interesting alternatives by...
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  1. 1.
    Barber PS, Griggs CS, Bonner JR, Rogers RD (2013) Electrospinning of chitin nanofibers directly from an ionic liquid extract of shrimp shells. Green Chem 15:601–607CrossRefGoogle Scholar
  2. 2.
    Berton P, Shamshina JL, Ostadjoo S, King CA, Rogers RD (2018) Enzymatic hydrolysis of ionic liquid-extracted chitin. Carbohydr Polym 199:228–235CrossRefGoogle Scholar
  3. 3.
    Devi R, Dhamodharan R (2018) Pretreatment in hot glycerol for facile and green separation of chitin from prawn shell waste. ACS Sustain Chem Eng 6(1):846–853CrossRefGoogle Scholar
  4. 4.
    Hirayama H, Yoshida J, Yamamoto K (2018) J-I Kadokawa facile acylation of α-chitin in ionic liquid. Carbohydr Polym 200:567–571CrossRefGoogle Scholar
  5. 5.
    Husson E, Hadad C, Huet H, Laclef S, Lesur D, Lambertyn V, Jamali A, Gottis S, Sarazin C, Nguyen Van Nhien A (2017) The effect of room temperature ionic liquids on the selective biocatalytic hydrolysis of chitin via sequential or simultaneous strategies. Green Chem 19:4122–4131CrossRefGoogle Scholar
  6. 6.
    King C, Shamshina JL, Gurau G, Berton P, Farahnadiah N, Khan AF, Rogers RD (2017) A platform for more sustainable chitin films from an ionic liquid process. Green Chem 19:117–126CrossRefGoogle Scholar
  7. 7.
    Melro E, Alves L, Antunes FE, Medronho B (2018) A brief overview on lignin dissolution. J Mol Liq 265:578–584CrossRefGoogle Scholar
  8. 8.
    Mine S, Izawa H, Kaneko Y, Kadokawa J-I (2009) Acetylation of alpha-chitin in ionic liquids. Carbohydr Res 344(16):2263–2265CrossRefGoogle Scholar
  9. 9.
    Prasad K, Murakami M-A, Kaneko Y, Takada A, Nakamura Y, Kadokawa J-I (2009) Weak gel of chitin with ionic liquid, 1-allyl-3-methylimidazolium bromide. Int J Biol Macromol 45(3):221–225CrossRefGoogle Scholar
  10. 10.
    Qin Y, Lu X, Sun N, Rogers RD (2010) Dissolution or extraction of crustacean shells using ionic liquids to obtain high molecular weight purified chitin and direct production of chitin films and fibers. Green Chem 12:968–971CrossRefGoogle Scholar
  11. 11.
    Remsing RC, Swatloski RP, Rogers RD, Moyna G (2006) Mechanism of cellulose dissolution in the ionic liquid 1-n-butyl-3-methylimidazolium chloride: a 13C and 35/37Cl NMR relaxation study on model systems. Chem Commun 2006:1271–1273CrossRefGoogle Scholar
  12. 12.
    Shamshina JL, Barber PS, Gurau G, Griggs CS, Rogers RD (2016) Pulping of Crustacean Waste Using Ionic Liquids: To Extract or Not To Extract. ACS Sustainable Chem Eng 4:6072–6081CrossRefGoogle Scholar
  13. 13.
    Shamshina JL, Zavgorodnya O, Choudhary H, Frye B, Newbury N, Rogers RD (2018) In Search of Stronger/Cheaper Chitin Nanofibers through Electrospinning of Chitin-Cellulose Composites Using an Ionic Liquid Platform. ACS Sustainable Chem Eng 6(11):14713–14722CrossRefGoogle Scholar
  14. 14.
    Shen X, Shamshina JL, Berton P, Bandormir J, Wang H, Gurau G, Rogers RD (2016) Comparison of hydrogels prepared with ionic liquid-isolated vs. commercial chitin and cellulose. ACS Sustain Chem Eng 4(2):471–480CrossRefGoogle Scholar
  15. 15.
    Silva SS, Manoa JF, Reis RL (2017) Ionic liquids in the processing and chemical modification of chitin and chitosan for biomedical applications. Green Chem 19:1208–1220CrossRefGoogle Scholar
  16. 16.
    Singh N, Chen J, Koziol KK, Hallam KR, Janas D, Patil AJ, Strachan A, Hanley JG, Rahatekar SS (2016) Chitin and carbon nanotube composites as biocompatible scaffolds for neuron growth. Nanoscale 8:8288–8299CrossRefGoogle Scholar
  17. 17.
    Swatloski RP, Spear SK, Holbrey JD, Rogers RD (2002) Dissolution of cellose with ionic liquids. J Am Chem Soc 124(18):4974–4975CrossRefGoogle Scholar
  18. 18.
    Takegawa A, Murakami M-A, Kaneko Y, Kadokawa J-I (2010) Preparation of chitin/cellulose composite gels and films with ionic liquids. Carbohydr Polym 79(1):85–90CrossRefGoogle Scholar
  19. 19.
    Wu Y, Sasaki T, Irie S, Sakurai K (2008) A novel biomass-ionic liquid platform for the utilization of native chitin. Polymer 49(9):2321–2327CrossRefGoogle Scholar
  20. 20.
    Xie H, Zhang S, Li S (2006) Chitin and chitosan dissolved in ionic liquids as reversible sorbents of CO2. Green Chem 8:630–633CrossRefGoogle Scholar
  21. 21.
    Younes I, Rinaudo M (2015) Chitin and chitosan preparation from marine sources, structure, properties and applications. Mar Drugs 13(3):1133–1174CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Caroline Hadad
    • 1
  • Eric Husson
    • 2
  • Albert Nguyen Van Nhien
    • 1
    Email author
  1. 1.Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources, UMR CNRS 7378Université de Picardie Jules VerneAmiensFrance
  2. 2.Unité de Génie Enzymatique et Cellulaire, UMR CNRS 7025Université de Picardie Jules VerneAmiensFrance

Section editors and affiliations

  • Buxing Han
    • 1
    • 2
  • Pete Licence
    • 3
  1. 1.Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics, Institute of ChemistryChinese Academy of SciencesBeijingChina
  2. 2.University of Chinese Academy of SciencesBeijingChina
  3. 3.University of NottinghamNottinghamUK