Fluorination

Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

CpFluor Deoxofluorination

  • Weilu Zhang
  • Xiao Shen
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_44-1

Introduction

Fluorine is one of the vital organic chemistry elements, which can lead to significant variations in molecules’ chemical and physical properties. Thus, organofluorine compounds have been widely used in functional materials, medicinal science, life science, and many other fields [ 1, 2, 3, 4]. In contrast to the abundance of inorganic fluorine-containing compounds, naturally occurring organofluorine compounds are scarce. Therefore, many efforts have been taken to develop fluorine-incorporation methods into organic molecules [ 5]. Among them, deoxofluorination of alcohols via nucleophilic fluorination is one of the major methods to acquire alkyl fluorides (Fig. 1). After SF 4 was successfully applied in deoxofluorination in 1958 [ 7], many deoxofluorination reagents have been invented [ 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17]. At present, the widely used reagents can be divided into three categories: 1) sulfur fluorides and their derivatives (SF reagents, Fig. 1a) [ 7, 8, 9...
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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.The Institute For Advanced StudiesWuhan UniversityWuhanChina