Fluorination

Living Edition
| Editors: Jinbo Hu, Teruo Umemoto

N-Fluoropyridinium Salt Fluorination for Preparing Aryl Fluorides

  • Kosuke Kawada
Living reference work entry
DOI: https://doi.org/10.1007/978-981-10-1855-8_40-1

Introduction

As stated in the introduction part of the entry “ N-Fluoropyridinium Salt Fluorination for Preparing Aryl Fluorides,” three types of N-fluoropyridinium salts as fluorinating reagents have been developed, namely, a series of N-fluoropyridinium salts firstly developed as easy-to-handle, reactive, and widely applicable electrophilic fluorinating reagents (Fig. 1a) [ 1, 2, 3, 4], a series of zwitterionic N-fluoropyridinium-2-sulfonates as highly selective electrophilic fluorinating reagents (Fig. 1b) [ 5], and N, N’-difluoro-2,2’-bipyridinium salts as highly reactive fluorinating reagents with the high content of usable fluorine atom (Fig. 1c) [ 6]. In the first and the second series of N-fluoropyridinium salts, a number of reagents having different substituents, thus different fluorinating power, have been developed. The fluorination power of N-fluoropyridinium salts is closely dependent on the electron density of nitrogen atom of the pyridine ring. Accordingly, the power...
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© Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  1. 1.Life Sciences DivisionMitsubishi CorporationTokyoJapan