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Polkörper- und Präimplantationsdiagnostik

  • Markus MontagEmail author
  • Bettina Toth
  • Thomas Strowitzki
Living reference work entry
Part of the Springer Reference Medizin book series (SRM)

Zusammenfassung

Präimplantationsdiagnostik bezeichnet die Untersuchung von Eizellen oder Embryonen vor dem Transfer in den Uterus. Generell kann unterschieden werden zwischen der Diagnose von strukturellen/numerischen Chromosomen-Fehlverteilungen (PGS) und der Diagnose von genetischen Erkrankungen oder Prädispositionen (PID). Untersuchungen der Eizelle erfolgen am 1. und 2. Polkörper und zumeist in Ländern mit gesetzlichen Einschränkungen. Untersuchungen an Embryonen werden zumeist an Trophektodermzellen der Blastozyste durchgeführt. Der Einsatz und Nutzen der PID ist unumstritten. Hingegen wird PGS in Verbindung mit Next Generation Sequencing zur Darstellung aller Chromosomen weltweit am häufigsten eingesetzt. Neuere Studien zeigen, dass die Rate an Embryonen mit Mosaik-Diagnose und die Häufigkeit von aneuploiden Embryonen von labor- als auch klinikspezifischen Einflüssen beeinflusst zu sein scheint. Daher wird der Nutzen von PGS kontrovers diskutiert.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2019

Authors and Affiliations

  • Markus Montag
    • 1
    Email author
  • Bettina Toth
    • 2
  • Thomas Strowitzki
    • 3
  1. 1.ilabcomm GmbHSt. AugustinDeutschland
  2. 2.Klinik für Gynäkologische Endokrinologie und ReproduktionsmedizinMedizinische Universität InnsbruckInnsbruckÖsterreich
  3. 3.Abt. für Gynäkologische Endokrinologie und FertilitätsstörungenUniversitätsklinikum Heidelberg FrauenklinikHeidelbergDeutschland

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