Kinetic Isotope Effects
Kinetic isotope effects reflect the consequences of the change in atomic mass on the kinetics of a reaction when a heavy isotope (e.g., deuterium) is substituted for a lighter atom (e.g., protium). The information obtained can help identify the contribution of bond-making and bond-breaking steps to the rate-limiting step of a reaction pathway, as well as assessing the role of quantum tunneling in a mechanism.
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