Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

mRNA Localization

  • Dierk NiessingEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_450-1



Studies of recent years indicate that gene regulation at the level of translation is as important as transcriptional control. Such posttranscriptional gene regulation occurs temporally as well as spatially. For the latter, numerous examples are available from fungi, invertebrates, and vertebrates, where mRNAs are transported to subcellular sites and locally translated into asymmetrically deposited protein products (Fig. 1) (Mofatteh and Bullock 2017). Throughout eukaryotes, mRNA localization and localized translation constitute an important mechanism to produce cellular asymmetry (Martin and Ephrussi 2009). Genome-wide assessments of mRNAs during the oogenesis and embryogenesis of the fruit fly Drosophila melanogaster showed that 27% and 71% of all expressed transcripts exhibit distinct subcellular patterns (Lecuyer et al. 2007; Jambor et al. 2015). Although these numbers are likely to be lower for other organisms, these examples...
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  1. Buxbaum AR, Haimovich G, Singer RH (2015) In the right place at the right time: visualizing and understanding mRNA localization. Nat Rev Mol Cell Biol 16(2):95–109CrossRefPubMedGoogle Scholar
  2. Eliscovich C, Singer RH (2017) RNP transport in cell biology: the long and winding road. Curr Opin Cell Biol 45:38–46CrossRefPubMedPubMedCentralGoogle Scholar
  3. Haag C, Steuten B, Feldbrügge M (2015) Membrane-coupled mRNA trafficking in fungi. Annu Rev Microbiol 69:265–281CrossRefPubMedGoogle Scholar
  4. Holt CE, Schuman EM (2013) The central dogma decentralized: new perspectives on RNA function and local translation in neurons. Neuron 80:648–657CrossRefPubMedPubMedCentralGoogle Scholar
  5. Jambor H, Surendranath V, Kalinka AT, Mejstrik P, Saalfeld S, Tomancak P (2015) Systematic imaging reveals features and changing localization of mRNAs in Drosophila development. elife 4:e05003CrossRefPubMedCentralGoogle Scholar
  6. Jansen RP, Niessing D, Baumann S, Feldbrügge M (2014) mRNA transport meets membrane traffic. Trends Genet 30(9):408–417CrossRefPubMedGoogle Scholar
  7. Jeffery WR, Tomlinson CR, Brodeur RD (1983) Localization of actin messenger RNA during early ascidian development. Dev Biol 99:408–417CrossRefPubMedGoogle Scholar
  8. Lecuyer E, Yoshida H, Parthasarathy N, Alm C, Babak T, Cerovina T, Hughes TR, Tomancak P, Krause HM (2007) Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell 131:174–187CrossRefPubMedGoogle Scholar
  9. Marchand V, Gaspar I, Ephrussi A (2012) An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes. Curr Opin Cell Biol 24(2):202–210CrossRefPubMedGoogle Scholar
  10. Martin KC, Ephrussi A (2009) mRNA localization: gene expression in the spatial dimension. Cell 136:719–730CrossRefPubMedPubMedCentralGoogle Scholar
  11. Mofatteh M, Bullock SL (2017) SnapShot: subcellular mRNA localization. Cell 169(1):178–178.e1CrossRefPubMedGoogle Scholar
  12. Paquin N, Chartrand P (2008) Local regulation of mRNA translation: new insights from the bud. Trends Cell Biol 18:105–111CrossRefPubMedGoogle Scholar
  13. Tübing F, Vendra G, Mikl M, Macchi P, Thomas S, Kiebler MA (2010) Dendritically localized transcripts are sorted into distinct ribonucleoprotein particles that display fast directional motility along dendrites of hippocampal neurons. J Neurosci 30:4160–4170CrossRefPubMedGoogle Scholar
  14. Wang ET, Taliaferro JM, Lee JA, Sudhakaran IP, Rossoll W, Gross C, Moss KR, Bassell GJ (2016) Dysregulation of mRNA localization and translation in genetic disease. J Neurosci 36(45):11418–11426CrossRefPubMedPubMedCentralGoogle Scholar
  15. Weil TT, Parton RM, Davis I (2010) Making the message clear: visualizing mRNA localization. Trends Cell Biol 20:380–390CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© European Biophysical Societies' Association (EBSA) 2018

Authors and Affiliations

  1. 1.Institute of Structural BiologyHelmholtz Zentrum München-German Research Center for Environmental HealthNeuherbergGermany
  2. 2.Institute of Pharmaceutical BiotechnologyUlm UniversityUlmGermany