Encyclopedia of Biophysics

Living Edition
| Editors: Gordon Roberts, Anthony Watts, European Biophysical Societies

Protein Structure Prediction and Structural Annotation of Proteomes

  • Daniel Barry RocheEmail author
  • Maria Teresa Buenavista
  • Liam James McGuffin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-35943-9_418-1



Protein structure prediction methods aim to predict the structures of proteins from their amino acid sequences, utilizing various computational algorithms. Structural genome annotation is the process of attaching biological information to every protein encoded within a genome via the production of three-dimensional protein models.


Proteins are essential molecules involved in both structural and functional roles of all living cells. Numerous diseases, notably Alzheimer’s, Parkinson’s, heart disease, and cancers, involve mutations in specific proteins, which affect their function. Thus, determining protein structure is essential to understanding functionality and is potentially helpful in developing treatments for the diseases or disorders. The ultimate goal is to determine...

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Copyright information

© European Biophysical Societies' Association (EBSA) 2018

Authors and Affiliations

  • Daniel Barry Roche
    • 1
  • Maria Teresa Buenavista
    • 2
    • 3
    • 4
  • Liam James McGuffin
    • 2
  1. 1.Institut de Biologie Computationnelle, LIRMM, CNRS-UMR 5506Université de MontpellierMontpellierFrance
  2. 2.School of Biological SciencesUniversity of ReadingReadingUK
  3. 3.BiocomputingMRC HarwellOxfordUK
  4. 4.Diamond Light Source Ltd.DidcotUK

Section editors and affiliations

  • Franca Fraternali

There are no affiliations available