Bacterial globins are proteins possessing the classical globin fold and the highly conserved active site residues required for ligand-binding function. Functions include binding of, or reaction with, oxygen, nitric oxide, carbon monoxide, or other ligands. Bacterial globins are classified into three major groups – myoglobin-like globins (two- or single-domain proteins), sensor globins, and truncated globins. NO detoxification is a well-characterized function of some, but there is inadequate functional data.
Globins are an ancient superfamily of diverse proteins (Vinogradov et al. 2006). The first report of a microbial globin was in yeast over half a century ago, but, in the past 20 years, increasing molecular studies have revealed details of their structures and functions and the regulation of their biosynthesis. There has been a dramatic increase in the understanding of bacterial globins and the links...
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