Hydrodynamics of Nucleic Acids: Modeling Overall Conformation and Dynamics
Shape of rigid structures can be represented with various models with the desired detail. The wormlike chain is a versatile model for the conformation of long nucleic acids. Overall hydrodynamic properties are the sedimentation and diffusion coefficients, intrinsic viscosity, and rotational and relaxation times.
The essential roles played by nucleic acids are, in many aspects, related to the overall conformation (i.e., size, shape, flexibility, etc.) and dynamics (intramolecular, diffusive, etc.) of the macromolecular chain. Although such roles will take place in the complex environment of the cell, for the understanding or characterization of such aspects, the proper way is the study of properties in dilute solution, where the features of the individual macromolecules are manifested without influence of their surroundings. Thus, solution properties like the...
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