Transient statistical/stochastic fluctuations in equilibrium thermodynamic properties that occur in any system in thermal contact with its surroundings.
Due to the incessant thermal motion of atoms and molecules, all objects that are in thermal contact with surroundings will experience statistical fluctuations in internal energy, volume, and other extensive thermodynamic properties, even at thermodynamic equilibrium. These fluctuations are usually imperceptible in everyday macroscopic objects, except in special circumstances*, but take on much greater significance for much smaller (mesoscopic, microscopic) objects. This is particularly important for biological macromolecules where fundamental thermodynamics dictates dynamic characteristics.
[*The effects of thermodynamic fluctuations on a larger scale are observable as the chaotic motion of small objects seen in Brownian...
- Callen HB (1960) Thermodynamics. Wiley, New YorkGoogle Scholar
- Cooper A, Johnson CM et al (2001) Heat does not come in different colours: entropy-enthalpy compensation, free energy windows, quantum confinement, pressure perturbation calorimetry, solvation and the multiple causes of heat capacity effects in biomolecular interactions. Biophys Chem 93(2–3):215–230CrossRefGoogle Scholar
- Feynman RP, Leighton RB et al (1963) The Feynman lectures on physics. Addison-Wesley, ReadingGoogle Scholar
- Hoffmann PM (2012) Life’s ratchet: how molecular machines extract order from chaos. Basic Books, New YorkGoogle Scholar