Drug Delivery: Polymers in the Development of Controlled Release Systems

  • Scott CampbellEmail author
  • Niels Smeets
Living reference work entry
Part of the Polymers and Polymeric Composites: A Reference Series book series (POPOC)


This chapter comprises an overview of the basic elements that one must take into account when developing a new drug delivery system. It begins with an outline of traditional methods to deliver drugs, relating these to important considerations that must be taken into account when developing a drug delivery system, including the importance of controlling the drug concentration and location, and the properties of the device and the therapeutic. This chapter then continues by describing various types of polymeric delivery systems, including implants, hydrogels, and nanoparticles, microgels, and micelle nanomedicines. This chapter then concludes with a brief perspective on the potential of nanomedicine drug delivery systems; a much more thorough perspective can be found in a follow-up chapter “Drug Delivery: Localized and Systemic Therapeutic Strategies with Polymer Systems.”

List of Abbreviations




Butyl methacrylate


Controlled-living free radical polymerization


Carboxymethyl cellulose


Hydrophobic block


Hydrophilic block


Enhanced permeability and retention


US Food and Drug Administration




Hyaluronic acid








Mononuclear phagocyte system


N-isopropyl acrylamide


Phenyl boronic acid


Poly(ethylene glycol)


Poly(glycolic acid)


Poly(L-lactic acid)


Poly(lactic acid-co-glycolic acid)


Poly(methyl methacrylate)


Poly(N-isopropyl acrylamide)


Poly(oligoethylene glycol methacrylate)


Polyvinyl alcohol


Arginine-glycine-aspartic acid




Superparamagnetic iron oxide nanoparticles


Glass transition temperature


Aggregation number


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Chemical EngineeringMcMaster UniversityHamiltonCanada
  2. 2.EcoSynthetixBurlingtonCanada

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