Antidiabetic and Antioxidant Activities of Bioactive Compounds from Endophytes

  • Rosa Martha Perez GutierrezEmail author
  • Adriana Neira González
Reference work entry
Part of the Reference Series in Phytochemistry book series (RSP)


The aim of the present chapter is to appraise the phytochemical and pharmacological potential of the endophytes. This chapter will further highlight the future research prospects of the study of endophytes with antioxidant and antidiabetic activities. Informations on endophytes were obtained from related publications using electronic scientific databases. Based on previous reports, it could be said that the endophytes have emerged as excellent source of compounds which could be used for the treatment of skin diseases and microbial infections and as anticancer and anti-inflammatory agents. The studies provide new knowledge on the isolation and characterization of novel bioactives especially in the discovery of novel therapeutic drugs with antioxidant and antidiabetic properties. however, current research on the pharmacological properties of all the endophyte species including bioassay-guided isolation of phytoconstituents and their mechanism of action, pharmacokinetics, bioavailability, efficacy, and safety should be carried out in the future to add more value to this study.


Endophytes Medicinal plants Marine plants Antioxidants Antidiabetic 



2,2-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid)


Advanced glycation end products


Silver nanoparticles


Alkaline phosphatase


Alanine aminotransferase


AMP-activated protein kinase


Aspartate aminotransferase




Not identified


Not identified


Cochliobolus sp.


Diaporthe sp.


Diaporthe sp.


Diaporthe sp.


Diaporthe phaseolorum


Diaporthe phaseolorum


Phomopsis sp.


Phomopsis sp.


Phomopsis sp.


Sordariomycetes sp.


Sordariomycetes sp.


Cardiovascular diseases






Ethyl acetate


Ferric reducing ability of plasma


Fourier-transform infrared spectroscopy


Gas chromatography mass spectrometry


Glutathione peroxidase


Internal transcribed spacer




Gene sequencing


Phenazine methosulfate-nicotinamide adenine dinucleotide


Reactive oxygen species


Superoxide dismutase


Type 2 diabetes mellitus


Transmission electron microscopy


Ultraviolet-visible spectroscopy


Aspergillus sp.


Peniophora sp.


Fusarium nematophilum


X-ray diffraction


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Rosa Martha Perez Gutierrez
    • 1
    Email author
  • Adriana Neira González
    • 2
  1. 1.Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias ExtractivasInstituto Politecnico Nacional (IPN) Unidad Profesional Adolfo Lopez Mateos S/N Av, Instituto Politécnico Nacional Ciudad de MexicoMexico CityMexico
  2. 2.Laboratorio de Productos NaturalesInstituto de Química, Universidad Nacional Autónoma de México, Ciudad UniversitariaMexico CityMexico

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