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Endophytes of Nothapodytes nimmoniana (J. Graham) Mabb.

  • Hosakatte Niranjana MurthyEmail author
  • Dayanand Dalawai
  • So-Young Park
  • Kee-Yoeup Paek
Reference work entry
Part of the Reference Series in Phytochemistry book series (RSP)

Abstract

Endophytes are excellent source of bioactive natural products. Fungal and bacterial endophytes have been isolated from medicinal plant Nothapodytes nimmoniana, and majority of them have the capability of accumulating camptothecin (CPT) similar to host plant. Entrophospora infrequens, Neurospora crassa, Fusarium oxysporum, Colletotrichum fructicola, and Corynespora cassiicola are some of the fungal isolates which have been cultured by following submerged fermentation and solid-state fermentation methods for the production of CPT. Here we presented the detailed account of various endophytes isolated from Nothapodytes nimmoniana and recent research developments made in this area.

Keywords

Axenic cultures Bioactive compounds Camptothecin Endophytes Fermentation Secondary metabolites 

Abbreviations

9-MCPT

9-methoxycamptothecin

A-549

Adenocarcinomic human alveolar basal epithelial cells (lung cancer cell line)

BEB

Beef extract broth

BOD

Biological oxygen demand

CCD

Central composite design

CDB

Czapek dox broth

COD

Chemical oxygen demand

CPT

Camptothecin

FDA

US Food and Drug Administration

HEP-2

Human epithelial type 2 (liver cancer cell line)

HPLC

High performance liquid chromatography

LC/MS

Liquid chromatography/mass spectroscopy

MEB

Malt extract broth

MS/MS

Mass spectroscopy/mass spectroscopy

OVCAR-2

Human epithelial carcinoma cell line of the ovary (ovarian cancer cell line)

PDB

Potato dextrose broth

RSM

Response surface methodology

SB

Sabouraud broth

SSF

Solid-state fermentation

TDS

Total dissolved solids

TSS

Total soluble solids

YEB

Yeast extract broth

Notes

Acknowledgments

This study was supported by DST-PURSE Phase II program and UGC-BSR Mid-Career Award grant [No. F.19-223/2018(BSR)].

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Hosakatte Niranjana Murthy
    • 1
    • 2
    Email author
  • Dayanand Dalawai
    • 1
  • So-Young Park
    • 2
  • Kee-Yoeup Paek
    • 2
  1. 1.Department of BotanyKarnatak UniversityDharwadIndia
  2. 2.Research Center for the Development of Advanced Horticultural TechnologyChungbuk National UniversityCheongjuRepublic of Korea

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