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Anxiety, Anger, Personality, and Heart Disease

  • Laura Fusar-PoliEmail author
  • Davide Arillotta
Living reference work entry

Abstract

For several centuries the connection between mind and heart has been debated among scholars. Particularly, it has been noticed that several psychopathological conditions might predispose to the onset and progression of cardiovascular diseases. The present chapter moves through the different aspects of this association. First, the role of anxiety in the etiopathogenesis of heart diseases has been discussed. Second, the prevalence and therapeutic options of anxiety disorders in individuals already suffering from a cardiovascular disease, as well as their role in the progression of these health conditions, have been explored. Finally, we described the interaction between some personality traits and cardiovascular health. Our chapter underlines the importance of investigating the presence of anxiety and personality disorders in people suffering from heart disease. Clinicians should accurately recognize mental health conditions and promptly treat them in cardiac patients who manifest psychological distress. Additionally, the prevention and the timely identification of cardiovascular issues in psychiatric patients appear to be of primary importance for limiting their progression and improving the short- and long-term outcome.

Keywords

Cardiovascular disease Heart disease Hypertension Anxiety Panic disorder Takotsubo Type A personality Type D personality 

References

  1. 1.
    Suls J. Toxic affect: are anger, anxiety, and depression independent risk factors for cardiovascular disease? Emot Rev. 2018;10(1):6–17.CrossRefGoogle Scholar
  2. 2.
    Descartes R. The passions of the soul. 1649. Indianapolis: Hackett Publishing Company; 1989.Google Scholar
  3. 3.
    James W. The stream of consciousness. In: Psychology. Cambridge: MIT Press; 1892.Google Scholar
  4. 4.
    da Costa JM. ART. I. – on irritable heart; a clinical study of a form of functional cardiac disorder and its consequences. Am J Med Sci. 1871;61(121):2–52.Google Scholar
  5. 5.
    World Health Organization. The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva: World Health Organization; 1992.Google Scholar
  6. 6.
    Friedman HS, Booth-Kewley S. The “disease-prone personality”: a meta-analytic view of the construct. Am Psychol. 1987;42(6):539.PubMedCrossRefGoogle Scholar
  7. 7.
    Booth-Kewley S, Friedman HS. Psychological predictors of heart disease: a quantitative review. Psychol Bull. 1987;101(3):343.PubMedCrossRefGoogle Scholar
  8. 8.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). Arlington: American Psychiatric Publications; 2013.CrossRefGoogle Scholar
  9. 9.
    Spielberger CD. Manual for the state-trait anger expression inventory (STAXI), vol. 6. Odessa: Psychological Assessment Resources; 1988.Google Scholar
  10. 10.
    Remes O, Brayne C, Van Der Linde R, Lafortune L. A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain Behav. 2016;6(7):e00497.PubMedPubMedCentralCrossRefGoogle Scholar
  11. 11.
    Perna G. Understanding anxiety disorders: the psychology and the psychopathology of defence mechanisms against threats. Riv Psichiatr. 2013;48(1):73–5.  https://doi.org/10.1708/1228.13618.
  12. 12.
    Simpson HB, Neria Y, Lewis-Fernández R, Schneier F. Anxiety disorders: theory, research and clinical perspectives. Cambridge: Cambridge University Press; 2010.CrossRefGoogle Scholar
  13. 13.
    Tully PJ, Cosh SM, Baumeister H. The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease. J Psychosom Res. 2014;77(6):439–48.  https://doi.org/10.1016/s0924-9338(15)30318-7.CrossRefGoogle Scholar
  14. 14.
    Lichtman JH, Bigger JT Jr, Blumenthal JA, Frasure-Smith N, Kaufmann PG, Lespérance FO, et al. Depression and coronary heart disease: recommendations for screening, referral, and treatment: a science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation. 2008;118(17):1768–75.PubMedCrossRefGoogle Scholar
  15. 15.
    Lee W, Wadsworth M, Hotopf M. The protective role of trait anxiety: a longitudinal cohort study. Psychol Med. 2006;36(3):345–51.PubMedCrossRefGoogle Scholar
  16. 16.
    Parker G, Hyett M, Hadzi-Pavlovic D, Brotchie H, Walsh W. GAD is good? Generalized anxiety disorder predicts a superior five-year outcome following an acute coronary syndrome. Psychiatry Res. 2011;188(3):383–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Tully PJ, Harrison NJ, Cheung P, Cosh S. Anxiety and cardiovascular disease risk: a review. Curr Cardiol Rep. 2016;18(12):120.PubMedCrossRefGoogle Scholar
  18. 18.
    Batelaan NM, Seldenrijk A, Bot M, Van Balkom AJ, Penninx BW. Anxiety and new onset of cardiovascular disease: critical review and meta-analysis. Br J Psychiatry. 2016;208(3):223–31.PubMedCrossRefGoogle Scholar
  19. 19.
    Celano CM, Daunis DJ, Lokko HN, Campbell KA, Huffman JC. Anxiety disorders and cardiovascular disease. Curr Psychiatry Rep. 2016;18(11):101.PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Fish F. The psychiatric aspects of paroxysmal tachycardia. Br J Psychiatry. 1964;110(465):205–10.PubMedCrossRefGoogle Scholar
  21. 21.
    Miles HH, Cobb S. Neurocirculatory asthenia, anxiety and neurosis. N Engl J Med. 1951;245(19):711–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Weiss E, Dlin B, Rollin HR, Fischer HK, Bepler C. Emotional factors in coronary occlusion: 1. Introduction and general summary. Arch Intern Med. 1957;99(4):628–41.CrossRefGoogle Scholar
  23. 23.
    Krantz DS, Manuck SB. Acute psychophysiologic reactivity and risk of cardiovascular disease: a review and methodologic critique. Psychol Bull. 1984;96(3):435.PubMedCrossRefGoogle Scholar
  24. 24.
    Kawachi I, Sparrow D, Vokonas PS, Weiss ST. Decreased heart rate variability in men with phobic anxiety (data from the Normative Aging Study). Am J Cardiol. 1995;75(14):882–5.PubMedCrossRefGoogle Scholar
  25. 25.
    Kamarck TW, Jennings JR. Biobehavioral factors in sudden cardiac death. Psychol Bull. 1991;109(1):42.PubMedCrossRefGoogle Scholar
  26. 26.
    Bankier B, Barajas J, Martinez-Rumayor A, Januzzi JL. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Eur Heart J. 2008;29(18):2212–7.  https://doi.org/10.1093/eurheartj/ehn326.CrossRefPubMedGoogle Scholar
  27. 27.
    Pitsavos C, Panagiotakos DB, Papageorgiou C, Tsetsekou E, Soldatos C, Stefanadis C. Anxiety in relation to inflammation and coagulation markers, among healthy adults: the ATTICA study. Atherosclerosis. 2006;185(2):320–6.  https://doi.org/10.1016/j.atherosclerosis.2005.06.001.CrossRefPubMedGoogle Scholar
  28. 28.
    Vogelzangs N, Beekman AT, de Jonge P, Penninx BW. Anxiety disorders and inflammation in a large adult cohort. Transl Psychiatry. 2013;3:e249.  https://doi.org/10.1038/tp.2013.27.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Hohensinner PJ, Niessner A, Huber K, Weyand CM, Wojta J. Inflammation and cardiac outcome. Curr Opin Infect Dis. 2011;24(3):259–64.  https://doi.org/10.1097/QCO.0b013e328344f50f.CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Moyer CF, Sajuthi D, Tulli H, Williams JK. Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis. Am J Pathol. 1991;138(4):951–60.PubMedPubMedCentralGoogle Scholar
  31. 31.
    Hasper D, Hummel M, Kleber FX, Reindl I, Volk HD. Systemic inflammation in patients with heart failure. Eur Heart J. 1998;19(5):761–5.PubMedCrossRefGoogle Scholar
  32. 32.
    Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation. 2003;107(11):1486–91.PubMedCrossRefGoogle Scholar
  33. 33.
    Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001;104(22):2673–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Mercer DA, Lavoie KL, Ditto B, Pelletier R, Campbell T, Arsenault A, et al. The interaction between anxiety and depressive symptoms on brachial artery reactivity in cardiac patients. Biol Psychol. 2014;102:44–50.  https://doi.org/10.1016/j.biopsycho.2014.07.012.CrossRefPubMedGoogle Scholar
  35. 35.
    Narita K, Murata T, Hamada T, Takahashi T, Kosaka H, Yoshida H, et al. Association between trait anxiety and endothelial function observed in elderly males but not in young males. Int Psychogeriatr. 2007;19(5):947–54.  https://doi.org/10.1017/s1041610206004571.CrossRefPubMedGoogle Scholar
  36. 36.
    Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(23_suppl_1):III-27–32.Google Scholar
  37. 37.
    Neumeister A, Bain E, Nugent AC, Carson RE, Bonne O, Luckenbaugh DA, et al. Reduced serotonin type 1A receptor binding in panic disorder. J Neurosci. 2004;24(3):589–91.  https://doi.org/10.1523/jneurosci.4921-03.2004.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Strike PC, Magid K, Brydon L, Edwards S, McEwan JR, Steptoe A. Exaggerated platelet and hemodynamic reactivity to mental stress in men with coronary artery disease. Psychosom Med. 2004;66(4):492–500.  https://doi.org/10.1097/01.psy.0000130492.03488.e7.CrossRefPubMedGoogle Scholar
  39. 39.
    Levine SP, Towell BL, Suarez AM, Knieriem LK, Harris MM, George JN. Platelet activation and secretion associated with emotional stress. Circulation. 1985;71(6):1129–34.PubMedCrossRefGoogle Scholar
  40. 40.
    Kokacya MH, Copoglu US, Kivrak Y, Ari M, Sahpolat M, Ulutas KT. Increased mean platelet volume in patients with panic disorder. Neuropsychiatr Dis Treat. 2015;11:2629–33.  https://doi.org/10.2147/ndt.s94147.CrossRefPubMedPubMedCentralGoogle Scholar
  41. 41.
    Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52.  https://doi.org/10.1016/s0140-6736(04)17018-9.CrossRefGoogle Scholar
  42. 42.
    Bonnet F, Irving K, Terra J-L, Nony P, Berthezène F, Moulin P. Anxiety and depression are associated with unhealthy lifestyle in patients at risk of cardiovascular disease. Atherosclerosis. 2005;178(2):339–44.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Murray J, Craigs CL, Hill KM, Honey S, House A. A systematic review of patient reported factors associated with uptake and completion of cardiovascular lifestyle behaviour change. BMC Cardiovasc Disord. 2012;12(1):120.PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Kawachi I, Sparrow D, Spiro A III, Vokonas P, Weiss ST. A prospective study of anger and coronary heart disease: the Normative Aging Study. Circulation. 1996;94(9):2090–5.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010;56(1):38–46.  https://doi.org/10.1016/j.jacc.2010.03.034.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Tully PJ, Cosh SM, Baune BT. A review of the affects of worry and generalized anxiety disorder upon cardiovascular health and coronary heart disease. Psychol Health Med. 2013;18(6):627–44.PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Chalmers JA, Quintana DS, Abbott MJ, Kemp AH. Anxiety disorders are associated with reduced heart rate variability: a meta-analysis. Front Psychol. 2014;5:80.Google Scholar
  48. 48.
    Hammel JC, Smitherman TA, McGlynn FD, Mulfinger AM, Lazarte AA, Gothard KD. Vagal influence during worry and cognitive challenge. Anxiety Stress Coping. 2011;24(2):121–36.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Batelaan NM, ten Have M, van Balkom AJ, Tuithof M, de Graaf R. Anxiety disorders and onset of cardiovascular disease: the differential impact of panic, phobias and worry. J Anxiety Disord. 2014;28(2):252–8.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Albert CM, Chae CU, Rexrode KM, Manson JE, Kawachi I. Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation. 2005;111(4):480–7.PubMedCrossRefPubMedCentralGoogle Scholar
  51. 51.
    Haines A, Imeson J, Meade T. Phobic anxiety and ischaemic heart disease. Br Med J (Clin Res Ed). 1987;295(6593):297–9.CrossRefGoogle Scholar
  52. 52.
    Brennan AM, Fargnoli JL, Williams CJ, Li T, Willett W, Kawachi I, et al. Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes. Diabetes Care. 2009;32(5):926–31.PubMedPubMedCentralCrossRefGoogle Scholar
  53. 53.
    Tully P, Turnbull D, Beltrame J, Horowitz J, Cosh S, Baumeister H, et al. Panic disorder and incident coronary heart disease: a systematic review and meta-regression in 1 131 612 persons and 58 111 cardiac events. Psychol Med. 2015;45(14):2909–20.PubMedCrossRefPubMedCentralGoogle Scholar
  54. 54.
    Kahn JP, Gorman JM, King DL, Fyer AJ, Liebowitz MR, Klein DF. Cardiac left ventricular hypertrophy and chamber dilatation in panic disorder patients: implications for idiopathic dilated cardiomyopathy. Psychiatry Res. 1990;32(1):55–61.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    Coryell W, Noyes R, House JD. Mortality among outpatients with anxiety disorders. Am J Psychiatry. 1986;143(4):508–10.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Mansour VM, Thompson JM, Esler MD, Wilkinson DJ, Jennings GL, Schwarz RG. Panic disorder: coronary spasm as a basis for cardiac risk? Med J Aust. 1998;168(8):390–2.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Zafar MU, Paz-Yepes M, Shimbo D, Vilahur G, Burg MM, Chaplin W, et al. Anxiety is a better predictor of platelet reactivity in coronary artery disease patients than depression. Eur Heart J. 2010;31(13):1573–82.PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Carey RM, Whelton PK. Prevention, detection, evaluation, and management of high blood pressure in adults: synopsis of the 2017 American College of Cardiology/American Heart Association hypertension guideline. Ann Intern Med. 2018;168(5):351–8.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315–81.  https://doi.org/10.1093/eurheartj/ehw106.CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Moschcowitz E. The psychogenic origin of organic diseases. N Engl J Med. 1935;212(14):603–11.CrossRefGoogle Scholar
  61. 61.
    Moses L, Daniels GE, Nickerson JL. Psychogenic factors in essential hypertension; methodology and preliminary report. Psychosom Med. 1956;18:471.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Binger C. On so-called psychogenic influences in essential hypertension. Psychosom Med. 1951;13(5):273–6.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Liu M-Y, Li N, Li WA, Khan H. Association between psychosocial stress and hypertension: a systematic review and meta-analysis. Neurol Res. 2017;39(6):573–80.  https://doi.org/10.1080/01616412.2017.1317904.CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Pan Y, Cai W, Cheng Q, Dong W, An T, Yan J. Association between anxiety and hypertension: a systematic review and meta-analysis of epidemiological studies. Neuropsychiatr Dis Treat. 2015;11:1121–30.  https://doi.org/10.2147/ndt.s77710.CrossRefPubMedPubMedCentralGoogle Scholar
  65. 65.
    Kivimäki M, Kawachi I. Work stress as a risk factor for cardiovascular disease. Curr Cardiol Rep. 2015;17(9):74.PubMedCentralCrossRefGoogle Scholar
  66. 66.
    Schnall PL, Landsbergis PA, Baker D. Job strain and cardiovascular disease. Annu Rev Public Health. 1994;15(1):381–411.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Dragano N, Siegrist J, Nyberg ST, Lunau T, Fransson EI, Alfredsson L, et al. Effort–reward imbalance at work and incident coronary heart disease: a multicohort study of 90,164 individuals. Epidemiology. 2017;28(4):619.PubMedPubMedCentralCrossRefGoogle Scholar
  68. 68.
    Timio M, Saronio P, Venanzi S, Gentili S, Verdura C, Timio F. Blood pressure in nuns in a secluded order: a 30-year follow-up. Miner Electrolyte Metab. 1999;25(1–2):73–9.  https://doi.org/10.1159/000057424.CrossRefPubMedPubMedCentralGoogle Scholar
  69. 69.
    Esler M. Mental stress and human cardiovascular disease. Neurosci Biobehav Rev. 2017;74:269–76.PubMedCrossRefPubMedCentralGoogle Scholar
  70. 70.
    Colussi G, Catena C, Darsiè D, Sechi LA. Benzodiazepines: an old class of new antihypertensive drugs? Am J Hypertens. 2017;31(4):402–4.CrossRefGoogle Scholar
  71. 71.
    Musman J, Paradis S, Panel M, Pons S, Barau C, Caccia C, et al. A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats. Biochem Pharmacol. 2017;142:87–95.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Erne P, Chiesi M, Longoni S, Fulbright J, Hermsmeyer K. Relaxation of rat vascular muscle by peripheral benzodiazepine modulators. J Clin Investig. 1989;84(2):493–8.PubMedCrossRefPubMedCentralGoogle Scholar
  73. 73.
    Kitajima T, Kanbayashi T, Saito Y, Takahashi Y, Ogawa Y, Sugiyama T, et al. Diazepam reduces both arterial blood pressure and muscle sympathetic nerve activity in human. Neurosci Lett. 2004;355(1–2):77–80.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    Gupta R, Santha N, Upadya M, Manissery JJ. Effect of different dosages of intravenous midazolam premedication on patients undergoing head and neck surgeries-A Double Blinded Randomized Controlled Study. J Clin Diagn Res. 2017;11(8):UC01.PubMedPubMedCentralGoogle Scholar
  75. 75.
    Grossman E, Nadler M, Sharabi Y, Thaler M, Shachar A, Shamiss A. Antianxiety treatment in patients with excessive hypertension. Am J Hypertens. 2005;18(9):1174–7.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Yilmaz S, Pekdemir M, Tural Ü, Uygun M. Comparison of alprazolam versus captopril in high blood pressure: a randomized controlled trial. Blood Press. 2011;20(4):239–43.PubMedCrossRefPubMedCentralGoogle Scholar
  77. 77.
    Mendelson N, Gontmacher B, Vodonos A, Novack V, Abu-AjAj M, Wolak A, et al. Benzodiazepine consumption is associated with lower blood pressure in ambulatory blood pressure monitoring (ABPM): retrospective analysis of 4938 ABPMs. Am J Hypertens. 2017;31(4):431–7.CrossRefGoogle Scholar
  78. 78.
    Sato H. Tako-tsubo-like left ventricular dysfunction due to multivessel coronary spasm. In: Clinical aspects of myocardial injury: from ischemia to heart failure. Tokyo: Kagakuhyoronsha Publishing Company; 1990. p. 56–64.Google Scholar
  79. 79.
    Medeiros K, O’connor MJ, Baicu CF, Fitzgibbons TP, Shaw P, Tighe DA, et al. Systolic and diastolic mechanics in stress cardiomyopathy. Circulation. 2014;129(16):1659–67.PubMedCrossRefPubMedCentralGoogle Scholar
  80. 80.
    Suzuki H, Matsumoto Y, Kaneta T, Sugimura K, Takahashi J, Fukumoto Y, et al. Evidence for brain activation in patients with takotsubo cardiomyopathy. Circ J. 2014;78(1):256–8.PubMedCrossRefGoogle Scholar
  81. 81.
    Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352(6):539–48.  https://doi.org/10.1056/NEJMoa043046.CrossRefPubMedGoogle Scholar
  82. 82.
    Ruschitzka F, Ghadri J-R, Cammann VL, Templin C, Yoshida T, Manfredini R, et al. International expert consensus document on takotsubo syndrome (part II): diagnostic workup, outcome, and management. Eur Heart J. 2018;39(22):2047–62.  https://doi.org/10.1093/eurheartj/ehy077.CrossRefPubMedPubMedCentralGoogle Scholar
  83. 83.
    Ghadri JR, Kato K, Cammann VL, Gili S, Jurisic S, Di Vece D, et al. Long-term prognosis of patients with takotsubo syndrome. J Am Coll Cardiol. 2018;72(8):874–82.  https://doi.org/10.1016/j.jacc.2018.06.016.CrossRefPubMedGoogle Scholar
  84. 84.
    Hanssen TA, Nordrehaug JE, Eide GE, Bjelland I, Rokne B. Anxiety and depression after acute myocardial infarction: an 18-month follow-up study with repeated measures and comparison with a reference population. Eur J Cardiov Prev Rehabil. 2009;16(6):651–9.CrossRefGoogle Scholar
  85. 85.
    Versteeg H, Roest AM, Denollet J. Persistent and fluctuating anxiety levels in the 18 months following acute myocardial infarction: the role of personality. Gen Hosp Psychiatry. 2015;37(1):1–6.PubMedCrossRefGoogle Scholar
  86. 86.
    Koivula M, Tarkka MT, Tarkka M, Laippala P, Paunonen-Ilmonen M. Fear and anxiety in patients at different time-points in the coronary artery bypass process. Int J Nurs Stud. 2002;39(8):811–22.PubMedCrossRefGoogle Scholar
  87. 87.
    Easton K, Coventry P, Lovell K, Carter L-A, Deaton C. Prevalence and measurement of anxiety in samples of patients with heart failure: meta-analysis. J Cardiovasc Nurs. 2016;31(4):367.PubMedPubMedCentralCrossRefGoogle Scholar
  88. 88.
    Brouwers C, Denollet J, Caliskan K, de Jonge N, Constantinescu A, Young Q, et al. Psychological distress in patients with a left ventricular assist device and their partners: an exploratory study. Eur J Cardiovasc Nurs. 2015;14(1):53–62.  https://doi.org/10.1177/1474515113517607.CrossRefPubMedGoogle Scholar
  89. 89.
    Modica M, Ferratini M, Torri A, Oliva F, Martinelli L, De Maria R, et al. Quality of life and emotional distress early after left ventricular assist device implant: a mixed-method study. Artif Organs. 2015;39(3):220–7.  https://doi.org/10.1111/aor.12362.CrossRefPubMedGoogle Scholar
  90. 90.
    Magyar-Russell G, Thombs BD, Cai JX, Baveja T, Kuhl EA, Singh PP, et al. The prevalence of anxiety and depression in adults with implantable cardioverter defibrillators: a systematic review. J Psychosom Res. 2011;71(4):223–31.PubMedCrossRefGoogle Scholar
  91. 91.
    Tully PJ, Cosh SM. Generalized anxiety disorder prevalence and comorbidity with depression in coronary heart disease: a meta-analysis. J Health Psychol. 2013;18(12):1601–16.PubMedCrossRefGoogle Scholar
  92. 92.
    Roest AM, Zuidersma M, de Jonge P. Myocardial infarction and generalised anxiety disorder: 10-year follow-up. Br J Psychiatry. 2012;200(4):324–9.  https://doi.org/10.1192/bjp.bp.111.103549.CrossRefPubMedGoogle Scholar
  93. 93.
    Tully PJ, Winefield HR, Baker RA, Denollet J, Pedersen SS, Wittert GA, et al. Depression, anxiety and major adverse cardiovascular and cerebrovascular events in patients following coronary artery bypass graft surgery: a five year longitudinal cohort study. BioPsychoSoc Med. 2015;9(1):14.PubMedPubMedCentralCrossRefGoogle Scholar
  94. 94.
    Huffman JC, Pollack MH. Predicting panic disorder among patients with chest pain: an analysis of the literature. Psychosomatics. 2003;44(3):222–36.PubMedCrossRefGoogle Scholar
  95. 95.
    Todaro JF, Shen B-J, Raffa SD, Tilkemeier PL, Niaura R. Prevalence of anxiety disorders in men and women with established coronary heart disease. J Cardpulm Rehabil. 2007;27(2):86–91.CrossRefGoogle Scholar
  96. 96.
    Fleet R, Lavoie K, Beitman BD. Is panic disorder associated with coronary artery disease? A critical review of the literature. J Psychosom Res. 2000;48(4–5):347–56.PubMedCrossRefGoogle Scholar
  97. 97.
    Celano CM, Suarez L, Mastromauro C, Januzzi JL, Huffman JC. Feasibility and utility of screening for depression and anxiety disorders in patients with cardiovascular disease. Circulation. 2013;6(4):498–504.PubMedGoogle Scholar
  98. 98.
    Gomez-Caminero A, Blumentals WA, Russo LJ, Brown RR, Castilla-Puentes R. Does panic disorder increase the risk of coronary heart disease? A cohort study of a national managed care database. Psychosom Med. 2005;67(5):688–91.PubMedCrossRefGoogle Scholar
  99. 99.
    Walters K, Rait G, Petersen I, Williams R, Nazareth I. Panic disorder and risk of new onset coronary heart disease, acute myocardial infarction, and cardiac mortality: cohort study using the general practice research database. Eur Heart J. 2008;29(24):2981–8.PubMedCrossRefGoogle Scholar
  100. 100.
    Farquhar JM, Stonerock GL, Blumenthal JA. Treatment of anxiety in patients with coronary heart disease: a systematic review. Psychosomatics. 2018;59(4):318–32.  https://doi.org/10.1016/j.psym.2018.03.008.CrossRefPubMedPubMedCentralGoogle Scholar
  101. 101.
    Ostuzzi G, Turrini G, Gastaldon C, Papola D, Rayner L, Caruso R, et al. Efficacy and acceptability of antidepressants in patients with ischemic heart disease: systematic review and meta-analysis. Int Clin Psychopharmacol. 2019;34(2):65–75.  https://doi.org/10.1097/yic.0000000000000248.CrossRefPubMedPubMedCentralGoogle Scholar
  102. 102.
    Alvarez W Jr, Pickworth KK. Safety of antidepressant drugs in the patient with cardiac disease: a review of the literature. Pharmacotherapy. 2003;23(6):754–71.PubMedCrossRefGoogle Scholar
  103. 103.
    Beach SR, Kostis WJ, Celano CM, Januzzi JL, Ruskin JN, Noseworthy PA, et al. Meta-analysis of selective serotonin reuptake inhibitor-associated QTc prolongation. J Clin Psychiatry. 2014;75(5):e441–9.  https://doi.org/10.4088/JCP.13r08672.CrossRefPubMedGoogle Scholar
  104. 104.
    Guck TP, Elsasser GN, Kavan MG, Barone EJ. Depression and congestive heart failure. Congest Heart Fail. 2003;9(3):163–9.PubMedCrossRefGoogle Scholar
  105. 105.
    Serebruany VL. Selective serotonin reuptake inhibitors and increased bleeding risk: are we missing something? Am J Med. 2006;119(2):113–6.  https://doi.org/10.1016/j.amjmed.2005.03.044.CrossRefPubMedGoogle Scholar
  106. 106.
    Roweth HG, Cook AA, Moroi M, Bonna AM, Jung SM, Bergmeier W, et al. Two novel, putative mechanisms of action for citalopram-induced platelet inhibition. Sci Rep. 2018;8(1):16677.  https://doi.org/10.1038/s41598-018-34389-5.CrossRefPubMedPubMedCentralGoogle Scholar
  107. 107.
    Kimmel SE, Schelleman H, Berlin JA, Oslin DW, Weinstein RB, Kinman JL, et al. The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression. Br J Clin Pharmacol. 2011;72(3):514–7.  https://doi.org/10.1111/j.1365-2125.2011.04008.x.CrossRefPubMedPubMedCentralGoogle Scholar
  108. 108.
    Wernicke J, Lledo A, Raskin J, Kajdasz DK, Wang F. An evaluation of the cardiovascular safety profile of duloxetine. Drug Saf. 2007;30(5):437–55.PubMedCrossRefPubMedCentralGoogle Scholar
  109. 109.
    Batista M, Dugernier T, Simon M, Haufroid V, Capron A, Fonseca S, et al. The spectrum of acute heart failure after venlafaxine overdose. Clin Toxicol. 2013;51(2):92–5.CrossRefGoogle Scholar
  110. 110.
    Seldenrijk A, Vis R, Henstra M, Ho KP, Salomons T, Overmeire F, et al. Systematic review of the side effects of benzodiazepines. Ned Tijdschr Geneeskd. 2017;161:D1052.PubMedPubMedCentralGoogle Scholar
  111. 111.
    Stonerock GL, Hoffman BM, Smith PJ, Blumenthal JA. Exercise as treatment for anxiety: systematic review and analysis. Ann Behav Med. 2015;49(4):542–56.PubMedPubMedCentralCrossRefGoogle Scholar
  112. 112.
    Stubbs B, Vancampfort D, Rosenbaum S, Firth J, Cosco T, Veronese N, et al. An examination of the anxiolytic effects of exercise for people with anxiety and stress-related disorders: a meta-analysis. Psychiatry Res. 2017;249:102–8.PubMedCrossRefPubMedCentralGoogle Scholar
  113. 113.
    Fiuza-Luces C, Santos-Lozano A, Joyner M, Carrera-Bastos P, Picazo O, Zugaza JL, et al. Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors. Nat Rev Cardiol. 2018;15:731–743.PubMedCrossRefPubMedCentralGoogle Scholar
  114. 114.
    Camfield DA. Nutritional-based nutraceuticals in the treatment of anxiety. In: Evidence-based herbal and nutritional treatments for anxiety in psychiatric disorders. Cham: Springer; 2017. p. 81–101.CrossRefGoogle Scholar
  115. 115.
    Cicero AFG, Colletti A. Nutraceuticals and dietary supplements to improve quality of life and outcomes in heart failure patients. Curr Pharm Des. 2017;23(8):1265–72.  https://doi.org/10.2174/1381612823666170124120518.CrossRefPubMedPubMedCentralGoogle Scholar
  116. 116.
    Sosnowska B, Penson P, Banach M. The role of nutraceuticals in the prevention of cardiovascular disease. Cardiovasc Diagn Ther. 2017;7(Suppl 1):S21–31.  https://doi.org/10.21037/cdt.2017.03.20.CrossRefPubMedPubMedCentralGoogle Scholar
  117. 117.
    Spielberger CD, Reheiser EC, Sydeman SJ. Measuring the experience, expression, and control of anger. Issues Compr Pediatr Nurs. 1995;18(3):207–32.PubMedCrossRefGoogle Scholar
  118. 118.
    Smith TW. Concepts and methods in the study of anger, hostility, and health. In: Anger, hostility, and the heart. Hillsdale: Lawrence Erlbaum Associates; 1994. p. 23–42.Google Scholar
  119. 119.
    Miller TQ, Smith TW, Turner CW, Guijarro ML, Hallet AJ. Meta-analytic review of research on hostility and physical health. Psychol Bull. 1996;119(2):322.PubMedCrossRefPubMedCentralGoogle Scholar
  120. 120.
    Selye H. The stress of life. New York: McGraw-Hill Book Company; 1956.Google Scholar
  121. 121.
    Diamond EL. The role of anger and hostility in essential hypertension and coronary heart disease. Psychol Bull. 1982;92(2):410.PubMedCrossRefGoogle Scholar
  122. 122.
    Gabbay FH, Krantz DS, Kop WJ, Hedges SM, Klein J, Gottdiener JS, et al. Triggers of myocardial ischemia during daily life in patients with coronary artery disease: physical and mental activities, anger and smoking. J Am Coll Cardiol. 1996;27(3):585–92.PubMedCrossRefGoogle Scholar
  123. 123.
    Steptoe A, Brydon L. Emotional triggering of cardiac events. Neurosci Biobehav Rev. 2009;33(2):63–70.PubMedCrossRefGoogle Scholar
  124. 124.
    Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol. 2009;53(11):936–46.PubMedCrossRefGoogle Scholar
  125. 125.
    Pimple P, Shah A, Rooks C, Bremner JD, Nye J, Ibeanu I, et al. Association between anger and mental stress-induced myocardial ischemia. Am Heart J. 2015;169(1):115–21.e2.  https://doi.org/10.1016/j.ahj.2014.07.031.CrossRefPubMedGoogle Scholar
  126. 126.
    Chen H, Zhang B, Xue W, Li J, Li Y, Fu K et al. Anger, hostility and risk of stroke: a meta-analysis of cohort studies. J Neurol. 2019.  https://doi.org/10.1007/s00415-019-09231-1.PubMedCrossRefGoogle Scholar
  127. 127.
    Trudel-Fitzgerald C, Gilsanz P, Mittleman MA, Kubzansky LD. Dysregulated blood pressure: can regulating emotions help? Curr Hypertens Rep. 2015;17(12):92.  https://doi.org/10.1007/s11906-015-0605-6.CrossRefPubMedPubMedCentralGoogle Scholar
  128. 128.
    Mezick EJ, Matthews KA, Hall M, Kamarck TW, Strollo PJ, Buysse DJ, et al. Low life purpose and high hostility are related to an attenuated decline in nocturnal blood pressure. Health Psychol. 2010;29(2):196–204.  https://doi.org/10.1037/a0017790.CrossRefPubMedPubMedCentralGoogle Scholar
  129. 129.
    Friedman M, Rosenman RH. Association of specific overt behavior pattern with blood and cardiovascular findings: blood cholesterol level, blood clotting time, incidence of arcus senilis, and clinical coronary artery disease. JAMA. 1959;169(12):1286–96.CrossRefGoogle Scholar
  130. 130.
    Spence JT, Helmreich RL, Pred RS. Impatience versus achievement strivings in the Type A pattern: differential effects on students’ health and academic achievement. J Appl Psychol. 1987;72(4):522.PubMedCrossRefGoogle Scholar
  131. 131.
    Kirkcaldy BD, Shephard RJ, Furnham AF. The influence of Type A behaviour and locus of control upon job satisfaction and occupational health. Personal Individ Differ. 2002;33(8):1361–71.  https://doi.org/10.1016/S0191-8869(02)00018-1.CrossRefGoogle Scholar
  132. 132.
    Ragland DR, Brand RJ. Type A behavior and mortality from coronary heart disease. N Engl J Med. 1988;318(2):65–9.PubMedCrossRefPubMedCentralGoogle Scholar
  133. 133.
    Friedman M. Type A behavior: its diagnosis and treatment. Boston: Springer Science & Business Media; 1996.CrossRefGoogle Scholar
  134. 134.
    Cooper T, Detre T, Weiss S. Coronary-prone behavior and coronary heart disease: a critical review. Circulation. 1981;63(6 I):1199–215.Google Scholar
  135. 135.
    Myrtek M. Meta-analyses of prospective studies on coronary heart disease, Type A personality, and hostility. Int J Cardiol. 2001;79(2–3):245–51.PubMedCrossRefPubMedCentralGoogle Scholar
  136. 136.
    Gostautas A, Perminas A. Impact of the relationship between smoking and stressogenic behavior (Type A behavior) and their cumulative effect on development of myocardial infarction and mortality (25-year follow-up data). Medicina (Kaunas). 2004;40(3):265–71.Google Scholar
  137. 137.
    Šmigelskas K, Žemaitienė N, Julkunen J, Kauhanen J. Type A behavior pattern is not a predictor of premature mortality. Int J Behav Med. 2015;22(2):161–9.PubMedCrossRefPubMedCentralGoogle Scholar
  138. 138.
    Petticrew MP, Lee K, McKee M. Type A behavior pattern and coronary heart disease: Philip Morris’s “crown jewel”. Am J Public Health. 2012;102(11):2018–25.PubMedPubMedCentralCrossRefGoogle Scholar
  139. 139.
    Denollet J. Biobehavioral research on coronary heart disease: where is the person? J Behav Med. 1993;16(2):115–41.PubMedCrossRefPubMedCentralGoogle Scholar
  140. 140.
    Denollet J, De Potter B. Coping subtypes for men with coronary heart disease: relationship to well-being, stress and Type-A behaviour. Psychol Med. 1992;22(3):667–84.PubMedCrossRefPubMedCentralGoogle Scholar
  141. 141.
    Watson D, Pennebaker JW. Health complaints, stress, and distress: exploring the central role of negative affectivity. Psychol Rev. 1989;96(2):234.PubMedCrossRefPubMedCentralGoogle Scholar
  142. 142.
    Asendorpf JB. Social inhibition: a general-developmental perspective. Seattle: Hogrefe & Huber Publishers; 1993.Google Scholar
  143. 143.
    Mols F, Denollet J. Type D personality among noncardiovascular patient populations: a systematic review. Gen Hosp Psychiatry. 2010;32(1):66–72.PubMedCrossRefPubMedCentralGoogle Scholar
  144. 144.
    Cao X, Wong EM, Chow Choi K, Cheng L, Ying Chair S. Interventions for cardiovascular patients with Type D personality: a systematic review. Worldviews Evid Based Nurs. 2016;13(4):314–23.PubMedCrossRefPubMedCentralGoogle Scholar
  145. 145.
    Kupper N, Denollet J. Type D personality as a risk factor in coronary heart disease: a review of current evidence. Curr Cardiol Rep. 2018;20(11):104.  https://doi.org/10.1007/s11886-018-1048-x.CrossRefPubMedPubMedCentralGoogle Scholar
  146. 146.
    Herrmann-Lingen C, Beutel ME, Bosbach A, Deter HC, Fritzsche K, Hellmich M, et al. A stepwise psychotherapy intervention for reducing risk in coronary artery disease (SPIRR-CAD): results of an observer-blinded, multicenter, randomized trial in depressed patients with coronary artery disease. Psychosom Med. 2016;78(6):704–15.  https://doi.org/10.1097/psy.0000000000000332.CrossRefPubMedPubMedCentralGoogle Scholar
  147. 147.
    Moran P, Stewart R, Brugha T, Bebbington P, Bhugra D, Jenkins R, et al. Personality disorder and cardiovascular disease: results from a national household survey. J Clin Psychol. 2007;68:69.Google Scholar
  148. 148.
    Leichsenring F, Leibing E, Kruse J, New AS, Leweke F. Borderline personality disorder. Lancet. 2011;377(9759):74–84.PubMedCrossRefPubMedCentralGoogle Scholar
  149. 149.
    Greggersen W, Rudolf S, Fassbinder E, Dibbelt L, Stoeckelhuber BM, Hohagen F, et al. Major depression, borderline personality disorder, and visceral fat content in women. Eur Arch Psychiatry Clin Neurosci. 2011;261(8):551–7.PubMedCrossRefPubMedCentralGoogle Scholar
  150. 150.
    Powers AD, Oltmanns TF. Borderline personality pathology and chronic health problems in later adulthood: the mediating role of obesity. J Pers Disord. 2013;4(2):152.CrossRefGoogle Scholar
  151. 151.
    Olssøn I, Dahl A. Personality problems are considerably associated with somatic morbidity and health care utilisation. Eur Psychiatry. 2009;24(7):442–9.PubMedCrossRefPubMedCentralGoogle Scholar
  152. 152.
    El-Gabalawy R, Katz LY, Sareen J. Comorbidity and associated severity of borderline personality disorder and physical health conditions in a nationally representative sample. Psychosom Med. 2010;72(7):641–7.PubMedCrossRefPubMedCentralGoogle Scholar
  153. 153.
    Chen M-H, Hsu J-W, Bai Y-M, Su T-P, Li C-T, Lin W-C, et al. Risk of stroke among patients with borderline personality disorder: a nationwide longitudinal study. J Affect Disord. 2017;219:80–5.PubMedCrossRefPubMedCentralGoogle Scholar
  154. 154.
    Grove JL, Smith TW, Crowell SE, Williams PG, Jordan KD. Borderline personality features, interpersonal correlates, and blood pressure response to social stressors: implications for cardiovascular risk. Pers Individ Differ. 2017;113:38–47.CrossRefGoogle Scholar
  155. 155.
    Carpenter RW, Wood PK, Trull TJ. Comorbidity of borderline personality disorder and lifetime substance use disorders in a nationally representative sample. J Personal Disord. 2016;30(3):336–50.CrossRefGoogle Scholar
  156. 156.
    Hjorthøj C, Østergaard MLD, Benros ME, Toftdahl NG, Erlangsen A, Andersen JT, et al. Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study. Lancet Psychiatry. 2015;2(9):801–8.PubMedCrossRefPubMedCentralGoogle Scholar
  157. 157.
    Sahoo S, Padhy SK, Padhee B, Singla N, Sarkar S. Role of personality in cardiovascular diseases: an issue that needs to be focused too! Indian Heart J. 2018;70:S471–S7.  https://doi.org/10.1016/j.ihj.2018.11.003.CrossRefPubMedGoogle Scholar
  158. 158.
    Kubzansky LD, Sparrow D, Vokonas P, Kawachi I. Is the glass half empty or half full? A prospective study of optimism and coronary heart disease in the normative aging study. Psychosom Med. 2001;63(6):910–6.PubMedCrossRefGoogle Scholar
  159. 159.
    Ronaldson A, Molloy GJ, Wikman A, Poole L, Kaski J-C, Steptoe A. Optimism and recovery after acute coronary syndrome: a clinical cohort study. Psychosom Med. 2015;77(3):311.PubMedPubMedCentralCrossRefGoogle Scholar
  160. 160.
    Pänkäläinen M, Kerola T, Kampman O, Kauppi M, Hintikka J. Pessimism and risk of death from coronary heart disease among middle-aged and older Finns: an eleven-year follow-up study. BMC Public Health. 2016;16(1):1124.PubMedPubMedCentralCrossRefGoogle Scholar
  161. 161.
    Lee HB, Offidani E, Ziegelstein RC, Bienvenu OJ, Samuels J, Eaton WW, et al. Five-Factor Model Personality Traits as predictors of incident coronary heart disease in the community: a 10.5-year cohort study based on the Baltimore Epidemiologic Catchment Area Follow-Up Study. Psychosomatics. 2014;55(4):352–61.PubMedCrossRefGoogle Scholar
  162. 162.
    Swan GE, Carmelli D. Curiosity and mortality in aging adults: a 5-year follow-up of the Western Collaborative Group Study. Psychol Aging. 1996;11(3):449.PubMedCrossRefGoogle Scholar
  163. 163.
    Goldberg LR. The structure of phenotypic personality traits. Am Psychol. 1993;48(1):26.PubMedCrossRefGoogle Scholar
  164. 164.
    Jokela M, Pulkki-Råback L, Elovainio M, Kivimäki M. Personality traits as risk factors for stroke and coronary heart disease mortality: pooled analysis of three cohort studies. J Behav Med. 2014;37(5):881–9.PubMedCrossRefPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Clinical and Experimental Medicine, Section of PsychiatryUniversity of CataniaCataniaItaly

Section editors and affiliations

  • Matteo Rocchetti
    • 1
  1. 1.Department of Brain and Behavioral SciencesUniversity of PaviaPaviaItaly

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