Antimicrobial Prophylaxis in High-Risk Oncology Patients

  • Jeffrey J. BrunoEmail author
  • Frank P. Tverdek
Reference work entry


Oncology patients are often vulnerable to the development of infection. Accordingly, antimicrobial prophylaxis may be necessary. In caring for oncology patients, critical care providers should be astute at determining the risk of infection, identifying patients appropriate for antimicrobial prophylaxis, and assessing the risk-benefit profile of available prophylactic options. Using best available evidence and current guidelines (when applicable), this chapter will provide a framework to guide the critical care clinician in addressing the above considerations for both the surgical population and those with malignancy and/or treatment-related immune compromise. In regard to surgical patients, emphasis will be placed on the prevention of surgical site infections following procedures for the management of malignancy and for which postoperative admission to the intensive care unit may be necessary. The remainder of the chapter will highlight principles for the prevention of bacterial, fungal, and viral infections among the immunocompromised oncology population.


Surgical procedures Antimicrobial prophylaxis Surgical site infection Immunocompromised Fungal infection Bacterial infection Pneumocystis Hepatitis Viral infection 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.The University of Texas MD Anderson Cancer CenterHoustonUSA

Section editors and affiliations

  • Todd W. Canada
    • 1
  • Jeffrey J. Bruno
    • 2
  1. 1.Clinical Pharmacy Svcs, Pharmacy Clinical ProgramsThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Clinical Pharmacy Specialist – Critical Care / Nutrition SupportThe University of Texas MD Anderson Cancer CenterHoustonUSA

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