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Complications and Toxicities Associated with Cancer Therapies in the Intensive Care Unit

  • Melvin J. Rivera
  • Bryan Do
  • Jeffrey C. Bryan
  • Terri Lynn Shigle
  • Rina PatelEmail author
Reference work entry

Abstract

Advances in the management of hematologic malignancies and solid tumors have given rise to diverse modalities to treat cancer other than cytotoxic chemotherapy, including targeted therapies, immunotherapies, and cellular therapies. Currently, there are over 175 FDA-approved antineoplastic agents in the United States, many with a diverse and profound toxicity profile. Complications of antineoplastic therapy may result in the need for intensive care unit (ICU) admission to provide acute symptom management. Accordingly, ICU providers caring for cancer patients should have a working knowledge of the toxicities and complications associated with antineoplastic therapy.

Keywords

Chemotherapy Immunotherapy Cancer Toxicity Oncology Critical care Intensive care Complications Adverse effects Antineoplastic agents 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Melvin J. Rivera
    • 1
  • Bryan Do
    • 2
  • Jeffrey C. Bryan
    • 3
  • Terri Lynn Shigle
    • 4
    • 5
  • Rina Patel
    • 6
    Email author
  1. 1.Thoracic / Head and Neck MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Lymphoma and MyelomaThe University of Texas MD Anderson Cancer CenterHoustonUSA
  3. 3.LeukemiaThe University of Texas MD Anderson Cancer CenterHoustonUSA
  4. 4.OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  5. 5.Stem Cell Transplantation and Cellular TherapyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  6. 6.Critical Care / Nutrition SupportThe University of Texas MD Anderson Cancer CenterHoustonUSA

Section editors and affiliations

  • Todd W. Canada
    • 1
  • Jeffrey J. Bruno
    • 2
  1. 1.Clinical Pharmacy Svcs, Pharmacy Clinical ProgramsThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Clinical Pharmacy Specialist – Critical Care / Nutrition SupportThe University of Texas MD Anderson Cancer CenterHoustonUSA

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