Enhanced Recovery After Surgery (ERAS) in the Oncologic Patient

  • Joshua BotdorfEmail author
  • Celia Robinson Ledet
  • Ninotchka Brydges
  • Danilo Lovinaria
  • Garry Brydges
Reference work entry


Enhanced Recovery After Surgery (ERAS) is a term used to describe perioperative care protocols that have been demonstrated to improve patient outcomes after major oncologic surgery. In 2001, a group of academic surgeons invented ERAS with the goal of developing optimal perioperative pathways that will provide optimal care throughout the patient’s journey. Some authors use other terms such as enhanced recovery programs (ERP) or fast-track surgery. ERAS guidelines include a series of perioperative evidence-based interventions to maintain physiological function, enhance mobilization, minimize pain, and facilitate early oral nutrition postoperatively by reducing perioperative surgical stress. Further, the guidelines strive to attenuate the loss of functional capacity after surgery (Lassen et al. World J Surg. 2013;37:240–58). The adoption of ERAS will improve outcome as evidenced by morbidity rate reduction, faster recovery, and decrease length of hospital stay (Thorell et al. World J Surg. 2016;40:2065–83). The effectiveness of ERAS protocols has shown to be beneficial in the maintenance of homeostasis via controlling metabolism and fluid shifts, and the support of the return of key functions through early detection and rescue of symptom burden. The principles of ERAS are gaining ground and spreading into a range of different surgical specialties and procedures. The utilization of evidence-based ERAS protocols will minimize healthcare team’s practice variation resulting in patient engagement, timely quality recovery, safety, positive outcomes, and cost reduction. The chapter will describe the implications of ERAS pathways when caring for oncologic patients perioperatively through interdisciplinary approach. A key focus for critical care teams is to provide a comprehensive overview and targeted areas of care to implement interventions consistent with new healthcare delivery trends.


Enhanced Recovery After Surgery (ERAS) Pathways Protocol Evidence based practice Perioperative Interprofessional Interdisciplinary Outcomes 


  1. 1.
    Abola RE, Bennett-Guerrero E, Kent ML, Feldman LS, Fiore JF Jr, Shaw AD, JKM T, Gan TJ, Miller TE, Hedrick TL, MD ME, Mythen MG, Bergamaschi R, Gupta R, Holubar SD, Senagore AJ, Wischmeyer PE, Carli F, Evans DC, Guilbert S, Kozar R, Pryor A, Thiele RH, Everett S, Grocott M. Perioperative Quality Initiative (POQI) 2 workgroup. American Society for enhanced recovery perioperative quality initiative joint consensus statement on patient-reported outcomes in an enhanced recovery pathway. Anesth Analg. 2018;126(6):1874–82Google Scholar
  2. 2.
    Adamina M, et al. Contemporary perioperative care strategies. Br J Surg. 2013;100(1):38–54. WileyGoogle Scholar
  3. 3.
    Alphonsus CS, Rodseth RN. The endothelial glycocalyx: a review of the vascular barrier. Anaesthesia. 2014;69(7):777–84.CrossRefPubMedGoogle Scholar
  4. 4.
    American Diabetes Association. Professional Practice Committee for the Standards of Medical Care in Diabetes-2016. Diabetes Care. 2016;39(Suppl 1):S107–8.Google Scholar
  5. 5.
    American Society of Regional Anesthesia & Pain Medicine (ASRA). Regional anesthesia. 2018. Viewed December 24, 2018.
  6. 6.
    Aviles C, Hockenberry M, Vrochides D, Iannitti D, Cochran A, Tezber K, Eller M, Desamero J. Perioperative care implementation: evidence-based practice for patients with pancreaticoduodenectomy using the enhanced recovery after surgery guidelines. Clin J Oncol Nurs. 2017;21(4):466.PubMedGoogle Scholar
  7. 7.
    Azhar RA, Bochner B, Catto J, Goh AC, Kelly J, Patel HD, Pruthi RS, Thalmann GN, Desai M. Enhanced recovery after urological surgery: a contemporary systematic review of outcomes, key elements, and research needs. Eur Urol. 2016;70(1):176–87.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Baldini G, Fawcett WJ. Anesthesia for colorectal surgery. Anesthesiol Clin. 2015;33(1):93–123. Elsevier.Google Scholar
  9. 9.
    Bartels K, Mayes LM, Dingmann C, Bullard KJ, Hopfer CJ, Binswanger IA. Opioid use and storage patterns by patients after hospital discharge following surgery. PLoS One. 2016;11(1):e0147972.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Basse L, Werner M, Kehlet H. Is urinary drainage necessary during continuous epidural analgesia after colonic resection? Reg Anesth Pain Med. 2000;25(5):498e501Google Scholar
  11. 11.
    Batchelor TJP, Rasburn NJ, Abdelnour-Berchtold E, Brunelli A, Cerfolio RJ, Gonzalez M, Ljungqvist O, Petersen RH, Popescu WM, Slinger PD, Naidu B. Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS). Eur J Cardiothorac Surg. 2019;55(1):91–115.CrossRefPubMedGoogle Scholar
  12. 12.
    Becker BF, Chappell D, Jacob M. Endothelial glycocalyx and coronary vascular permeability: the fringe benefit. Basic Res Cardiol. 2010;105(6):687–701.CrossRefPubMedGoogle Scholar
  13. 13.
    Blanton E, Lamvu G, Patanwala I, Barron KI, Witzeman K, Tu FF, As-Sanie S. Non-opioid pain management in benign minimally invasive hysterectomy: a systematic review. Am J Obstet Gynecol. 2016/2017;216(6):557–67.Google Scholar
  14. 14.
    Brackenbury WJ. Voltage-gated sodium channels and metastatic disease. Channels. 2012;6(5):352–61.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Brandstrup B, Tonnesen H, Beier-Holgersen R, Hjortso E, Ording H, Lindorff-Larsen K, et al. Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg. 2003;238:641–8.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Brettner F, von Dossow V, Chappell D. The endothelial glycocalyx and perioperative lung injury. Curr Opin Anaesthesiol. 2017/2016;30(1):36.Google Scholar
  17. 17.
    Cerantola Y, Valerio M, Persson B, Jichlinski P, Ljungqvist O, Hubner M, …, Naesheimh T. Guidelines for perioperative care after radical cystectomy for bladder cancer: Enhanced Recovery After Surgery (ERAS®) society recommendations. Clin Nutr. 2013;32(6):879–87.Google Scholar
  18. 18.
    Chen R, Chen T, Chen T, Lin L, Chang C, Chang H, Wu C. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. Ann N Y Acad Sci. 2005;1042(1):262–71.CrossRefPubMedGoogle Scholar
  19. 19.
    Choi W, Baek S, Joo E, Yoon S, Kim E, Hong B, Hwang J, Kim Y. Comparison of the effect of spinal anesthesia and general anesthesia on 5-year tumor recurrence rates after transurethral resection of bladder tumors. Oncotarget. 2017;8(50):87667.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Coyle MJ, Main B, Hughes C, Craven R, Alexander R, Porter G, Thomas S. Enhanced recovery after surgery (ERAS) for head and neck oncology patients. Clin Otolaryngol. 2016;41(2):118–26.CrossRefPubMedGoogle Scholar
  21. 21.
    Cronin-Fenton DP, Heide-Jørgensen U, Ahern TP, Lash TL, Christiansen PM, Ejlertsen B, Sjøgren P, Kehlet H, Sørensen HT. Opioids and breast cancer recurrence: a Danish population-based cohort study. Cancer. 2015;121(19):3507–14.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Cruz FF, Rocco PRM, Pelosi P. Anti-inflammatory properties of anesthetic agents. Crit Care. 2017;21(1):67.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46(9):e825–73.CrossRefGoogle Scholar
  24. 24.
    Dort JC, Farwell DG, Findlay M, Huber GF, Kerr P, Shea-Budgell MA, …, Harris J. Optimal perioperative care in major head and neck cancer surgery with free flap reconstruction: a consensus review and recommendations from the enhanced recovery after surgery society. JAMA Otolaryngol Head Neck Surg. 2017;143(3):292–303.Google Scholar
  25. 25.
    Dubb R, Nydahl P, Hermes C, Schwabbauer N, Toonstra A, Parker AM, Kaltwasser A, Needham DM. Barriers and strategies for early mobilization of patients in intensive care units. Ann Am Thorac Soc. 2016;13(5):724–30.CrossRefPubMedGoogle Scholar
  26. 26.
    Dubowitz JA, Sloan EK, Riedel BJ. Implicating anaesthesia and the perioperative period in cancer recurrence and metastasis. Clin Exp Metastasis. 2018;35(4):347–58.CrossRefPubMedGoogle Scholar
  27. 27.
    Eikermann M, Grosse-Sundrup M, Zaremba S, Henry ME, Bittner EA, Hoffmann U, Chamberlin NL. Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. Anesthesiology. 2012;116(1):35–46.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    El Alili M, van Dongen JM, Huirne JAF, van Tulder MW, Bosmans JE. Reporting and analysis of trial-based cost-effectiveness evaluations in obstetrics and gynaecology. PharmacoEconomics. 2017;35(10):1007–33.CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Feldheiser A, Aziz O, Baldini G, Cox BPBW, Fearon KCH, Feldman LS, …, Miller T. Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol Scand. 2016;60(3):289–334.Google Scholar
  30. 30.
    Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Henderson WR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283–97.CrossRefGoogle Scholar
  31. 31.
    Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramèr MR. Society for Ambulatory Anesthesia. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014;118(1):85–113.Google Scholar
  32. 32.
    García Escobar I, Antonio Rebollo M, García Adrián S, Rodríguez-Garzotto A, Muñoz Martín A, Cancer&Thrombosis Working Group of the Spanish Society of Medical Oncology (SEOM). Safety and efficacy of primary thromboprophylaxis in cancer patients. Clin Transl Oncol. 2017;19(1):1–11.CrossRefPubMedGoogle Scholar
  33. 33.
    Grasu RM, Cata JP, Dang AQ, Tatsui CE, Rhines LD, Hagan KB, Bhavsar S, Raty SR, Arunkumar R, Potylchansky Y, Lipski I, Arnold BA, McHugh TM, Bird JE, Rodriguez-Restrepo A, Hernandez M, Popat KU. Implementation of an Enhanced Recovery After Spine Surgery program at a large cancer center: a preliminary analysis. J Neurosurg Spine. 2018;17:1–11.Google Scholar
  34. 34.
    Guay J, Ochroch EA, Kopp S. Intraoperative use of low volume ventilation to decrease postoperative mortality, mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury. Cochrane Database Syst Rev. 2018;7:CD011151.PubMedGoogle Scholar
  35. 35.
    Güldner A, Kiss T, Serpa Neto A, Hemmes SN, Canet J, Spieth PM, Rocco PR, Schultz MJ, Pelosi P, Gama de Abreu M. Intraoperative protective mechanical ventilation for prevention of postoperative pulmonary complications: a comprehensive review of the role of tidal volume, positive end-expiratory pressure, and lung recruitment maneuvers. Anesthesiology. 2015;123(3):692–713.CrossRefPubMedGoogle Scholar
  36. 36.
    Gustafsson U, et al. Guidelines for perioperative care in elective colorectal surgery: Enhanced Recovery After Surgery (ERAS ®) society recommendations: 2018. World J Surg. 2019;43(3):659–95. Springer International Publishing.Google Scholar
  37. 37.
    Hagan KB, Bhavsar S, Raza SM, Arnold B, Arunkumar R, Dang A, Gottumukkala V, Popat K, Pratt G, Rahlfs T, Cata JP. Enhanced recovery after surgery for oncological craniotomies. J Clin Neurosci. 2016;24:10–6.CrossRefPubMedGoogle Scholar
  38. 38.
    Harvin JA, Green CE, Vincent LE, Motley KL, Podbielski J, Miller CC, Tyson JE, Holcomb JB, Wade CE, Kao LS. Multi-modal Analgesic Strategies for Trauma (MAST): protocol for a pragmatic randomized trial. Trauma Surg Acute Care Open. 2018;19;3(1).Google Scholar
  39. 39.
    Haspel AC, Coviello VF, Stevens M. Retrospective study of tracheostomy indications and perioperative complications on oral and maxillofacial surgery service. J Oral Maxillofac Surg. 2012;70(4):890–5.CrossRefPubMedGoogle Scholar
  40. 40.
    Helander EM, Webb MP, Bias M, Whang EE, Kaye AD, Urman RD. A comparison of multimodal analgesic approaches in institutional enhanced recovery after surgery protocols for colorectal surgery: pharmacological agents. J Laparoendosc Adv Surg Tech. 2017;27(9):93–908.Google Scholar
  41. 41.
    Helviz Y, Einav S. A systematic review of the high-flow nasal cannula for adult patients. Crit Care. 2018;22(1):71.CrossRefPubMedPubMedCentralGoogle Scholar
  42. 42.
    Hilton WM, Lotan Y, Parekh DJ, Basler JW, Svatek RS. Alvimopan for prevention of postoperative paralytic ileus in radical cystectomy patients: a cost-effectiveness analysis. BJU Int. 2013;111(7):1054–60.CrossRefPubMedGoogle Scholar
  43. 43.
    Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm. 2009;15(6):485–94.PubMedGoogle Scholar
  44. 44.
    Jenks PJ, Laurent M, McQuarry S, Watkins R. Clinical and economic burden of surgical site infection (SSI) and predicted financial consequences of elimination of SSI from an English hospital. J Hosp Infect. 2013/2014;86(1):24–33.Google Scholar
  45. 45.
    Joliat GR, Labgaa I, Petermann D, Hübner M, Griesser AC, Demartines N, Schäfer M. Cost–benefit analysis of an enhanced recovery protocol for pancreaticoduodenectomy. Br J Surg. 2015;102(13):1676–83.CrossRefPubMedGoogle Scholar
  46. 46.
    Joliat G, Labgaa I, Hübner M, Blanc C, Griesser A, Schäfer M, Demartines N. Cost–benefit analysis of the implementation of an enhanced recovery program in liver surgery. World J Surg. 2016;40(10):2441–50.CrossRefPubMedGoogle Scholar
  47. 47.
    Juneja R. Opioids and cancer recurrence. Curr Opin Support Palliat Care. 2014;8(2):91–101.CrossRefPubMedGoogle Scholar
  48. 48.
    Kayambu G, Boots R, Paratz J. Physical therapy for the critically ill in the ICU: a systematic review and meta-analysis. Crit Care Med. 2013;41(6):1543–54.Google Scholar
  49. 49.
    Khan NR, Patel PG, Sharpe JP, Lee SL, Sorenson J. Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis. J Neurosurg. 2018;129(4):906–15.CrossRefPubMedGoogle Scholar
  50. 50.
    Kunstman JW, Klemen ND, Fonseca AL, Araya DL, Salem RR. Nasogastric drainage may be unnecessary after pancreaticoduodenectomy: a comparison of routine vs selective decompression. J Am Coll Surg. 2013;217(3):481–8.CrossRefPubMedGoogle Scholar
  51. 51.
    Lassen K, Kjaeve J, Fetveit T, et al. Allowing normal food at will after major upper gastrointestinal surgery does not increase morbidity: a randomized multicenter trial. Ann Surg. 2008;247:721–9.CrossRefPubMedGoogle Scholar
  52. 52.
    Lassen K, Coolsen MM, Slim K, Carli F, de Aguilar-Nascimento JE, Schäfer M, …, Braga M. Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS®) society recommendations. World J Surg. 2013;37(2):240–58.Google Scholar
  53. 53.
    Legesse Laloto T, Hiko Gemeda D, Abdella SH. Incidence and predictors of surgical site infection in Ethiopia: prospective cohort. BMC Infect Dis. 2017;17(1):119.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Lemanu DP, Singh PP, Stowers MDJ, Hill AG. A systematic review to assess cost effectiveness of enhanced recovery after surgery programmes in colorectal surgery. Color Dis Off J Assoc Coloproctol Great Brit Ireland. 2014;16(5):338–46.Google Scholar
  55. 55.
    Le-Wendling L, Nin O, Capdevila X. Cancer recurrence and regional anesthesia: the theories, the data, and the future in outcomes. Pain Med (Malden, Mass). 2016;17(4):756–75.Google Scholar
  56. 56.
    Li X, Wang J, Chen K, Li Y, Wang H, Mu Y, Chen Y. Effect of different types of anesthesia on intraoperative blood glucose of diabetic patients: a PRISMA-compliant systematic review and meta-analysis. Medicine. 2017;96(13):e6451.CrossRefPubMedPubMedCentralGoogle Scholar
  57. 57.
    Lin Q, Zhou H, Li D, Ye J, Hong J, Hu Y. Effect of perioperative goal-directed fluid therapy on clinical outcome in elective colorectal resection. Zhonghua Wei Chang Wai Ke Za Zhi = Chin J Gastrointest Surg. 2015;18(7):671.Google Scholar
  58. 58.
    Liu M, Liu W, Yang X, Guo H, Peng H. Pectoralis major myocutaneous flap for head and neck defects in the era of free flaps: harvesting technique and indications. Sci Rep. 2017;7(1):46256.CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Ljungqvist O. ERAS—enhanced recovery after surgery. J Parenter Enter Nutr. 2014;38(5):559–66. Scholar
  60. 60.
    Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017;152(3):292–8.CrossRefPubMedGoogle Scholar
  61. 61.
    Ma X, Hu Y, Zhao Z, Zhao J, Zheng L, Qiu Y, Huang J, Wu X, Mao X, Yang J, Li S, Gu M, Wang Q. Anti-inflammatory effects of propofol are mediated by apolipoprotein M in a hepatocyte nuclear factor-1α-dependent manner. Arch Biochem Biophys. 2013;533(1–2):1–10.CrossRefPubMedGoogle Scholar
  62. 62.
    Manning MW, Dunkman WJ, Miller TE. Perioperative fluid and hemodynamic management within an enhanced recovery pathway. J Surg Oncol. 2017;116(5):592–600.CrossRefPubMedGoogle Scholar
  63. 63.
    Marjanovic G, Kuvendziska J, Holzner PA, Glatz T, Sick O, Seifert G, Kulemann B, Küsters S, Fink J, Timme S, Hopt UT, Wellner U, Keck T, Karcz WK. A prospective clinical study evaluating the development of bowel wall edema during laparoscopic and open visceral surgery. J Gastrointest Surg. 2014;18(12):2149–54.CrossRefPubMedGoogle Scholar
  64. 64.
    McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, McCarthy MS, Davanos E, Rice TW, Cresci GA, Gervasio JM, Sacks GS, Roberts PR, Compher C, Society of Critical Care Medicine, American Society for Parenteral and Enteral Nutrition. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2016;40(2):159–211.CrossRefGoogle Scholar
  65. 65.
    Melloul E, Hübner M, Scott M, Snowden C, Prentis J, Dejong CH, …, Clavien PA. Guidelines for perioperative care for liver surgery: Enhanced Recovery After Surgery (ERAS) society recommendations. World J Surg. 2016;40(10):2425–40.Google Scholar
  66. 66.
    Melnyk M, et al. Enhanced Recovery after Surgery (ERAS) protocols: time to change practice? Can Urol Assoc J. 2011;5(5):342–8.Google Scholar
  67. 67.
    Messenger DE, Curtis NJ, Jones A, Jones EL, Smart NJ, Francis NK. Factors predicting outcome from enhanced recovery programmes in laparoscopic colorectal surgery: a systematic review. Surg Endosc. 2017;31(5):2050–71.CrossRefPubMedGoogle Scholar
  68. 68.
    Mion G, Villevieille T. Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings). CNS Neurosci Ther. 2013;19(6):370–80.CrossRefPubMedPubMedCentralGoogle Scholar
  69. 69.
    Miralpeix E, Nick AM, Meyer LA, Cata J, Lasala J, Mena GE, Gottumukkala V, Iniesta-Donate M, Salvo G, Ramirez PT. A call for new standard of care in perioperative gynecologic oncology practice: impact of enhanced recovery after surgery (ERAS) programs. Gynecol Oncol. 2016;141(2):371–8.CrossRefPubMedPubMedCentralGoogle Scholar
  70. 70.
    Mortensen K, Nilsson M, Slim K, Schäfer M, Mariette C, Braga M, …, Enhanced Recovery After Surgery (ERAS®) Group. Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery (ERAS®) society recommendations. Br J Surg. 2014;101(10):1209–29.Google Scholar
  71. 71.
    Nair BG, Horibe M, Neradilek MB, Newman S, Peterson GN. The effect of intraoperative blood glucose management on postoperative blood glucose levels in noncardiac surgery patients. Anesth Analg. 2016;122(3):893–902.CrossRefPubMedGoogle Scholar
  72. 72.
    Nelson R, Tse B, Edwards S. Systematic review of prophylactic nasogastric decompression after abdominal operations. Br J Surg. 2005;92(6):673e80.CrossRefGoogle Scholar
  73. 73.
    Nelson R, Edwards S, Tse B. Prophylactic nasogastric decompression after abdominal surgery. Cochrane Database Syst Rev. 2007;18(3):CD004929.Google Scholar
  74. 74.
    Nelson G, Altman AD, Nick A, Meyer LA, Ramirez PT, Achtari C, …, Acheson N. Guidelines for pre-and intra-operative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) society recommendations-Part I. Gynecol Oncol. 2015;140(2):313–22.Google Scholar
  75. 75.
    Nelson G, Altman AD, Nick A, Meyer LA, Ramirez PT, Achtari C, …, Acheson N. Guidelines for postoperative care in gynecologic/oncology surgery: Enhanced Recovery After Surgery (ERAS®) society recommendations-Part II. Gynecol Oncol. 2016;140(2):323–32.Google Scholar
  76. 76.
    Nelson G, Kiyang LN, Crumley ET, Chuck A, Nguyen T, Faris P, Wasylak T, Basualdo-Hammond C, McKay S, Ljungqvist O, Gramlich LM, Örebro universitet & Institutionen för medicinska vetenskaper. Implementation of Enhanced Recovery After Surgery (ERAS) across a provincial healthcare system: the ERAS Alberta colorectal surgery experience. World J Surg. 2016;40(5):1092–103.Google Scholar
  77. 77.
    New York School of Regional Anesthesia (NYSORA). Regional anesthesia techniques. 2018. Viewed December 24, 2018.
  78. 78.
    Nimmo SM, Foo ITH, Paterson HM. Enhanced recovery after surgery: pain management. J Surg Oncol. 2017;116(5):583–91.CrossRefPubMedGoogle Scholar
  79. 79.
    Nisanevich V, Felsenstein I, Almogy G, Weissman C, Einav S, Matot I. Effect of intraoperative fluid management on outcome after intraabdominal surgery. Anesthesiology. 2005;103:25–32.CrossRefPubMedGoogle Scholar
  80. 80.
    Novotny V, Hakenberg OW, Wiessner D, Heberling U, Litz RJ, Oehlschlaeger S, Wirth MP. Perioperative complications of radical cystectomy in a contemporary series. Eur Urol. 2006/2007;51(2):397–402.Google Scholar
  81. 81.
    Nygren J, Thacker J, Carli F, Fearon KC, Norderval S, Lobo DN, Ljungqvist O, Soop M, Ramirez J, Enhanced Recovery After Surgery Society. Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) society recommendations. Clin Nutr. 2012;31(6):801–16.CrossRefPubMedGoogle Scholar
  82. 82.
    Nygren J, Thacker J, Carli F, Fearon KCH, Norderval S, Lobo DN, …, Ramirez J. Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS®) society recommendations. World J Surg. 2013;37(2):285–305.Google Scholar
  83. 83.
    Nyquist P, Bautista C, Jichici D, Burns J, Chhangani S, DeFilippis M, Goldenberg FD, Kim K, Liu-DeRyke X, Mack W, Meyer K. Prophylaxis of venous thrombosis in neurocritical care patients: an evidence-based guideline: a statement for healthcare professionals from the neurocritical care society. Neurocrit Care. 2016;24(1):47–60.CrossRefPubMedGoogle Scholar
  84. 84.
    Oberleithner H. Two barriers for sodium in vascular endothelium? Ann Med. 2012;44(S1):S143–8.CrossRefPubMedPubMedCentralGoogle Scholar
  85. 85.
    Oderda GM, Gan TJ, Johnson BH, Robinson SB. Effect of opioid-related adverse events on outcomes in selected surgical patients. J Pain Palliat Care Pharmacother. 2013;27(1):62–70.CrossRefPubMedGoogle Scholar
  86. 86.
    Park CS. Predictive roles of intraoperative blood glucose for post-transplant outcomes in liver transplantation. World J Gastroenterol. 2015;21(22):6835–41.CrossRefPubMedPubMedCentralGoogle Scholar
  87. 87.
    Parra-Sanchez I, Abdallah R, You J, Fu AZ, Grady M, Cummings K III, Apfel C, Sessler DI. A time-motion economic analysis of postoperative nausea and vomiting in ambulatory surgery. Can J Anesth/J Can Anesth. 2012;59(4):366–75.CrossRefGoogle Scholar
  88. 88.
    Pędziwiatr M, Pisarska M, Kisielewski M, Matłok M, Major P, Wierdak M, Budzyński A, Ljungqvist O, Örebro universitet & Institutionen för medicinska vetenskaper. Is ERAS in laparoscopic surgery for colorectal cancer changing risk factors for delayed recovery? Med Oncol. 2016;33(3):1–10.CrossRefGoogle Scholar
  89. 89.
    Pillinger NL, Kam P. Endothelial glycocalyx: basic science and clinical implications. Anaesth Intensive Care. 2017;45(3):295.CrossRefPubMedGoogle Scholar
  90. 90.
    Pisarska M, Małczak P, Major P, Wysocki M, Budzyński A, Pędziwiatr M. Enhanced recovery after surgery protocol in oesophageal cancer surgery: systematic review and meta-analysis. PLoS One. 2017;12(3):e0174382.CrossRefPubMedPubMedCentralGoogle Scholar
  91. 91.
    Plank LD, Connolly AB, Hill GL. Sequential changes in the metabolic response in severely septic patients during the first 23 days after the onset of peritonitis. Ann Surg. 1998;228:146–58.CrossRefPubMedPubMedCentralGoogle Scholar
  92. 92.
    Pulley DD. Preoperative evaluation of the patient with substance use disorder and perioperative considerations. Anesthesiol Clin. 2016;34(1):201–11. Elsevier.Google Scholar
  93. 93.
    Rasmussen MS, Jorgensen LN, Wille-Jorgensen P. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2009;21(1):CD004318.Google Scholar
  94. 94.
    Robins HI, Dennis WH, Slattery JS, Lange TA, Yatvin MB. Systemic lidocaine enhancement of hyperthermia-induced tumor regression in transplantable murine tumor models. Cancer Res. 1983;43(7):3187.PubMedGoogle Scholar
  95. 95.
    Roger S, Guennec JL, Besson P. Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastastic breast cancer cell line. Br J Pharmacol. 2004;141(4):610–5.CrossRefPubMedPubMedCentralGoogle Scholar
  96. 96.
    Roulin D, Donadini A, Gander S, Griesser A, Blanc C, Hübner M, Schäfer M, Demartines N. Cost-effectiveness of the implementation of an enhanced recovery protocol for colorectal surgery. Br J Surg. 2013;100(8):1108–14.CrossRefPubMedGoogle Scholar
  97. 97.
    Rujirojindakul P, Liabsuetrakul T, McNeil E, Chanchayanon T, Wasinwong W, Oofuvong M, Rergkliang C, Chittithavorn V. Safety and efficacy of intensive intraoperative glycaemic control in cardiopulmonary bypass surgery: a randomised trial. Acta Anaesthesiol Scand. 2014;58(5):588–96.CrossRefPubMedGoogle Scholar
  98. 98.
    Scott MJ, Baldini G, Fearon KCH, Feldheiser A, Feldman LS, Gan TJ, Ljungqvist O, Lobo DN, Rockall TA, Schricker T, Carli F, Institutionen för läkarutbildning & Örebro universitet. Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 1: pathophysiological considerations. Acta Anaesthesiol Scand. 2015;59(10):1212–31.CrossRefPubMedPubMedCentralGoogle Scholar
  99. 99.
    Shepard J, Ward W, Milstone A, Carlson T, Frederick J, Hadhazy E, Perl T. Financial impact of surgical site infections on hospitals: the hospital management perspective. JAMA Surg. 2013;148(10):907–14.CrossRefPubMedGoogle Scholar
  100. 100.
    Simanek R, Vormittag R, Hassler M, Roessler K, Schwarz M, Zielinski C, et al. Venous thromboembolism and survival in patients with high-grade glioma. Neuro-Oncology. 2007;9(2):89–95.CrossRefPubMedPubMedCentralGoogle Scholar
  101. 101.
    Singh T, Sankla P, Smith G. Tracheostomy or delayed extubation after maxillofacial free-flap reconstruction? Br J Oral Maxillofac Surg. 2016;54(8):878–82.CrossRefPubMedGoogle Scholar
  102. 102.
    Steele SR, Bleier J, Champagne B, Hassan I, Russ A, Senagore AJ, Sylla P, Pigazzi A. Improving outcomes and cost-effectiveness of colorectal surgery. J Gastrointest Surg. 2014;18(11):1944–56.CrossRefPubMedGoogle Scholar
  103. 103.
    Stollings LM, Jia L, Tang P, Dou H, Lu B, Xu Y. Immune modulation by volatile anesthetics. Anesthesiology. 2016;125(2):399–411.CrossRefPubMedPubMedCentralGoogle Scholar
  104. 104.
    Stowers MDJ, Lemanu DP, Hill AG. Health economics in enhanced recovery after surgery programs. Can J Anesth/J Can Anesth. 2015;62(2):219–30.CrossRefGoogle Scholar
  105. 105.
    Strunden MS, Tank S, Kerner T. Perioperative fluid therapy: defining a clinical algorithm between insufficient and excessive. J Clin Anesth. 2016;35:384–91.CrossRefPubMedGoogle Scholar
  106. 106.
    Sun Y, Li T, Gan TJ. The effects of perioperative regional anesthesia and analgesia on cancer recurrence and survival after oncology surgery: a systematic review and meta-analysis. Reg Anesth Pain Med. 2015;40(5):589–98.CrossRefPubMedGoogle Scholar
  107. 107.
    Sun H, Song Y, Wang X. Effects of different anesthetic methods on cellular immune and neuroendocrine functions in patients with hepatocellular carcinoma before and after surgery. J Clin Lab Anal. 2016;30(6):1175–82.CrossRefPubMedGoogle Scholar
  108. 108.
    Tan M, Law LS, Gan TJ. Optimizing pain management to facilitate Enhanced Recovery After Surgery pathways. Can J Anesth/J Can Anesth. 2015;62(2):203–18.CrossRefGoogle Scholar
  109. 109.
    Temple-Oberle C, Shea-Budgell MA, Tan M, Semple JL, Schrag C, Barreto M, Blondeel P, Hamming J, Dayan J, Ljungqvist O, ERAS Society. Consensus review of optimal perioperative care in breast reconstruction: Enhanced Recovery after Surgery (ERAS) society recommendations. Plast Reconstr Surg. 2017;139(5):1056e–71e.CrossRefPubMedGoogle Scholar
  110. 110.
    Thorell A, MacCormick AD, Awad S, Reynolds N, Roulin D, Demartines N, …, Lobo DN. Guidelines for perioperative care in bariatric surgery: Enhanced Recovery After Surgery (ERAS) society recommendations. World J Surg. 2016;40(9), 2065–83.
  111. 111.
    Touchette DR, Yang Y, Tiryaki F, Galanter WL. Economic analysis of alvimopan for prevention and management of postoperative ileus. Pharmacotherapy. 2012;32(2):120–8.CrossRefPubMedGoogle Scholar
  112. 112.
    Ultrasound for Regional Anesthesia (USRA). Anatomy and sonoanatomy. 2018. Viewed December 24, 2018.
  113. 113.
    Vadivelu N, et al. Perioperative analgesia and challenges in the drug addicted and drug-dependent patient. Best Pract Res Clin Anaesthesiol. 2014;28(1):91–101. Elsevier.Google Scholar
  114. 114.
    Varadhan KK, Lobo DN. A meta-analysis of randomised controlled trials of intravenous fluid therapy in major elective open abdominal surgery: getting the balance right. Proc Nutr Soc. 2010;69(4):488–98.CrossRefPubMedGoogle Scholar
  115. 115.
    Varrier M, Ostermann M. Fluid composition and clinical effects. Crit Care Clin. 2015;31(4):823–37.CrossRefPubMedGoogle Scholar
  116. 116.
    Venara A, Neunlist M, Slim K, Barbieux J, Colas PA, Hamy A, Meurette G. Postoperative ileus: pathophysiology, incidence, and prevention. J Visc Surg. 2016;153(6):439–46.CrossRefPubMedGoogle Scholar
  117. 117.
    Vendler MMI, Haidari TA, Waage JE, Kleif J, Kristensen B, Gögenur I, Bertelsen CA, Copenhagen cOmplete Mesocolic Excision Study group (COMES) & the Copenhagen cOmplete Mesocolic Excision Study group (COMES). Incidence of venous thromboembolic events in enhanced recovery after surgery for colon cancer: a retrospective, population-based cohort study. Color Dis Off J Assoc Coloproctol Great Brit Ireland. 2017;19(11):O393–401.Google Scholar
  118. 118.
    Votta-Velis EG, Piegler T, Minshall RD, Aguirre J, Beck-Schimmer B, Schwartz DE, Borgeat A. Regional anaesthesia and cancer metastases: the implication of local anaesthetics. Acta Anaesthesiol Scand. 2013;57(10):1211–29.CrossRefPubMedGoogle Scholar
  119. 119.
    Vukovic N, Dinic L. Enhanced recovery after surgery protocols in major urologic surgery. Front Med. 2018;5:93.CrossRefGoogle Scholar
  120. 120.
    Wada H, Seki S, Takahashi T, Kawarabayashi N, Higuchi H, Habu Y, Sugahara S, Kazama T. Combined spinal and general anesthesia attenuates liver metastasis by preserving TH1/TH2 cytokine balance. Anesthesiology. 2007;106(3):499–506.CrossRefPubMedGoogle Scholar
  121. 121.
    Weinbroum AA. Non-opioid IV adjuvants in the perioperative period: pharmacological and clinical aspects of ketamine and gabapentinoids. Pharmacol Res. 2012;65(4):411–29.CrossRefPubMedGoogle Scholar
  122. 122.
    Wigmore TJ, Mohammed K, Jhanji S. Long-term survival for patients undergoing volatile versus IV anesthesia for cancer surgery: a retrospective analysis. Anesthesiology. 2016;124(1):69–79.CrossRefPubMedGoogle Scholar
  123. 123.
    Wu G, Chen R, Chen T, Ueng Y. Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation. Toxicol Appl Pharmacol. 2008;228(1):105–13.CrossRefPubMedGoogle Scholar
  124. 124.
    Wu AK, Auerbach AD, Aaronson DS. National incidence and outcomes of postoperative urinary retention in the Surgical Care Improvement Project. Am J Surg. 2012;204(2):167–71.CrossRefPubMedGoogle Scholar
  125. 125.
    Xuan W, Hankin J, Zhao H, Yao S, Ma D. The potential benefits of the use of regional anesthesia in cancer patients. Int J Cancer. 2015;137(12):2774–84.CrossRefPubMedGoogle Scholar
  126. 126.
    Yang Z, Zheng Q, Wang Z. Meta-analysis of the need for nasogastric or nasojejunal decompression after gastrectomy for gastric cancer. Br J Surg. 2008;95(7):809–16.CrossRefPubMedGoogle Scholar
  127. 127.
    Yuan J, Sun Y, Pan C, Li T. Goal-directed fluid therapy for reducing risk of surgical site infections following abdominal surgery – a systematic review and meta-analysis of randomized controlled trials. Int J Surg. 2017;39:74–87.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Joshua Botdorf
    • 1
    Email author
  • Celia Robinson Ledet
    • 2
  • Ninotchka Brydges
    • 5
  • Danilo Lovinaria
    • 3
  • Garry Brydges
    • 4
    • 6
  1. 1.Department of Critical Care and Respiratory Care, Division of Anesthesia, Critical Care and Pain MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Surgical OncologyThe University of Texas, MD Anderson Cancer CenterHoustonUSA
  3. 3.University of Minnesota Nurse Anesthesia ProgramMinneapolisUSA
  4. 4.Anesthesiology – CRNA SupportThe University of Texas MD Anderson Cancer CenterHoustonUSA
  5. 5.Department of Critical Care and Respiratory CareThe University of Texas MD Anderson Cancer CenterHoustonUSA
  6. 6.Division of Anesthesia, Critical Care and Pain Medicine, Department of AnesthesiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

Section editors and affiliations

  • Garry Brydges
    • 1
  1. 1.Division of Anesthesia, Critical Care and Pain Medicine, Department of AnesthesiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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