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Neutropenic Fever in the Intensive Care Unit

  • R. Scott StephensEmail author
Reference work entry

Abstract

Neutropenic fever is a common and potentially life-threatening condition in patients treated for cancer. Rapid initiation of appropriate antimicrobial therapy is necessary to decrease the risk of mortality. Most infections are due to gram-positive organisms, but the mortality rate is higher for gram-negative infections. Multidrug-resistant organisms are an emerging threat to neutropenic patients. Increasing data suggest that the pathophysiology of neutropenic fever and neutropenic sepsis is substantially different from non-neutropenic fever and sepsis. Additional research is needed to both further elucidate the pathogenesis of neutropenic fever and to develop additional effective antimicrobials.

Keywords

Neutropenia Neutropenic Fever Sepsis Gram negative Gram positive Fungal 

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Oncology and Bone Marrow Transplant Critical Care, Division of Pulmonary and Critical Care MedicineJohns Hopkins UniversityBaltimoreUSA

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