Transfusion-Related Acute Lung Injury (TRALI)

  • Adriana Maria Knopfelmacher
Reference work entry


TRALI is an adult respiratory distress syndrome occurring within 6 h of transfusion that presents with fever, cyanosis, dyspnea, and opacity of the pulmonary fields on frontal chest radiograph. TRALI has been described with all blood components, and its mechanism has been associated with donor HLA antibodies and some biologic response modifiers that trigger a leukocyte damage of the lung capillaries leading to leakage of fluid in the alveolar spaces. There is a 20% mortality as consequence of TRALI, and many patients require oxygen support and mechanical ventilation.


TRALI Transfusion fatality 


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Adriana Maria Knopfelmacher
    • 1
  1. 1.Department of Laboratory MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA

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