Clinical Immunology in Diagnoses of Maxillofacial Disease

  • Nathaniel TreisterEmail author
  • Arturo Saavedra
  • Alessandro Villa
Reference work entry


There is an immunological basis for a wide spectrum of oral medicine conditions, ranging from autoimmunity to infection. While patient history and physical examination serve as the cornerstones for clinical diagnosis, in many situations additional laboratory testing is necessary in order to arrive at a definitive diagnosis. As such, a comprehensive understanding of clinical immunology and its relevance to the pathogenesis and diagnosis of oral medicine conditions is essential. This chapter provides an overview of the immune system, indications for immunological work-up, a summary of clinical immunology tests relevant to the practice of oral medicine, and a discussion of the oral medicine conditions for which clinical immunological testing may be indicated.


ELISA Immunoblotting Immunofluorescence Antibody titer analysis Connective tissue disease Serology Allergy testing Prick testing Patch testing Histopathology Oral immunology Oral vesiculobullous disorders 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nathaniel Treister
    • 1
    Email author
  • Arturo Saavedra
    • 2
  • Alessandro Villa
    • 1
    • 3
  1. 1.Department of Oral Medicine, Infection and ImmunityHarvard School of Dental MedicineBostonUSA
  2. 2.Department of DermatologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  3. 3.Division of Oral Medicine and DentistryBrigham and Women’s HospitalBostonUSA

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