Odontogenic Bacterial Infections

  • Stuart G. DashperEmail author
  • Alf Nastri
  • Paul V. Abbott
Reference work entry


The oral cavity is home to over 700 species of bacteria, known as the human oral microbiome. The oral cavity is an ideal environment for bacterial colonization and growth. Although the majority of these bacteria are beneficial to human health and do not cause disease, under particular circumstances, bacterial infections can occur. The most common bacterial diseases that occur in the oral cavity are in the form of dental caries, periodontal diseases, and pulp, root canal, and periapical diseases. These diseases are overwhelmingly due to bacteria that are part of the normal oral microbiota, and not exogenous pathogens. Pulp and root canal diseases can lead to periradicular conditions such as apical periodontitis, apical abscesses, facial cellulitis (with possible airway involvement), and osteomyelitis. Management of these diseases is based initially on obtaining a complete history and performing a thorough clinical and radiographic examination in order to develop an accurate diagnosis. Various treatment procedures can be provided, depending on the diagnosis – these range from simple dental restorations, periodontal treatment (scaling, root planing), root canal treatment to extraction of the tooth. Various medical and surgical procedures plus the use of antimicrobial drug therapy are required in cases with severe infections and/or systemic signs of the infection. Other conditions such as osteonecrosis of the jaws must be differentiated from oral infections but they may have secondary bacterial involvement.


Oral microbiome Dental caries Periodontal diseases Gingivitis Pulpitis Apical periodontitis Apical abscesses Facial cellulitis Oesteomyelitis Osteonecrosis 


  1. Abbott PV. Medicaments: aids to success in endodontics. Part 2. Clinical recommendations. Aust Dent J. 1990;35(6):491–6.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Abbott PV. The periapical space – a dynamic interface. Aust Endod J. 2002;28(3):96–107.PubMedCrossRefPubMedCentralGoogle Scholar
  3. Abbott PV. Assessing restored teeth with pulp and periapical diseases for the presence of cracks, caries and marginal breakdown. Aust Dent J. 2004a;49(1):33–9; quiz 45.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Abbott PV. Classification, diagnosis and clinical manifestations of apical periodontitis. Endod Top. 2004b;8:36–54.CrossRefGoogle Scholar
  5. Abbott PV. Diagnosis and management planning for root-filled teeth with persisting or new apical pathosis. Endod Top. 2011;19:1–21.CrossRefGoogle Scholar
  6. Abbott PV. Examination and diagnosis of pulp, root canal, and periapical/periradicular conditions. In: Rotstein II, Raleigh JI, editors. Ingle’s endodontics. Shelton: PMPH-USA Ltd; 2016. p. 215–66.Google Scholar
  7. Abbott P, Leow N. Predictable management of cracked teeth with reversible pulpitis. Aust Dent J. 2009;54(4):306–15.PubMedCrossRefPubMedCentralGoogle Scholar
  8. Abbott PV, Yu C. A clinical classification of the status of the pulp and the root canal system. Aust Dent J. 2007;52(1 Suppl):S17–31.PubMedCrossRefPubMedCentralGoogle Scholar
  9. Adler CJ, Dobney K, Weyrich LS, Kaidonis J, Walker AW, Haak W, Bradshaw CJA, Townsend G, Soltysiak A, Alt KW, Parkhill J, Cooper A. Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions. Nat Genet. 2013;45(4):450–5.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Alam DS, Nuara M, Christian J. Analysis of outcomes of vascularized flap reconstruction in patients with advanced mandibular osteoradionecrosis. Otolaryngol Head Neck Surg. 2009;141(2):196–201.PubMedCrossRefPubMedCentralGoogle Scholar
  11. Allen MR, Burr DB. The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data. J Oral Maxillofac Surg. 2009;67(5 Suppl):61–70.PubMedCrossRefPubMedCentralGoogle Scholar
  12. Armfield J, Roberts-Thomson K, Spencer A. Australia’s health 2000: the seventh biennial health report of the Australian Institute of Health & Welfare, Canberra; 2000.Google Scholar
  13. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999;4(1):1–6.PubMedCrossRefPubMedCentralGoogle Scholar
  14. Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science. 2005;307(5717):1915–20.CrossRefGoogle Scholar
  15. Baron R, Ferrari S, Russell RG. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone. 2011;48(4):677–92.PubMedCrossRefPubMedCentralGoogle Scholar
  16. Baumgartner JC, Mader CL. A scanning electron microscopic evaluation of four root canal irrigation regimens. J Endod. 1987;13(4):147–57.PubMedCrossRefPubMedCentralGoogle Scholar
  17. Baumgartner JC, Xia T. Antibiotic susceptibility of bacteria associated with endodontic abscesses. J Endod. 2003;29(1):44–7.PubMedCrossRefPubMedCentralGoogle Scholar
  18. Bevin CR, Inwards CY, Keller EE. Surgical management of primary chronic osteomyelitis: a long-term retrospective analysis. J Oral Maxillofac Surg. 2008;66(10):2073–85.PubMedCrossRefPubMedCentralGoogle Scholar
  19. Bornstein MM, Bingisser AC, Reichart PA, Sendi P, Bosshardt DD, von Arx T. Comparison between radiographic (2-dimensional and 3-dimensional) and histologic findings of periapical lesions treated with apical surgery. J Endod. 2015;41(6):804–11.PubMedCrossRefPubMedCentralGoogle Scholar
  20. Bottin R, Marioni G, Rinaldi R, Boninsegna M, Salvadori L, Staffieri A. Deep neck infection: a present-day complication. A retrospective review of 83 cases (1998–2001). Eur Arch Otorhinolaryngol. 2003;260(10):576–9.PubMedCrossRefPubMedCentralGoogle Scholar
  21. Bridgeman A, Wiesenfeld D, Hellyar A, Sheldon W. Major maxillofacial infections. An evaluation of 107 cases. Aust Dent J. 1995;40(5):281–8.PubMedCrossRefPubMedCentralGoogle Scholar
  22. Byrne SJ, Dashper SG, Darby IB, Adams GG, Hoffmann B, Reynolds EC. Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque. Oral Microbiol Immunol. 2009;24(6):469–77.PubMedCrossRefPubMedCentralGoogle Scholar
  23. Bystrom A, Happonen RP, Sjogren U, Sundqvist G. Healing of periapical lesions of pulpless teeth after endodontic treatment with controlled asepsis. Endod Dent Traumatol. 1987;3(2):58–63.PubMedCrossRefPubMedCentralGoogle Scholar
  24. Castellarin M, Warren RL, Freeman JD, Dreolini L, Krzywinski M, Strauss J, Barnes R, Watson P, Allen-Vercoe E, Moore RA, Holt RA. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 2012;22(2):299–306.PubMedPubMedCentralCrossRefGoogle Scholar
  25. Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS. A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Periodontol. 2018;89(1 Suppl):S1-S8. Scholar
  26. Chaine A, Pitak-Arnnop P, Hivelin M, Dhanuthai K, Bertrand JC, Bertolus C. Postoperative complications of fibular free flaps in mandibular reconstruction: an analysis of 25 consecutive cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(4):488–95.PubMedCrossRefPubMedCentralGoogle Scholar
  27. Cornejo OE, Lefebure T, Bitar PD, Lang P, Richards VP, Eilertson K, Do T, Beighton D, Zeng L, Ahn SJ, Burne RA, Siepel A, Bustamante CD, Stanhope MJ. Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans. Mol Biol Evol. 2013;30(4):881–93.PubMedCrossRefPubMedCentralGoogle Scholar
  28. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol. 1995;49:711–45.PubMedCrossRefPubMedCentralGoogle Scholar
  29. Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010;8(7):481–90.PubMedCrossRefPubMedCentralGoogle Scholar
  30. Dashper SG, Seers CA, Tan KH, Reynolds EC. Virulence factors of the oral spirochete Treponema denticola. J Dent Res. 2011;90(6):691–703.PubMedPubMedCentralCrossRefGoogle Scholar
  31. Delanian S, Lefaix JL. The radiation-induced fibroatrophic process: therapeutic perspective via the antioxidant pathway. Radiother Oncol. 2004;73(2):119–31.PubMedCrossRefPubMedCentralGoogle Scholar
  32. Delanian S, Chatel C, Porcher R, Depondt J, Lefaix JL. Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial. Int J Radiat Oncol Biol Phys. 2011;80(3):832–9.PubMedCrossRefPubMedCentralGoogle Scholar
  33. Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG. The human oral microbiome. J Bacteriol. 2010;192(19):5002–17.PubMedPubMedCentralCrossRefGoogle Scholar
  34. Eke PI, Dye BA, Wei L, Thornton-Evans GO, Genco RJ, Douglass G, Page R, CDC Periodontal Disease Surveillance Workgroup: James Beck. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91(10):914–20.PubMedCrossRefPubMedCentralGoogle Scholar
  35. Ellen RP, Galimanas VB. Spirochetes at the forefront of periodontal infections. Periodontol 2000. 2005;38:13–32.PubMedCrossRefPubMedCentralGoogle Scholar
  36. Eyrich GK, Harder C, Sailer HF, Langenegger T, Bruder E, Michel BA. Primary chronic osteomyelitis associated with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO syndrome). J Oral Pathol Med. 1999;28(10):456–64.PubMedCrossRefPubMedCentralGoogle Scholar
  37. Fabricius L, Dahlen G, Holm SE, Moller AJ. Influence of combinations of oral bacteria on periapical tissues of monkeys. Scand J Dent Res. 1982a;90(3):200–6.PubMedPubMedCentralGoogle Scholar
  38. Fabricius L, Dahlen G, Ohman AE, Moller AJ. Predominant indigenous oral bacteria isolated from infected root canals after varied times of closure. Scand J Dent Res. 1982b;90(2):134–44.PubMedPubMedCentralGoogle Scholar
  39. Facklam R. What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev. 2002;15(4):613–30.PubMedPubMedCentralCrossRefGoogle Scholar
  40. Fejerskov O, Kidd EAM. Dental caries: the disease and its clinical management. Oxford: Blackwell Munksgaard; 2003.Google Scholar
  41. Flynn TR. Surgical management of orofacial infections. Atlas Oral Maxillofac Surg Clin North Am. 2000;8(1):77–100.PubMedCrossRefPubMedCentralGoogle Scholar
  42. Franklin C, Jones A. A survey of oral and maxillofacial pathology specimens submitted by general dental practitioners over a 30-year period. Br Dent J. 2006;200:447–50.PubMedCrossRefPubMedCentralGoogle Scholar
  43. Garberoglio R, Brannstrom M. Scanning electron microscopic investigation of human dentinal tubules. Arch Oral Biol. 1976;21(6):355–62.PubMedCrossRefPubMedCentralGoogle Scholar
  44. Goda A, Maruyama F, Michi Y, Nakagawa I, Harada K. Analysis of the factors affecting the formation of the microbiome associated with chronic osteomyelitis of the jaw. Clin Microbiol Infect. 2014;20(5):O309–17.PubMedCrossRefPubMedCentralGoogle Scholar
  45. Gui MJ, Dashper SG, Slakeski N, Chen YY, Reynolds EC. Spheres of influence: Porphyromonas gingivalis outer membrane vesicles. Mol Oral Microbiol. 2016;31(5):365–78.PubMedCrossRefPubMedCentralGoogle Scholar
  46. Ha WN, Kelloway E, Dost F, Farah CS. A retrospective analysis of oral and maxillofacial pathology in an Australian paediatric population. Aust Dent J. 2014;59(2):221–5.PubMedCrossRefPubMedCentralGoogle Scholar
  47. Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409–19.PubMedPubMedCentralCrossRefGoogle Scholar
  48. Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe. 2011;10(5):497–506.PubMedPubMedCentralCrossRefGoogle Scholar
  49. Har-El G, Aroesty JH, Shaha A, Lucente FE. Changing trends in deep neck abscess. A retrospective study of 110 patients. Oral Surg Oral Med Oral Pathol. 1994;77(5):446–50.PubMedCrossRefPubMedCentralGoogle Scholar
  50. Hargreaves K, Abbott PV. Drugs for pain management in dentistry. Aust Dent J. 2005;50(4 Suppl 2):S14–22.PubMedCrossRefPubMedCentralGoogle Scholar
  51. Heggie AA, Shand JM, Aldred MJ, Talacko AA. Juvenile mandibular chronic osteomyelitis: a distinct clinical entity. Int J Oral Maxillofac Surg. 2003;32(5):459–68.PubMedCrossRefPubMedCentralGoogle Scholar
  52. Hudson JW. Osteomyelitis of the jaws: a 50-year perspective. J Oral Maxillofac Surg. 1993;51(12):1294–301.PubMedCrossRefPubMedCentralGoogle Scholar
  53. Jacinto RC, Gomes BP, Shah HN, Ferraz CC, Zaia AA, Souza-Filho FJ. Incidence and antimicrobial susceptibility of Porphyromonas gingivalis isolated from mixed endodontic infections. Int Endod J. 2006;39(1):62–70.PubMedCrossRefPubMedCentralGoogle Scholar
  54. Jansson L, Ehnevid H, Lindskog S, Blomlof L. Development of periapical lesions. Swed Dent J. 1993;17(3):85–93.PubMedPubMedCentralGoogle Scholar
  55. Jones A, Franklin C. An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent. 2006;16:19–30.PubMedCrossRefPubMedCentralGoogle Scholar
  56. Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol. 1965;20:340–9.PubMedCrossRefPubMedCentralGoogle Scholar
  57. Kakehashi S, Stanley HR, Fitzgerald R. The exposed germ-free pulp: effects of topical corticosteroid medication and restoration. Oral Surg Oral Med Oral Pathol. 1969;27(1):60–7.PubMedCrossRefPubMedCentralGoogle Scholar
  58. Kapil V, Haydar SM, Pearl V, Lundberg JO, Weitzberg E, Ahluwalia A. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med. 2013;55:93–100.PubMedPubMedCentralCrossRefGoogle Scholar
  59. Kelloway E, Ha W, Dost F, Farah CS. A retrospective analysis of oral and maxillofacial pathology in an Australian adult population. Aust Dent J. 2014;59(2):215–20.PubMedCrossRefPubMedCentralGoogle Scholar
  60. Korzen BH, Krakow AA, Green DB. Pulpal and periapical tissue responses in conventional and monoinfected gnotobiotic rats. Oral Surg Oral Med Oral Pathol. 1974;37(5):783–802.PubMedCrossRefPubMedCentralGoogle Scholar
  61. Kwang S, Abbott PV. Bacterial contamination of the fitting surfaces of restorations in teeth with pulp and periapical disease: a scanning electron microscopy study. Aust Dent J. 2012;57(4):421–8.PubMedCrossRefPubMedCentralGoogle Scholar
  62. Landesberg R, Cozin M, Cremers S, Woo V, Kousteni S, Sinha S, Garrett-Sinha L, Raghavan S. Inhibition of oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg. 2008;66(5):839–47.PubMedPubMedCentralCrossRefGoogle Scholar
  63. Lederberg J, McCray A. ‘Ome sweet ‘omics – a genealogical treasury of words. Scientist. 2001;15:8–10.Google Scholar
  64. Lew DP, Waldvogel FA. Osteomyelitis. N Engl J Med. 1997;336(14):999–1007.PubMedCrossRefPubMedCentralGoogle Scholar
  65. Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and phenol-soluble modulins on the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun. 2016;84(9):2586–94.PubMedPubMedCentralCrossRefGoogle Scholar
  66. Lyons A, Ghazali N. Osteoradionecrosis of the jaws: current understanding of its pathophysiology and treatment. Br J Oral Maxillofac Surg. 2008;46(8):653–60.PubMedCrossRefPubMedCentralGoogle Scholar
  67. MacDonald-Jankowski DS. Idiopathic osteosclerosis in the jaws of Britons and of the Hong Kong Chinese: radiology and systematic review. Dentomaxillofac Radiol. 1999;28(6):357–63.PubMedCrossRefPubMedCentralGoogle Scholar
  68. Marsh PD. Microbiology of dental plaque biofilms and their role in oral health and caries. Dent Clin North Am. 2010;54(3):441–54.PubMedCrossRefPubMedCentralGoogle Scholar
  69. Marsh PD, Martin MV. Oral microbiology. Oxford: Wright Publishers; 1999.Google Scholar
  70. Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg. 1983;41(5):283–8.PubMedCrossRefPubMedCentralGoogle Scholar
  71. Marx RE, Johnson RP, Kline SN. Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc. 1985;111(1):49–54.PubMedCrossRefPubMedCentralGoogle Scholar
  72. Meyer I. Infectious diseases of the jaws. J Oral Surg. 1970;28(1):17–26.PubMedPubMedCentralGoogle Scholar
  73. Meyer MS, Joshipura K, Giovannucci E, Michaud DS. A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control. 2008;19(9):895–907.PubMedPubMedCentralCrossRefGoogle Scholar
  74. Miller W. The microorganisms of the human mouth. Philadelphia: SS White Manufacturing Company; 1890.Google Scholar
  75. Moller AJ. Microbiological examination of root canals and periapical tissues of human teeth. Methodological studies. Odontol Tidskr. 1966;74(5): Suppl:1–380.Google Scholar
  76. Moller AJ, Fabricius L, Dahlen G, Ohman AE, Heyden G. Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. Scand J Dent Res. 1981;89(6):475–84.PubMedPubMedCentralGoogle Scholar
  77. Montonen M, Lindqvist C. Diagnosis and treatment of diffuse sclerosing osteomyelitis of the jaws. Oral Maxillofac Surg Clin North Am. 2003;15(1):69–78.PubMedCrossRefPubMedCentralGoogle Scholar
  78. Morrish RB Jr, Chan E, Silverman S Jr, Meyer J, Fu KK, Greenspan D. Osteonecrosis in patients irradiated for head and neck carcinoma. Cancer. 1981;47(8):1980–3.PubMedCrossRefPubMedCentralGoogle Scholar
  79. Nair PN. Apical periodontitis: a dynamic encounter between root canal infection and host response. Periodontol 2000. 1997;13:121–48.PubMedCrossRefPubMedCentralGoogle Scholar
  80. Nair PNR, Pajarola G, Schroeder H. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81:93–102.CrossRefGoogle Scholar
  81. Nerwich A, Figdor D, Messer HH. pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide. J Endod. 1993;19(6):302–6.PubMedCrossRefPubMedCentralGoogle Scholar
  82. Ng HM, Kin LX, Dashper SG, Slakeski N, Butler CA, Reynolds EC. Bacterial interactions in pathogenic subgingival plaque. Microb Pathog. 2016;94:60–9.PubMedCrossRefPubMedCentralGoogle Scholar
  83. O’Dell K, Sinha U. Osteoradionecrosis. Oral Maxillofac Surg Clin North Am. 2011;23(3):455–64.PubMedCrossRefPubMedCentralGoogle Scholar
  84. Orth RK, O’Brien-Simpson NM, Dashper SG, Reynolds EC. Synergistic virulence of Porphyromonas gingivalis and Treponema denticola in a murine periodontitis model. Mol Oral Microbiol. 2011;26(4):229–40.PubMedCrossRefPubMedCentralGoogle Scholar
  85. Parhiscar A, Har-El G. Deep neck abscess: a retrospective review of 210 cases. Ann Otol Rhinol Laryngol. 2001;110(11):1051–4.PubMedCrossRefPubMedCentralGoogle Scholar
  86. Pineda C, Espinosa R, Pena A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy. Semin Plast Surg. 2009;23(2):80–9.PubMedPubMedCentralCrossRefGoogle Scholar
  87. Ricucci D, Loghin S, Siqueira JF Jr. Correlation between clinical and histologic pulp diagnoses. J Endod. 2014;40(12):1932–9.PubMedCrossRefPubMedCentralGoogle Scholar
  88. Ricucci D, Siqueira JF Jr, Loghin S, Berman LH. The cracked tooth: histopathologic and histobacteriologic aspects. J Endod. 2015;41(3):343–52.PubMedCrossRefPubMedCentralGoogle Scholar
  89. Ritchie SC, Wurtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin AP, Kangas AJ, Soininen P, Aalto K, Seppala I, Raitoharju E, Salmi M, Maksimow M, Mannisto S, Kahonen M, Juonala M, Ripatti S, Lehtimaki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M. The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection. Cell Syst. 2015;1(4):293–301.PubMedCrossRefPubMedCentralGoogle Scholar
  90. Robertson D, Smith AJ. The microbiology of the acute dental abscess. J Med Microbiol. 2009;58(Pt 2):155–62.PubMedCrossRefPubMedCentralGoogle Scholar
  91. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw – 2014 update. J Oral Maxillofac Surg. 2014;72(10):1938–56.PubMedCrossRefPubMedCentralGoogle Scholar
  92. Schwartz HC, Kagan AR. Osteoradionecrosis of the mandible: scientific basis for clinical staging. Am J Clin Oncol. 2002;25(2):168–71.PubMedCrossRefPubMedCentralGoogle Scholar
  93. Sedghizadeh PP, Kumar SK, Gorur A, Schaudinn C, Shuler CF, Costerton JW. Identification of microbial biofilms in osteonecrosis of the jaws secondary to bisphosphonate therapy. J Oral Maxillofac Surg. 2008;66(4):767–75.PubMedCrossRefPubMedCentralGoogle Scholar
  94. Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 2016;164(3):337–40.CrossRefGoogle Scholar
  95. Siqueira JF Jr, Rocas IN. Treponema species associated with abscesses of endodontic origin. Oral Microbiol Immunol. 2004;19(5):336–9.PubMedCrossRefPubMedCentralGoogle Scholar
  96. Siqueira JF Jr, Rocas IN. Microbiology and treatment of acute apical abscesses. Clin Microbiol Rev. 2013;26(2):255–73.PubMedPubMedCentralCrossRefGoogle Scholar
  97. Siquiera JF. Endodontic infections and the etiology of apical periodontitis – an overview. In: Siquiera JF, editor. Treatment of endodontic infections. Berlin: Quintessence Publishing; 2011. p. 7–16.Google Scholar
  98. Siquiera JF, Rôças IN. The invaders: bacterial biofilm communities and pathogenicity. In: Siquiera JF, editor. Treatment of endodontic infections. Berlin: Quintessence Publishing; 2011; p. 17–39.Google Scholar
  99. Skucaite N, Peciuliene V, Vitkauskiene A, Machiulskiene V. Susceptibility of endodontic pathogens to antibiotics in patients with symptomatic apical periodontitis. J Endod. 2010;36(10):1611–6.PubMedCrossRefPubMedCentralGoogle Scholar
  100. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25(2):134–44.PubMedCrossRefPubMedCentralGoogle Scholar
  101. Sonis ST, Watkins BA, Lyng GD, Lerman MA, Anderson KC. Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients. Oral Oncol. 2009;45(2):164–72.PubMedCrossRefPubMedCentralGoogle Scholar
  102. Spangberg LS. Infatuated by Enterococci. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(5):577–8.PubMedCrossRefPubMedCentralGoogle Scholar
  103. Stockham S, Stamford JE, Roberts CT, Fitzsimmons TR, Marchant C, Bartold PM, Zilm PS. Abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of Fusobacterium nucleatum sub-species to the murine placenta. PLoS One. 2015;10(3):e0120050.PubMedPubMedCentralCrossRefGoogle Scholar
  104. Suei Y, Taguchi A, Tanimoto K. Diffuse sclerosing osteomyelitis of the mandible: its characteristics and possible relationship to synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome. J Oral Maxillofac Surg. 1996;54(10):1194–9; discussion 1199–200.PubMedCrossRefPubMedCentralGoogle Scholar
  105. Suei Y, Taguchi A, Tanimoto K. Diagnosis and classification of mandibular osteomyelitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):207–14.PubMedCrossRefPubMedCentralGoogle Scholar
  106. Sundqvist G. Bacteriologic studies of necrotic dental pulps. PhD, University of Umea; 1976.Google Scholar
  107. Sundqvist G. Endodontic microbiology. In: Spångberg LSW, editor. Experimental endodontics. Boca Raton: CRC Press Inc; 1990. p. 131–53.Google Scholar
  108. Tan KH, Seers CA, Dashper SG, Mitchell HL, Pyke JS, Meuric V, Slakeski N, Cleal SM, Chambers JL, McConville MJ, Reynolds EC. Porphyromonas gingivalis and Treponema denticola exhibit metabolic symbioses. PLoS Pathog. 2014;10(3):e1003955.PubMedPubMedCentralCrossRefGoogle Scholar
  109. Therapeutic Guidelines. Post-treatment pain management. Therapeutic Guidelines Oral and Dental Version. 2012a;2:127–36.Google Scholar
  110. Therapeutic Guidelines. Acute odontogenic and salivary gland infections. Therapeutic Guidelines Oral and Dental Version. 2012b;2:61–70.Google Scholar
  111. Topazian RG, Goldberg MH, Hupp JR. Oral and maxillofacial infections. Philadelphia: W.B. Saunders; 2002.Google Scholar
  112. Underhill TE, Laine FJ, George J. Diagnostic imaging of maxillofacial infections. Oral Maxillofac Surg Clin North Am. 2003;15(1):39–49.PubMedCrossRefPubMedCentralGoogle Scholar
  113. Wood J, Bonjean K, Ruetz S, Bellahcene A, Devy L, Foidart JM, Castronovo V, Green JR. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther. 2002;302(3):1055–61.PubMedCrossRefPubMedCentralGoogle Scholar
  114. Yu C, Abbott PV. An overview of the dental pulp: its functions and responses to injury. Aust Dent J. 2007;52(1 Suppl):S4–16.PubMedCrossRefPubMedCentralGoogle Scholar
  115. Zijnge V, van Leeuwen MB, Degener JE, Abbas F, Thurnheer T, Gmur R, Harmsen HJ. Oral biofilm architecture on natural teeth. PLoS One. 2010;5(2):e9321.PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Stuart G. Dashper
    • 1
    Email author
  • Alf Nastri
    • 2
  • Paul V. Abbott
    • 3
  1. 1.Melbourne Dental School, Oral Health Cooperative Research CentreThe University of MelbourneMelbourneAustralia
  2. 2.Department of Maxillofacial Surgery, Royal Melbourne HospitalThe University of MelbourneMelbourneAustralia
  3. 3.UWA Dental School and Oral Health Centre of Western AustraliaThe University of Western AustraliaPerthAustralia

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