Oral Manifestations of Systemic Diseases and Their Treatments

  • Sue-Ching Yeoh
  • Hong Hua
  • Juan Fernando Yepes
  • Douglas E. PetersonEmail author
Reference work entry


The oral cavity can be affected by a wide range of systemic diseases, as well as systemic treatments for those diseases. Types of disorders include cardiovascular disease, gastrointestinal disease, endocrinopathies, hematologic disease, cancer, obesity, osteoporosis, and neurologic disease. Oral lesions caused by treatment of systemic diseases can also be clinically significant, including those caused by cancer therapies and as well as medications that result in salivary compromise.

This chapter will address the impact of key selected systemic diseases and/or systemic treatment on oral tissues. While the majority of such adverse effects on the oral cavity involve the oral mucosa, selected disorders can affect the dentition, periodontium, and/or salivary gland structures as well.


Oral cavity Oral manifestations Systemic disease Systemic treatment Treatment effects Dental considerations Medication-induced oral abnormalities 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Sue-Ching Yeoh
    • 1
    • 2
  • Hong Hua
    • 3
  • Juan Fernando Yepes
    • 4
  • Douglas E. Peterson
    • 5
    Email author
  1. 1.Sydney Oral MedicineBaulkham HillsAustralia
  2. 2.Chris O’Brien LifehouseCamperdownAustralia
  3. 3.Department of Oral MedicinePeking University, School of StomatologyBeijingChina
  4. 4.Department of Pediatric DentistryJames Whitcomb Riley Hospital for Children, Indiana University School of DentistryIndianapolisUSA
  5. 5.Department of Oral Health and Diagnostic Sciences, School of Dental MedicineNeag Comprehensive Cancer Center, UConn HealthFarmingtonUSA

Section editors and affiliations

  • Camile S. Farah
    • 1
  1. 1.UWA Dental SchoolUniversity of Western AustraliaPerthAustralia

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