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Soft and Hard Tissue Operative Investigations in the Diagnosis and Treatment of Oral Disease

  • Marieke T. BrandsEmail author
  • Ivan Alajbeg
  • Peter A. Brennan
  • Camile S. Farah
Reference work entry

Abstract

Specialists in oral medicine frequently carry out interventional procedures in the oral cavity. These procedures are usually for diagnostic purposes, but in many instances oral medicine specialists also undertake minor oral surgical procedures as definitive treatment for either mucosal, soft tissue, or hard tissue lesions. This chapter provides an overview of the most common diagnostic procedures used in the oral cavity including soft and hard tissue biopsies. Ancillary techniques such as fine needle aspiration biopsy, the use of fluorescence, toluidine blue, cryotherapy, and lasers are also discussed. Biopsy technique, indications, and pitfalls in addition to medicolegal considerations are covered.

Keywords

Biopsy Incisional Excisional Fine needle aspiration Cytology Malignancy Oral lesions Diagnostic procedures Surgery Laser Cryotherapy Suturing 

References

  1. Alkan A, Etoz OA. A new anatomical landmark to simplify temporomandibular joint arthrocentesis. Br J Oral Maxillofac Surg. 2010;48(4):310–1.PubMedCrossRefGoogle Scholar
  2. Baghani Z, Kadkhodazadeh M. Periodontal dressing: a review article. J Dent Res Dent Clin Dent Prospects. 2013;7(4):183–91.PubMedPubMedCentralGoogle Scholar
  3. Balasubramaniam AM, Sriraman R, Sindhuja P, Mohideen K, Parameswar RA, Muhamed Haris KT. Autofluorescence based diagnostic techniques for oral cancer. J Pharm Bioallied Sci. 2015;7(Suppl 2):S374–7.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Bankfalvi A, Piffko J. Prognostic and predictive factors in oral cancer: the role of the invasive tumour front. J Oral Pathol Med. 2000;29(7):291–8.PubMedCrossRefGoogle Scholar
  5. Baurmash HD. Mucoceles and ranulas. J Oral Maxillofac Surg. 2003;61(3):369–78.PubMedCrossRefGoogle Scholar
  6. Baust JG, Gage AA. The molecular basis of cryosurgery. BJU Int. 2005;95(9):1187–91.PubMedCrossRefGoogle Scholar
  7. Belcher JM. A perspective on periodontal microsurgery. Int J Periodontics Restorative Dent. 2001;21(2):191–6.PubMedGoogle Scholar
  8. Bhatia N, Matias MA, Farah CS. Assessment of a decision making protocol to improve the efficacy of VELscope™ in general dental practice: a prospective evaluation. Oral Oncol. 2014;50(10):1012–9PubMedCrossRefGoogle Scholar
  9. Bornstein MM, Winzap-Kalin C, Cochran DL, Buser D. The CO2 laser for excisional biopsies of oral lesions: a case series study. Int J Periodontics Restorative Dent. 2005;25(3):221–9.PubMedGoogle Scholar
  10. Bouchard C, Goulet JP, El-Ouazzani M, Turgeon AF. Temporomandibular lavage versus nonsurgical treatments for temporomandibular disorders: a systematic review and meta-analysis. J Oral Maxillofac Surg. 2017;75(7):1352–62.PubMedCrossRefGoogle Scholar
  11. Brands WG. The standard for the duty to inform patients about risks: from the responsible dentist to the reasonable patient. Br Dent J. 2006;201(4):207–10.PubMedCrossRefGoogle Scholar
  12. Brennan PA, Brands MT, Caldwell L, Fonseca FP, Turley N, Foley S, Rahimi S. Surgical specimen handover from the operating theatre to laboratory-can we improve patient safety by learning from aviation and other high-risk organisations? J Oral Pathol Med. 2017;47:117–20.PubMedCrossRefGoogle Scholar
  13. Buckmiller LM, Richter GT, Suen JY. Diagnosis and management of hemangiomas and vascular malformations of the head and neck. Oral Dis. 2010;16(5):405–18.PubMedCrossRefGoogle Scholar
  14. Cai Y, Wang R, Yang SF, Zhao YF, Zhao JH. Sclerotherapy for the mucoceles of the anterior lingual salivary glands with pingyangmycin. Oral Dis. 2014;20(5):473–6.PubMedCrossRefGoogle Scholar
  15. Chen S, Forman M, Sadow PM, August M. The diagnostic accuracy of incisional biopsy in the oral cavity. J Oral Maxillofac Surg. 2016;74(5):959–64.PubMedCrossRefGoogle Scholar
  16. Costa JR, Torriani MA, Hosni ES, D'Avila OP, de Figueiredo PJ. Sclerotherapy for vascular malformations in the oral and maxillofacial region: treatment and follow-up of 66 lesions. J Oral Maxillofac Surg. 2011;69(6):e88–92.PubMedCrossRefGoogle Scholar
  17. De Veld DC, Witjes MJ, Sterenborg HJ, Roodenburg JL. The status of in vivo autofluorescence spectroscopy and imaging for oral oncology. Oral Oncol. 2005;41(2):117–31.PubMedCrossRefGoogle Scholar
  18. Delli K, Spijkervet FK, Vissink A. Salivary gland diseases: infections, sialolithiasis and mucoceles. Monogr Oral Sci. 2014;24:135–48.PubMedCrossRefGoogle Scholar
  19. Di Palma S, Simpson R, Skalova A, Leivo I. Major and minor salivary glands. In: Slootweg P, Cardesa A, editors. Pathology of the head and neck. Berlin/Heidelberg: Springer; 2006. p. 132–70.Google Scholar
  20. Dieterich-Miller CA, Safford PL. Psychosocial development of children with hemangiomas: home, school, health care collaboration. Child Health Care. 1992;21(2):84–9.PubMedCrossRefGoogle Scholar
  21. Dilsiz A, Aydin T, Gursan N. Capillary hemangioma as a rare benign tumor of the oral cavity: a case report. Cases J. 2009;2:8622.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Dost F, Do L, Farah CS. Lesion evaluation, screening and identification of oral neoplasia study: an assessment of high-risk Australian populations. Community Dent Oral Epidemiol. 2016;44(1):64–75.PubMedCrossRefGoogle Scholar
  23. Dost F, Le Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(6):725–33.PubMedCrossRefGoogle Scholar
  24. Epstein JB, Oakley C, Millner A, Emerton S, van der Meij E, Le N. The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;83(5):537–47.PubMedCrossRefGoogle Scholar
  25. Epstein JB, Scully C, Spinelli J. Toluidine blue and Lugol's iodine application in the assessment of oral malignant disease and lesions at risk of malignancy. J Oral Pathol Med. 1992;21(4):160–3.PubMedCrossRefGoogle Scholar
  26. Farah CS. Narrow band imaging-guided resection of oral cavity cancer decreases local recurrence and increases survival. Oral Dis. 2018;24(1–2):89–97.PubMedCrossRefGoogle Scholar
  27. Farah CS, Dalley AJ, Nguyen P, Batstone M, Kordbacheh F, Perry-Keene J, Fielding D. Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: a prospective gene expression profiling study. Head Neck. 2016;38(6):832–9.PubMedCrossRefGoogle Scholar
  28. Farah CS, Fox SA, Dalley AJ. Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of narrow band imaging guided resection. Sci Rep. 2018;8(1):823.PubMedPubMedCentralCrossRefGoogle Scholar
  29. Farah CS, Kordbacheh F, John K, Bennett N, Fox SA. Molecular classification of autofluorescence excision margins in oral potentially malignant disorders. Oral Dis. 2018;24(5):732–740.PubMedCrossRefGoogle Scholar
  30. Farah CS, McIntosh L, Georgiou A, McCullough MJ. Efficacy of tissue autofluorescence imaging (VELScope) in the visualization of oral mucosal lesions. Head Neck. 2012;34(6):856–62.PubMedCrossRefGoogle Scholar
  31. Farah CS, Savage NW. Cryotherapy for treatment of oral lesions. Aust Dent J. 2006;51(1):2–5.PubMedCrossRefGoogle Scholar
  32. Fischer EG. To fix or not to fix: Michel's is the solution. Int J Surg Pathol. 2006;14(1):108.PubMedCrossRefGoogle Scholar
  33. Forman MS, Chuang SK, August M. The accuracy of clinical diagnosis of oral lesions and patient-specific risk factors that affect diagnosis. J Oral Maxillofac Surg. 2015;73(10):1932–7.PubMedCrossRefGoogle Scholar
  34. Fuller C, Camilon R, Nguyen S, Jennings J, Day T, Gillespie MB. Adjunctive diagnostic techniques for oral lesions of unknown malignant potential: systematic review with meta-analysis. Head Neck. 2015;37(5):755–62.PubMedCrossRefGoogle Scholar
  35. Gage AA, Baust J. Mechanisms of tissue injury in cryosurgery. Cryobiology. 1998;37(3):171–86.PubMedCrossRefGoogle Scholar
  36. Gandolfo S, Pentenero M, Broccoletti R, Pagano M, Carrozzo M, Scully C. Toluidine blue uptake in potentially malignant oral lesions in vivo: clinical and histological assessment. Oral Oncol. 2006;42(1):89–95.PubMedCrossRefGoogle Scholar
  37. Garg A, Tripathi A, Chowdhry S, Sharma A, Biswas G. Cryosurgery: painless and fearless management of mucocele in young patient. J Clin Diagn Res. 2014;8(8):ZD04–6.PubMedPubMedCentralGoogle Scholar
  38. Guarda-Nardini L, Manfredini D, Ferronato G. Arthrocentesis of the temporomandibular joint: a proposal for a single-needle technique. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(4):483–6.PubMedCrossRefGoogle Scholar
  39. Gupta A, Singh M, Ibrahim R, Mehrotra R. Utility of toluidine blue staining and brush biopsy in precancerous and cancerous oral lesions. Acta Cytol. 2007;51(5):788–94.PubMedCrossRefGoogle Scholar
  40. Hedge MC, Kamath PM, Shreedharan S, Dannana NK, Raju RM. Supravital staining: It's role in detecting early malignancies. Indian J Otolaryngol Head Neck Surg. 2006;58(1):31–4.PubMedPubMedCentralGoogle Scholar
  41. Horbach SE, Rigter IM, Smitt JH, Reekers JA, Spuls PI, van der Horst CM. Intralesional bleomycin injections for vascular malformations: a systematic review and meta-analysis. Plast Reconstr Surg. 2016;137(1):244–56.PubMedCrossRefGoogle Scholar
  42. Iro H, Zenk J, Escudier MP, Nahlieli O, Capaccio P, Katz P, Brown J, McGurk M. Outcome of minimally invasive management of salivary calculi in 4,691 patients. Laryngoscope. 2009;119(2):263–8.PubMedCrossRefGoogle Scholar
  43. James K, Toner M, Stassen LF. Performing mucosal tissue biopsies in general dental practice. J Ir Dent Assoc. 2011;57(4):203–8.PubMedGoogle Scholar
  44. Janssen AJ. Informing patients about small risks: a comparative approach. Eur J Health Law. 2006;13(2):159–72.PubMedCrossRefGoogle Scholar
  45. Kawczyk-Krupka A, Waskowska J, Raczkowska-Siostrzonek A, Kosciarz-Grzesiok A, Kwiatek S, Straszak D, Latos W, Koszowski R, Sieron A. Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia. Photodiagn Photodyn Ther. 2012;9(2):148–55.CrossRefGoogle Scholar
  46. Kocer U, Ozdemir R, Tiftikcioglu YO, Karaaslan O. Soft tissue hemangioma formation within a previously excised intraosseous hemangioma site. J Craniofac Surg. 2004;15(1):82–3.PubMedCrossRefGoogle Scholar
  47. Kondori I, Mottin RW, Laskin DM. Accuracy of dentists in the clinical diagnosis of oral lesions. Quintessence Int. 2011;42(7):575–7.PubMedGoogle Scholar
  48. Kujan O, Pemberton MN, Schwarz M, Sloan P. Evaluation of an innovative oral brush for potential applications using liquid based cytology. J Oral Sci. 2018;60(1):45–50.PubMedCrossRefGoogle Scholar
  49. Kumaraswamy KL, Vidhya M, Rao PK, Mukunda A. Oral biopsy: oral pathologist’s perspective. J Cancer Res Ther. 2012;8(2):192–8.PubMedCrossRefGoogle Scholar
  50. Levy O, Topilski M, Brazowski E, Yaron M, Tishler M. Sarcoidosis presenting as primary Sjogren’s syndrome. Isr Med Assoc J. 2001;3(1):63–4.PubMedGoogle Scholar
  51. Liboon J, Funkhouser W, Terris DJ. A comparison of mucosal incisions made by scalpel, CO2 laser, electrocautery, and constant-voltage electrocautery. Otolaryngol Head Neck Surg. 1997;116(3):379–85.PubMedCrossRefGoogle Scholar
  52. Lingen MW, Kalmar JR, Karrison T, Speight PM. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol. 2008;44(1):10–22.PubMedCrossRefGoogle Scholar
  53. Lynch DP, Morris LF. The oral mucosal punch biopsy: indications and technique. J Am Dent Assoc. 1990;121(1):145–9.PubMedCrossRefGoogle Scholar
  54. Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C. Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions. Cochrane Database Syst Rev. 2015;5:CD010276.Google Scholar
  55. Mashberg A. Reevaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing prospective study of oral cancer III. Cancer. 1980;46(4):758–63.PubMedCrossRefGoogle Scholar
  56. McGurk M, Escudier MP, Brown JE. Modern management of salivary calculi. Br J Surg. 2005;92(1):107–12.PubMedCrossRefGoogle Scholar
  57. McIntosh L, McCullough MJ, Farah CS. The assessment of diffused light illumination and acetic acid rinse (Microlux/DL) in the visualisation of oral mucosal lesions. Oral Oncol. 2009;45(12):e227–31.PubMedCrossRefGoogle Scholar
  58. Mehrotra R, Hullmann M, Smeets R, Reichert TE, Driemel O. Oral cytology revisited. J Oral Pathol Med. 2009;38(2):161–6.PubMedCrossRefGoogle Scholar
  59. Meleti M, Vescovi P, Mooi WJ, van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105(5):606–16.PubMedCrossRefGoogle Scholar
  60. Melrose RJ, Handlers JP, Kerpel S, Summerlin DJ, Tomich CJ, American Academy of Oral and Maxillofacial Pathology. The use of biopsy in dental practice. The position of the American Academy of oral and maxillofacial pathology. Gen Dent. 2007;55(5):457–61; quiz 462–453, 488PubMedGoogle Scholar
  61. Mishra M, Singh G, Gaur A, Tandon S, Singh A. Role of sclerotherapy in management of vascular malformation in the maxillofacial region: our experience. Natl J Maxillofac Surg. 2017;8(1):64–9.PubMedPubMedCentralCrossRefGoogle Scholar
  62. Monje-Gil F, Nitzan D, Gonzalez-Garcia R. Temporomandibular joint arthrocentesis. Review of the literature. Med Oral Patol Oral Cir Bucal. 2012;17(4):e575–81.PubMedPubMedCentralCrossRefGoogle Scholar
  63. Moralis A, Kunkel M, Reichert TE, Kosmehl H, Driemel O. Identification of a recurrent oral squamous cell carcinoma by brush cytology. Mund Kiefer Gesichtschir. 2007;11(6):355–8.PubMedCrossRefGoogle Scholar
  64. Moule I, Parsons PA, Irvine GH. Avoiding artefacts in oral biopsies: the punch biopsy versus the incisional biopsy. Br J Oral Maxillofac Surg. 1995;33(4):244–7.PubMedCrossRefGoogle Scholar
  65. Neeli AS, Umarani M, Kotrashetti SM, Baliga S. Arthrocentesis for the treatment of internal derangement of the temporomandibular joint. J Maxillofac Oral Surg. 2010;9(4):350–4.PubMedCrossRefGoogle Scholar
  66. Nelson WJ. Guide to suturing. J Oral Maxillofac Surg. 2015;73(8 Suppl):1–62.PubMedCrossRefGoogle Scholar
  67. Odeyinde SO, Kangesu L, Badran M. Sclerotherapy for vascular malformations: complications and a review of techniques to avoid them. J Plast Reconstr Aesthet Surg. 2013;66(2):215–23.PubMedCrossRefGoogle Scholar
  68. Oliver RJ, Sloan P, Pemberton MN. Oral biopsies: methods and applications. Br Dent J. 2004;196(6):329–33; quiz 362PubMedCrossRefGoogle Scholar
  69. Patel AN, Simpson RC, Cohen SN. In a patient with an immunobullous disorder, is transportation of the skin biopsy in normal saline adequate for direct immunofluorescence analysis? A critically appraised topic. Br J Dermatol. 2013;169(1):6–10.PubMedCrossRefGoogle Scholar
  70. Patel KJ, De Silva HL, Tong DC, Love RM. Concordance between clinical and histopathologic diagnoses of oral mucosal lesions. J Oral Maxillofac Surg. 2011;69(1):125–33.PubMedCrossRefGoogle Scholar
  71. Pitiyage G, Tilakaratne WM, Tavassoli M, Warnakulasuriya S. Molecular markers in oral epithelial dysplasia: review. J Oral Pathol Med. 2009;38(10):737–52.PubMedCrossRefGoogle Scholar
  72. Pogrel MA, McCracken KJ, Daniels TE. Histologic evaluation of the width of soft tissue necrosis adjacent to carbon dioxide laser incisions. Oral Surg Oral Med Oral Pathol. 1990;70(5):564–8.PubMedCrossRefGoogle Scholar
  73. Rashid A, Warnakulasuriya S. The use of light-based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review. J Oral Pathol Med. 2015;44(5):307–28.PubMedCrossRefGoogle Scholar
  74. Reibel J. Prognosis of oral pre-malignant lesions: significance of clinical, histopathological, and molecular biological characteristics. Crit Rev Oral Biol Med. 2003;14(1):47–62.PubMedCrossRefGoogle Scholar
  75. Rezende KM, Moraes Pde C, Oliveira LB, Thomaz LA, Junqueira JL, Bonecker M. Cryosurgery as an effective alternative for treatment of oral lesions in children. Braz Dent J. 2014;25(4):352–6.PubMedCrossRefGoogle Scholar
  76. Roodenburg JL, Witjes MJ, de Veld DC, Tan IB, Nauta JM. Lasers in dentistry 8. Use of lasers in oral and maxillofacial surgery. Ned Tijdschr Tandheelkd. 2002;109(12):470–4.PubMedGoogle Scholar
  77. Sadiq Z, Moss C, Stocker J. Staining from silver nitrate. Br Dent J. 2002;193(6):299.PubMedCrossRefGoogle Scholar
  78. Sako K, Marchetta FC, Hayes RL. Cryotherapy of intraoral leukoplakia. Am J Surg. 1972;124(4):482–4.PubMedCrossRefGoogle Scholar
  79. Saruhanoglu A, Atikler M, Ergun S, Ofluoglu D, Tanyeri H. Comparison of two different labial salivary gland biopsy incision techniques: a randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2013;18(6):e851–5.PubMedCrossRefGoogle Scholar
  80. Schoinohoriti OK, Chrysomali E, Iatrou I, Perrea D. Evaluation of lateral thermal damage and reepithelialization of incisional wounds created by CO2-laser, monopolar electrosurgery, and radiosurgery: a pilot study on porcine oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113(6):741–7.PubMedCrossRefGoogle Scholar
  81. Sciubba JJ. Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group. J Am Dent Assoc. 1999;130(10):1445–57.PubMedCrossRefGoogle Scholar
  82. Sekine J, Nakatani E, Hideshima K, Iwahashi T, Sasaki H. Diagnostic accuracy of oral cancer cytology in a pilot study. Diagn Pathol. 2017;12(1):27.PubMedPubMedCentralCrossRefGoogle Scholar
  83. Seoane J, Varela-Centelles P, Ramirez JR, Romero MA, De La Cruz A. Artefacts produced by suture traction during incisional biopsy of oral lesions. Clin Otolaryngol Allied Sci. 2002;27(6):549–53.PubMedCrossRefGoogle Scholar
  84. Seoane J, Varela-Centelles PI, Ramirez JR, Cameselle-Teijeiro J, Romero MA. Artefacts in oral incisional biopsies in general dental practice: a pathology audit. Oral Dis. 2004;10(2):113–7.PubMedCrossRefGoogle Scholar
  85. Shokrollahi K, Raymond E, Murison MSC. Lasers: principles and surgical applications. J Surg. 2004;2(2):28–34.CrossRefGoogle Scholar
  86. Silverman EB, Read RW, Boyle CR, Cooper R, Miller WW, McLaughlin RM. Histologic comparison of canine skin biopsies collected using monopolar electrosurgery, CO2 laser, radiowave radiosurgery, skin biopsy punch, and scalpel. Vet Surg. 2007;36(1):50–6.PubMedCrossRefGoogle Scholar
  87. Silverman RA. Hemangiomas and vascular malformations. Pediatr Clin N Am. 1991;38(4):811–34.CrossRefGoogle Scholar
  88. Singh Nanda KD, Mehta A, Nanda J. Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med. 2012;41(1):106–12.PubMedCrossRefGoogle Scholar
  89. Sinha R, Sarkar S, Khaitan T, Kabiraj A, Maji A. Nonsurgical Management of Oral Mucocele by Intralesional Corticosteroid Therapy. Int J Dent. 2016;2016:2896748.PubMedPubMedCentralCrossRefGoogle Scholar
  90. Sinha UK, Gallagher LA. Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope. 2003;113(2):228–36.PubMedCrossRefGoogle Scholar
  91. Sperandio M, Klinikowski MF, Brown AL, Shirlaw PJ, Challacombe SJ, Morgan PR, Warnakulasuriya S, Odell EW. Image-based DNA ploidy analysis aids prediction of malignant transformation in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121(6):643–50.PubMedCrossRefGoogle Scholar
  92. Sridharan G, Shankar AA. Toluidine blue: a review of its chemistry and clinical utility. J Oral Maxillofac Pathol. 2012;16(2):251–5.PubMedPubMedCentralCrossRefGoogle Scholar
  93. Stanley MW. Selected problems in fine needle aspiration of head and neck masses. Mod Pathol. 2002;15(3):342–50.PubMedCrossRefGoogle Scholar
  94. Suter VG, Altermatt HJ, Bornstein MM. A randomized controlled clinical and histopathological trial comparing excisional biopsies of oral fibrous hyperplasias using CO2 and Er:YAG laser. Lasers Med Sci. 2017;32(3):573–81.PubMedCrossRefGoogle Scholar
  95. Suter VG, Altermatt HJ, Dietrich T, Reichart PA, Bornstein MM. Does a pulsed mode offer advantages over a continuous wave mode for excisional biopsies performed using a carbon dioxide laser? J Oral Maxillofac Surg. 2012;70(8):1781–8.PubMedCrossRefGoogle Scholar
  96. Tozoglu S, Al-Belasy FA, Dolwick MF. A review of techniques of lysis and lavage of the TMJ. Br J Oral Maxillofac Surg. 2011;49(4):302–9.PubMedCrossRefGoogle Scholar
  97. Tuncer I, Ozcakir-Tomruk C, Sencift K, Cologlu S. Comparison of conventional surgery and CO2 laser on intraoral soft tissue pathologies and evaluation of the collateral thermal damage. Photomed Laser Surg. 2010;28(1):75–9.PubMedCrossRefGoogle Scholar
  98. van der Hem PS, Nauta JM, van der Wal JE, Roodenburg JL. The results of CO2 laser surgery in patients with oral leukoplakia: a 25 year follow up. Oral Oncol. 2005;41(1):31–7.PubMedCrossRefGoogle Scholar
  99. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol. 2010;46(6):423–5.PubMedCrossRefGoogle Scholar
  100. van der Waal RI, Schulten EA, van der Meij EH, van de Scheur MR, Starink TM, van der Waal I. Cheilitis granulomatosa: overview of 13 patients with long-term follow-up – results of management. Int J Dermatol. 2002;41(4):225–9.PubMedCrossRefGoogle Scholar
  101. Vesnaver A, Dovsak DA. Treatment of vascular lesions in the head and neck using Nd:YAG laser. J Craniomaxillofac Surg. 2006;34(1):17–24.PubMedCrossRefGoogle Scholar
  102. Vu A, Farah CS. Narrow band imaging: clinical applications in oral and oropharyngeal cancer. Oral Dis. 2016;22(5):383–90.PubMedCrossRefGoogle Scholar
  103. Vu AN, Farah CS. Efficacy of narrow band imaging for detection and surveillance of potentially malignant and malignant lesions in the oral cavity and oropharynx: a systematic review. Oral Oncol. 2014;50(5):413–20.PubMedCrossRefGoogle Scholar
  104. Vu AN, Matias M, Farah CS. Diagnostic accuracy of Narrow Band Imaging for the detection of oral potentially malignant disorders. Oral Dis. 2015;21(4):519–29.PubMedCrossRefGoogle Scholar
  105. Yeh CJ. Simple cryosurgical treatment for oral lesions. Int J Oral Maxillofac Surg. 2000;29(3):212–6.PubMedCrossRefGoogle Scholar
  106. Yu CH, Lin HP, Cheng SJ, Sun A, Chen HM. Cryotherapy for oral precancers and cancers. J Formos Med Assoc. 2014;113(5):272–7.PubMedCrossRefGoogle Scholar
  107. Zhang J, Li HB, Zhou SY, Chen KS, Niu CQ, Tan XY, Jiang YZ, Lin QQ. Comparison between absolute ethanol and bleomycin for the treatment of venous malformation in children. Exp Ther Med. 2013;6(2):305–9.PubMedPubMedCentralCrossRefGoogle Scholar
  108. Zheng JW, Yang XJ, Wang YA, He Y, Ye WM, Zhang ZY. Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: an evaluation of 297 consecutive patients. Oral Oncol. 2009;45(10):872–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Marieke T. Brands
    • 1
    Email author
  • Ivan Alajbeg
    • 2
  • Peter A. Brennan
    • 1
  • Camile S. Farah
    • 3
  1. 1.Department of Oral and Maxillofacial SurgeryQueen Alexandra HospitalPortsmouthUK
  2. 2.University of Zagreb School of Dental MedicineZagrebCroatia
  3. 3.UWA Dental School and Oral Health Centre of Western AustraliaFaculty of Health and Medical Sciences, University of Western AustraliaPerthAustralia

Section editors and affiliations

  • Michael J. McCullough
    • 1
  1. 1.Oral Anatomy, Medicine, and Surgery Section, Melbourne, Dental School, Faculty of Medicine, Dentistry & Health, SciencesThe University of MelbourneCarltonAustralia

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