Somatic Mutations and Genome
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Somatic mutations are mutations occurring in somatic cells of a multicellular organism. They can be passed to daughter cells after cell division but cannot be inherited in the progenies of the organism, in contrast to germline mutations.
DNA mutations can occur in the germline or somatic cells when DNA damage is not repaired or repaired with mistakes. Germline mutations are easily recognized and their frequencies can be calculated. Mutations in the germline pass to a child who carries the mutation in every cell. Somatic cell mutations, on the other hand, are difficult to detect because they are carried by individual cells (Dou et al. 2018). Chromosome aberrations could be detected with low-resolution, low-throughput technologies, such as fluorescence in situ hybridization (FISH). Most somatic mutations are, however, small lesions which are difficult to detect. Recent advancement of...
- Zhang L, Dong X, Lee M et al (2019) Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan. bioRxiv 535906. https://doi.org/10.1101/535906