Genetic Control of Aging
The genetic control of aging is the contribution of genetic variation to lifespan and longevity.
The present day lifespan of individuals is higher than it has ever been before. Concomitant with the increase in global lifespan is the increase in the burden of late-life diseases, since advanced age is the greatest common risk factor for most chronic debilitating diseases.
Heritability studies have convincingly demonstrated that aging is subject to genetic control, with additive effects comprising a small fraction of total lifespan heritability. This opens the door for genetic studies of aging, which aim to understand the pathways underlying this process and, using that knowledge, to develop strategies for prevention, intervention, and therapy. Thus far, these studies have shown an inverse effect of multiple...
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