Encyclopedia of Gerontology and Population Aging

Living Edition
| Editors: Danan Gu, Matthew E. Dupre

Reproductive Cell-Cycle Theory of Aging

  • Marta Silva
  • Wenhua ZhengEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-69892-2_435-1



The reproductive-cell cycle theory defines aging as any change occurring in an organism throughout a lifetime under the control of the hypothalamic-pituitary-gonadal (HPG) axis reproduction hormones (Bowen and Atwood 2004; Atwood and Bowen 2011).


The reproductive-cell cycle theory of aging proposes that the reproduction hormones control aging in an antagonistic pleiotropic manner by governing growth and development in early life stages and driving to senescence in late stages. The major changes occurring throughout a lifetime comprise cell growth, differentiation, and apoptosis. Accordingly, the regulation of these processes, by HPG hormone signaling, allows the control of the aging process (Bowen and Atwood 2004; Atwood and Bowen 2011).

Key Research Findings

According to the reproductive-cell cycle theory of aging (See “Aging theories”) , a suitable HPG hormone signaling is fundamental to normal growth and development from...

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Authors and Affiliations

  1. 1.Faculty of Health Sciences, Centre of Reproduction, Development and Aging, Institute of Translational MedicineUniversity of MacauMacau SARChina

Section editors and affiliations

  • Wenhua Zheng
    • 1
  1. 1.Faculty of Health SciencesUniversity of MacauTaipa, MacauChina