Prick and Intracutaneous Testing and IgE Testing

  • Vera MahlerEmail author
Reference work entry


Immediate-type allergies are frequent in specific occupational environments.

Most important is to consider the possibility of occupational factors in allergic diseases.

Depending on the substance, immunological and nonimmunological mechanisms may be relevant for symptom elicitation.

According to European Directive 2001/83/EC in vivo test allergens are medicinal products, whereas test allergens for in vitro use are medical devices following respective regulations. Standardized test preparations for in vivo and/or in vitro testing for specific IgE to occupational allergen sources are rare. False-negative as well as false-positive test reactions may occur with current test methods for detection of specific IgE to occupational allergen sources. Compared to ubiquitous inhalant allergens (cut-off ≥ 3.00 mm wheal diameter), for occupational allergens, a different cut-off (wheal diameter ≥ 1.5 mm) applies.

Skin prick testing, intracutaneous testing and in vitro investigation of specific IgE constitute one component in a stepwise assessment for diagnosis of allergen-induced occupational diseases.

High- and low-molecular-weight allergens have to be considered as occupational allergen sources in specific work environments.


Specific igE Skin prick test Intradermal test Intracutaneous test Diagnostic algorithm Type I Allergy Contact urticaria Occupational/work-related thinitis/asthma Molecular allergy diagnostics Component-resolved diagnosis Exposures 


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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Division of AllergologyPaul-Ehrlich-InstitutLangenGermany
  2. 2.Medical FacultyFriedrich-Alexander-University Erlangen-NurembergErlangenGermany

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