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Some Other Metals

  • Anneli JulanderEmail author
  • Carola Lidén
Reference work entry

Abstract

Several metals such as aluminum, beryllium, copper, gold, mercury, palladium, platinum, and rhodium are able to cause skin sensitization, allergic contact dermatitis, and other skin effects.

Pure metals, alloys, and metal compounds have different abilities to cause sensitization and dermatitis. Furthermore many of the metals and their compounds are also known to cause systemic toxicity and cancer.

The clinical relevance of patch test reactivity to some of these metals is not known. The prevalence of contact allergy in occupationally exposed groups, consumers, or dermatitis patients is also not known for all of these metals. However, some of the precious metals are increasingly used in dental alloys and jewelry and may pose new health risks.

Keywords

Alloys Aluminum Arsenic Beryllium Cadmium Copper Dentistry Granuloma Jewelry Metal compounds Mercury Metal salts Occupational exposure Palladium Platinum Rhodium Silver Systemic toxicity Skin effects Tin 

References

  1. Baker DB, Gann PH, Brooks SM, Gallagher J, Bernstein IL (1990) Cross-sectional study of platinum salts sensitization among precious metals refinery workers. Am J Ind Med 18(6):653–664PubMedCrossRefGoogle Scholar
  2. Basketter DA, Gerberick GF, Kimber I, Loveless SE (1996) The local lymph node assay: a viable alternative to currently accepted skin sensitization tests. Food Chem Toxicol 34(10):985–997PubMedCrossRefGoogle Scholar
  3. Basketter DA, Lea LJ, Cooper KJ, Ryan CA, Gerberick GF, Dearman RJ, Kimber I (1999) Identification of metal allergens in the local lymph node assay. Am J Contact Dermat 10(4):207–212PubMedGoogle Scholar
  4. Bergfors E, Trollfors B (2013) Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminium-adsorbed vaccines-prognosis and outcome after booster vaccination. Eur J Pediatr 172(2):171–177PubMedCrossRefGoogle Scholar
  5. Berlin JM, Taylor JS, Sigel JE, Bergfeld WF, Dweik RA (2003) Beryllium dermatitis. J Am Acad Dermatol 49(5):939–941PubMedCrossRefPubMedCentralGoogle Scholar
  6. Böhler-Sommeregger K, Lindemayr H (1986) Contact sensitivity to aluminium. Contact Dermatitis 15(5):278–281PubMedCrossRefPubMedCentralGoogle Scholar
  7. Burrows D, Adams RM, Flint GN (1999) Metals. In: Adams RM (ed) Occupational skin disease. W.B. Saunders Company, Philadelphia, pp 395–433Google Scholar
  8. Cristaudo A, Sera F, Severino V, De Rocco M, Di Lella E, Picardo M (2005) Occupational hypersensitivity to metal salts, including platinum, in the secondary industry. Allergy 60(2):159–164CrossRefGoogle Scholar
  9. Curtis GH (1951) Cutaneous hypersensitivity due to beryllium; a study of thirteen cases. AMA Arch Derm Syphilol 64(4):470–482PubMedCrossRefPubMedCentralGoogle Scholar
  10. Daenen M, Rogiers P, Van de Walle C, Rochette F, Demedts M, Nemery B (1999) Occupational asthma caused by palladium. Eur Respir J 13(1):213–216PubMedCrossRefGoogle Scholar
  11. Day GA, Dufresne A, Stefaniak AB, Schuler CR, Stanton ML, Miller WE, Kent MS, Deubner DC, Kreiss K, Hoover MD (2007) Exposure pathway assessment at a copper-beryllium alloy facility. Ann Occup Hyg 51(1):67–80PubMedPubMedCentralGoogle Scholar
  12. Drake PL, Hazelwood KJ (2005) Exposure-related health effects of silver and silver compounds: a review. Ann Occup Hyg 49(7):575–585PubMedPubMedCentralGoogle Scholar
  13. Ergun R, Evcik E, Ergun D, Ergan B, Ozkan E, Gunduz O (2017) High-resolution computed tomography and pulmonary function findings of occupational arsenic exposure in workers. Balkan Med J 34(3):263–268PubMedPubMedCentralCrossRefGoogle Scholar
  14. Fage SW, Faurschou A, Thyssen JP (2014) Copper hypersensitivity. Contact Dermatitis 71(4):191–201PubMedCrossRefPubMedCentralGoogle Scholar
  15. Faurschou A, Menné T, Johansen JD, Thyssen JP (2011) Metal allergen of the 21st century–a review on exposure, epidemiology and clinical manifestations of palladium allergy. Contact Dermatitis 64(4):185–195PubMedCrossRefPubMedCentralGoogle Scholar
  16. Fowler JF Jr, Perryman JH, Quinlan B (2008) Positive patch-test reactions to platinum are rare. Dermatitis 19(3):146–147PubMedCrossRefPubMedCentralGoogle Scholar
  17. Franken A, Eloff FC, Du Plessis J, Badenhorst CJ, Jordaan A, Du Plessis JL (2014) In vitro permeation of platinum and rhodium through Caucasian skin. Toxicol In Vitro 28(8):1396–1401PubMedCrossRefPubMedCentralGoogle Scholar
  18. Fukuyama T, Ueda H, Hayashi K, Tajima Y, Shuto Y, Kosaka T, Harada T (2008) Sensitizing potential of chromated copper arsenate in local lymph node assays differs with the solvent used. J Immunotoxicol 5(2):99–106PubMedCrossRefPubMedCentralGoogle Scholar
  19. Gawkrodger DJ (2004) Occupational skin cancers. Occup Med (Lond) 54(7):458–463CrossRefGoogle Scholar
  20. Gebhart M, Geier J (1996) Evaluation of patch test results with denture material series. Contact Dermatitis 34(3):191–195PubMedCrossRefGoogle Scholar
  21. Geier J, Vieluf D, Fuchs T (1996) Patch testing with cadmium chloride. Contact Dermatitis 34(1):73–74PubMedCrossRefGoogle Scholar
  22. Goh CL (1985) Irritant dermatitis from tri-N-butyl tin oxide in paint. Contact Dermatitis 12(3):161–163PubMedCrossRefGoogle Scholar
  23. Goossens A, Cattaert N, Nemery B, Boey L, De Graef E (2011) Occupational allergic contact dermatitis caused by rhodium solutions. Contact Dermatitis 64(3):158–161PubMedCrossRefGoogle Scholar
  24. Hostynek JJ, Maibach HI (2004) Copper hypersensitivity: dermatologic aspects. Dermatol Ther 17(4):328–333PubMedCrossRefPubMedCentralGoogle Scholar
  25. Hostynek JJ, Maibach HI (2006) Skin penetration by metal compounds with special reference to copper. Toxicol Mech Methods 16(5):245–265PubMedCrossRefGoogle Scholar
  26. IARC (International Agency for Research on Cancer) (2012) Monograph: occupational exposures during Aluminium production. Vol 100(F) chemical agents and related occupations. World Health Organization, LyonGoogle Scholar
  27. Jansen Van Rensburg S, Franken A, Du Plessis J, Du Plessis JL (2017) The influence of pH on the in vitro permeation of rhodium through human skin. Toxicol Ind Health 33(6):487–494PubMedCrossRefGoogle Scholar
  28. Järup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182PubMedPubMedCentralCrossRefGoogle Scholar
  29. Julander A, Skare L, Mulder M, Grander M, Vahter M, Lidén C (2010) Skin deposition of nickel, cobalt, and chromium in production of gas turbines and space propulsion components. Ann Occup Hyg 54(3):340–350PubMedGoogle Scholar
  30. Kanerva L, Komulainen M, Estlander T, Jolanki R (1993) Occupational allergic contact dermatitis from mercury. Contact Dermatitis 28(1):26–28PubMedCrossRefGoogle Scholar
  31. Karlberg AT, Boman A, Wahlberg JE (1983) Copper–a rare sensitizer. Contact Dermatitis 9(2):134–139PubMedCrossRefGoogle Scholar
  32. Kligman AM (1966) The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers. J Invest Dermatol 47(5):393–409PubMedCrossRefGoogle Scholar
  33. Kreiss K, Day GA, Schuler CR (2007) Beryllium: a modern industrial hazard. Annu Rev Public Health 28:259–277PubMedCrossRefGoogle Scholar
  34. Krewski D, Yokel RA, Nieboer E, Borchelt D, Cohen J, Harry J, Kacew S, Lindsay J, Mahfouz AM, Rondeau V (2007) Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev 10(Suppl 1):1–269PubMedPubMedCentralCrossRefGoogle Scholar
  35. Larese Filon F, Crosera M, Mauro M, Baracchini E, Bovenzi M, Montini T, Fornasiero P, Adami G (2016) Palladium nanoparticles exposure: evaluation of permeation through damaged and intact human skin. Environ Pollut 214:497–503PubMedCrossRefGoogle Scholar
  36. Lee JY, Yoo JM, Cho BK, Kim HO (2001) Contact dermatitis in Korean dental technicians. Contact Dermatitis 45(1):13–16PubMedCrossRefGoogle Scholar
  37. Lidén C (1994) Cold-impregnated aluminium. A new source of nickel exposure. Contact Dermatitis 31(1):22–24PubMedCrossRefGoogle Scholar
  38. Lidén C, Wahlberg JE, Maibach HI (1995) Skin. In: Goyer RA, Klaassen CD, Waalkes MP (eds) Metal toxicology. Academic, San Diego, pp 447–464CrossRefGoogle Scholar
  39. Lidén C, Nordenadler M, Skare L (1998) Metal release from gold-containing jewelry materials: no gold release detected. Contact Dermatitis 39(6):281–285PubMedCrossRefGoogle Scholar
  40. Lidén C, Skare L, Nise G, Vahter M (2008) Deposition of nickel, chromium, and cobalt on the skin in some occupations - assessment by acid wipe sampling. Contact Dermatitis 58(6):347–354PubMedCrossRefGoogle Scholar
  41. Lidén C, Bruze M, Thyssen JP, Menné T (2011) Metals. In: Johansen JD, Frosch P, Lepoittevin J-P (eds) Contact dermatitis, 5th edn. Springer, Berlin, pp 643–680CrossRefGoogle Scholar
  42. Mauro M, Crosera M, Bianco C, Adami G, Montini T, Fornasiero P, Jaganjac M, Bovenzi M, Filon FL (2015) Permeation of platinum and rhodium nanoparticles through intact and damaged human skin. J Nanopart Res 17(6):253CrossRefGoogle Scholar
  43. Menné T, Andersen KE, Kaaber K, Osmundsen PE, Andersen JR, Yding F, Valeur G (1987) Tin: an overlooked contact sensitizer? Contact Dermatitis 16(1):9–10PubMedCrossRefPubMedCentralGoogle Scholar
  44. Molin L, Wahlberg JE (1975) Toxic skin reactions caused by tributyltin oxide (tbto) in socks. Berufsdermatosen 23(4):138–142PubMedPubMedCentralGoogle Scholar
  45. Munro-Ashman D, Munro DD, Hughes TH (1969) Contact dermatitis from palladium. Trans St Johns Hosp Dermatol Soc 55(2):196–197PubMedPubMedCentralGoogle Scholar
  46. Muris J, Kleverlaan CJ, Feilzer AJ, Rustemeyer T (2008) Sodium tetrachloropalladate (Na2[PdCl4]) as an improved test salt for palladium allergy patch testing. Contact Dermatitis 58(1):42–46PubMedCrossRefPubMedCentralGoogle Scholar
  47. Muris J, Goossens A, Goncalo M, Bircher AJ, Gimenez-Arnau A, Foti C, Rustemeyer T, Feilzer AJ, Kleverlaan CJ (2015) Sensitization to palladium and nickel in Europe and the relationship with oral disease and dental alloys. Contact Dermatitis 72(5):286–296PubMedCrossRefPubMedCentralGoogle Scholar
  48. Nielsen NH, Skov L (1998) Occupational allergic contact dermatitis in a patient with a positive patch test to tin. Contact Dermatitis 39(2):99–100PubMedCrossRefPubMedCentralGoogle Scholar
  49. Peters T, Hani N, Kirchberg K, Gold H, Hunzelmann N, Scharffetter-Kochanek K (1998) Occupational contact sensitivity to aluminium in a machine construction plant worker. Contact Dermatitis 39(6):322–323PubMedCrossRefPubMedCentralGoogle Scholar
  50. Pirot F, Millet J, Kalia YN, Humbert P (1996a) In vitro study of percutaneous absorption, cutaneous bioavailability and bioequivalence of zinc and copper from five topical formulations. Skin Pharmacol 9(4):259–269PubMedCrossRefGoogle Scholar
  51. Pirot F, Panisset F, Agache P, Humbert P (1996b) Simultaneous absorption of copper and zinc through human skin in vitro: influence of counter-ion and vehicle. Skin Pharmacol 9(1):43–52PubMedCrossRefGoogle Scholar
  52. Pluut OA, Bianco C, Jakasa I, Visser MJ, Krystek P, Larese-Filon F, Rustemeyer T, Kezic S (2015) Percutaneous penetration of silver from a silver containing garment in healthy volunteers and patients with atopic dermatitis. Toxicol Lett 235(2):116–122PubMedCrossRefGoogle Scholar
  53. Quenan S, Huber C, Pasche-Koo F, Piletta P (2014) Airborne allergic contact dermatitis caused by tin. Contact Dermatitis 71(3):184–185PubMedCrossRefGoogle Scholar
  54. Rietschel RL, Fowler JFJ (2008) Metals. In: Fisher’s contact dermatitis, 6th edn. BC Decker Inc, Hamilton, pp 641–699Google Scholar
  55. Sartorelli P, Montomoli L, Sisinni AG, Barabesi L, Bussani R, Cherubini Di Simplicio F (2003) Percutaneous penetration of inorganic mercury from soil: an in vitro study. Bull Environ Contam Toxicol 71(6):1091–1099PubMedCrossRefGoogle Scholar
  56. SCCS (Scientific Committee on Consumer Safety) (2014) Opinion on the safety of aluminium in cosmetic products. SCCS 1525/14, Revision of 18 June 2014. European Union 2014. ISSN 1831–4767Google Scholar
  57. Siemund I, Mowitz M, Zimerson E, Bruze M, Hindsen M (2017) Variation in aluminium patch test reactivity over time. Contact Dermatitis 75:288CrossRefGoogle Scholar
  58. Stefaniak AB, Virji MA, Day GA (2011) Release of beryllium from beryllium-containing materials in artificial skin surface film liquids. Ann Occup Hyg 55(1):57–69PubMedPubMedCentralGoogle Scholar
  59. Stingeni L, Brunelli L, Lisi P (2004) Contact sensitivity to rhodium and iridium in consecutively patch tested subjects. Contact Dermatitis 51(5–6):316–317PubMedCrossRefPubMedCentralGoogle Scholar
  60. Takeuchi Y, Iwase N, Suzuki M, Tsuyuki S (2000) Lichen planus with involvement of all twenty nails and the oral mucous membrane. J Dermatol 27(2):94–98PubMedCrossRefGoogle Scholar
  61. Vahter M, Åkesson A, Lidén C, Ceccatelli S, Berglund M (2007) Gender differences in the disposition and toxicity of metals. Environ Res 104(1):85–95PubMedCrossRefGoogle Scholar
  62. Wahlberg JE (1977) Routine patch testing with cadmium chloride. Contact Dermatitis 3(6):293–296PubMedCrossRefGoogle Scholar
  63. Wahlberg JE, Boman A (1979) Guinea pig maximization test method - cadmium chloride. Contact Dermatitis 5(6):405PubMedCrossRefGoogle Scholar
  64. Wahlberg JE, Boman A (1985) Guinea pig maximization test. Curr Probl Dermatol 14:59–106PubMedCrossRefGoogle Scholar
  65. Wahlberg JE, Boman AS (1992) Cross-reactivity to palladium and nickel studied in the guinea pig. Acta Derm Venereol 72(2):95–97PubMedPubMedCentralGoogle Scholar
  66. Wahlberg JE, Lidén C (1999) Cross-reactivity patterns of palladium and nickel studied by repeated open applications (ROATs) to the skin of guinea pigs. Contact Dermatitis 41(3):145–149PubMedCrossRefGoogle Scholar
  67. Watsky KL (2007) Occupational allergic contact dermatitis to platinum, palladium, and gold. Contact Dermatitis 57(6):382–383PubMedCrossRefGoogle Scholar
  68. Wild P, Bourgkard E, Paris C (2009) Lung cancer and exposure to metals: the epidemiological evidence. Methods Mol Biol 472:139–167PubMedCrossRefGoogle Scholar
  69. Wöhrl S, Hemmer W, Focke M, Götz M, Jarisch R (2001) Copper allergy revisited. J Am Acad Dermatol 45(6):863–870PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Environmental MedicineKarolinska InstitutetStockholmSweden

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