Immunology and Barrier Function of the Skin
A disturbed epidermal barrier may lead to irritant contact dermatitis.
An enhanced penetration through skin barrier may facilitate sensitization.
Immunological effects induced by pre-irritation and barrier alteration may further lead to the induction of allergic Type IV-contact dermatitis and Type I (immediate-type reaction) reactions or aggravate allergic reactions.
KeywordsAtopic eczema (AE) Cornified cell envelope Epidermal permeability barrier Filaggrin Keratohyalin Netherton’s syndrome (NS) Transepidermal water loss (TEWL)
- Elias PM, Feingold KR (2006) Permeability barrier homeostasis. In: Elias PM, Feingold KR (eds) Skin barrier. Taylor and Francis, New York/LondonGoogle Scholar
- Fartasch M (2005) Atopic dermatitis and other skin diseases. In: Fluhr J, Elsner P, Berardesca E, Maibach F (eds) Bioengineering of the skin: water and stratum corneum, 2nd edn. CRC Press, Boca Raton, pp 160–169Google Scholar
- Grabbe S, Steinert M, Mahnke K et al (1996) Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 98:1158–1164PubMedPubMedCentralCrossRefGoogle Scholar
- Hoath S (2001) The skin as a neurodevelopmental interface. Neo Rev 2:269–281Google Scholar
- Menon G, Fartasch M (2010) Structural and functional correlations of skin barrier in health and disease: models and evaluation. In: Monteiro-Riviere NA (ed) Toxicology of the skin: targets organ series. Informa Healthcare, New YorkGoogle Scholar