Metrology for Metal Nanoparticles

  • Natalia L. PacioniEmail author
Reference work entry


Applications and implications of manufactured or engineered metal nanoparticles (MNP) are also, in most cases, dependent on concentration. Thus, determining accurately the amount of MNP is relevant in different fields beyond analytical chemistry and requires a good knowledge on how to report the concentration and which are the analytical methodologies suitable to quantify these analytes. This chapter intends to give the main concepts and analytical strategies developed up to date for MNP, in a manner easily accessible for readers from different areas of expertise. It covers useful methodologies for determining MNP in synthesis outcomes as well as at environmental trace levels, including their limitations.


  1. 1.
    Bureau International des Poids et Mesures What is metrology? Accessed 03 July 2017
  2. 2.
    McNaught AD, Wilkinson A (1997) IUPAC. Compendium of chemical terminology, (the “gold book”), 2nd edn. Blackwell Scientific Publications, OxfordGoogle Scholar
  3. 3.
    Laborda F, Bolea E, Cepriá G, Gómez M, Jiménez M, Pérez-Arantegui J, Castillo J (2016) Detection, characterization and quantification of inorganic engineered nanomaterials: a review of techniques and methodological approaches for the analysis of complex samples. Anal Chim Acta 904:10–32. Scholar
  4. 4.
    Xing B, Vecitis CD, Senesi N (2016) Engineered nanoparticles and the environment. Biophysicochemical processes and toxicity. Wiley, New JerseyCrossRefGoogle Scholar
  5. 5.
    Buzea C, Pacheco I, Robbie K (2007) Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2:MR17–MR71. Scholar
  6. 6.
    López-Serrano A, Olivas R, Landaluze J, Cámara C (2015) Nanoparticles: a global vision. Characterization, separation, and quantification methods. Potential environmental and health impact. Anal Methods 6:38–56CrossRefGoogle Scholar
  7. 7.
    Cooke M (2009) Emerging contaminants-nanomaterials (EPA 505-F-09-011)Google Scholar
  8. 8.
    Kühnel D, Nickel C (2014) The OECD expert meeting on ecotoxicology and environmental fate – towards the development of improved OECD guidelines for the testing of nanomaterials. Sci Total Environ 472:347–353. Scholar
  9. 9.
    Grassian V, Haes A, Mudunkotuwa I, Demokritou P, Kane A, Murphy C, Hutchison J, Isaacs J, Jun Y, Karn B, Khondaker S, Larsen S, Lau B, Pettibone J, Sadik O, Saleh N, Teague C (2016) NanoEHS – defining fundamental science needs: no easy feat when the simple itself is complex. Env Sci Nano 27. Scholar
  10. 10.
    Zänker H, Schierz A (2012) Engineered nanoparticles and their identification among natural nanoparticles. Annu Rev Anal Chem 5:107–132. Scholar
  11. 11.
    Ahumada M, Lissi E, Montagut AM, Valenzuela-Henríquez F, Pacioni NL, Alarcón EI (2017) Association models for binding of molecules to nanostructures. Analyst 142:2067–2089CrossRefGoogle Scholar
  12. 12.
    Baalousha M, Lead JR (2015) Characterization of nanomaterials in complex environmental and biological media. Elsevier, NetherlandsGoogle Scholar
  13. 13.
    Thomas R (2004) Robert practical guide to ICP-MS. Marcel Dekker, New YorkGoogle Scholar
  14. 14.
    Laborda F, Bolea E, Jiménez-Lamana J (2014) Single particle inductively coupled plasma mass spectrometry: a powerful tool for nanoanalysis. Anal Chem 86:2270–2278. Scholar
  15. 15.
    Huynh K, Siska E, Heithmar E, Tadjiki S, Pergantis S (2016) Detection and quantification of silver nanoparticles at environmentally relevant concentrations using asymmetric flow field–flow fractionation online with single particle inductively coupled plasma mass spectrometry. Anal Chem 88:4909–4916. Scholar
  16. 16.
    Borges D, Holcombe J (2017) Graphite furnace atomic absorption spectrometry. In: Encyclopedia of analytical chemistry. Meyers R. Ed. Wiley, Chichester, pp 1–20.
  17. 17.
    Gallego-Urrea J, Tuoriniemi J, Hassellöv M (2011) Applications of particle-tracking analysis to the determination of size distributions and concentrations of nanoparticles in environmental, biological and food samples. TrAC Trends Anal Chem 30:473–483. Scholar
  18. 18.
    Anabitarte F, Cobo A, Lopez-Higuera J (2012) Laser-induced breakdown spectroscopy: fundamentals, applications, and challenges. ISRN Spectrosc 2012:1–12. Scholar
  19. 19.
    Thang N, Knopp R, Geckeis H, Kim J, Beck H (1999) Detection of nanocolloids with flow-field flow fractionation and laser-induced breakdown detection. Anal Chem 72:1–5CrossRefGoogle Scholar
  20. 20.
    Cayuela A, Soriano M, Carrión M, Valcárcel M (2014) Functionalized carbon dots as sensors for gold nanoparticles in spiked samples: formation of nanohybrids. Anal Chim Acta 820:133–138. Scholar
  21. 21.
    Cayuela A, Soriano M, Valcárcel M (2015) Reusable sensor based on functionalized carbon dots for the detection of silver nanoparticles in cosmetics via inner filter effect. Anal Chim Acta 872:70–76. Scholar
  22. 22.
    Pacioni NL, Veglia AV (2016) Analytical strategy to detect metal nanoparticles in mixtures without previous separation. Sens Actuators B Chem 228:557–564. Scholar
  23. 23.
    Mahmoudi M, Lohse S, Murphy C, Suslick K (2016) Identification of nanoparticles with a colorimetric sensor array. ACS Sens 1:17–21. Scholar
  24. 24.
    Weinberg H, Galyean A, Leopold M (2011) Evaluating engineered nanoparticles in natural waters. TrAC Trends Anal Chem 30:72–83. Scholar
  25. 25.
    Chao J, Liu J, Yu S, Feng Y, Tan Z, Liu R, Yin Y (2011) Speciation analysis of silver nanoparticles and silver ions in antibacterial products and environmental waters via cloud point extraction-based separation. Anal Chem 83:6875–6882. Scholar
  26. 26.
    Liu J, Yu S, Yin Y, Chao J (2012) Methods for separation, identification, characterization and quantification of silver nanoparticles. TrAC Trends Anal Chem 33:95–106. Scholar
  27. 27.
    Kammer F, Legros S, Hofmann T, Larsen E, Loeschner K (2011) Separation and characterization of nanoparticles in complex food and environmental samples by field-flow fractionation. TrAC Trends Anal Chem 30:425–436. Scholar

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Authors and Affiliations

  1. 1.Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química OrgánicaCórdobaArgentina
  2. 2.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)INFIQC-Ciudad UniversitariaCórdobaArgentina

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