The MRC2 gene encodes the constitutively recycling type I transmembrane receptor Endo180 (Wu et al. 1996; Sheikh et al. 2000; Isacke et al. 1990), which is also cited in the literature as urokinase plasminogen activator receptor associated protein (uPARAP) following its identification as part of a trimolecular complex with pro-urokinase plasminogen activator (pro-uPA) and its receptor urokinase plasminogen activator receptor ( uPAR) (Behrendt et al. 2000). Endo180 is a member of the mannose receptor family, which also includes the mannose receptor (MR; CD206), M-type phospholipase A2 receptor, and DEC-205 (CD205) (East and Isacke 2002). The constitutive recycling of Endo180 between clathrin-coated pits at the plasma...
- Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, et al. Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells. J Neurooncol. 2010. https://doi.org/10.1007/s11060-010-0398-z.