G Protein Beta/Gamma
Five different isoforms of Gbeta have been identified, numbered 1 to 5. Ggamma isoforms are numbered from 1 to 5 and 7 to 13.
G protein beta5 can also be known as Flailer, Flail, Flr, Hug.
G protein gamma2 is also known as G protein gamma6.
G protein β and γ subunits were first discovered as components of G proteins over 30 years ago. Since then, their role has evolved significantly from simple inhibitors of G protein αsubunits to independent signaling regulators modulating a number of different cellular effectors. Although several isoforms of Gα were cloned in the early 1980s, it was not until 1986 that the transducin Gβ subunit was cloned...