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Encyclopedia of Signaling Molecules pp 5719–5727Cite as

TRP (Transient Receptor Potential Cation Channel)

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Synonyms

Ankyrine-rich TRP channel, ANKTM1, TRPA1; Classic TRP channels, TRPC1-7; Melastatin-like TRP channels, TRPM1-8; Mucolipins, TRPML1-3; Polycystines, TRPPs; TRP; TRPL; Vanilloid-like TRP channels, TRPV1-6

Historical Background

Calcium is integrated in many physiological processes like muscle contraction, hormone secretion, and intracellular signaling processes (calcium signaling). Prerequisite for this role is the 10,000-fold gradient across the plasma membrane with 2.5 mM extracellular and resting intracellular calcium ion concentration of approximately 100 nM. Calcium ATPases (Plasma membrane calcium-transporting ATPase) and transporters manage the extrusion of calcium whereas calcium-permeable ion channels enable rapid increases in intracellular calcium up to micromolar concentrations. The biological functions of calcium are mediated by direct calcium binding of the modulated proteins or by protein–protein interaction with calcium sensor proteins (calmodulin, CaBP,...

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References

  • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–84.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Birnbaumer L. The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca2+ concentrations. Annu Rev Pharmacol Toxicol. 2009;49:395–426.

    Article  PubMed  CAS  Google Scholar 

  • Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997;389:816–24.

    Article  PubMed  CAS  Google Scholar 

  • Christensen AP, Corey DP. TRP channels in mechanosensation: direct or indirect activation? Nat Rev Neurosci. 2007;8:510–21.

    Article  PubMed  CAS  Google Scholar 

  • Harteneck C. Function and pharmacology of TRPM cation channels. Naunyn Schmiedebergs Arch Pharmacol. 2005;371:307–14.

    Article  PubMed  CAS  Google Scholar 

  • Harteneck C, Reiter B. TRP channels activated by extracellular hypo-osmoticity in epithelia. Biochem Soc Trans. 2007;35:91–5.

    Article  PubMed  CAS  Google Scholar 

  • Harteneck C, Plant TD, Schultz G. From worm to man: three subfamilies of TRP channels. Trends Neurosci. 2000;23:159–66.

    Article  PubMed  CAS  Google Scholar 

  • Hoenderop JG, Bindels RJ. Calciotropic and magnesiotropic TRP channels. Physiol Bethesda. 2008;23:32–40.

    Article  CAS  Google Scholar 

  • Liedtke W. Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. Exp Physiol. 2007;92:507–12.

    Article  PubMed  CAS  Google Scholar 

  • Montell C, Rubin GM. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron. 1989;2:1313–23.

    Article  PubMed  CAS  Google Scholar 

  • Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol Cell. 2002;9:229–31.

    Article  PubMed  CAS  Google Scholar 

  • Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov. 2009;8:55–68.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Puertollano R, Kiselyov K. TRPMLs: in sickness and in health. Am J Physiol Ren Physiol. 2009;296:F1245–54.

    Article  CAS  Google Scholar 

  • Talavera K, Nilius B, Voets T. Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci. 2008;31:287–95.

    Article  PubMed  CAS  Google Scholar 

  • Venkatachalam K, Montell C. TRP channels. Annu Rev Biochem. 2007;76:387–417.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vriens J, Appendino G, Nilius B. Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol. 2009;75:1262–79.

    Article  PubMed  CAS  Google Scholar 

  • Woudenberg-Vrenken TE, Bindels RJ, Hoenderop JG. The role of transient receptor potential channels in kidney disease. Nat Rev Nephrol. 2009;5:441–9.

    Article  PubMed  CAS  Google Scholar 

  • Wu LJ, Sweet TB, Clapham DE. International union of basic and clinical pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev. 2010;62:381–404.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhou J. Polycystins and primary cilia: primers for cell cycle progression. Annu Rev Physiol. 2009;71:83–113.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Interfaculty Center of Pharmacogenomics and Pharmaceutical Research (ICePhA), Eberhard-Karls-University, Wilhelmstraße 56, 72074, Tübingen, Germany

    Christian Harteneck

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  1. Christian Harteneck
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Correspondence to Christian Harteneck .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Harteneck, C. (2018). TRP (Transient Receptor Potential Cation Channel). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_72

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