Regulatory particle triple-A (Rpt) subunits are associated with the ubiquitin-proteasome system, a central mechanism of protein breakdown with a rich historical background. Aaron Ciechanover, Avram Hershko, and Irwin Rose were awarded the 2004 Nobel Prize in Chemistry for their “discovery of ubiquitin-mediated protein degradation” by proteasomes and have outlined some of this history in reviews (e.g., Ciechanover 2010). The term “proteasome” was first coined by Arrigo et al. (1988) for a “large alkaline multifunctional protease” known to mediate energy-dependent intracellular protein breakdown, once it was clear that this protease was related to the ring-shaped “prosomes” of unknown function commonly found in eukaryotic cells. The Rpt nomenclature was later...
This work was funded in part by grants from the National Institutes of Health (GM57498) and the Department of Energy Office of Basic Energy Sciences (DE-FG02-05ER15650).
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