Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Julie A. Maupin-FurlowEmail author
  • Hugo V. Miranda
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_65


Historical Background

Regulatory particle triple-A (Rpt) subunits are associated with the ubiquitin-proteasome system, a central mechanism of protein breakdown with a rich historical background. Aaron Ciechanover, Avram Hershko, and Irwin Rose were awarded the 2004 Nobel Prize in Chemistry for their “discovery of ubiquitin-mediated protein degradation” by proteasomes and have outlined some of this history in reviews (e.g., Ciechanover 2010). The term “proteasome” was first coined by Arrigo et al. (1988) for a “large alkaline multifunctional protease” known to mediate energy-dependent intracellular protein breakdown, once it was clear that this protease was related to the ring-shaped “prosomes” of unknown function commonly found in eukaryotic cells. The Rpt nomenclature was later...

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This work was funded in part by grants from the National Institutes of Health (GM57498) and the Department of Energy Office of Basic Energy Sciences (DE-FG02-05ER15650).


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Microbiology and Cell ScienceUniversity of FloridaGainesvilleUSA