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Encyclopedia of Signaling Molecules pp 1927–1940Cite as

G Protein α i/o/z

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Synonyms

Adenylyl cyclase inhibitory Gi alpha subunit; G alpha (o); G alpha z; G protein alpha i; G protein alpha o; G protein alpha z; G protein a i; G protein a o; G protein a z; Gi protein alpha subunit; GNAI; GNAO; GNAO1; GNAZ; Go alpha subunit; Guanine nucleotide binding protein, alpha inhibiting; Guanine nucleotide binding protein, alpha o; Guanine nucleotide binding protein, alpha z subunit; Guanine nucleotide binding regulatory protein, alpha i; Gz alpha subunit

Historical Background: Discovery of G Protein α i as the Inhibitor of Hormone-Stimulated Adenylyl Cyclase Activity

During the discovery purification that identified G protein (alpha) s (Gαs) as the adenylyl cyclase activator, Gilman and colleagues noted a 41 kDa contaminating protein (now known as G protein alpha i (Gαi)) that persisted into the final stages of the Gsαβγ heterotrimer purification. Hormonal activation and inhibition of adenylyl cyclasewere known at the time to be GTP-dependent. The 41 kDa protein was...

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Authors and Affiliations

  1. Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 114 Doughty St., STB331, Charleston, SC, 29425, USA

    Joe B. Blumer

  2. Department of Neurosciences, Medical University of South Carolina, 114 Doughty St., STB331, Charleston, SC, 29425, USA

    Joe B. Blumer

  3. Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Ave., 711, Rochester, NY, 14642, USA

    Gregory G. Tall

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  1. Joe B. Blumer
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  2. Gregory G. Tall
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Correspondence to Joe B. Blumer .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Blumer, J.B., Tall, G.G. (2018). G Protein α i/o/z. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_648

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