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Encyclopedia of Signaling Molecules pp 1769–1778Cite as

Flotillin-1 (FLOT1)

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Synonyms

Reggie-2 (Reg-2)

Historical Background

Flotillin-1 was originally identified in 1997, when Bickel et al. analyzed caveolin-rich membrane fractions from mouse lung and isolated a 45 kDa protein that was microsequenced. Degenerate primers were designed from the peptide sequences and used for PCR of mouse lung cDNA. The PCR-product was then used as a probe for screening of a 3T3-L1 adipocyte cDNA library. The characterized sequence showed similarity to the ESA protein. An antipeptide antibody identified a 47 kDa protein on Western blots. Because this protein was detected in floating, caveolin-rich, Triton X-100-insoluble membrane fractions, it was termed “flotillin-1.” The similar ESA protein (47% identity) was renamed as “flotillin-2.” Also in 1997, Schulte et al. identified and characterized two proteins that were induced in regenerating fish retinal ganglion cell axons after injury and thus were named “reggie-1” and “reggie-2.” In 1998, Lang et al. cloned the rat reggie...

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References

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Author information

Authors and Affiliations

  1. Max F. Perutz Laboratories (MFPL), Medical University of Vienna, A-1030, Vienna, Austria

    Rainer Prohaska & Ulrich Salzer

Authors
  1. Rainer Prohaska
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  2. Ulrich Salzer
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Corresponding author

Correspondence to Rainer Prohaska .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Prohaska, R., Salzer, U. (2018). Flotillin-1 (FLOT1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_645

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