Delta Glutamate Receptor (GluD1, GluD2)
The δ1 glutamate receptor (GluRδ1 and GluD1) and the δ2 glutamate receptor (GluRδ2 and GluD2) were cloned by homology screening in 1993 at the end of the “gold rush” for cloning of ionotropic glutamate receptor (iGluR) cDNA. They were regarded as orphan receptors for a long time since their endogenous ligands were unknown. GluD1 is highly expressed in hair cells of the auditory and vestibular systems in adult mice. Indeed, deletion of a gene encoding GluD1 (grid1) in mice leads to deficit in high-frequency hearing. In contrast, GluD2 is predominantly expressed in cerebellar Purkinje cells and deletion of a gene encoding GluD2 (grid2) results in cerebellar ataxia and characteristic phenotypes at parallel fiber (PF)–Purkinje cell synapses. Functionally, the long-term depression (LTD) of synaptic transmission, which is thought to underlie motor coordination and motor learning, is completely blunted. Morphologically,...
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