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FoxO1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 92 Accesses

Synonyms

FKH1; FKHR; Forkhead box O1; Forkhead box protein O1; Forkhead in rhabdomyosarcoma

Background

FoxO1 [NCBI Accession:NM002015] belongs to the forkhead box O family that is characterized by a highly conserved DNA binding motif, known as forkhead box or winged helix domain (Accili and Arden 2004). This family contains four distinct isoforms namely FoxO1, FoxO3, FoxO4, and FoxO6, all of which are ubiquitously expressed in the body. FoxO1, also known as FKHR (forkhead in rhabdomyosarcoma), is initially described by Galili et al. (1993) as the product of the t(2;13)(q35;q14) translocation associated with alveolar rhabdomyosarcoma, a cancer of connective tissue that usually develops in children. Subsequent studies characterize FoxO1 as a key nuclear factor that mediates the inhibitory effect of insulin or insulin-like growth factor 1 (IGF-1) on the expression of genes, whose functions are instrumental for cell growth, differentiation, oxidative stress, survival, and metabolism in...

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Authors and Affiliations

  1. Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, 4401 Penn Avenue, 15224, Pittsburgh, PA, USA

    Jun Yamauchi & H. Henry Dong

  2. Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busandaehak-ro 63beon-gil, Geumjeong-gu, 609-735, Busan, Korea

    Dae Hyun Kim

Authors
  1. Jun Yamauchi
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  2. Dae Hyun Kim
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  3. H. Henry Dong
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Correspondence to H. Henry Dong .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Yamauchi, J., Kim, D.H., Henry Dong, H. (2018). FoxO1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_634

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