Synonyms
Historical Background
Rab23 (Ras-related protein Rab 23) belongs to the Rab family of monomeric small guanosine triphosphatases (GTPases) involved in the regulation of membrane traffic. Rab GTPases are conserved from yeast to humans and coordinate the delivery of cargo to its correct destination within eukaryotic cells. Rab proteins regulate many membrane trafficking steps, including vesicle formation, budding, motility along the cytoskeleton, docking, and membrane fusion (Zerial and McBride 2001; Stenmark 2009). More than 60 members of the Rab family have been identified in humans to date (Zerial and McBride 2001). Rab proteins function as molecular switches cycling from an active GTP (guanosine triphosphate)-bound form to an inactive GDP (guanosine diphosphate)-bound form. The GDP/GTP exchange factors (GEFs) catalyze the conversion from GDP to GTP-bound forms, whereas GTP hydrolysis to GDP is catalyzed by GTPase-activating...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Alessandri JL, Dagoneau N, Laville JM, Baruteau J, Hebert JC, Cormier-Daire V. RAB23 mutation in a large family from Comoros Islands with Carpenter syndrome. Am J Med Genet A. 2010;152A:982–6.
Boehlke C, Bashkurov M, Buescher A, et al. Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels. J Cell Sci. 2010;123(9):1460–7.
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF. Vertebrate smoothened functions at the primary cilium. Nature. 2005;437:1018–21.
Doudney K, Stanier P. Epithelial cell polarity genes are required for neural tube closure. Am J Med Genet C: Semin Med Genet. 2005;135C:42–7.
Eggenschwiler JT, Espinoza E, Anderson KV. Rab23 is an essential negative regulator of the mouse sonic hedgehog signalling pathway. Nature. 2001;412:194–8.
Eggenschwiler JT, Bulgakov OV, Qin J, Li T, Anderson KV. Mouse Rab23 regulates hedgehog signaling from smoothened to gli proteins. Dev Biol. 2006;290:1–12.
Ericson J, Rashbass P, Schedl A, et al. Pax6 controls progenitor cell identity and neuronal fate in response to graded shh signaling. Cell. 1997;90:169–80.
Evans TM, Ferguson C, Wainwright BJ, Parton RG, Wicking C. Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic. 2003;4:869–84.
Fanto M, McNeill H. Planar polarity from flies to vertebrates. J Cell Sci. 2004;117:527–33.
Gunther T, Struwe M, Aguzzi A, Schughart K. Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994;120:3119–30.
Hou Q, Wu YH, Grabsch H, et al. Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer Res. 2008;68:4623–30.
Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426:83–7.
Jenkins D, Seelow D, Jehee FS, et al. RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity. Am J Hum Genet. 2007;80:1162–70.
Kim J, Kato M, Beachy PA. Gli2 trafficking links hedgehog-dependent activation of smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2009;106:21666–71.
Leung KF, Baron R, Ali BR, Magee AI, Seabra MC. Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. J Biol Chem. 2007;282:1487–97.
Liu YJ, Wang Q, Li W, et al. Rab23 is a potential biological target for treating hepatocellular carcinoma. World J Gastroenterol. 2007;13:1010–7.
Olkkonen VM, Peterson JR, Dupree P, Lutcke A, Zerial M, Simons K. Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain. Gene. 1994;138:207–11.
Park TJ, Haigo SL, Wallingford JB. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. Nat Genet. 2006;38:303–11.
Pataki C, Matusek T, Kurucz E, Ando I, Jenny A, Mihaly J. Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs. Genetics. 2010;184(4):1051–65.
Rohatgi R, Milenkovic L, Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science. 2007;317:372–6.
Sheffield VC. The blind leading the obese: the molecular pathophysiology of a human obesity syndrome. Trans Am Clin Climatol Assoc. 2010;121:172–81. Discussion 181–2.
Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol. 2009;10:513–25.
Veland IR, Awan A, Pedersen LB, Yoder BK, Christensen ST. Primary cilia and signaling pathways in mammalian development, health and disease. Nephron Physiol. 2009;111:p39–53.
Yang L, Clinton JM, Blackburn ML, et al. Rab23 regulates differentiation of ATDC5 chondroprogenitor cells. J Biol Chem. 2008;283:10649–57.
Yoshimura S, Egerer J, Fuchs E, Haas AK, Barr FA. Functional dissection of Rab GTPases involved in primary cilium formation. J Cell Biol. 2007;178:363–9.
Zerial M, McBride H. Rab proteins as membrane organizers. Nat Rev Mol Cell Biol. 2001;2:107–17.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Gual-Soler, M., Taguchi, T., Stow, J.L., Wicking, C. (2018). Rab23. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_62
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_62
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences