Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

EphA3, Erythropoietin-Producing Hepatocellular Carcinoma Cell Receptor A3

  • Renping ZhouEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_628


Historical Background

A fragment of EphA3 was first cloned in 1991 by Sajjadi et al., in an expression-cloning screen of a chicken embryonic cDNA library using antibodies against phosphotyrosine (Sajjadi et al. 1991). Using this cDNA fragment as a probe, full-length cDNA from both chicken and mouse embryos were identified (Sajjadi et al. 1991). Human EphA3 was independently isolated as a cell surface antigen of a pre-B-cell leukemia cell line (Boyd et al. 1992; Wicks et al. 1992). EphA3 is a member of a large family of tyrosine kinase receptors, which plays many critical roles in both physiological and pathological conditions (Pasquale 2008).

EphA3 Protein

The full-length human EphA3 protein consists of 983 amino acids, organized into the typical extracellular, transmembrane, and intracellular domains as that of other Eph family tyrosine kinase receptors (Wicks et al. 1992). A splice variant, which contains...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Chemical Biology, Susan Lehman Cullman Laboratory for Cancer Research, Ernest Mario School of PharmacyRutgers UniversityPiscatawayUSA