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Encyclopedia of Signaling Molecules pp 5557–5566Cite as

TPL2

  • Reference work entry
  • First Online:

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Synonyms

Cancer Osaka thyroid oncogene; COT; Map3k8; Mitogen-activated protein kinase kinase kinase 8; Tumor progression locus 2

Historical Background

The Tpl2 gene, also known as COT and MAP3K8 (Vougioukalaki et al. 2011), was independently discovered by three research teams in the early 1990s. COT (Cancer Osaka thyroid) was initially described by Miyoshi et al. as a putative human proto-oncogene, isolated from a human thyroid carcinoma cell line and discovered to have a rearranged 3′ end in the last coding exon (Miyoshi et al. 1991). The rat homologue of COT, named tumor progression locus (Tpl2), was identified by Tsichlis et al. as a proto-oncogene that is activated by provirus integration in Moloney murine leukemia virus (MoMuLV)-induced T-cell lymphomas and capable to transform NIH 3T3 fibroblasts in vitro (Patriotis et al. 1993). In mice, the Tpl2gene locus is also targeted by provirus insertion in mouse mammary tumor virus (MMTV)-associated mammary carcinomas in mice (Erny et...

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Acknowledgments

Dimitra Vyrla was supported through the action “Funding of Postdoctoral Researchers” of the Operational Program “Development of Human Resources, Education and Lifelong Learning,” 2014–2020, implemented by State Schlolarships Foundation (IKY) and cofinanced by the European Social Fund and the Greek State.

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Authors and Affiliations

  1. Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, Heraklion, Crete, Greece

    Dimitra Virla & Aristides G. Eliopoulos

  2. Institute for Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas (FORTH), Heraklion, Crete, Greece

    Aristides G. Eliopoulos

  3. Department of Clinical Chemistry, University of Crete Medical School, Heraklion, Crete, Greece

    Christos Tsatsanis

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  1. Dimitra Virla
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Correspondence to Aristides G. Eliopoulos .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Virla, D., Tsatsanis, C., Eliopoulos, A.G. (2018). TPL2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_626

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