Reference work entry
The homeodomain-interacting protein kinase 2 (HIPK2) was first described in 1998 as member of a novel protein kinase family (HIPK1-3) able to interact with homeodomain transcription factors of the NK-2 family and to enhance their repressor activity (Kim et al. 1998). Over the next years, it was shown that HIPK2 very likely is an autophosphorylating Ser/Thr kinase which localizes to nuclear speckles (see Fig. 1), and a number of interaction partners and putative targets such as the death receptor CD95, the corepressor Groucho, or a STAT3 peptide were identified. The HIPK2 genes were mapped to Chr. 7q32–42 in humans and to Chr. 6B in the mouse.
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