Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MEK5/ERK5

  • Nhat-Tu Le
  • Nguyet Minh Hoang
  • Keigi Fujiwara
  • Jun-ichi Abe
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_617

Synonyms

Introduction

Mitogen-activated protein kinases (MAPKs) are evolutionarily conserved proteins that regulate multiple intracellular processes in all eukaryotic species, from protozoa to plants and vertebrates. Activation of the MAPK family is achieved by three distinct tiers of upstream kinases: The first tier is MAP kinase kinase kinases (MAPKKKs or MAP3Ks), which can respond to various extracellular signals such as mechanical stresses, oxidative stresses, and growth factors, and transduces these extracellular signals into intracellular signaling cascades that regulate various cellular responses. MAPKKKs include MEKK1/2/3/4 and A-/B-/C-Raf (Boulton et al. 1991; Widmann et al. 1999). These kinases activate their downstream...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Nhat-Tu Le
    • 1
  • Nguyet Minh Hoang
    • 1
  • Keigi Fujiwara
    • 1
  • Jun-ichi Abe
    • 1
  1. 1.Department of CardiologyThe University of Texas, MD Anderson Cancer CenterHoustonUSA